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The map label for this gene is csgA [H]

Identifier: 73539845

GI number: 73539845

Start: 165924

End: 166604

Strand: Direct

Name: csgA [H]

Synonym: Reut_A0139

Alternate gene names: 73539845

Gene position: 165924-166604 (Clockwise)

Preceding gene: 73539844

Following gene: 73539846

Centisome position: 4.36

GC content: 68.14

Gene sequence:

>681_bases
TTGCCAACCGCACTCATCCTCGGTGCCTCGCGCGGCATCGGTCTTGAATTCGTACGCCAGTACCGAGCCGACGGCTGGCG
CGTCATCGCGGCGGCGCGTACGCCCGAAGGCGTCGCGGCGCTGAAGGCGCTCGGCGCCGAAGCGCATCAGGCCGATCTGA
CCGATCCCGGTGCGGTGGCAGGGCTCGGCTGGAAGCTTGATGGCGAATCGCTCGATGTCGCCATCTACAACGCCGGCGTG
CTCGGCCCGCGCACCGAAGGCGCGCAGCCGGTCACGCGCGAGGACTTCGACCGCGTGATGCACGTGAACGTGCTCGGCCC
GATGATGGCATTGCCGCTGGTGCTGCCCTACGTCGAAACCGGACAGGGCGGACACGGCGGTGTGCTCGCGGTACTGTCAT
CGCGCATGGGTAGCCTCGGCTCCATGGACAGCAACGGCAGCTGGCTGTATCGCGTGAGCAAGGCCGGCGTCAACGCGGCG
CTGAAGTCCGTGGCACTCGACGCCCGCCATGCCACCTGCGTGGCGCTACATCCGGGCTGGGTGCAGACCGACATGGGTGG
CAAGGGCGCCGACCTCACGCCGCAGCAGAGCGTGAAGGGCTTGCGCCAGGTGCTGGCTGGCGCCAAGCGCCGTGACAACG
GCAGCTTCTTCAATTACGACGGCACCCCGATCCCCTGGTAA

Upstream 100 bases:

>100_bases
GATCGTCTGATTCAACCCAGCATGTTCCCCCCTCTCCCGCTTGCGAAAGAGGGGGGGGCAAACAACCCGATCATCTGAAC
CTCGCCTCAGGAGATAACCC

Downstream 100 bases:

>100_bases
GCGCGGGCCCGACTCATCGAACAAAGACACGACATGCTGCTGACATCCGAACAGGAAATGATTCGCGACGCCGTGCGCCA
GTTCGCGCAAGAGGTGATCG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MPTALILGASRGIGLEFVRQYRADGWRVIAAARTPEGVAALKALGAEAHQADLTDPGAVAGLGWKLDGESLDVAIYNAGV
LGPRTEGAQPVTREDFDRVMHVNVLGPMMALPLVLPYVETGQGGHGGVLAVLSSRMGSLGSMDSNGSWLYRVSKAGVNAA
LKSVALDARHATCVALHPGWVQTDMGGKGADLTPQQSVKGLRQVLAGAKRRDNGSFFNYDGTPIPW

Sequences:

>Translated_226_residues
MPTALILGASRGIGLEFVRQYRADGWRVIAAARTPEGVAALKALGAEAHQADLTDPGAVAGLGWKLDGESLDVAIYNAGV
LGPRTEGAQPVTREDFDRVMHVNVLGPMMALPLVLPYVETGQGGHGGVLAVLSSRMGSLGSMDSNGSWLYRVSKAGVNAA
LKSVALDARHATCVALHPGWVQTDMGGKGADLTPQQSVKGLRQVLAGAKRRDNGSFFNYDGTPIPW
>Mature_225_residues
PTALILGASRGIGLEFVRQYRADGWRVIAAARTPEGVAALKALGAEAHQADLTDPGAVAGLGWKLDGESLDVAIYNAGVL
GPRTEGAQPVTREDFDRVMHVNVLGPMMALPLVLPYVETGQGGHGGVLAVLSSRMGSLGSMDSNGSWLYRVSKAGVNAAL
KSVALDARHATCVALHPGWVQTDMGGKGADLTPQQSVKGLRQVLAGAKRRDNGSFFNYDGTPIPW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Caenorhabditis elegans, GI17532177, Length=246, Percent_Identity=27.6422764227642, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193207563, Length=248, Percent_Identity=28.2258064516129, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17558990, Length=247, Percent_Identity=28.3400809716599, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17558996, Length=252, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17558994, Length=248, Percent_Identity=27.8225806451613, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559962, Length=245, Percent_Identity=28.1632653061224, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559964, Length=244, Percent_Identity=29.9180327868852, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17558992, Length=247, Percent_Identity=29.5546558704453, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17541382, Length=252, Percent_Identity=26.1904761904762, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=256, Percent_Identity=28.125, Blast_Score=76, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640547, Length=249, Percent_Identity=30.9236947791165, Blast_Score=104, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 23669; Mature: 23538

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTALILGASRGIGLEFVRQYRADGWRVIAAARTPEGVAALKALGAEAHQADLTDPGAVA
CCCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCHHCCCCCCCCEE
GLGWKLDGESLDVAIYNAGVLGPRTEGAQPVTREDFDRVMHVNVLGPMMALPLVLPYVET
ECCEEECCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHHHHHHHHHHHHHHHHHHCC
GQGGHGGVLAVLSSRMGSLGSMDSNGSWLYRVSKAGVNAALKSVALDARHATCVALHPGW
CCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEHHCHHHHHHHHHHCCCCCEEEEECCCE
VQTDMGGKGADLTPQQSVKGLRQVLAGAKRRDNGSFFNYDGTPIPW
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure 
PTALILGASRGIGLEFVRQYRADGWRVIAAARTPEGVAALKALGAEAHQADLTDPGAVA
CCEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCHHCCCCCCCCEE
GLGWKLDGESLDVAIYNAGVLGPRTEGAQPVTREDFDRVMHVNVLGPMMALPLVLPYVET
ECCEEECCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHEEHHHHHHHHHHHHHHHHHHCC
GQGGHGGVLAVLSSRMGSLGSMDSNGSWLYRVSKAGVNAALKSVALDARHATCVALHPGW
CCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEHHCHHHHHHHHHHCCCCCEEEEECCCE
VQTDMGGKGADLTPQQSVKGLRQVLAGAKRRDNGSFFNYDGTPIPW
EEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]