Click here to switch to the map view.

The map label for this gene is ilvA [H]

Identifier: 73538734

GI number: 73538734

Start: 1635110

End: 1636693

Strand: Reverse

Name: ilvA [H]

Synonym: Reut_B4909

Alternate gene names: 73538734

Gene position: 1636693-1635110 (Counterclockwise)

Preceding gene: 73538736

Following gene: 73538732

Centisome position: 60.04

GC content: 67.05

Gene sequence:

>1584_bases
ATGCCGGCACAAGCCGCCGATCTTGCCACCGAATATCGCGATGTCCATGCGCCGGACGTTGCCGACCAGAACAGTTACCT
CAGGCGCATCCTGAATGCGCGCGTCTACGACGTCGCGCGCGAGACCGAGCTCGAGCTGGCGCGCAACCTGTCCGCGCGCA
CCGGCAACGCAATCTGGCTCAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGATCCGCGGCGCCTACAACAAGATG
GCCAATCTGGATGCGCAGGCACTGCAGCGCGGCGTGATCACTGCATCGGCGGGAAACCACGCGCAGGGCGTGGCGCTGTC
GGCCCGGCACCTTGGCGTGCGCGCGGTGATCGTGGTGCCGACGACGGCGCCGCAGGTCAAGGTCGATGCCGTGCGTGCGC
ATGGCGGCCCCACGGTCGAAGTGGTCCAGGCCGGTGCGTCCTATACCGATGCCTGGCGCCACGCAATGCATCTGCAGCAG
CAGCTTGGCCTGACCTTCATCCCGGCCTTCGACGATCCCGACGTGATCGCGGGCCAGGGCACCGTGGGCGCGGAGATCCT
GGCGCGCCATCGCGGGCCGCTCGACGCCATTTTCGTGCCTGTCGGGGGCGGCAGCCTTGCTGCGGGCATCGCCACGTACG
TGAAGGCAGTGCGCCCCGAAATCCGCGTGATCGGCGTGCAGACGCAGGACTCATGCGCGATGGCGCAGTCGCTGCGCGCG
GGACGGCGCGTGGAACTCGGCGATGTGGGCCTGTTCTCGGATGGCACCGCGGTGAAGCTGGTCGGCGAGGAAACCTTCCG
TCTATGCCGGGCGTATCTCGATGATGTCATGACGGTCAGCACGGATGCCGTGTGCGCCGCCATCAAGGATGTGTTCGAGG
ACACACGCAGCGTGCTCGAACCCGCCGGTGCGCTGGCCGTTGCCGCCGCCAAGCAATACGCGCAACAGCATGGCCTGCAG
GGCCGGACGCTGGTGGCGGTGACGTCGGGCGCCAACGTCAACTTCGAGCGCATGCGCTTCGTCGCCGAGCGCGCGGAAAT
TGGCGATGCGCGCGAAGCCGTGTTCGCGGTGACGATGCCCGAGGCGCGCGGCACTTTCCTGCGCTTCTGCGATCTCGCCG
GCAGCCGCAGCATCACAGAGTTCAGCTACCGCATTGCCGATGCGCAAACCGCGCACGTGTTTGTCGGCATGCGCGTGCGG
GATCGTACCGAGGCTGCGCAGATTGCCGGCACCTTCAGCGCGCAAGGCTTTGCCACGGTCAACCTGACCGGCGACGAACT
GGCCAAGCAGCACCTGCGGCATATGGTGGGCGGCCGCTCCGTACTCGCTGGCGGCGAGAGACTGTTCCGCTTTGCATTCC
CCGAGCGGCCCGGCGCGTTGATGACCTTTCTGCGCGCGCTGCCGGCCGACTGGAACATCAGCCTCTTCCATTACCGCAAT
GATGGCGGTGACGCTGCGTCTGTGCTTGTCGGCATCCAGATGCCCGAGGCGGCTGCACAGCGCAGCGACGCGGTGCTGGC
CGCGCTCGGCTACCCGTACTGGGAGGAAAGCGCCAATCCGGCCTATCGCCTGTTCCTGGCATAG

Upstream 100 bases:

>100_bases
GGGTTAGCGCGCGTCCTCAGATCAGTTACCGCAAAACCCGCCCTGAGGCGGGTTTTTTGTTTCCGTCTCCTGGGCACACA
TTCAGCACAGGAGCCCCGCC

Downstream 100 bases:

>100_bases
GCCGGCAGCGCACGGATTCGCCGTCGAACTTTCTCAGTGCCTGACCGCGCCCCGGCCGCAGTCGTCGGCGCGATGCATCA
GGCGGCGCAGGCTCGGGTTC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPAQAADLATEYRDVHAPDVADQNSYLRRILNARVYDVARETELELARNLSARTGNAIWLKREDNQPVFSFKIRGAYNKM
ANLDAQALQRGVITASAGNHAQGVALSARHLGVRAVIVVPTTAPQVKVDAVRAHGGPTVEVVQAGASYTDAWRHAMHLQQ
QLGLTFIPAFDDPDVIAGQGTVGAEILARHRGPLDAIFVPVGGGSLAAGIATYVKAVRPEIRVIGVQTQDSCAMAQSLRA
GRRVELGDVGLFSDGTAVKLVGEETFRLCRAYLDDVMTVSTDAVCAAIKDVFEDTRSVLEPAGALAVAAAKQYAQQHGLQ
GRTLVAVTSGANVNFERMRFVAERAEIGDAREAVFAVTMPEARGTFLRFCDLAGSRSITEFSYRIADAQTAHVFVGMRVR
DRTEAAQIAGTFSAQGFATVNLTGDELAKQHLRHMVGGRSVLAGGERLFRFAFPERPGALMTFLRALPADWNISLFHYRN
DGGDAASVLVGIQMPEAAAQRSDAVLAALGYPYWEESANPAYRLFLA

Sequences:

>Translated_527_residues
MPAQAADLATEYRDVHAPDVADQNSYLRRILNARVYDVARETELELARNLSARTGNAIWLKREDNQPVFSFKIRGAYNKM
ANLDAQALQRGVITASAGNHAQGVALSARHLGVRAVIVVPTTAPQVKVDAVRAHGGPTVEVVQAGASYTDAWRHAMHLQQ
QLGLTFIPAFDDPDVIAGQGTVGAEILARHRGPLDAIFVPVGGGSLAAGIATYVKAVRPEIRVIGVQTQDSCAMAQSLRA
GRRVELGDVGLFSDGTAVKLVGEETFRLCRAYLDDVMTVSTDAVCAAIKDVFEDTRSVLEPAGALAVAAAKQYAQQHGLQ
GRTLVAVTSGANVNFERMRFVAERAEIGDAREAVFAVTMPEARGTFLRFCDLAGSRSITEFSYRIADAQTAHVFVGMRVR
DRTEAAQIAGTFSAQGFATVNLTGDELAKQHLRHMVGGRSVLAGGERLFRFAFPERPGALMTFLRALPADWNISLFHYRN
DGGDAASVLVGIQMPEAAAQRSDAVLAALGYPYWEESANPAYRLFLA
>Mature_526_residues
PAQAADLATEYRDVHAPDVADQNSYLRRILNARVYDVARETELELARNLSARTGNAIWLKREDNQPVFSFKIRGAYNKMA
NLDAQALQRGVITASAGNHAQGVALSARHLGVRAVIVVPTTAPQVKVDAVRAHGGPTVEVVQAGASYTDAWRHAMHLQQQ
LGLTFIPAFDDPDVIAGQGTVGAEILARHRGPLDAIFVPVGGGSLAAGIATYVKAVRPEIRVIGVQTQDSCAMAQSLRAG
RRVELGDVGLFSDGTAVKLVGEETFRLCRAYLDDVMTVSTDAVCAAIKDVFEDTRSVLEPAGALAVAAAKQYAQQHGLQG
RTLVAVTSGANVNFERMRFVAERAEIGDAREAVFAVTMPEARGTFLRFCDLAGSRSITEFSYRIADAQTAHVFVGMRVRD
RTEAAQIAGTFSAQGFATVNLTGDELAKQHLRHMVGGRSVLAGGERLFRFAFPERPGALMTFLRALPADWNISLFHYRND
GGDAASVLVGIQMPEAAAQRSDAVLAALGYPYWEESANPAYRLFLA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=303, Percent_Identity=33.993399339934, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI33469958, Length=305, Percent_Identity=30.1639344262295, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI19923959, Length=302, Percent_Identity=28.476821192053, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1790207, Length=512, Percent_Identity=51.171875, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1789505, Length=308, Percent_Identity=37.987012987013, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17537387, Length=385, Percent_Identity=32.2077922077922, Blast_Score=138, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71991565, Length=303, Percent_Identity=31.6831683168317, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=291, Percent_Identity=28.8659793814433, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320930, Length=516, Percent_Identity=44.9612403100775, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322631, Length=304, Percent_Identity=35.1973684210526, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=275, Percent_Identity=25.4545454545455, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355833, Length=377, Percent_Identity=28.9124668435013, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24645328, Length=313, Percent_Identity=27.4760383386581, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56751; Mature: 56620

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAQAADLATEYRDVHAPDVADQNSYLRRILNARVYDVARETELELARNLSARTGNAIWL
CCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
KREDNQPVFSFKIRGAYNKMANLDAQALQRGVITASAGNHAQGVALSARHLGVRAVIVVP
EECCCCCEEEEEECCHHHHHHCCCHHHHHCCCEEECCCCCCCCEEEEEEECCEEEEEEEE
TTAPQVKVDAVRAHGGPTVEVVQAGASYTDAWRHAMHLQQQLGLTFIPAFDDPDVIAGQG
CCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEEECCC
TVGAEILARHRGPLDAIFVPVGGGSLAAGIATYVKAVRPEIRVIGVQTQDSCAMAQSLRA
CHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHC
GRRVELGDVGLFSDGTAVKLVGEETFRLCRAYLDDVMTVSTDAVCAAIKDVFEDTRSVLE
CCEEEECCCEEECCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
PAGALAVAAAKQYAQQHGLQGRTLVAVTSGANVNFERMRFVAERAEIGDAREAVFAVTMP
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
EARGTFLRFCDLAGSRSITEFSYRIADAQTAHVFVGMRVRDRTEAAQIAGTFSAQGFATV
CCCCHHHHHHHCCCCCCHHHHEEEECCCCEEEEEEEEEECCHHHHHHHHEEECCCCEEEE
NLTGDELAKQHLRHMVGGRSVLAGGERLFRFAFPERPGALMTFLRALPADWNISLFHYRN
EECHHHHHHHHHHHHHCCCCEECCCHHEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEEC
DGGDAASVLVGIQMPEAAAQRSDAVLAALGYPYWEESANPAYRLFLA
CCCCEEEEEEEEECCHHHHHCCCCEEEECCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
PAQAADLATEYRDVHAPDVADQNSYLRRILNARVYDVARETELELARNLSARTGNAIWL
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
KREDNQPVFSFKIRGAYNKMANLDAQALQRGVITASAGNHAQGVALSARHLGVRAVIVVP
EECCCCCEEEEEECCHHHHHHCCCHHHHHCCCEEECCCCCCCCEEEEEEECCEEEEEEEE
TTAPQVKVDAVRAHGGPTVEVVQAGASYTDAWRHAMHLQQQLGLTFIPAFDDPDVIAGQG
CCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCEEECCC
TVGAEILARHRGPLDAIFVPVGGGSLAAGIATYVKAVRPEIRVIGVQTQDSCAMAQSLRA
CHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHC
GRRVELGDVGLFSDGTAVKLVGEETFRLCRAYLDDVMTVSTDAVCAAIKDVFEDTRSVLE
CCEEEECCCEEECCCCEEEEECHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
PAGALAVAAAKQYAQQHGLQGRTLVAVTSGANVNFERMRFVAERAEIGDAREAVFAVTMP
CCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
EARGTFLRFCDLAGSRSITEFSYRIADAQTAHVFVGMRVRDRTEAAQIAGTFSAQGFATV
CCCCHHHHHHHCCCCCCHHHHEEEECCCCEEEEEEEEEECCHHHHHHHHEEECCCCEEEE
NLTGDELAKQHLRHMVGGRSVLAGGERLFRFAFPERPGALMTFLRALPADWNISLFHYRN
EECHHHHHHHHHHHHHCCCCEECCCHHEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEEC
DGGDAASVLVGIQMPEAAAQRSDAVLAALGYPYWEESANPAYRLFLA
CCCCEEEEEEEEECCHHHHHCCCCEEEECCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA