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The map label for this gene is hpd [H]

Identifier: 73538853

GI number: 73538853

Start: 1761046

End: 1762119

Strand: Reverse

Name: hpd [H]

Synonym: Reut_B5028

Alternate gene names: 73538853

Gene position: 1762119-1761046 (Counterclockwise)

Preceding gene: 73538857

Following gene: 73538852

Centisome position: 64.64

GC content: 67.5

Gene sequence:

>1074_bases
ATGAGCGCCGCTGAAGCCTGGGACAATCCGCTGGGCATCCAGGGTTACGAGTTCATCGAATTCGCCTCGCCGGATCCGGC
TGCGCTCGGCCGCACCTTCGAGCGTTTCGGCTTTGCGGCCATTGCCGAGCACCGCCACAAGGCGGTCAGGCTCTACCGCC
AGGGCGAGATGAATTTCATCGTGGACGCGGAGCCCGATTCCTTCGCGACGCGCTACGCGGCCGAGTACGGCTTGTCGATC
TGCGCCGTCGGCATTCGCGTGACCGACGCCGCCGCAGCCTACGCGCGCGCGCTCGACGCCGGCGCGTGGCCGTTCGAAGG
TGGCACCGTGGGTCCGATGGAGCTGAACATCCCGGCCATCCAGGGCATCGGCCAGTCGGTCATCTATTTCATCGACCGCT
GGCGTGGGAAGGAAGGACGCCCCGGCGATGTCGGCGACATCTCGATCTATGACGTCGACTTCCGTCCCATGCCGCAGGGC
AACCGGCCGCGCGACGCGGGCCTCGTCCGAGTCGATCACCTGACGCAGGCGGTCGAGCCCGGCCATCTCGAGGAATGGAG
CGATTTTTACCGCAAGGTGCTTGGCTTCCGGGAAATCCACGAAGTCCATCCCGACTGGCAGGTGGCCAGCGACGCGTGCG
TGCTGCTGTCGCCGTGCGGGCAGATCCGGATCCCGCTGTACGAGAAGGGGACGCCGCGCCACGACCGCATGCGCCATTAC
CTGTCGGACCCGCATGGCGAGGGCATCCAGCACATCGCGCTGGCCACGGATGACCTGGCGGCCAGCGCCGCGGTCCTGGC
AGCCAGTGGCGTGCAGTTCGTGCAGCCGCCGGCCGCTTACTACGGCACGCTCGATGGGCGCCTGCCGGGGCATGGCCTCG
ATCCCGCCACACTGCAGCGCTACGGCATCCTCGTGGACGGCACCGTGCGCGCGGATGGCGGGCAGGACCGCTTTCTCCAG
GCCTTTGCAAAGCGCGAGGCGGGCGAGTTCTTCTTCGAGATCGTCCAGCGCGACGGTCACCATGGCTTCGGCGAGGGCAA
CCTGGCTGTACTGGAATCGTTGGCGGGGGAGTGA

Upstream 100 bases:

>100_bases
CGGGCACATTGTTATGATCGGACGACCTTGCCGCCGGCCCTGTCGCATTGCTTGTCCGCGCGGCCTGCCACACAGCCCCA
ACCAACACAGGAGCCCCGAC

Downstream 100 bases:

>100_bases
GACGGTCCGGCTTCGGAGGCCGCTCCCGACTGGCCGGGCCTGATGCTGCCCTTGGGGGACTGCGGTCGCATGGACCCTTG
CTTAGCGCATCCTAAGCAAT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSAAEAWDNPLGIQGYEFIEFASPDPAALGRTFERFGFAAIAEHRHKAVRLYRQGEMNFIVDAEPDSFATRYAAEYGLSI
CAVGIRVTDAAAAYARALDAGAWPFEGGTVGPMELNIPAIQGIGQSVIYFIDRWRGKEGRPGDVGDISIYDVDFRPMPQG
NRPRDAGLVRVDHLTQAVEPGHLEEWSDFYRKVLGFREIHEVHPDWQVASDACVLLSPCGQIRIPLYEKGTPRHDRMRHY
LSDPHGEGIQHIALATDDLAASAAVLAASGVQFVQPPAAYYGTLDGRLPGHGLDPATLQRYGILVDGTVRADGGQDRFLQ
AFAKREAGEFFFEIVQRDGHHGFGEGNLAVLESLAGE

Sequences:

>Translated_357_residues
MSAAEAWDNPLGIQGYEFIEFASPDPAALGRTFERFGFAAIAEHRHKAVRLYRQGEMNFIVDAEPDSFATRYAAEYGLSI
CAVGIRVTDAAAAYARALDAGAWPFEGGTVGPMELNIPAIQGIGQSVIYFIDRWRGKEGRPGDVGDISIYDVDFRPMPQG
NRPRDAGLVRVDHLTQAVEPGHLEEWSDFYRKVLGFREIHEVHPDWQVASDACVLLSPCGQIRIPLYEKGTPRHDRMRHY
LSDPHGEGIQHIALATDDLAASAAVLAASGVQFVQPPAAYYGTLDGRLPGHGLDPATLQRYGILVDGTVRADGGQDRFLQ
AFAKREAGEFFFEIVQRDGHHGFGEGNLAVLESLAGE
>Mature_356_residues
SAAEAWDNPLGIQGYEFIEFASPDPAALGRTFERFGFAAIAEHRHKAVRLYRQGEMNFIVDAEPDSFATRYAAEYGLSIC
AVGIRVTDAAAAYARALDAGAWPFEGGTVGPMELNIPAIQGIGQSVIYFIDRWRGKEGRPGDVGDISIYDVDFRPMPQGN
RPRDAGLVRVDHLTQAVEPGHLEEWSDFYRKVLGFREIHEVHPDWQVASDACVLLSPCGQIRIPLYEKGTPRHDRMRHYL
SDPHGEGIQHIALATDDLAASAAVLAASGVQFVQPPAAYYGTLDGRLPGHGLDPATLQRYGILVDGTVRADGGQDRFLQA
FAKREAGEFFFEIVQRDGHHGFGEGNLAVLESLAGE

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI14249394, Length=315, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17555220, Length=220, Percent_Identity=30.9090909090909, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550752, Length=197, Percent_Identity=27.4111675126904, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356105, Length=193, Percent_Identity=26.4248704663212, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24667510, Length=193, Percent_Identity=26.9430051813472, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 39106; Mature: 38975

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAEAWDNPLGIQGYEFIEFASPDPAALGRTFERFGFAAIAEHRHKAVRLYRQGEMNFI
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VDAEPDSFATRYAAEYGLSICAVGIRVTDAAAAYARALDAGAWPFEGGTVGPMELNIPAI
EECCCCHHHHHHHHHHCCEEEEEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHH
QGIGQSVIYFIDRWRGKEGRPGDVGDISIYDVDFRPMPQGNRPRDAGLVRVDHLTQAVEP
HHCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHCCC
GHLEEWSDFYRKVLGFREIHEVHPDWQVASDACVLLSPCGQIRIPLYEKGTPRHDRMRHY
CCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCCCCEEEEEECCCCCHHHHHHHH
LSDPHGEGIQHIALATDDLAASAAVLAASGVQFVQPPAAYYGTLDGRLPGHGLDPATLQR
HCCCCCCCCEEEEEECHHHHHHHHHHHHCCCHHCCCCHHHHCCCCCCCCCCCCCHHHHHH
YGILVDGTVRADGGQDRFLQAFAKREAGEFFFEIVQRDGHHGFGEGNLAVLESLAGE
CCEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SAAEAWDNPLGIQGYEFIEFASPDPAALGRTFERFGFAAIAEHRHKAVRLYRQGEMNFI
CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VDAEPDSFATRYAAEYGLSICAVGIRVTDAAAAYARALDAGAWPFEGGTVGPMELNIPAI
EECCCCHHHHHHHHHHCCEEEEEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHH
QGIGQSVIYFIDRWRGKEGRPGDVGDISIYDVDFRPMPQGNRPRDAGLVRVDHLTQAVEP
HHCHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHCCC
GHLEEWSDFYRKVLGFREIHEVHPDWQVASDACVLLSPCGQIRIPLYEKGTPRHDRMRHY
CCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCEEEECCCCCEEEEEECCCCCHHHHHHHH
LSDPHGEGIQHIALATDDLAASAAVLAASGVQFVQPPAAYYGTLDGRLPGHGLDPATLQR
HCCCCCCCCEEEEEECHHHHHHHHHHHHCCCHHCCCCHHHHCCCCCCCCCCCCCHHHHHH
YGILVDGTVRADGGQDRFLQAFAKREAGEFFFEIVQRDGHHGFGEGNLAVLESLAGE
CCEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]