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The map label for this gene is fkpA [H]

Identifier: 73538732

GI number: 73538732

Start: 1633098

End: 1633538

Strand: Reverse

Name: fkpA [H]

Synonym: Reut_B4907

Alternate gene names: 73538732

Gene position: 1633538-1633098 (Counterclockwise)

Preceding gene: 73538734

Following gene: 73538729

Centisome position: 59.92

GC content: 69.61

Gene sequence:

>441_bases
ATGAAACGCATCGCCCTGCTTTTCAGCGCCATGACCTTCGCCTGCGCCGCCATGGCGGCCGCTCCGGGTGCCTCGGCACC
GGCCGCATCGGCCCCTGCGGCCGCCGCGCAGACGCTGCCTTCCGGCATGACGATCCAGCATCTGGTCAAGGGCACCGGGC
CGTCGCCGAAGGCAACCGATACGGTCCAGGTCCACTACCGCGGCACGCTGGCCGACGGTACCGAATTCGACAGCTCGTAC
AAGCGTGGCCAGCCGATCTCGTTCCCGCTGAACCGCGTGATTCCCTGCTGGACCGAAGGCGTGCAGACCATGCAGGTGGG
CGGCAAGGCCAGGCTGACCTGCCCGGCGGCTACCGCCTACGGTGCGCGCGGTGTGCCGGGCACCATCCCGCCGAACGCCA
CGCTGACGTTCGAGGTGGTGCTGCTCGGCATCGGCGGCTGA

Upstream 100 bases:

>100_bases
GCAGCCGGTGCACCATGCGCCGCTGGAGCATGCGTCGGAGGGTCGGAGCGTCGGTTACACTGCCCGCTCTTTCCACTACG
CCGTTGCAATCGGATTTCCC

Downstream 100 bases:

>100_bases
GTGTTTGGCCGCCGAGTCCTATTGCTGCGGTGTCCCGGAGGCGGGCGCCGCAGGCAGCGCAGGCTCCGCGGCCGGTCCGG
ATGCCGGTGCCGGCGCTGAC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKRIALLFSAMTFACAAMAAAPGASAPAASAPAAAAQTLPSGMTIQHLVKGTGPSPKATDTVQVHYRGTLADGTEFDSSY
KRGQPISFPLNRVIPCWTEGVQTMQVGGKARLTCPAATAYGARGVPGTIPPNATLTFEVVLLGIGG

Sequences:

>Translated_146_residues
MKRIALLFSAMTFACAAMAAAPGASAPAASAPAAAAQTLPSGMTIQHLVKGTGPSPKATDTVQVHYRGTLADGTEFDSSY
KRGQPISFPLNRVIPCWTEGVQTMQVGGKARLTCPAATAYGARGVPGTIPPNATLTFEVVLLGIGG
>Mature_146_residues
MKRIALLFSAMTFACAAMAAAPGASAPAASAPAAAAQTLPSGMTIQHLVKGTGPSPKATDTVQVHYRGTLADGTEFDSSY
KRGQPISFPLNRVIPCWTEGVQTMQVGGKARLTCPAATAYGARGVPGTIPPNATLTFEVVLLGIGG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=47.1698113207547, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=47.1698113207547, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=45.2830188679245, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI4503729, Length=100, Percent_Identity=48, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI224809331, Length=139, Percent_Identity=37.410071942446, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=48.2758620689655, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=48.2758620689655, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=48.2758620689655, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI224809329, Length=94, Percent_Identity=44.6808510638298, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI224809327, Length=94, Percent_Identity=44.6808510638298, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI4758384, Length=94, Percent_Identity=44.6808510638298, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI4503727, Length=125, Percent_Identity=41.6, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI192448443, Length=100, Percent_Identity=39, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789745, Length=129, Percent_Identity=48.062015503876, Blast_Score=114, Evalue=2e-27,
Organism=Escherichia coli, GI87082390, Length=125, Percent_Identity=46.4, Blast_Score=111, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=48.1132075471698, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17540882, Length=87, Percent_Identity=45.9770114942529, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17561782, Length=103, Percent_Identity=45.6310679611651, Blast_Score=75, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=54.5454545454545, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324194, Length=112, Percent_Identity=43.75, Blast_Score=94, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323482, Length=119, Percent_Identity=39.4957983193277, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323566, Length=111, Percent_Identity=39.6396396396396, Blast_Score=73, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24655568, Length=91, Percent_Identity=52.7472527472528, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24583150, Length=108, Percent_Identity=47.2222222222222, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281363946, Length=93, Percent_Identity=47.3118279569892, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17352457, Length=93, Percent_Identity=47.3118279569892, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24647110, Length=126, Percent_Identity=41.2698412698413, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356629, Length=140, Percent_Identity=37.8571428571429, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 14845; Mature: 14845

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIALLFSAMTFACAAMAAAPGASAPAASAPAAAAQTLPSGMTIQHLVKGTGPSPKATD
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCC
TVQVHYRGTLADGTEFDSSYKRGQPISFPLNRVIPCWTEGVQTMQVGGKARLTCPAATAY
EEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHCCCCHHCCCCEEECCCEEEEECCCHHCC
GARGVPGTIPPNATLTFEVVLLGIGG
CCCCCCCCCCCCCEEEEEEEEEECCC
>Mature Secondary Structure
MKRIALLFSAMTFACAAMAAAPGASAPAASAPAAAAQTLPSGMTIQHLVKGTGPSPKATD
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCC
TVQVHYRGTLADGTEFDSSYKRGQPISFPLNRVIPCWTEGVQTMQVGGKARLTCPAATAY
EEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHCCCCHHCCCCEEECCCEEEEECCCHHCC
GARGVPGTIPPNATLTFEVVLLGIGG
CCCCCCCCCCCCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]