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The map label for this gene is mdtD [H]

Identifier: 73538690

GI number: 73538690

Start: 1577582

End: 1579003

Strand: Reverse

Name: mdtD [H]

Synonym: Reut_B4865

Alternate gene names: 73538690

Gene position: 1579003-1577582 (Counterclockwise)

Preceding gene: 73538691

Following gene: 73538689

Centisome position: 57.92

GC content: 66.67

Gene sequence:

>1422_bases
ATGACCACGCCCATGCCTGACGACCGCACCCGCCGCATCATGCTGTGGGTGGTGGCGGTCGGCTTCTTCATGCAGACGCT
GGATTCCACCATCGTCAACACTGCGCTGCCGTCCATGGCGCGCAGCCTTGGCGAAAGCCCGCTGCGCATGCAGTCGGTCG
TGATCGCCTACTCGCTGACCATGGCCGTGATCATCCCGGCCTCCGGCTGGCTGGCAGACCGCTTTGGCACGCGCACCATC
TTCCAGACCGCCATCGCGCTGTTCGTGCTCGGCTCGTTGCTGTGTGCGTACGCGGGCACGCTGCCGTTCCTGGTCGCCGC
GCGCGTGGTGCAGGGCGTGGGCGGCGCCATGCTGCTGCCGGTGGGCCGGTTGTCCGTGCTGCGCACGTTCCCGCGCGACC
AATACCTGCAGGCGCTCAGTTTCGTCGCCATCCCGGGCATGATCGGTCCGCTGATCGGCCCGACGCTGGGCGGCTGGCTC
ACGCAGGCGCTGTCGTGGCACTGGATCTTCCTGATCAACGTGCCCGTCGGTATCCTCGGCGCGCTCGCGACGGTGCGGTA
CATGCCGAACGCGCGCCAGTCCGGCATCGGCCACTTCGACGTGGCCGGCTATGTGCTGCTCGCTGTCGCCATGCTGGCGC
TGTCGTTCTCGCTTGACGGGCTCGCCGAAATGGGCTTCCAGCACGCCACCGTGCTGATGCTGCTGATCGCCAGCATGGCC
GCGCTGACCGCCTACGTGCTGCACGCGGGCAAGCGGCGCCAGCCGCTGTTTCCGCTGCGGCTCTTTCGCATCCACAGCTT
CAGCGTGGGCTTGCTCGGCAACCTGTTCGCGCGGATCGGCAATGGCTCCATGCCGTTCCTGATTCCGCTCACGCTGCAGG
TGAGCCTTGGTTATTCGCCGTTCGATGCAGGCCTGATGATGCTGCCCGTCACCGCTGCCGGCATGGCGTCCAAGCGCCTC
GCCACGCGCCTGATCGAGCAGCACGGCTACCGCCGCGTGCTGGTCACCAACACGTTCGCCGTAGGCGTCGTGATGGCGGC
GTTCGCGCTGATCACGCCGCAGCGGCCACTGTGGACGGTGATTCCGCTGCTCGCGCTGTTCGGCATGGTCAACTCCATCC
AGTTCACGGCGATGAACACCGTCACGCTCAAGGACCTGAGCGGCACCGGCGCCAGCAGCGGCAACAGCATGCTTTCGATG
GTGCAGATGCTGTCGATGAGTCTCGCGGTGACGTCGGCGGGCGCGCTGCTGACCACCTTCGAGCATGGCTTCGGCAACGG
GCCATCGGGGGTGCTGCCGGCGTTTCACGCGACATTCATCTGCATGGGGCTGATCACATGTGCTTCGGCCTGGATCTTCA
TGCAACTCTCGCCGCAGGAGTCGCGGGCGGTGGTGCATCGGACCGAGAGGGCGGAAGGGTAA

Upstream 100 bases:

>100_bases
TAAGACACACGCGGACTTGCCACGCCACCCTCCGCCGAACTAAGGTTGCGGCTTTGGCCGGTAGTCCGGCCAGCCTCGGA
ACACCTCGGAGTACGCAGCC

Downstream 100 bases:

>100_bases
GCTATGTCCGAATACGCCTTTCCCGGTGAACCCGGATCGCCTCCGATATCCATACCACGATGCACATCGTGTTCGCGAAA
TAGAATCCGGCCCTGATGCC

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTTPMPDDRTRRIMLWVVAVGFFMQTLDSTIVNTALPSMARSLGESPLRMQSVVIAYSLTMAVIIPASGWLADRFGTRTI
FQTAIALFVLGSLLCAYAGTLPFLVAARVVQGVGGAMLLPVGRLSVLRTFPRDQYLQALSFVAIPGMIGPLIGPTLGGWL
TQALSWHWIFLINVPVGILGALATVRYMPNARQSGIGHFDVAGYVLLAVAMLALSFSLDGLAEMGFQHATVLMLLIASMA
ALTAYVLHAGKRRQPLFPLRLFRIHSFSVGLLGNLFARIGNGSMPFLIPLTLQVSLGYSPFDAGLMMLPVTAAGMASKRL
ATRLIEQHGYRRVLVTNTFAVGVVMAAFALITPQRPLWTVIPLLALFGMVNSIQFTAMNTVTLKDLSGTGASSGNSMLSM
VQMLSMSLAVTSAGALLTTFEHGFGNGPSGVLPAFHATFICMGLITCASAWIFMQLSPQESRAVVHRTERAEG

Sequences:

>Translated_473_residues
MTTPMPDDRTRRIMLWVVAVGFFMQTLDSTIVNTALPSMARSLGESPLRMQSVVIAYSLTMAVIIPASGWLADRFGTRTI
FQTAIALFVLGSLLCAYAGTLPFLVAARVVQGVGGAMLLPVGRLSVLRTFPRDQYLQALSFVAIPGMIGPLIGPTLGGWL
TQALSWHWIFLINVPVGILGALATVRYMPNARQSGIGHFDVAGYVLLAVAMLALSFSLDGLAEMGFQHATVLMLLIASMA
ALTAYVLHAGKRRQPLFPLRLFRIHSFSVGLLGNLFARIGNGSMPFLIPLTLQVSLGYSPFDAGLMMLPVTAAGMASKRL
ATRLIEQHGYRRVLVTNTFAVGVVMAAFALITPQRPLWTVIPLLALFGMVNSIQFTAMNTVTLKDLSGTGASSGNSMLSM
VQMLSMSLAVTSAGALLTTFEHGFGNGPSGVLPAFHATFICMGLITCASAWIFMQLSPQESRAVVHRTERAEG
>Mature_472_residues
TTPMPDDRTRRIMLWVVAVGFFMQTLDSTIVNTALPSMARSLGESPLRMQSVVIAYSLTMAVIIPASGWLADRFGTRTIF
QTAIALFVLGSLLCAYAGTLPFLVAARVVQGVGGAMLLPVGRLSVLRTFPRDQYLQALSFVAIPGMIGPLIGPTLGGWLT
QALSWHWIFLINVPVGILGALATVRYMPNARQSGIGHFDVAGYVLLAVAMLALSFSLDGLAEMGFQHATVLMLLIASMAA
LTAYVLHAGKRRQPLFPLRLFRIHSFSVGLLGNLFARIGNGSMPFLIPLTLQVSLGYSPFDAGLMMLPVTAAGMASKRLA
TRLIEQHGYRRVLVTNTFAVGVVMAAFALITPQRPLWTVIPLLALFGMVNSIQFTAMNTVTLKDLSGTGASSGNSMLSMV
QMLSMSLAVTSAGALLTTFEHGFGNGPSGVLPAFHATFICMGLITCASAWIFMQLSPQESRAVVHRTERAEG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=472, Percent_Identity=45.3389830508475, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1788392, Length=474, Percent_Identity=50, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788710, Length=335, Percent_Identity=31.3432835820896, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789042, Length=329, Percent_Identity=29.483282674772, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081983, Length=437, Percent_Identity=30.4347826086957, Blast_Score=138, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6325455, Length=129, Percent_Identity=34.8837209302326, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6319770, Length=273, Percent_Identity=23.8095238095238, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=28.6666666666667, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=176, Percent_Identity=28.9772727272727, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50715; Mature: 50584

Theoretical pI: Translated: 10.86; Mature: 10.86

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPMPDDRTRRIMLWVVAVGFFMQTLDSTIVNTALPSMARSLGESPLRMQSVVIAYSLT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MAVIIPASGWLADRFGTRTIFQTAIALFVLGSLLCAYAGTLPFLVAARVVQGVGGAMLLP
HHHEECCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHH
VGRLSVLRTFPRDQYLQALSFVAIPGMIGPLIGPTLGGWLTQALSWHWIFLINVPVGILG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEECCHHHHH
ALATVRYMPNARQSGIGHFDVAGYVLLAVAMLALSFSLDGLAEMGFQHATVLMLLIASMA
HHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHH
ALTAYVLHAGKRRQPLFPLRLFRIHSFSVGLLGNLFARIGNGSMPFLIPLTLQVSLGYSP
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCC
FDAGLMMLPVTAAGMASKRLATRLIEQHGYRRVLVTNTFAVGVVMAAFALITPQRPLWTV
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCCHHHH
IPLLALFGMVNSIQFTAMNTVTLKDLSGTGASSGNSMLSMVQMLSMSLAVTSAGALLTTF
HHHHHHHHHHHCEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
EHGFGNGPSGVLPAFHATFICMGLITCASAWIFMQLSPQESRAVVHRTERAEG
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTPMPDDRTRRIMLWVVAVGFFMQTLDSTIVNTALPSMARSLGESPLRMQSVVIAYSLT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
MAVIIPASGWLADRFGTRTIFQTAIALFVLGSLLCAYAGTLPFLVAARVVQGVGGAMLLP
HHHEECCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHH
VGRLSVLRTFPRDQYLQALSFVAIPGMIGPLIGPTLGGWLTQALSWHWIFLINVPVGILG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEECCHHHHH
ALATVRYMPNARQSGIGHFDVAGYVLLAVAMLALSFSLDGLAEMGFQHATVLMLLIASMA
HHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHH
ALTAYVLHAGKRRQPLFPLRLFRIHSFSVGLLGNLFARIGNGSMPFLIPLTLQVSLGYSP
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCC
FDAGLMMLPVTAAGMASKRLATRLIEQHGYRRVLVTNTFAVGVVMAAFALITPQRPLWTV
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHCCCCCHHHH
IPLLALFGMVNSIQFTAMNTVTLKDLSGTGASSGNSMLSMVQMLSMSLAVTSAGALLTTF
HHHHHHHHHHHCEEEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHH
EHGFGNGPSGVLPAFHATFICMGLITCASAWIFMQLSPQESRAVVHRTERAEG
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA