BacMap

Definition	Ralstonia eutropha JMP134 chromosome chromosome 2, complete sequence.
Accession	NC_007348
Length	2,726,152

Click here to switch to the map view.

The map label for this gene is fadH [H]

Identifier: 73539028

GI number: 73539028

Start: 1953017

End: 1953901

Strand: Direct

Name: fadH [H]

Synonym: Reut_B5205

Alternate gene names: 73539028

Gene position: 1953017-1953901 (Clockwise)

Preceding gene: 73539027

Following gene: 73539029

Centisome position: 71.64

GC content: 67.57

Gene sequence:

>885_bases
ATGCAATATCGTTCCGTATTCCACCGCGAGCTGTTTGCCGGACGCACCGTACTGGTCACCGGCGGCGGCAGCGGCATCGG
CCGCTGCACCGCGCACGAACTTGCGAGCCTTGGCGCCAGCCTGGCGCTCGCGGGCCGCAAGATCGAAAAACTCGAACAGG
TCCGTGCGGAAATCGACGCCGCCGAACCGGGCGCCGCACAACGCATTTCGCTGCACGTGTGCGACATCCGCGACGAGGAG
CAGGTACGCCACACCATCGTCAACGTGCTGGCCGTGCATGGTCGTATCGACGGTCTCTTCAACAACGCCGGCGGGCAGTT
CCCGTCGCCGCTGCGCGACATCAGTCTCAAGGGCTGGGAAGCGGTCGTGCGCAACAACCTGACCGGCGGCTTCTTGGTCG
CGCGCGAGTGCTACACGCAGTGGATGGAAGCCAACGGTGGCGCCATCGTCAACATCATCGCCGACATGTGGAACGGCATG
CCGGGCATGGGACATTCCGGCGCGGCGCGCGCGGGCATGTTGTCGTTCACGGAAACCGCCGCGTGCGAATGGGCCGCGTC
GGGCGTGCGCGTCAATGCTGTAGCCCCGGGCTGGATCGCGTCCAGCGGCTTCGACACCTATCCGCCCGCGTTCCAGGAAA
AGATCCGCCAGCTCGCGCGCAAGGTGCCGCTGCAGCGGCTTGGCACGGAGGCGGAAGTTTCCGCCGCGGTGGCCTTTCTG
CTGTCCCCGGCAGCGGCGTTCATCACGGGCTCGACGCTGCGCGTCGACGGCGGCGTCCCCAACGCCAAGCATACGTGGGC
CCTGCCCGCGCACCAGCGCTCCGAGCCATTCAACGGCTTCCCGCTCTACGAGCTGCCCGATTGCCTGGCGCCGGCCGCGG
AGTGA

Upstream 100 bases:

>100_bases
GCAGCGGCTACGCCGCGTTCGCCCGCCAGCGCTATGAGAGCCAGGGCAAACTGGTCAAGCGGCTTGGCCTGAGTACCAAT
CCCTGAACCCGGAGACACGC

Downstream 100 bases:

>100_bases
CCCGACAATGCCCGCAAACATGGTTCTGCAACCGCCCAATCCCCGCTACTACACCGCCGACCACGAAGCATTCCGCGCCT
CGGTCCGCCGCTTCTTCGAG

Product: Short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MQYRSVFHRELFAGRTVLVTGGGSGIGRCTAHELASLGASLALAGRKIEKLEQVRAEIDAAEPGAAQRISLHVCDIRDEE
QVRHTIVNVLAVHGRIDGLFNNAGGQFPSPLRDISLKGWEAVVRNNLTGGFLVARECYTQWMEANGGAIVNIIADMWNGM
PGMGHSGAARAGMLSFTETAACEWAASGVRVNAVAPGWIASSGFDTYPPAFQEKIRQLARKVPLQRLGTEAEVSAAVAFL
LSPAAAFITGSTLRVDGGVPNAKHTWALPAHQRSEPFNGFPLYELPDCLAPAAE

Sequences:

>Translated_294_residues
MQYRSVFHRELFAGRTVLVTGGGSGIGRCTAHELASLGASLALAGRKIEKLEQVRAEIDAAEPGAAQRISLHVCDIRDEE
QVRHTIVNVLAVHGRIDGLFNNAGGQFPSPLRDISLKGWEAVVRNNLTGGFLVARECYTQWMEANGGAIVNIIADMWNGM
PGMGHSGAARAGMLSFTETAACEWAASGVRVNAVAPGWIASSGFDTYPPAFQEKIRQLARKVPLQRLGTEAEVSAAVAFL
LSPAAAFITGSTLRVDGGVPNAKHTWALPAHQRSEPFNGFPLYELPDCLAPAAE
>Mature_294_residues
MQYRSVFHRELFAGRTVLVTGGGSGIGRCTAHELASLGASLALAGRKIEKLEQVRAEIDAAEPGAAQRISLHVCDIRDEE
QVRHTIVNVLAVHGRIDGLFNNAGGQFPSPLRDISLKGWEAVVRNNLTGGFLVARECYTQWMEANGGAIVNIIADMWNGM
PGMGHSGAARAGMLSFTETAACEWAASGVRVNAVAPGWIASSGFDTYPPAFQEKIRQLARKVPLQRLGTEAEVSAAVAFL
LSPAAAFITGSTLRVDGGVPNAKHTWALPAHQRSEPFNGFPLYELPDCLAPAAE

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=272, Percent_Identity=43.3823529411765, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI10190704, Length=257, Percent_Identity=31.9066147859922, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=31.8897637795276, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI32483357, Length=264, Percent_Identity=28.4090909090909, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=31.3008130081301, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI15277342, Length=252, Percent_Identity=31.3492063492063, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI126723750, Length=260, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI5031737, Length=263, Percent_Identity=26.615969581749, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI31542939, Length=196, Percent_Identity=31.6326530612245, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI7705925, Length=256, Percent_Identity=30.859375, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4503817, Length=177, Percent_Identity=29.3785310734463, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI224922801, Length=180, Percent_Identity=31.1111111111111, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI66933014, Length=202, Percent_Identity=23.7623762376238, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=31.0756972111554, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=29.8039215686275, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=28.968253968254, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=29.8449612403101, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=27.8884462151394, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=32.8063241106719, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082160, Length=271, Percent_Identity=27.3062730627306, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=27.710843373494, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790717, Length=257, Percent_Identity=28.4046692607004, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=27.6, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789057, Length=258, Percent_Identity=28.2945736434109, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787526, Length=249, Percent_Identity=26.5060240963855, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787820, Length=191, Percent_Identity=26.1780104712042, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=33.3333333333333, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=32.4110671936759, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17562910, Length=279, Percent_Identity=27.9569892473118, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=27.9693486590038, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=31.3492063492063, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=31.4741035856574, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=278, Percent_Identity=29.8561151079137, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=28.2442748091603, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=28.4090909090909, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=30.8, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=27.2030651340996, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=27.6923076923077, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17561272, Length=242, Percent_Identity=28.099173553719, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=27.0992366412214, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=27.4131274131274, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=29.2307692307692, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=27.7153558052434, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=26.9230769230769, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=265, Percent_Identity=27.9245283018868, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=26.3358778625954, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=24.5059288537549, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=29.1338582677165, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=27.9850746268657, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=25.6916996047431, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=261, Percent_Identity=29.5019157088123, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=26.9961977186312, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=251, Percent_Identity=23.5059760956175, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=201, Percent_Identity=28.8557213930348, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=31.2, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323882, Length=198, Percent_Identity=31.3131313131313, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6322861, Length=294, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=34.8837209302326, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=34.5098039215686, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=32.9411764705882, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28571526, Length=256, Percent_Identity=35.546875, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24639444, Length=256, Percent_Identity=31.25, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=29.8804780876494, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=25.0980392156863, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24644337, Length=255, Percent_Identity=32.9411764705882, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357673, Length=193, Percent_Identity=31.0880829015544, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17737361, Length=259, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=26.0204081632653, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 31357; Mature: 31357

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYRSVFHRELFAGRTVLVTGGGSGIGRCTAHELASLGASLALAGRKIEKLEQVRAEIDA
CCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AEPGAAQRISLHVCDIRDEEQVRHTIVNVLAVHGRIDGLFNNAGGQFPSPLRDISLKGWE
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHH
AVVRNNLTGGFLVARECYTQWMEANGGAIVNIIADMWNGMPGMGHSGAARAGMLSFTETA
HHHHCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCCHHHCHHHHHHHH
ACEWAASGVRVNAVAPGWIASSGFDTYPPAFQEKIRQLARKVPLQRLGTEAEVSAAVAFL
HHHHHHCCEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHH
LSPAAAFITGSTLRVDGGVPNAKHTWALPAHQRSEPFNGFPLYELPDCLAPAAE
HHHHHHHHCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCCCHHCCHHHCCCCC
>Mature Secondary Structure
MQYRSVFHRELFAGRTVLVTGGGSGIGRCTAHELASLGASLALAGRKIEKLEQVRAEIDA
CCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AEPGAAQRISLHVCDIRDEEQVRHTIVNVLAVHGRIDGLFNNAGGQFPSPLRDISLKGWE
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCHHH
AVVRNNLTGGFLVARECYTQWMEANGGAIVNIIADMWNGMPGMGHSGAARAGMLSFTETA
HHHHCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCCCCCHHHCHHHHHHHH
ACEWAASGVRVNAVAPGWIASSGFDTYPPAFQEKIRQLARKVPLQRLGTEAEVSAAVAFL
HHHHHHCCEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHH
LSPAAAFITGSTLRVDGGVPNAKHTWALPAHQRSEPFNGFPLYELPDCLAPAAE
HHHHHHHHCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCCCHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]