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The map label for this gene is tdh [C]

Identifier: 73539117

GI number: 73539117

Start: 2055940

End: 2056911

Strand: Reverse

Name: tdh [C]

Synonym: Reut_B5294

Alternate gene names: 73539117

Gene position: 2056911-2055940 (Counterclockwise)

Preceding gene: 73539118

Following gene: 73539116

Centisome position: 75.45

GC content: 65.23

Gene sequence:

>972_bases
GTGAAGGCAATTCGTGTGGTGCCGGGCCCGGAGGGCGGCAAGGTCGAGGTGCAGGATATTCCGGTTCCCGTCGCGGGGCC
GGGCCAGGTGCTGGTCAGGGTTCGTGCATCGGGCCTGAACCGCGGTGAGATTAACCAGGCGAAGGAGTTGCGTACCGGCA
ATACCATCACCACCGGCGTCGAGTTCGCGGGCGAGGTGGCCGAAGTCGGTGAAGGCGTGCACGGCTGGCGCAAGGGCGAC
CGCGTCATGGGGCACGGCAAGGGCTGCCAGGCTGAATATGTCGTTTCCGATCCGATGGCGCTGATCGCCGTGCCGGACGG
CATGTCGTGGATCGATGCCGCCGCGTTTCCGAATGTCTTTATCACGGCACACGACGCGCTGGTGGTGAACGGCCAGCTCA
AGCAGGGCGAGTCGGTGCTGGTCAACGGTGCGTCGGGCGGCGTGGCGATGGCTGCCATCCAGATCGCGTCGCTGATGGGC
GCCAAACCGGTGATTGCCCAGTCGCGTTCGGCCGCCAAGCTCGACAAGCTCAGCCAGTACGGTGTGGACGTCTGCATCGA
TTCGTCGAAGGACGACCAGGTCGAAAAGGTGATGGAGGCGACCGGCAACAAGGGCGTCGACGTCATCATCGACACGGTCG
GCGGGCCGGTGTTCGAAGCCAATATGAAGAGCCTTGCCGTTCAGGGGCGCCTGGTGAACATCGCGCGGCTAGGCTCGGCC
ACGGCGCAGATCGACCTGGCCCAGCTATGGCTCAAGCGTCTGCACCTGATCGGCGTGACGTTCCGTACCCGCACCGAGCA
GGAGCGGCTCGAATGCATCCAGGCGTGCGCGCGCGACATGCTGCCGTTCCTGCGTGCCGGCCGCGTGCGGCTGCCGATCG
ACCGTACCTTTGCCATGACCGATATCCACGCGGCGCACGCATACATGAAGCAGGACCAGCACGTCGGCAAGATCGTGCTG
CTGGTCGACTGA

Upstream 100 bases:

>100_bases
GCTGACGCTGCTTTCGCTGATCCGTGCGACGGCGCTCGGCCAGGCGTGAGACAGCAAGGAATCAGTCAGTAATCGAACGA
AACAAAGCAAGGAGCCAACA

Downstream 100 bases:

>100_bases
ATCCACCGATAGAAGAGGAGACATCATGACCATTGAAATCAAGCCGCTGACCGGTTCGGTCGGTGCATCCGTGACCGGCG
TCAACCTGAATGACCCGATC

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Acryloyl-CoA reductase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MKAIRVVPGPEGGKVEVQDIPVPVAGPGQVLVRVRASGLNRGEINQAKELRTGNTITTGVEFAGEVAEVGEGVHGWRKGD
RVMGHGKGCQAEYVVSDPMALIAVPDGMSWIDAAAFPNVFITAHDALVVNGQLKQGESVLVNGASGGVAMAAIQIASLMG
AKPVIAQSRSAAKLDKLSQYGVDVCIDSSKDDQVEKVMEATGNKGVDVIIDTVGGPVFEANMKSLAVQGRLVNIARLGSA
TAQIDLAQLWLKRLHLIGVTFRTRTEQERLECIQACARDMLPFLRAGRVRLPIDRTFAMTDIHAAHAYMKQDQHVGKIVL
LVD

Sequences:

>Translated_323_residues
MKAIRVVPGPEGGKVEVQDIPVPVAGPGQVLVRVRASGLNRGEINQAKELRTGNTITTGVEFAGEVAEVGEGVHGWRKGD
RVMGHGKGCQAEYVVSDPMALIAVPDGMSWIDAAAFPNVFITAHDALVVNGQLKQGESVLVNGASGGVAMAAIQIASLMG
AKPVIAQSRSAAKLDKLSQYGVDVCIDSSKDDQVEKVMEATGNKGVDVIIDTVGGPVFEANMKSLAVQGRLVNIARLGSA
TAQIDLAQLWLKRLHLIGVTFRTRTEQERLECIQACARDMLPFLRAGRVRLPIDRTFAMTDIHAAHAYMKQDQHVGKIVL
LVD
>Mature_323_residues
MKAIRVVPGPEGGKVEVQDIPVPVAGPGQVLVRVRASGLNRGEINQAKELRTGNTITTGVEFAGEVAEVGEGVHGWRKGD
RVMGHGKGCQAEYVVSDPMALIAVPDGMSWIDAAAFPNVFITAHDALVVNGQLKQGESVLVNGASGGVAMAAIQIASLMG
AKPVIAQSRSAAKLDKLSQYGVDVCIDSSKDDQVEKVMEATGNKGVDVIIDTVGGPVFEANMKSLAVQGRLVNIARLGSA
TAQIDLAQLWLKRLHLIGVTFRTRTEQERLECIQACARDMLPFLRAGRVRLPIDRTFAMTDIHAAHAYMKQDQHVGKIVL
LVD

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl- CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA [H]

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI22538446, Length=321, Percent_Identity=33.9563862928349, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI22538444, Length=321, Percent_Identity=33.9563862928349, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI194239674, Length=334, Percent_Identity=28.7425149700599, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI13236495, Length=334, Percent_Identity=28.7425149700599, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI18379349, Length=311, Percent_Identity=28.9389067524116, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI41872631, Length=315, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI194239676, Length=173, Percent_Identity=36.9942196531792, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI24308257, Length=331, Percent_Identity=24.1691842900302, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI28557745, Length=324, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI47519420, Length=363, Percent_Identity=26.4462809917355, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790045, Length=360, Percent_Identity=24.4444444444444, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI226510941, Length=334, Percent_Identity=27.5449101796407, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790485, Length=339, Percent_Identity=25.3687315634218, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082125, Length=363, Percent_Identity=23.9669421487603, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71987554, Length=364, Percent_Identity=22.8021978021978, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17507255, Length=301, Percent_Identity=27.5747508305648, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319520, Length=315, Percent_Identity=24.4444444444444, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=24.633431085044, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=341, Percent_Identity=24.633431085044, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=21.9941348973607, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24581345, Length=227, Percent_Identity=27.7533039647577, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330659, Length=270, Percent_Identity=25.9259259259259, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920632, Length=270, Percent_Identity=25.9259259259259, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.3.1.84 [H]

Molecular weight: Translated: 34415; Mature: 34415

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIRVVPGPEGGKVEVQDIPVPVAGPGQVLVRVRASGLNRGEINQAKELRTGNTITTGV
CCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECH
EFAGEVAEVGEGVHGWRKGDRVMGHGKGCQAEYVVSDPMALIAVPDGMSWIDAAAFPNVF
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEECCCEEEEECCCCCCHHHHHCCCCEE
ITAHDALVVNGQLKQGESVLVNGASGGVAMAAIQIASLMGAKPVIAQSRSAAKLDKLSQY
EEECCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHC
GVDVCIDSSKDDQVEKVMEATGNKGVDVIIDTVGGPVFEANMKSLAVQGRLVNIARLGSA
CCEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEECCHHHHHHCCEEEEEEHHCCC
TAQIDLAQLWLKRLHLIGVTFRTRTEQERLECIQACARDMLPFLRAGRVRLPIDRTFAMT
HHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEHH
DIHAAHAYMKQDQHVGKIVLLVD
HHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MKAIRVVPGPEGGKVEVQDIPVPVAGPGQVLVRVRASGLNRGEINQAKELRTGNTITTGV
CCCEEECCCCCCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEECH
EFAGEVAEVGEGVHGWRKGDRVMGHGKGCQAEYVVSDPMALIAVPDGMSWIDAAAFPNVF
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEECCCEEEEECCCCCCHHHHHCCCCEE
ITAHDALVVNGQLKQGESVLVNGASGGVAMAAIQIASLMGAKPVIAQSRSAAKLDKLSQY
EEECCEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHC
GVDVCIDSSKDDQVEKVMEATGNKGVDVIIDTVGGPVFEANMKSLAVQGRLVNIARLGSA
CCEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEECCHHHHHHCCEEEEEEHHCCC
TAQIDLAQLWLKRLHLIGVTFRTRTEQERLECIQACARDMLPFLRAGRVRLPIDRTFAMT
HHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCEEEHH
DIHAAHAYMKQDQHVGKIVLLVD
HHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]