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The map label for this gene is creC [H]

Identifier: 73539890

GI number: 73539890

Start: 208371

End: 209816

Strand: Reverse

Name: creC [H]

Synonym: Reut_A0184

Alternate gene names: 73539890

Gene position: 209816-208371 (Counterclockwise)

Preceding gene: 73539891

Following gene: 73539889

Centisome position: 5.51

GC content: 67.36

Gene sequence:

>1446_bases
ATGCATATCGGGCTTCGCATCTTTTTCGGCTTCTTCGTGATCGTCGGGCTGGCCGCTTTCCTCACGCTGCGCGTCTTTGT
GCAGGAGGTAAAGCCCGGCGTCCGGCAGGCCATGGAGGACACGCTCGTCGATACCGCCAATGTGCTGGCAGCCTTGGCGG
CGGACGACATGAAGCACGGTCGGATCAACGAAGGCGCCTTCGCCCAGCGGCTGGCGCGGCTGCAGGACACGCCCGTCGAT
GCAAGCGTCTGGGGCCTGCGCAAGCAGTCGGTCGGCTACCGCATCTACGTCACCGACACGCATGGCATCGTCCGTTTCGA
CACCAGCGGCAGCGCGGTCGGCGCCGACTATTCGCGCTGGAACGACGTCTACCTGACGCTGCAGGGCAAGTACGGCGCGC
GCAGCACGCGCGCCAATCCCGATGACGAGAACAGCACGGTCATGCACGTCGCCGCGCCGATTCGCGATCCCGACAATGGC
CAGACCATCGGCGTGCTGACCGTCGCCAAGCCGAATCTCGCGATGGCGCCGTTCATCGAGCGCAGCCAGCGCAAGATCCT
GCTGTACGGTCTGCTGCTGATGGGCGTCGCGTTCGCGGTTGGCCTGGTCTGCACGCTGTGGCTGGTGTTCGGGCTGCGCC
GGCTGCAGCGCTACGCGCGCACCGTGGCAGCCGGCGAGCGCGCGGAAATGCCGCTGCACGGCGCGAGCGAGCTGGCCGAA
CTGGGGCGCGCGGTGGAAACCATGCGGCTGCGGCTCGAAGGCAAGCAGTATGTCGAGCACTACATCCACACGCTCACGCA
CGAGATGAAGAGCCCGCTGGCGGCGATCAGCGGCGCGGCGGAGCTGCTGCAGGAAGACATGCCACCGGCGGACCGTCAGC
GCTTTGTCGCGAATATCCGCGGCCAGTCCCAGCGCCTGGCCCAGATGATCCGCAAGCTGCTGGCGCTGGCCGCGGTGGAA
CAGCGGCAGCGGCTGGACCATGCCGAGCGCGTCGCGCTGTTGCCATTGCTGCAGGCACTCGTCGATGAGCTCGAACCGCG
TGCGCGCCAGCGCGGCGTGACGTTTGCCCTCGCACCGGACGCCGAACCTGCACTGGCCGTGCTGGGCGATCCCTTCATGC
TGCGGCAGGCCGTCACCAACCTGCTCGAAAACGCGCTCGATTTCGCGCCAGCCGGCAGCACGGTGCTGATAGATGTAACC
GGCGCGCCGGCCGGCCAAATCGCCATACAAGTTGCCGACGATGGTCCTGGCATCCCTGACTACGCGCTGCCGCGCCTGTT
CGAACGATTCTATTCGCTGCCCCGCCCGGACGGCCGGGACAAGAGCACGGGCCTCGGCCTCTGCTTCGTGCGCGAGGTCG
CGACGCTGCATCACGGCGACATCACCATTCACAATCGCGACGGTGGTGGCGCGCTTGCCACGCTCACGCTGCCGGCCGCG
TCCTGA

Upstream 100 bases:

>100_bases
CGCGCCAAGCTGCGCGCACTCGATGCCGCCAGCGACCCGATCCGCACGCACCGCGGCATGGGCTACTCCATCGAACCATG
ACGGTCGACCGGGCCTGAAC

Downstream 100 bases:

>100_bases
CCCAGCCGGCACGCACTTCACAGCGGGCACACAAACGCTTCACACCGGCCCCGCGGTCTGCGCACACGCGGTAGCTAATC
TGGCCGGCACCATCACTCCC

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MHIGLRIFFGFFVIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAALAADDMKHGRINEGAFAQRLARLQDTPVD
ASVWGLRKQSVGYRIYVTDTHGIVRFDTSGSAVGADYSRWNDVYLTLQGKYGARSTRANPDDENSTVMHVAAPIRDPDNG
QTIGVLTVAKPNLAMAPFIERSQRKILLYGLLLMGVAFAVGLVCTLWLVFGLRRLQRYARTVAAGERAEMPLHGASELAE
LGRAVETMRLRLEGKQYVEHYIHTLTHEMKSPLAAISGAAELLQEDMPPADRQRFVANIRGQSQRLAQMIRKLLALAAVE
QRQRLDHAERVALLPLLQALVDELEPRARQRGVTFALAPDAEPALAVLGDPFMLRQAVTNLLENALDFAPAGSTVLIDVT
GAPAGQIAIQVADDGPGIPDYALPRLFERFYSLPRPDGRDKSTGLGLCFVREVATLHHGDITIHNRDGGGALATLTLPAA
S

Sequences:

>Translated_481_residues
MHIGLRIFFGFFVIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAALAADDMKHGRINEGAFAQRLARLQDTPVD
ASVWGLRKQSVGYRIYVTDTHGIVRFDTSGSAVGADYSRWNDVYLTLQGKYGARSTRANPDDENSTVMHVAAPIRDPDNG
QTIGVLTVAKPNLAMAPFIERSQRKILLYGLLLMGVAFAVGLVCTLWLVFGLRRLQRYARTVAAGERAEMPLHGASELAE
LGRAVETMRLRLEGKQYVEHYIHTLTHEMKSPLAAISGAAELLQEDMPPADRQRFVANIRGQSQRLAQMIRKLLALAAVE
QRQRLDHAERVALLPLLQALVDELEPRARQRGVTFALAPDAEPALAVLGDPFMLRQAVTNLLENALDFAPAGSTVLIDVT
GAPAGQIAIQVADDGPGIPDYALPRLFERFYSLPRPDGRDKSTGLGLCFVREVATLHHGDITIHNRDGGGALATLTLPAA
S
>Mature_481_residues
MHIGLRIFFGFFVIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAALAADDMKHGRINEGAFAQRLARLQDTPVD
ASVWGLRKQSVGYRIYVTDTHGIVRFDTSGSAVGADYSRWNDVYLTLQGKYGARSTRANPDDENSTVMHVAAPIRDPDNG
QTIGVLTVAKPNLAMAPFIERSQRKILLYGLLLMGVAFAVGLVCTLWLVFGLRRLQRYARTVAAGERAEMPLHGASELAE
LGRAVETMRLRLEGKQYVEHYIHTLTHEMKSPLAAISGAAELLQEDMPPADRQRFVANIRGQSQRLAQMIRKLLALAAVE
QRQRLDHAERVALLPLLQALVDELEPRARQRGVTFALAPDAEPALAVLGDPFMLRQAVTNLLENALDFAPAGSTVLIDVT
GAPAGQIAIQVADDGPGIPDYALPRLFERFYSLPRPDGRDKSTGLGLCFVREVATLHHGDITIHNRDGGGALATLTLPAA
S

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=477, Percent_Identity=45.7023060796646, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1786600, Length=251, Percent_Identity=28.6852589641434, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=28.6885245901639, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=29.2576419213974, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786783, Length=219, Percent_Identity=28.7671232876712, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=27.7551020408163, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789403, Length=212, Percent_Identity=32.5471698113208, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=27.0042194092827, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790551, Length=205, Percent_Identity=31.219512195122, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87081816, Length=270, Percent_Identity=28.5185185185185, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=27.8008298755187, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=303, Percent_Identity=25.0825082508251, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=323, Percent_Identity=24.4582043343653, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788549, Length=212, Percent_Identity=26.4150943396226, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788713, Length=222, Percent_Identity=23.8738738738739, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=26.6423357664234, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790436, Length=229, Percent_Identity=27.9475982532751, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=365, Percent_Identity=24.6575342465753, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52503; Mature: 52503

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGLRIFFGFFVIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAALAADDMKHG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RINEGAFAQRLARLQDTPVDASVWGLRKQSVGYRIYVTDTHGIVRFDTSGSAVGADYSRW
CCCCCHHHHHHHHHCCCCCCHHHHCCHHHCCCEEEEEEECCCEEEECCCCCCCCCCCCCC
NDVYLTLQGKYGARSTRANPDDENSTVMHVAAPIRDPDNGQTIGVLTVAKPNLAMAPFIE
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCCCHHHH
RSQRKILLYGLLLMGVAFAVGLVCTLWLVFGLRRLQRYARTVAAGERAEMPLHGASELAE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LGRAVETMRLRLEGKQYVEHYIHTLTHEMKSPLAAISGAAELLQEDMPPADRQRFVANIR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
GQSQRLAQMIRKLLALAAVEQRQRLDHAERVALLPLLQALVDELEPRARQRGVTFALAPD
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHCCCEEEECCC
AEPALAVLGDPFMLRQAVTNLLENALDFAPAGSTVLIDVTGAPAGQIAIQVADDGPGIPD
CCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCC
YALPRLFERFYSLPRPDGRDKSTGLGLCFVREVATLHHGDITIHNRDGGGALATLTLPAA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCC
S
C
>Mature Secondary Structure
MHIGLRIFFGFFVIVGLAAFLTLRVFVQEVKPGVRQAMEDTLVDTANVLAALAADDMKHG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RINEGAFAQRLARLQDTPVDASVWGLRKQSVGYRIYVTDTHGIVRFDTSGSAVGADYSRW
CCCCCHHHHHHHHHCCCCCCHHHHCCHHHCCCEEEEEEECCCEEEECCCCCCCCCCCCCC
NDVYLTLQGKYGARSTRANPDDENSTVMHVAAPIRDPDNGQTIGVLTVAKPNLAMAPFIE
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCCCCHHHH
RSQRKILLYGLLLMGVAFAVGLVCTLWLVFGLRRLQRYARTVAAGERAEMPLHGASELAE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LGRAVETMRLRLEGKQYVEHYIHTLTHEMKSPLAAISGAAELLQEDMPPADRQRFVANIR
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
GQSQRLAQMIRKLLALAAVEQRQRLDHAERVALLPLLQALVDELEPRARQRGVTFALAPD
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHCCCEEEECCC
AEPALAVLGDPFMLRQAVTNLLENALDFAPAGSTVLIDVTGAPAGQIAIQVADDGPGIPD
CCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCC
YALPRLFERFYSLPRPDGRDKSTGLGLCFVREVATLHHGDITIHNRDGGGALATLTLPAA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]