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The map label for this gene is frmA [H]

Identifier: 73539024

GI number: 73539024

Start: 1946556

End: 1947641

Strand: Reverse

Name: frmA [H]

Synonym: Reut_B5201

Alternate gene names: 73539024

Gene position: 1947641-1946556 (Counterclockwise)

Preceding gene: 73539025

Following gene: 73539016

Centisome position: 71.44

GC content: 65.65

Gene sequence:

>1086_bases
ATGAAAGCCGCTGTCCTGCATCAACCCAAGTCCCCGCTGGTGATCGAAGACGTTGCCATCGGCAAGCCTGGCCCGCATGA
AGTCCTGATCCGGACCGCCGCTGTTGGCGTGTGCCATTCGGACCTGCATTTCCTGGATGGCGCCTACCCGCATCCGATGC
CCGCAGTACTTGGCCACGAAGCCGCCGGCGTGGTGGAGCAGGTCGGCGAACTGGTGCGCACGGTCAGGCCCGGCGACCAC
GTGATCACCTGCCTGTCGGCCTATTGCGGCCATTGCGAGCACTGCCTGACCGGCCACCTGTCGTTGTGCACCGAGCCGGA
TACGCGCCGAGGCGAAGACGAACCGCCGCGCCTGACGGCGCACCACGGCGGCCCGATGAATCAGTTCATCAACCTGTCCG
CGTTTGCCGAGCAGATGCTCGTACACGAGCATGCGCTGGTTGCGATCCGCCGCGACATGCCGCTTGACCGCGCCGCACTG
ATTGGTTGCGCCGTGACCACCGGGTTCGGCGCGGTGGTTCATACCGCGCGCGTGCAGCCCGGCGAAACCGTGGCCGTCAT
CGGCTGCGGCGGTATCGGATTGGCCACCATCAACGGTGCGGCCATCGCGGGCGCTGGCCGCATCATCGCTATCGACCGCG
TGCCTGGCAAGCTGGAACTGGCGCGACAATTCGGCGCGACCGATGTCGTCCAGGCCGGTGACGATACCGTCGACGCCGTG
CGCGCGCTGACCGGCGGCGGCGTGCACCATGCGTTCGAGGCGATCGGCCTCAAGCAAACTGCCGAGCAGGCCTTCGCGAT
GCTGCGCCGCGGCGGCACGGCCACCATCATCGGCATGATTGCACCGGGCGTGAAGATCGAACTCAAGGGCAGCGACTTCC
TTGGCGAGAAGAAGATCCAGGGCTCGCTGATGGGCTCCAACCGCTTTCCGGTGGACATGCCGCGCATGGTGGATTTCTAC
ATGGCGGGACGGCTCAAGCTCGACGAACTGATCTCGCGGCGCCTGCCGCTCGAAGAGATCAACAGCGCGTTTGATGAACT
TAGGCGCGGAGAACTGGCGCGTTCGGTGGTGGTGTTTGGGGACTGA

Upstream 100 bases:

>100_bases
TCTCCGATCGGCGGTAATGTGCGGGCTGCGCCCCGGAACCCACTGACGGCCGCCCGCGCTGCCCCGGCAATCGCGCAGCG
GCCTGCACGCAAGGAGATCC

Downstream 100 bases:

>100_bases
GGAAGTTGCTGGCAGGTTGATCGGGGCCGCAGCCGCTTGCGGCGCGGCCCTGTCGACTCCACTGGTTTACGACCGCATTC
GATTCAGTTCATCGATACGC

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKAAVLHQPKSPLVIEDVAIGKPGPHEVLIRTAAVGVCHSDLHFLDGAYPHPMPAVLGHEAAGVVEQVGELVRTVRPGDH
VITCLSAYCGHCEHCLTGHLSLCTEPDTRRGEDEPPRLTAHHGGPMNQFINLSAFAEQMLVHEHALVAIRRDMPLDRAAL
IGCAVTTGFGAVVHTARVQPGETVAVIGCGGIGLATINGAAIAGAGRIIAIDRVPGKLELARQFGATDVVQAGDDTVDAV
RALTGGGVHHAFEAIGLKQTAEQAFAMLRRGGTATIIGMIAPGVKIELKGSDFLGEKKIQGSLMGSNRFPVDMPRMVDFY
MAGRLKLDELISRRLPLEEINSAFDELRRGELARSVVVFGD

Sequences:

>Translated_361_residues
MKAAVLHQPKSPLVIEDVAIGKPGPHEVLIRTAAVGVCHSDLHFLDGAYPHPMPAVLGHEAAGVVEQVGELVRTVRPGDH
VITCLSAYCGHCEHCLTGHLSLCTEPDTRRGEDEPPRLTAHHGGPMNQFINLSAFAEQMLVHEHALVAIRRDMPLDRAAL
IGCAVTTGFGAVVHTARVQPGETVAVIGCGGIGLATINGAAIAGAGRIIAIDRVPGKLELARQFGATDVVQAGDDTVDAV
RALTGGGVHHAFEAIGLKQTAEQAFAMLRRGGTATIIGMIAPGVKIELKGSDFLGEKKIQGSLMGSNRFPVDMPRMVDFY
MAGRLKLDELISRRLPLEEINSAFDELRRGELARSVVVFGD
>Mature_361_residues
MKAAVLHQPKSPLVIEDVAIGKPGPHEVLIRTAAVGVCHSDLHFLDGAYPHPMPAVLGHEAAGVVEQVGELVRTVRPGDH
VITCLSAYCGHCEHCLTGHLSLCTEPDTRRGEDEPPRLTAHHGGPMNQFINLSAFAEQMLVHEHALVAIRRDMPLDRAAL
IGCAVTTGFGAVVHTARVQPGETVAVIGCGGIGLATINGAAIAGAGRIIAIDRVPGKLELARQFGATDVVQAGDDTVDAV
RALTGGGVHHAFEAIGLKQTAEQAFAMLRRGGTATIIGMIAPGVKIELKGSDFLGEKKIQGSLMGSNRFPVDMPRMVDFY
MAGRLKLDELISRRLPLEEINSAFDELRRGELARSVVVFGD

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=366, Percent_Identity=37.7049180327869, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI34577061, Length=366, Percent_Identity=37.7049180327869, Blast_Score=245, Evalue=4e-65,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=36.6120218579235, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=34.4262295081967, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=35.6164383561644, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI71743840, Length=365, Percent_Identity=35.6164383561644, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=34.8189415041783, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI71565154, Length=365, Percent_Identity=34.5205479452055, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI71565152, Length=371, Percent_Identity=33.6927223719677, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI156627571, Length=364, Percent_Identity=26.3736263736264, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=39.344262295082, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI1788073, Length=354, Percent_Identity=30.225988700565, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI226510992, Length=368, Percent_Identity=25.8152173913043, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=26.7267267267267, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081918, Length=335, Percent_Identity=27.1641791044776, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786518, Length=372, Percent_Identity=27.4193548387097, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI87082125, Length=363, Percent_Identity=24.7933884297521, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=28.2798833819242, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790045, Length=369, Percent_Identity=25.2032520325203, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786825, Length=402, Percent_Identity=24.1293532338308, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787863, Length=358, Percent_Identity=24.3016759776536, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082401, Length=360, Percent_Identity=21.3888888888889, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=371, Percent_Identity=36.3881401617251, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71997431, Length=373, Percent_Identity=36.1930294906166, Blast_Score=234, Evalue=5e-62,
Organism=Caenorhabditis elegans, GI17565904, Length=336, Percent_Identity=36.0119047619048, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17562876, Length=358, Percent_Identity=27.9329608938547, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17562584, Length=362, Percent_Identity=28.7292817679558, Blast_Score=121, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=357, Percent_Identity=28.0112044817927, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=365, Percent_Identity=27.1232876712329, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17562582, Length=366, Percent_Identity=27.8688524590164, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=38.9645776566758, Blast_Score=252, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6323961, Length=366, Percent_Identity=29.2349726775956, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319621, Length=363, Percent_Identity=29.2011019283747, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323729, Length=365, Percent_Identity=29.3150684931507, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324486, Length=364, Percent_Identity=29.1208791208791, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6319258, Length=287, Percent_Identity=28.2229965156794, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323099, Length=361, Percent_Identity=26.8698060941828, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319257, Length=354, Percent_Identity=26.8361581920904, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=358, Percent_Identity=26.2569832402235, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=358, Percent_Identity=26.2569832402235, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=39.1304347826087, Blast_Score=254, Evalue=6e-68,
Organism=Drosophila melanogaster, GI17737897, Length=360, Percent_Identity=28.3333333333333, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17137530, Length=356, Percent_Identity=26.9662921348315, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 38283; Mature: 38283

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVLHQPKSPLVIEDVAIGKPGPHEVLIRTAAVGVCHSDLHFLDGAYPHPMPAVLGHE
CCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCH
AAGVVEQVGELVRTVRPGDHVITCLSAYCGHCEHCLTGHLSLCTEPDTRRGEDEPPRLTA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCHHCCCCCCCCCCCCCCCEEEE
HHGGPMNQFINLSAFAEQMLVHEHALVAIRRDMPLDRAALIGCAVTTGFGAVVHTARVQP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHEEEECCC
GETVAVIGCGGIGLATINGAAIAGAGRIIAIDRVPGKLELARQFGATDVVQAGDDTVDAV
CCEEEEEECCCCCEEEECCCEEECCCCEEEEECCCCHHHHHHHCCCCHHHHCCCHHHHHH
RALTGGGVHHAFEAIGLKQTAEQAFAMLRRGGTATIIGMIAPGVKIELKGSDFLGEKKIQ
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCCHHHC
GSLMGSNRFPVDMPRMVDFYMAGRLKLDELISRRLPLEEINSAFDELRRGELARSVVVFG
CEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCEEEEEC
D
C
>Mature Secondary Structure
MKAAVLHQPKSPLVIEDVAIGKPGPHEVLIRTAAVGVCHSDLHFLDGAYPHPMPAVLGHE
CCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCH
AAGVVEQVGELVRTVRPGDHVITCLSAYCGHCEHCLTGHLSLCTEPDTRRGEDEPPRLTA
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHCCHHCCCCCCCCCCCCCCCEEEE
HHGGPMNQFINLSAFAEQMLVHEHALVAIRRDMPLDRAALIGCAVTTGFGAVVHTARVQP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHEEEECCC
GETVAVIGCGGIGLATINGAAIAGAGRIIAIDRVPGKLELARQFGATDVVQAGDDTVDAV
CCEEEEEECCCCCEEEECCCEEECCCCEEEEECCCCHHHHHHHCCCCHHHHCCCHHHHHH
RALTGGGVHHAFEAIGLKQTAEQAFAMLRRGGTATIIGMIAPGVKIELKGSDFLGEKKIQ
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEEEECCCCCCCCHHHC
GSLMGSNRFPVDMPRMVDFYMAGRLKLDELISRRLPLEEINSAFDELRRGELARSVVVFG
CEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCEEEEEC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]