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The map label for this gene is atoC [H]

Identifier: 73538901

GI number: 73538901

Start: 1813807

End: 1815210

Strand: Reverse

Name: atoC [H]

Synonym: Reut_B5076

Alternate gene names: 73538901

Gene position: 1815210-1813807 (Counterclockwise)

Preceding gene: 73538903

Following gene: 73538900

Centisome position: 66.59

GC content: 66.1

Gene sequence:

>1404_bases
ATGTCTCACATCCTGATTGTCGACGACGACGAGAATGCCTGCGCCGCGCTGGCCGAGATCGTGGCACTGGAAGGGTTCAC
CGCCTCGACCGCGGGCAGCCTGCGTGAAGCCCGCCTGCAGATCGGCTGGCGCATGCCGGACGTGATCCTGGCTGACCTGC
GCCTGCCGGACGGCAACGGCCTGGAGCTGTTTGCCGAAGTGGCATCTTCGGGCGTGGAAATTATCCTCACCACCGGTTAC
GCGAGCGTAGACAGTGCCGTGGAAGCCCTGCGCTCGGGCGCCACCGATTACCTCGTCAAGCCCATCAACGTGGCGCGTCT
GCAGACCGTGCTGAAGCGGCTCGCCAATACCGGAGCGCTGCGCGCGGAAATCCATTCGCTGCGCGGCGAATTGCGCCGCT
ATGGCCGGTTTGGCCGGTTGCTGGGCAGTTCCGACGTCATGCAGGCGGTCTACGACCAGCTCGCGCGGGTGGCGCCGACA
GAGGCCACTGTGCTGCTGATCGGCGAGAGCGGCACCGGCAAGGAACTGGCGATGCAGACGGTGCATGAGTTGTCCGCGCG
GCGGCGGCAGCCGTTCCTGGCGGTCAACTGCGGCGCCATCTCGCCGACGCTGATCGAAACCGAGATGTTCGGCCACGAGC
GGGGCAGCTTCACGGGCGCCGACCGCCAGCACAAGGGCTATTTCGAGCGCGCCGACGGCGGCACGCTGTTCCTTGACGAA
ATCACCGAGATGCCTGCCGAGCTGCAGGTCAAGCTGCTGCGCGTGCTCGAAACCGGCAGCTTCATGCGGGTCGGTACCAA
CCGCGAGCAGCACGCCGATGTGCGGGTGCTCGCGGCGACCAACCGCAATCCTGAAGAGGCCGTCGCCGAGGGCAAGCTGC
GCGCGGACCTGTTCCACCGCCTCAATGTGTTTCCGGTAGAACTGCCGCCGCTGCGCGCACGTGGCGACGACGTGATCCAG
ATTGCCAATACGATGCTGGAGCAGCTCAATGCCGAGCAGGGCACTGCGCGGCGCTTCGCACCCAACGTGCTCGACAGCCT
GCGCCAGCACATGTGGCCAGGCAATGTGCGCGAGTTGCGCAATTTTGTGCAGCGCGCCTACATCATGGCCGATGACGACC
TGATCACCGAAGTACAGGTGCCGCTGCAGGCTGCGGCGGCGCAGGCGCCGGCCGCCGCGATGGTATCGGTGCCGGTGGGC
ATGTCGCTGGCCGATGCCGACCGGCAGCTCATCTTCGCGACACTGGAACAATGTGCCGGGGTGAAAAAGCACGCTGCGGA
AATTCTTGGCATCAGCCTCAAGACCCTGTACAACCGGCTGGAAGATTATGCAGCGCGAGGCGAGCTGCCCGAGTGGCTGC
GTGCCGCGCGCACCAGCCAGGGCGGCATCCCAGCCAGCGGCTGA

Upstream 100 bases:

>100_bases
GGGAAGATTGTTTATTCCCCCGGCAACGCTATTGCGCGCTATTCGCTATTCGCTATTTGCTATCCCCAGGTCAACTTCCC
GGCCTCCGGGCCGCGCAACC

Downstream 100 bases:

>100_bases
CACCCACGGGCTCGCCACGACGGTATCGGCTGGCCCCGCTTGAGCTGGGTTGCATGCTTTTTGCATGGCAACTGCGTGAA
AAACCGGGGCAACAAGATCA

Product: Fis-type helix-turn-helix domain-containing protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSHILIVDDDENACAALAEIVALEGFTASTAGSLREARLQIGWRMPDVILADLRLPDGNGLELFAEVASSGVEIILTTGY
ASVDSAVEALRSGATDYLVKPINVARLQTVLKRLANTGALRAEIHSLRGELRRYGRFGRLLGSSDVMQAVYDQLARVAPT
EATVLLIGESGTGKELAMQTVHELSARRRQPFLAVNCGAISPTLIETEMFGHERGSFTGADRQHKGYFERADGGTLFLDE
ITEMPAELQVKLLRVLETGSFMRVGTNREQHADVRVLAATNRNPEEAVAEGKLRADLFHRLNVFPVELPPLRARGDDVIQ
IANTMLEQLNAEQGTARRFAPNVLDSLRQHMWPGNVRELRNFVQRAYIMADDDLITEVQVPLQAAAAQAPAAAMVSVPVG
MSLADADRQLIFATLEQCAGVKKHAAEILGISLKTLYNRLEDYAARGELPEWLRAARTSQGGIPASG

Sequences:

>Translated_467_residues
MSHILIVDDDENACAALAEIVALEGFTASTAGSLREARLQIGWRMPDVILADLRLPDGNGLELFAEVASSGVEIILTTGY
ASVDSAVEALRSGATDYLVKPINVARLQTVLKRLANTGALRAEIHSLRGELRRYGRFGRLLGSSDVMQAVYDQLARVAPT
EATVLLIGESGTGKELAMQTVHELSARRRQPFLAVNCGAISPTLIETEMFGHERGSFTGADRQHKGYFERADGGTLFLDE
ITEMPAELQVKLLRVLETGSFMRVGTNREQHADVRVLAATNRNPEEAVAEGKLRADLFHRLNVFPVELPPLRARGDDVIQ
IANTMLEQLNAEQGTARRFAPNVLDSLRQHMWPGNVRELRNFVQRAYIMADDDLITEVQVPLQAAAAQAPAAAMVSVPVG
MSLADADRQLIFATLEQCAGVKKHAAEILGISLKTLYNRLEDYAARGELPEWLRAARTSQGGIPASG
>Mature_466_residues
SHILIVDDDENACAALAEIVALEGFTASTAGSLREARLQIGWRMPDVILADLRLPDGNGLELFAEVASSGVEIILTTGYA
SVDSAVEALRSGATDYLVKPINVARLQTVLKRLANTGALRAEIHSLRGELRRYGRFGRLLGSSDVMQAVYDQLARVAPTE
ATVLLIGESGTGKELAMQTVHELSARRRQPFLAVNCGAISPTLIETEMFGHERGSFTGADRQHKGYFERADGGTLFLDEI
TEMPAELQVKLLRVLETGSFMRVGTNREQHADVRVLAATNRNPEEAVAEGKLRADLFHRLNVFPVELPPLRARGDDVIQI
ANTMLEQLNAEQGTARRFAPNVLDSLRQHMWPGNVRELRNFVQRAYIMADDDLITEVQVPLQAAAAQAPAAAMVSVPVGM
SLADADRQLIFATLEQCAGVKKHAAEILGISLKTLYNRLEDYAARGELPEWLRAARTSQGGIPASG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=39.0243902439024, Blast_Score=322, Evalue=4e-89,
Organism=Escherichia coli, GI1790437, Length=453, Percent_Identity=39.0728476821192, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=35.3448275862069, Blast_Score=263, Evalue=3e-71,
Organism=Escherichia coli, GI1788905, Length=446, Percent_Identity=33.6322869955157, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1789087, Length=315, Percent_Identity=40.6349206349206, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI87082117, Length=337, Percent_Identity=38.8724035608309, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=38.5579937304075, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI87082152, Length=267, Percent_Identity=45.3183520599251, Blast_Score=218, Evalue=9e-58,
Organism=Escherichia coli, GI87081872, Length=305, Percent_Identity=39.0163934426229, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1786524, Length=400, Percent_Identity=37.25, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1787583, Length=310, Percent_Identity=34.8387096774194, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1789828, Length=235, Percent_Identity=34.8936170212766, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI87081858, Length=281, Percent_Identity=28.4697508896797, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786838, Length=115, Percent_Identity=35.6521739130435, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786911, Length=124, Percent_Identity=33.0645161290323, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50883; Mature: 50752

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHILIVDDDENACAALAEIVALEGFTASTAGSLREARLQIGWRMPDVILADLRLPDGNG
CCEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCC
LELFAEVASSGVEIILTTGYASVDSAVEALRSGATDYLVKPINVARLQTVLKRLANTGAL
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCHH
RAEIHSLRGELRRYGRFGRLLGSSDVMQAVYDQLARVAPTEATVLLIGESGTGKELAMQT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHH
VHELSARRRQPFLAVNCGAISPTLIETEMFGHERGSFTGADRQHKGYFERADGGTLFLDE
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEHHH
ITEMPAELQVKLLRVLETGSFMRVGTNREQHADVRVLAATNRNPEEAVAEGKLRADLFHR
HHCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHCHHHHHHHHH
LNVFPVELPPLRARGDDVIQIANTMLEQLNAEQGTARRFAPNVLDSLRQHMWPGNVRELR
CCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHCCCCCHHHHH
NFVQRAYIMADDDLITEVQVPLQAAAAQAPAAAMVSVPVGMSLADADRQLIFATLEQCAG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCC
VKKHAAEILGISLKTLYNRLEDYAARGELPEWLRAARTSQGGIPASG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SHILIVDDDENACAALAEIVALEGFTASTAGSLREARLQIGWRMPDVILADLRLPDGNG
CEEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCC
LELFAEVASSGVEIILTTGYASVDSAVEALRSGATDYLVKPINVARLQTVLKRLANTGAL
HHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHCCCHH
RAEIHSLRGELRRYGRFGRLLGSSDVMQAVYDQLARVAPTEATVLLIGESGTGKELAMQT
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHH
VHELSARRRQPFLAVNCGAISPTLIETEMFGHERGSFTGADRQHKGYFERADGGTLFLDE
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEHHH
ITEMPAELQVKLLRVLETGSFMRVGTNREQHADVRVLAATNRNPEEAVAEGKLRADLFHR
HHCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHCHHHHHHHHH
LNVFPVELPPLRARGDDVIQIANTMLEQLNAEQGTARRFAPNVLDSLRQHMWPGNVRELR
CCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHCCCCCHHHHH
NFVQRAYIMADDDLITEVQVPLQAAAAQAPAAAMVSVPVGMSLADADRQLIFATLEQCAG
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCC
VKKHAAEILGISLKTLYNRLEDYAARGELPEWLRAARTSQGGIPASG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]