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The map label for this gene is wecB [H]

Identifier: 73538775

GI number: 73538775

Start: 1677493

End: 1678644

Strand: Reverse

Name: wecB [H]

Synonym: Reut_B4950

Alternate gene names: 73538775

Gene position: 1678644-1677493 (Counterclockwise)

Preceding gene: 73538781

Following gene: 73538774

Centisome position: 61.58

GC content: 63.63

Gene sequence:

>1152_bases
ATGAAAATCCTTTCGGTATTTGGCACACGTCCCGAAGCCATCAAGATGGCCCCGCTGGTCAAGACACTTGGGGGCAGCGC
GGAAATCGACTCCGTCGTCTGTGTGACCGGCCAGCATCAGCAGATGCTGCAGCAGGTCCTGGACCTGTTCGACATCGTTC
CCCAGTACAACCTGGAACTGATGACGCGTAACCAGACGCTCAACGGCCTGAGTTCGCGGCTGCTGGCATCGTTTGACGAC
GTGCTCGAGACGGTGCGTCCCGACAGGATTCTCGTGCATGGCGATACGACCTCGGCCATGGTTTCCGCCCTGGCGGCGTT
CCATCGCCGCATCCCGGTGGGCCATGTCGAGGCAGGTCTGCGGACTGGCGACCTGTCGCAGCCCTGGCCCGAGGAGATGA
ACCGCCGCACCATTGATGTCTGCGCCGACCTGCTGTTCGCGCCAACTGAATCTTCACGTCATAACCTGCAGGCCGAAAAC
CTGGGCGGCCGCATCGTGGTCACTGGTAATACCGTGATCGACGCACTGCTCCAGACGACTGGCCGGATCCTCGCAGACCA
GCCGTTCCGCGAGCGGCTCGATGCGCATTTCCCGTTTCTTCGCGACGACCGCAAGCTGCTGCTGGTCACGGGCCACCGCC
GGGAGAATTTCGGCACCGGTTTCGCCAATATCTGCGAGGCCCTGGCACAACTGGCGCGGCGCGACGACATCCAGATCGTC
TACCCGGTCCACCTCAACCCCAACGTTCAGGGCCCCGTGCAGGACAAACTGTCGGGCTTGCCCAACGTGCATCTGATCGA
GCCGCTCGATTACGCGCTGTTCGTGCGGCTGATGCAGCGGGCCCACGTCATCCTGACCGATTCCGGTGGCGTGCAGGAAG
AAGCCCCGTCGCTGGGCAAGCCCGTGCTGGTGATGCGCAATGTCACCGAGCGTCCCGAGGCGGTGCATGCCGGGACGGTC
AGGCTGGTTGGTACCGAGGTCGCGAGCATCGTGCATTCGGTCACCCACCTTTATGACAATGACGATGCCTGGCGTGCGTT
CTCGCAGCGGCTGAATCCTTACGGCGATGGCCACGCTTCGCAGCGCATCGTGGCGGCGCTCACGGGGGCGCCCATGGGCG
AGTTCCTGCACGACCAGCAGGCGGCGGCGTGA

Upstream 100 bases:

>100_bases
GCACTTGTGGCGGAAACACTAGCGTGGCGCGATCACAACACAAAGTCATGTTGTCCATAGCTACACCGTGGTAGGCTGTC
AAGTTATTTTGTGTGACATT

Downstream 100 bases:

>100_bases
CCGCCATGACGCTTTCCGCTCCGGCCCGCCATGCCCGCCCTGCGGCGCACCACGGGGCGGCCGCATTCTGATGGGAACCA
TGGACACCGTGTCGCTAGTC

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKILSVFGTRPEAIKMAPLVKTLGGSAEIDSVVCVTGQHQQMLQQVLDLFDIVPQYNLELMTRNQTLNGLSSRLLASFDD
VLETVRPDRILVHGDTTSAMVSALAAFHRRIPVGHVEAGLRTGDLSQPWPEEMNRRTIDVCADLLFAPTESSRHNLQAEN
LGGRIVVTGNTVIDALLQTTGRILADQPFRERLDAHFPFLRDDRKLLLVTGHRRENFGTGFANICEALAQLARRDDIQIV
YPVHLNPNVQGPVQDKLSGLPNVHLIEPLDYALFVRLMQRAHVILTDSGGVQEEAPSLGKPVLVMRNVTERPEAVHAGTV
RLVGTEVASIVHSVTHLYDNDDAWRAFSQRLNPYGDGHASQRIVAALTGAPMGEFLHDQQAAA

Sequences:

>Translated_383_residues
MKILSVFGTRPEAIKMAPLVKTLGGSAEIDSVVCVTGQHQQMLQQVLDLFDIVPQYNLELMTRNQTLNGLSSRLLASFDD
VLETVRPDRILVHGDTTSAMVSALAAFHRRIPVGHVEAGLRTGDLSQPWPEEMNRRTIDVCADLLFAPTESSRHNLQAEN
LGGRIVVTGNTVIDALLQTTGRILADQPFRERLDAHFPFLRDDRKLLLVTGHRRENFGTGFANICEALAQLARRDDIQIV
YPVHLNPNVQGPVQDKLSGLPNVHLIEPLDYALFVRLMQRAHVILTDSGGVQEEAPSLGKPVLVMRNVTERPEAVHAGTV
RLVGTEVASIVHSVTHLYDNDDAWRAFSQRLNPYGDGHASQRIVAALTGAPMGEFLHDQQAAA
>Mature_383_residues
MKILSVFGTRPEAIKMAPLVKTLGGSAEIDSVVCVTGQHQQMLQQVLDLFDIVPQYNLELMTRNQTLNGLSSRLLASFDD
VLETVRPDRILVHGDTTSAMVSALAAFHRRIPVGHVEAGLRTGDLSQPWPEEMNRRTIDVCADLLFAPTESSRHNLQAEN
LGGRIVVTGNTVIDALLQTTGRILADQPFRERLDAHFPFLRDDRKLLLVTGHRRENFGTGFANICEALAQLARRDDIQIV
YPVHLNPNVQGPVQDKLSGLPNVHLIEPLDYALFVRLMQRAHVILTDSGGVQEEAPSLGKPVLVMRNVTERPEAVHAGTV
RLVGTEVASIVHSVTHLYDNDDAWRAFSQRLNPYGDGHASQRIVAALTGAPMGEFLHDQQAAA

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=369, Percent_Identity=57.1815718157182, Blast_Score=402, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42189; Mature: 42189

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILSVFGTRPEAIKMAPLVKTLGGSAEIDSVVCVTGQHQQMLQQVLDLFDIVPQYNLEL
CCEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEE
MTRNQTLNGLSSRLLASFDDVLETVRPDRILVHGDTTSAMVSALAAFHRRIPVGHVEAGL
EECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHCCC
RTGDLSQPWPEEMNRRTIDVCADLLFAPTESSRHNLQAENLGGRIVVTGNTVIDALLQTT
CCCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEEECHHHHHHHHHHH
GRILADQPFRERLDAHFPFLRDDRKLLLVTGHRRENFGTGFANICEALAQLARRDDIQIV
CHHHCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
YPVHLNPNVQGPVQDKLSGLPNVHLIEPLDYALFVRLMQRAHVILTDSGGVQEEAPSLGK
EEEEECCCCCCCHHHHHCCCCCEEEECHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCC
PVLVMRNVTERPEAVHAGTVRLVGTEVASIVHSVTHLYDNDDAWRAFSQRLNPYGDGHAS
CEEEECCCCCCCCHHCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHH
QRIVAALTGAPMGEFLHDQQAAA
HHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKILSVFGTRPEAIKMAPLVKTLGGSAEIDSVVCVTGQHQQMLQQVLDLFDIVPQYNLEL
CCEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEE
MTRNQTLNGLSSRLLASFDDVLETVRPDRILVHGDTTSAMVSALAAFHRRIPVGHVEAGL
EECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHCCC
RTGDLSQPWPEEMNRRTIDVCADLLFAPTESSRHNLQAENLGGRIVVTGNTVIDALLQTT
CCCCCCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCEEEEECHHHHHHHHHHH
GRILADQPFRERLDAHFPFLRDDRKLLLVTGHRRENFGTGFANICEALAQLARRDDIQIV
CHHHCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
YPVHLNPNVQGPVQDKLSGLPNVHLIEPLDYALFVRLMQRAHVILTDSGGVQEEAPSLGK
EEEEECCCCCCCHHHHHCCCCCEEEECHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCC
PVLVMRNVTERPEAVHAGTVRLVGTEVASIVHSVTHLYDNDDAWRAFSQRLNPYGDGHAS
CEEEECCCCCCCCHHCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHH
QRIVAALTGAPMGEFLHDQQAAA
HHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]