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The map label for this gene is glmS [H]

Identifier: 73539936

GI number: 73539936

Start: 255947

End: 257785

Strand: Direct

Name: glmS [H]

Synonym: Reut_A0230

Alternate gene names: 73539936

Gene position: 255947-257785 (Clockwise)

Preceding gene: 73539935

Following gene: 73539941

Centisome position: 6.72

GC content: 67.16

Gene sequence:

>1839_bases
ATGTGTGGCATCGTCGGCGCGGTTTCCACGCGCAACATCGTTCCGGTCCTGATCGAAGGCCTGCGCCGCCTCGAATACCG
CGGCTATGACTCCTGCGGCGTCGCCGTCGTGCGCGATAACGCTGTCGAGCGCGCACGCACGGTGTCGCGCGTGGCCGATC
TGGACGCCCAGACGCAGGCATCGGGCCTGGCGGGCACCACTGGCGTTGCGCACACGCGCTGGGCCACGCATGGCAAGCCC
GACACCGTGAACGCCCACCCGCACCTGTCCGGCGAAACCATCGCGCTGGTGCACAACGGCATCATCGAAAACTACGAGCC
ACTGCGCGAAGAGTTGCGCGCGGTCGGCTACGGCTTCGAGTCGCAGACCGACACCGAAGTCGTCGCCCACCTGATCCACC
AGGCCTACTGCTATCCGAGCAGCGCCACGCGCGGCGACCTGTTCGCATCGGTGCGCGCCGTGACCAAGCGCCTGCACGGC
GCCTACGCGATCGCCGTGTTCGCCAAGGACCAGCCCGAGCGCGTGGTCGGTGCACGCGCCGGCTCGCCGCTGGTGGTGGC
GCTCGGCGACGGCGAGGCCTTCCTCGCTTCGGACGCGCTGGCCGTGGCCGGCACGGCCAACCGCATCATCTACCTGGAAG
AGGGCGATGTCGTCGAGGTCACGCGCGACGGCGTGACCATCCACGACGGCCATGATCACCCGGTCGAACGCGAAGTGCGC
GTGGTGGAAGCGCATGCCGCCACGGTGGATCTGGGGCCGTACCGCCACTTCATGCAGAAGGAAATCTTCGAGCAGCCGCG
CGCGCTCGGCGACACGCTGGAAGGCGTCGACGGTATCTCGCCCGCGCTGTTCGGCGATCGTGCCGCCGAGGTGTTCCCGG
AGATCGACAGCGTCCTGATCCTGGCGTGCGGCACCAGCTACTACTCGGGCTGTACGGCGAAGTACTGGCTCGAAAGCATC
GCAAAGATCCCCACGCAGGTCGAAGTGGCCAGCGAGTACCGCTACCGGGACACGGTACCCAATCCGCGTGCGTTGGTCGT
GGTGATCTCGCAATCCGGTGAGACCGCCGACACCATGGCCGCGCTGCGCCATGCGCGCGCGCTCGGTCATACGCATACGC
TGTCGATCTGCAACGTGGCGACCAGCGCCATGGTTCGCGAGACCGAGATGCGCTTCCTTACGCGCGCCGGTACGGAAATC
GGCGTGGCGTCGACCAAGGCCTTCACCACTCAGCTCGCCGCGCTGTACATGCTGACGCTGGCCCTGGCCAAGGTGCGCGG
TTTCCTGTCGGAAGAAGCCGAGGCCAAGGACATGGCCAACCTGCGCCACCTGCCCGCCGCGCTGCATGGCGTGCTGGCGC
TGGAGCCGCAGATCATCGCGTGGTCGGAAGATTTCGCGCGCCGCGAGAACGCGCTGTTCCTCGGCCGCGGCATGCATTAC
CCGATCGCGCTTGAGGGCGCGCTCAAGCTCAAGGAAATCTCGTACATCCACGCCGAGGCGTATCCCGCCGGCGAACTCAA
GCACGGCCCGCTCGCGCTGGTGACCGAGGCCATGCCCGTGGTCACTGTGGCGCCGAACGATGCACTGCTCGAGAAGCTGA
AGTCCAACATTCAGGAAGTGCGCGCACGCGGCGGCCGCCTGTACGTGTTCGCCGACAGCGACACGCACATCCAGTCGACG
GATGGCATCCAGGTGATCCGCATGCCCGAGCACTATGGCGCCCTGTCGCCGATCCTGCATGTGGTGCCGCTGCAGCTGCT
GGCGTATCACACGGCGTGCGCACGCGGTACCGACGTGGACAAGCCGCGGAACCTGGCGAAGTCGGTGACGGTGGAGTAA

Upstream 100 bases:

>100_bases
ATACGACGGACGCAGTGTTGCGGCCGTTCCGGCGCGCCGCTGTGGCTGCGCAGGCATTGAAACAGGCGCCGGCATCGGCG
CCGAGCACGGGGGTACAGCC

Downstream 100 bases:

>100_bases
TCGGGCGCGCCTGGCGGCGCGTAAAACACATACGCCCGGCAAGAATGAGCCCCGCTTGTGCGGGGCTTCTTTATTAGGCG
AGATGGCAGGGCGTTACTTG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVVRDNAVERARTVSRVADLDAQTQASGLAGTTGVAHTRWATHGKP
DTVNAHPHLSGETIALVHNGIIENYEPLREELRAVGYGFESQTDTEVVAHLIHQAYCYPSSATRGDLFASVRAVTKRLHG
AYAIAVFAKDQPERVVGARAGSPLVVALGDGEAFLASDALAVAGTANRIIYLEEGDVVEVTRDGVTIHDGHDHPVEREVR
VVEAHAATVDLGPYRHFMQKEIFEQPRALGDTLEGVDGISPALFGDRAAEVFPEIDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMAALRHARALGHTHTLSICNVATSAMVRETEMRFLTRAGTEI
GVASTKAFTTQLAALYMLTLALAKVRGFLSEEAEAKDMANLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGMHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGRLYVFADSDTHIQST
DGIQVIRMPEHYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVVRDNAVERARTVSRVADLDAQTQASGLAGTTGVAHTRWATHGKP
DTVNAHPHLSGETIALVHNGIIENYEPLREELRAVGYGFESQTDTEVVAHLIHQAYCYPSSATRGDLFASVRAVTKRLHG
AYAIAVFAKDQPERVVGARAGSPLVVALGDGEAFLASDALAVAGTANRIIYLEEGDVVEVTRDGVTIHDGHDHPVEREVR
VVEAHAATVDLGPYRHFMQKEIFEQPRALGDTLEGVDGISPALFGDRAAEVFPEIDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMAALRHARALGHTHTLSICNVATSAMVRETEMRFLTRAGTEI
GVASTKAFTTQLAALYMLTLALAKVRGFLSEEAEAKDMANLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGMHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGRLYVFADSDTHIQST
DGIQVIRMPEHYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE
>Mature_612_residues
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVVRDNAVERARTVSRVADLDAQTQASGLAGTTGVAHTRWATHGKP
DTVNAHPHLSGETIALVHNGIIENYEPLREELRAVGYGFESQTDTEVVAHLIHQAYCYPSSATRGDLFASVRAVTKRLHG
AYAIAVFAKDQPERVVGARAGSPLVVALGDGEAFLASDALAVAGTANRIIYLEEGDVVEVTRDGVTIHDGHDHPVEREVR
VVEAHAATVDLGPYRHFMQKEIFEQPRALGDTLEGVDGISPALFGDRAAEVFPEIDSVLILACGTSYYSGCTAKYWLESI
AKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMAALRHARALGHTHTLSICNVATSAMVRETEMRFLTRAGTEI
GVASTKAFTTQLAALYMLTLALAKVRGFLSEEAEAKDMANLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGMHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEVRARGGRLYVFADSDTHIQST
DGIQVIRMPEHYGALSPILHVVPLQLLAYHTACARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=688, Percent_Identity=36.6279069767442, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=36.5356622998544, Blast_Score=398, Evalue=1e-111,
Organism=Escherichia coli, GI1790167, Length=616, Percent_Identity=53.0844155844156, Blast_Score=633, Evalue=0.0,
Organism=Escherichia coli, GI87082251, Length=320, Percent_Identity=24.0625, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788651, Length=171, Percent_Identity=28.6549707602339, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=715, Percent_Identity=34.5454545454545, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17532899, Length=714, Percent_Identity=33.7535014005602, Blast_Score=356, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=37.7622377622378, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17554892, Length=248, Percent_Identity=26.2096774193548, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322745, Length=453, Percent_Identity=37.0860927152318, Blast_Score=264, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=30, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6323730, Length=207, Percent_Identity=35.7487922705314, Blast_Score=113, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323958, Length=176, Percent_Identity=28.4090909090909, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21357745, Length=693, Percent_Identity=37.6623376623377, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI28573187, Length=263, Percent_Identity=25.0950570342205, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24659598, Length=263, Percent_Identity=23.1939163498099, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66233; Mature: 66233

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVVRDNAVERARTVSRVADLDAQTQA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHC
SGLAGTTGVAHTRWATHGKPDTVNAHPHLSGETIALVHNGIIENYEPLREELRAVGYGFE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHCCHHHHHHHHHHHCCCCC
SQTDTEVVAHLIHQAYCYPSSATRGDLFASVRAVTKRLHGAYAIAVFAKDQPERVVGARA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHCCC
GSPLVVALGDGEAFLASDALAVAGTANRIIYLEEGDVVEVTRDGVTIHDGHDHPVEREVR
CCCEEEEECCCCEEECCCCEEEECCCCEEEEEECCCEEEEECCCEEEECCCCCCCCHHEE
VVEAHAATVDLGPYRHFMQKEIFEQPRALGDTLEGVDGISPALFGDRAAEVFPEIDSVLI
EEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCCEEE
LACGTSYYSGCTAKYWLESIAKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMA
EEECCHHHCCCCHHHHHHHHHHCCCEEEHHHHCHHCCCCCCCCEEEEEEECCCCHHHHHH
ALRHARALGHTHTLSICNVATSAMVRETEMRFLTRAGTEIGVASTKAFTTQLAALYMLTL
HHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
ALAKVRGFLSEEAEAKDMANLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGMHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECHHHHHCCCEEEEECCCCC
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEV
CEEECCCEEEHHHHEEEECCCCCCCCCCCCHHEEECCCCEEEECCCHHHHHHHHHHHHHH
RARGGRLYVFADSDTHIQSTDGIQVIRMPEHYGALSPILHVVPLQLLAYHTACARGTDVD
HHCCCEEEEEECCCCCEECCCCEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGAVSTRNIVPVLIEGLRRLEYRGYDSCGVAVVRDNAVERARTVSRVADLDAQTQA
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHC
SGLAGTTGVAHTRWATHGKPDTVNAHPHLSGETIALVHNGIIENYEPLREELRAVGYGFE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHCCHHHHHHHHHHHCCCCC
SQTDTEVVAHLIHQAYCYPSSATRGDLFASVRAVTKRLHGAYAIAVFAKDQPERVVGARA
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHCCC
GSPLVVALGDGEAFLASDALAVAGTANRIIYLEEGDVVEVTRDGVTIHDGHDHPVEREVR
CCCEEEEECCCCEEECCCCEEEECCCCEEEEEECCCEEEEECCCEEEECCCCCCCCHHEE
VVEAHAATVDLGPYRHFMQKEIFEQPRALGDTLEGVDGISPALFGDRAAEVFPEIDSVLI
EEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHCCCCCEEE
LACGTSYYSGCTAKYWLESIAKIPTQVEVASEYRYRDTVPNPRALVVVISQSGETADTMA
EEECCHHHCCCCHHHHHHHHHHCCCEEEHHHHCHHCCCCCCCCEEEEEEECCCCHHHHHH
ALRHARALGHTHTLSICNVATSAMVRETEMRFLTRAGTEIGVASTKAFTTQLAALYMLTL
HHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
ALAKVRGFLSEEAEAKDMANLRHLPAALHGVLALEPQIIAWSEDFARRENALFLGRGMHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECHHHHHCCCEEEEECCCCC
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEV
CEEECCCEEEHHHHEEEECCCCCCCCCCCCHHEEECCCCEEEECCCHHHHHHHHHHHHHH
RARGGRLYVFADSDTHIQSTDGIQVIRMPEHYGALSPILHVVPLQLLAYHTACARGTDVD
HHCCCEEEEEECCCCCEECCCCEEEEECCHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCC
KPRNLAKSVTVE
CHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]