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The map label for this gene is phoR [H]

Identifier: 73538766

GI number: 73538766

Start: 1665321

End: 1667720

Strand: Reverse

Name: phoR [H]

Synonym: Reut_B4941

Alternate gene names: 73538766

Gene position: 1667720-1665321 (Counterclockwise)

Preceding gene: 73538767

Following gene: 73538765

Centisome position: 61.17

GC content: 68.38

Gene sequence:

>2400_bases
ATGACGCCGGTATCCGCATCCGGTAAGTCGGGGCGACGTGCGCCGGATGCCGCCTTCGGGCGTCGCACGCTCGTCGAATG
GGCCTTGCTGCTGGCTGCCGTGCTGGCGCTGGTGACGGTCGTCGCGCGCCATGGCTGGGCCGAGCGTGCGGACCTGGCCA
TCTACGATCTATCCATCCAGGCGCAGCACCATGCGGCGCGCGACGATATTGTCATTGTCGCCATCGACGACGCGAGCATC
ACGGCCATCGGCCGCTGGCCCTGGCGCCGCACGGTACTGGCTGCGCTGGTGGACCGCATTGCCGCCGGTCAACCGCGCGT
GATCGGCATGGACGTGATCCTGACCGAGCGCGACACGCGCTATCCGAAGGACGATGCCGTGCTTGCCCGCAGCTTCGCCG
CAGCGGGCAACGTGGTGCTGCCCGCGCTGGCCGAATCATCAGCCAATGGCATGGTGGTGCGATATCCGCTGGCCGGGCTA
CGCGCTGACGTCGGGCACATCAACCTCACGGTGGACGCCGACGGCGTGGCGCGGCAGCTATACCTGCTCGAAGGGCCCGC
ACCTGTGAAACAAGCCGGGCTGCCCCACGTGGCGGTGGTCATGGCGTCATGGGGTCGGACGCAGCCACCCGTCGTCAGCT
ATCGCCATGAGCCGGCCAGCGTGATCGACGCGTTCGGCTGGGAGCGCCGATACCGCTTGCGCATCCCGTTCGCGGGCCCG
CCGGGCACGTTTGCCCGCGTTTCGGCGCGCGACCTGCTGGAAGGCCGCATCGACCCCGCCATATTCCGTGACAAGGCCGT
ACTGTTCGGCGCCATCGCGACCGGGATGGGCGACGTATTGCCCACGCCGGTAGCGCGCGACGGGCGCGGCATGAGCGGCG
TGGAAATCCTGGCCAATACGGTGCAGACGCTGCTGGACAACGATGCCATCGTCGTGGTGCCGCGGGCCTGGCAGGTGGCG
TGCACCGTGCTGGCCATACTGGCGGCCGCGCTCGCCGCGCTGGTGCTGACGCCGCGCGGCGCGCTGCTCGCGACAGGTGT
GATGGTGGCGGTGCTGCTTGGCGGGCCGCCGCTGCTGCTCGCCGGTGCTCGGCTGTGGTTTGCGCCCGCAGCGGCGCTGC
TTGGTTGCCTGATGTTTTATCCGTTATGGAGCTGGCGCCGCCAGGAAGCCGCACTTCGCTTCCTCGCGCAGGAACTGGCG
CGCCATGAGCGCGAGCCCGACCTGCCTTCCGCTTCCACGGCCATTGGCGCCACGCTGGAGAGCCGCATGCGTGCGGTCTA
TCGCATGAGTTCGCGGCTGCATGACCTGCGCCGCTTCCTCGCCGACGGGCTCGAAAGCCTGCCTGAGCCGACGGTGATCT
GCAACCTGGAAGGCGGGGTGCTGCTTGCGAACCGGCGCTGTGTGGCGCTCGTTCCCGGAGTGCTCGGCGCAGGCAACGGC
AGCATCGCGCAGAGCGGCCATGCCGATATGGATGGTGGCGCGCGTCCGGATATCCGCGCGGTGATCGCCGTATTGTTCGC
CGCGCCGGAACCGGCGCTGGAGTACTGGCAGGCGCTGCATGCGCGCAGCACCGCAGCCGGCGGTCTCGACGATGGCATCG
AACTGGCCGCGCGCAATGAGCGCCGCTATCTCATGCATGGCGCGCCGCTGCATGACGAGCAGGGCAGCGTAGCCGGGCTG
ATCGTCAGCTTTATCGACATCACAGCGATTCGCGTGGCCGAGCGCCAGCGCGAGCAGATGCTGCGTTTCCTGTCGCACGA
CATGCGCTCGCCACAGGCGTCGATTCTCGCGCTGATCGACCTGCATCGCGGCGCAGCCGGCGACGGGCCGCCCGCCGAAC
TGCTCACGCGCATCGGAGCGCATGCCCGACGCACCATGTCGCTGGCCGATGACTTCATTCGCGTCGCGCGCGCAGAAACA
CAGCCGCTCGCGCTTCAAGATGTGGATCTGGCGGGGCTCGTGCTGGACGCCACGGACGAGATGTGGGCGCTGGCCAATGC
CGGCGGGGTGCAGCTCAACGTGCACGTGCCCAATGATCCGGCTATGGTCCGTGCCGAGCCTGCGCTGCTTGTGCGGGCGA
TTGGCAATCTCGTCAGTAACGCGATCAAGTTCAGTCCGCGCGGCGCGGCGGTCATGGTGGCATTGCAGGCTGAGCCGGAT
CGCTTCGTTGTGTCGGTGTCGGACCACGGGCCCGGCATCCCGCTTGCGAAGCAGCAACGGCTGTTCGCGCCATTTGCGCG
GCTGCATGAACATGAGGCCGGTGCGCCGGCCGGCAGCGGGCTTGGTCTGGTGCTGGCAAAGACCGTGGTGGAGCGCCACG
GTGGCAACATCCGCGTGGCGAGCGATGCAGGGGCGCGGGCGACATTCTCGCTGCACCTGCCTACTTCACCATGTTACTGA

Upstream 100 bases:

>100_bases
TCATTCTCCGCGCCGCAGCGTCTCGACATCGTCGCGCTCCTGCGTGACGGACAGGGCGTCACGATCCGGCTCGGCAACGG
CGCCCGCGACGAAGGCGGCC

Downstream 100 bases:

>100_bases
GCGCCGTTCGACACAATTGTTGGCAGTTGCCTTGGGCGGGTTTGCCTACGATGTCGGGGTCGTGCGGCCCCGCTACGCAC
GGCTTGTAACGCCCGCTCCA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 799; Mature: 798

Protein sequence:

>799_residues
MTPVSASGKSGRRAPDAAFGRRTLVEWALLLAAVLALVTVVARHGWAERADLAIYDLSIQAQHHAARDDIVIVAIDDASI
TAIGRWPWRRTVLAALVDRIAAGQPRVIGMDVILTERDTRYPKDDAVLARSFAAAGNVVLPALAESSANGMVVRYPLAGL
RADVGHINLTVDADGVARQLYLLEGPAPVKQAGLPHVAVVMASWGRTQPPVVSYRHEPASVIDAFGWERRYRLRIPFAGP
PGTFARVSARDLLEGRIDPAIFRDKAVLFGAIATGMGDVLPTPVARDGRGMSGVEILANTVQTLLDNDAIVVVPRAWQVA
CTVLAILAAALAALVLTPRGALLATGVMVAVLLGGPPLLLAGARLWFAPAAALLGCLMFYPLWSWRRQEAALRFLAQELA
RHEREPDLPSASTAIGATLESRMRAVYRMSSRLHDLRRFLADGLESLPEPTVICNLEGGVLLANRRCVALVPGVLGAGNG
SIAQSGHADMDGGARPDIRAVIAVLFAAPEPALEYWQALHARSTAAGGLDDGIELAARNERRYLMHGAPLHDEQGSVAGL
IVSFIDITAIRVAERQREQMLRFLSHDMRSPQASILALIDLHRGAAGDGPPAELLTRIGAHARRTMSLADDFIRVARAET
QPLALQDVDLAGLVLDATDEMWALANAGGVQLNVHVPNDPAMVRAEPALLVRAIGNLVSNAIKFSPRGAAVMVALQAEPD
RFVVSVSDHGPGIPLAKQQRLFAPFARLHEHEAGAPAGSGLGLVLAKTVVERHGGNIRVASDAGARATFSLHLPTSPCY

Sequences:

>Translated_799_residues
MTPVSASGKSGRRAPDAAFGRRTLVEWALLLAAVLALVTVVARHGWAERADLAIYDLSIQAQHHAARDDIVIVAIDDASI
TAIGRWPWRRTVLAALVDRIAAGQPRVIGMDVILTERDTRYPKDDAVLARSFAAAGNVVLPALAESSANGMVVRYPLAGL
RADVGHINLTVDADGVARQLYLLEGPAPVKQAGLPHVAVVMASWGRTQPPVVSYRHEPASVIDAFGWERRYRLRIPFAGP
PGTFARVSARDLLEGRIDPAIFRDKAVLFGAIATGMGDVLPTPVARDGRGMSGVEILANTVQTLLDNDAIVVVPRAWQVA
CTVLAILAAALAALVLTPRGALLATGVMVAVLLGGPPLLLAGARLWFAPAAALLGCLMFYPLWSWRRQEAALRFLAQELA
RHEREPDLPSASTAIGATLESRMRAVYRMSSRLHDLRRFLADGLESLPEPTVICNLEGGVLLANRRCVALVPGVLGAGNG
SIAQSGHADMDGGARPDIRAVIAVLFAAPEPALEYWQALHARSTAAGGLDDGIELAARNERRYLMHGAPLHDEQGSVAGL
IVSFIDITAIRVAERQREQMLRFLSHDMRSPQASILALIDLHRGAAGDGPPAELLTRIGAHARRTMSLADDFIRVARAET
QPLALQDVDLAGLVLDATDEMWALANAGGVQLNVHVPNDPAMVRAEPALLVRAIGNLVSNAIKFSPRGAAVMVALQAEPD
RFVVSVSDHGPGIPLAKQQRLFAPFARLHEHEAGAPAGSGLGLVLAKTVVERHGGNIRVASDAGARATFSLHLPTSPCY
>Mature_798_residues
TPVSASGKSGRRAPDAAFGRRTLVEWALLLAAVLALVTVVARHGWAERADLAIYDLSIQAQHHAARDDIVIVAIDDASIT
AIGRWPWRRTVLAALVDRIAAGQPRVIGMDVILTERDTRYPKDDAVLARSFAAAGNVVLPALAESSANGMVVRYPLAGLR
ADVGHINLTVDADGVARQLYLLEGPAPVKQAGLPHVAVVMASWGRTQPPVVSYRHEPASVIDAFGWERRYRLRIPFAGPP
GTFARVSARDLLEGRIDPAIFRDKAVLFGAIATGMGDVLPTPVARDGRGMSGVEILANTVQTLLDNDAIVVVPRAWQVAC
TVLAILAAALAALVLTPRGALLATGVMVAVLLGGPPLLLAGARLWFAPAAALLGCLMFYPLWSWRRQEAALRFLAQELAR
HEREPDLPSASTAIGATLESRMRAVYRMSSRLHDLRRFLADGLESLPEPTVICNLEGGVLLANRRCVALVPGVLGAGNGS
IAQSGHADMDGGARPDIRAVIAVLFAAPEPALEYWQALHARSTAAGGLDDGIELAARNERRYLMHGAPLHDEQGSVAGLI
VSFIDITAIRVAERQREQMLRFLSHDMRSPQASILALIDLHRGAAGDGPPAELLTRIGAHARRTMSLADDFIRVARAETQ
PLALQDVDLAGLVLDATDEMWALANAGGVQLNVHVPNDPAMVRAEPALLVRAIGNLVSNAIKFSPRGAAVMVALQAEPDR
FVVSVSDHGPGIPLAKQQRLFAPFARLHEHEAGAPAGSGLGLVLAKTVVERHGGNIRVASDAGARATFSLHLPTSPCY

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG4252

COG function: function code T; Predicted transmembrane sensor domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=284, Percent_Identity=27.8169014084507, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=225, Percent_Identity=31.5555555555556, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI48994928, Length=267, Percent_Identity=26.5917602996255, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=27.1929824561404, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=29.6943231441048, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788713, Length=379, Percent_Identity=25.065963060686, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790346, Length=213, Percent_Identity=25.8215962441315, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI145693157, Length=225, Percent_Identity=25.3333333333333, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=29.3023255813954, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1786600, Length=388, Percent_Identity=23.9690721649485, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=214, Percent_Identity=28.9719626168224, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=23.1441048034935, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=204, Percent_Identity=25, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 85068; Mature: 84937

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPVSASGKSGRRAPDAAFGRRTLVEWALLLAAVLALVTVVARHGWAERADLAIYDLSIQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEE
AQHHAARDDIVIVAIDDASITAIGRWPWRRTVLAALVDRIAAGQPRVIGMDVILTERDTR
ECCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCC
YPKDDAVLARSFAAAGNVVLPALAESSANGMVVRYPLAGLRADVGHINLTVDADGVARQL
CCCHHHHHHHHHHHCCCEEEEHHHCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEE
YLLEGPAPVKQAGLPHVAVVMASWGRTQPPVVSYRHEPASVIDAFGWERRYRLRIPFAGP
EEEECCCCHHHCCCCCEEHHHHHCCCCCCCEEEECCCCHHHHHHCCCCCEEEEEECCCCC
PGTFARVSARDLLEGRIDPAIFRDKAVLFGAIATGMGDVLPTPVARDGRGMSGVEILANT
CCCHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
VQTLLDNDAIVVVPRAWQVACTVLAILAAALAALVLTPRGALLATGVMVAVLLGGPPLLL
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHH
AGARLWFAPAAALLGCLMFYPLWSWRRQEAALRFLAQELARHEREPDLPSASTAIGATLE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
SRMRAVYRMSSRLHDLRRFLADGLESLPEPTVICNLEGGVLLANRRCVALVPGVLGAGNG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCEEEEECCCCCCCCC
SIAQSGHADMDGGARPDIRAVIAVLFAAPEPALEYWQALHARSTAAGGLDDGIELAARNE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
RRYLMHGAPLHDEQGSVAGLIVSFIDITAIRVAERQREQMLRFLSHDMRSPQASILALID
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEE
LHRGAAGDGPPAELLTRIGAHARRTMSLADDFIRVARAETQPLALQDVDLAGLVLDATDE
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEEECCCH
MWALANAGGVQLNVHVPNDPAMVRAEPALLVRAIGNLVSNAIKFSPRGAAVMVALQAEPD
HHHHCCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
RFVVSVSDHGPGIPLAKQQRLFAPFARLHEHEAGAPAGSGLGLVLAKTVVERHGGNIRVA
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
SDAGARATFSLHLPTSPCY
CCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
TPVSASGKSGRRAPDAAFGRRTLVEWALLLAAVLALVTVVARHGWAERADLAIYDLSIQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEE
AQHHAARDDIVIVAIDDASITAIGRWPWRRTVLAALVDRIAAGQPRVIGMDVILTERDTR
ECCCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCC
YPKDDAVLARSFAAAGNVVLPALAESSANGMVVRYPLAGLRADVGHINLTVDADGVARQL
CCCHHHHHHHHHHHCCCEEEEHHHCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCEEEE
YLLEGPAPVKQAGLPHVAVVMASWGRTQPPVVSYRHEPASVIDAFGWERRYRLRIPFAGP
EEEECCCCHHHCCCCCEEHHHHHCCCCCCCEEEECCCCHHHHHHCCCCCEEEEEECCCCC
PGTFARVSARDLLEGRIDPAIFRDKAVLFGAIATGMGDVLPTPVARDGRGMSGVEILANT
CCCHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
VQTLLDNDAIVVVPRAWQVACTVLAILAAALAALVLTPRGALLATGVMVAVLLGGPPLLL
HHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHH
AGARLWFAPAAALLGCLMFYPLWSWRRQEAALRFLAQELARHEREPDLPSASTAIGATLE
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
SRMRAVYRMSSRLHDLRRFLADGLESLPEPTVICNLEGGVLLANRRCVALVPGVLGAGNG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCEEEEECCCCCCCCC
SIAQSGHADMDGGARPDIRAVIAVLFAAPEPALEYWQALHARSTAAGGLDDGIELAARNE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCC
RRYLMHGAPLHDEQGSVAGLIVSFIDITAIRVAERQREQMLRFLSHDMRSPQASILALID
CEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEE
LHRGAAGDGPPAELLTRIGAHARRTMSLADDFIRVARAETQPLALQDVDLAGLVLDATDE
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEEEECCCH
MWALANAGGVQLNVHVPNDPAMVRAEPALLVRAIGNLVSNAIKFSPRGAAVMVALQAEPD
HHHHCCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCC
RFVVSVSDHGPGIPLAKQQRLFAPFARLHEHEAGAPAGSGLGLVLAKTVVERHGGNIRVA
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
SDAGARATFSLHLPTSPCY
CCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]