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The map label for this gene is nuoF2 [H]

Identifier: 73538478

GI number: 73538478

Start: 1340896

End: 1342638

Strand: Reverse

Name: nuoF2 [H]

Synonym: Reut_B4652

Alternate gene names: 73538478

Gene position: 1342638-1340896 (Counterclockwise)

Preceding gene: 73538479

Following gene: 73538477

Centisome position: 49.25

GC content: 67.18

Gene sequence:

>1743_bases
ATGAATCAGGTTGTCATCCCGATCGAGGCCACCGGCCTTGGAAGGCTGCGCAAGCGCCGCCAGCCCAAAGGCAGGCAGGT
GGACGCTGCCGCGCTGGCGGAAGTCCGCGCGGCGCTTGGCGACATGCCGCGCCGCCGAGACCTGTTGATCGAACATCTCC
ACTGCATCCAGGACCGTTACGGTCAGCTGGCCATGCCGCATCTTGTCGCGCTGGCGCAGGAACTTGGTCTGGCGATGACC
GAGGTCTACGAGGTTGCGACGTTCTACCACCACTTCGACGTGGTGCGCGAAGATGCGGACGGCCACATCGCGCCGCCGCC
GGCACTGACGGTGCGCGTATGCGAGGGCATTGCCTGCGAGATGGCCGGGGCGCAGGTGCTGATCGACAAGCTGCCCGCCG
TGCTTGGCACGGACGTACGTGTGGTGGCCGCGCCGTGCATCGGCCGGTGCGAGAAAGCGCCGGCCGTGCTGGCCGGACAG
AAGCCGGTCGATGGCGCGACGGTGGAGGCCGTCGCGAGTTGCGTGGCGGCGGGCACCGTTCGCGATGCCATCGCCGCGCA
GAACAGCTATGGCGCGTACAAGGCAAACGGCGGCTATGGCCTGCTCAAAGCGCTTGTGCAGGAAGGCTCGCTCGATCCGG
CAGCCGTGATTTGCACGATGGAAGACTCCGGCCTGCGCGGCCTGGGCGGCGCCGGTTTCCCGACCGGCCGCAAATGGCGC
ATCGTGTCCGGGGAGCCGGCACCACGGCTCATGGCCGTGAACATCGACGAAGGCGAGCCCGGCACCTTCAAGGACCGCGT
CTACCTGGAGCGCGATCCGCACCGTTTTCTGGAGGGCATGCTGATCGCTGCCGCTGTGACGCAGGTTGCTGCGATCTATA
TCTACCTGCGCGACGAATACGCGGGCTGCCGCGCCATCCTGACGCAAGCGCTGCAGGAACTGCACGACGACCCGCCGGTA
CCGGACCTGCCGCGCATAGAACTGCGCCGCGGCGCGGGCGCCTATATTTGCGGCGAAGAGTCCGCCATGATCGAATCGAT
CGAAGGCAAGCGCGGCATGCCGCGCCTGCGGCCGCCCTATGTGGCGCAGGTCGGGCTGTTCGGCAGGCCGACGCTCGAGC
ACAACTTCGAAACGCTCTACTGGGTGCGCGACATCCTGGAGAAGGGGGCCGAGTGGTTTGCGTCGCAGGGCCGGCATGGC
CGCAAGGGGCTGCGCTCGTTCTCGGTGTCGGGGCGCGTGCGCCAGCCCGGCGTGCACCTGGCGCCGGCCGGTATCACCGT
GCGCGAGCTGATCGATGAATACTGCGGCGGCATGATCGACGGACACACGTTCTACGCGTACCTGCCCGGCGGTGCGTCGG
GCGGCATCCTGCCTGCGTCGATGGGCAATATACCGCTCGACTTCGACACGTTGCAGCCGCACGGCTGCTTTATCGGCTCG
GCGGCCATCATCGTGCTGTCCGACCACGACAGCGCGGTGGCCGCGGCGCGCAACCTGATGCACTTTTTCAAACACGAGTC
GTGCGGGCAATGCACGCCATGCCGCGTCGGCACCGCCAAGGCGCTTGATCTGATCCGCCAGCCGCAATGGGACTTGCCCG
CGCTGGAAGACCTGTCCGCCGTGATGCGCGACGCCTCGATCTGCGGGCTCGGACAGGCTGCGCCAAATCCCGTCGATTGT
GTGATCCGTTACTTTCCCCATGAACTGCAGGCGGCGCCAGACCGCCCGGAGGCACAGGCATGA

Upstream 100 bases:

>100_bases
AAGACAAGAATGAGAGCGACAGGAAGGCTGCCCGCAAGGGCGTCTTCCTGAACGCCTTTATAGCGACGCCATGATCGCCC
CCGCAGGAGACAGAAGACCC

Downstream 100 bases:

>100_bases
ACGCGCTGACACGCGCCGAACGCGCGCTGGTGGAATCCACGGAACCATCCGTCACGTTCACGCTGAATGGCCGTGAAGTC
AGTGCGCAGCCCGGCGAAAG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MNQVVIPIEATGLGRLRKRRQPKGRQVDAAALAEVRAALGDMPRRRDLLIEHLHCIQDRYGQLAMPHLVALAQELGLAMT
EVYEVATFYHHFDVVREDADGHIAPPPALTVRVCEGIACEMAGAQVLIDKLPAVLGTDVRVVAAPCIGRCEKAPAVLAGQ
KPVDGATVEAVASCVAAGTVRDAIAAQNSYGAYKANGGYGLLKALVQEGSLDPAAVICTMEDSGLRGLGGAGFPTGRKWR
IVSGEPAPRLMAVNIDEGEPGTFKDRVYLERDPHRFLEGMLIAAAVTQVAAIYIYLRDEYAGCRAILTQALQELHDDPPV
PDLPRIELRRGAGAYICGEESAMIESIEGKRGMPRLRPPYVAQVGLFGRPTLEHNFETLYWVRDILEKGAEWFASQGRHG
RKGLRSFSVSGRVRQPGVHLAPAGITVRELIDEYCGGMIDGHTFYAYLPGGASGGILPASMGNIPLDFDTLQPHGCFIGS
AAIIVLSDHDSAVAAARNLMHFFKHESCGQCTPCRVGTAKALDLIRQPQWDLPALEDLSAVMRDASICGLGQAAPNPVDC
VIRYFPHELQAAPDRPEAQA

Sequences:

>Translated_580_residues
MNQVVIPIEATGLGRLRKRRQPKGRQVDAAALAEVRAALGDMPRRRDLLIEHLHCIQDRYGQLAMPHLVALAQELGLAMT
EVYEVATFYHHFDVVREDADGHIAPPPALTVRVCEGIACEMAGAQVLIDKLPAVLGTDVRVVAAPCIGRCEKAPAVLAGQ
KPVDGATVEAVASCVAAGTVRDAIAAQNSYGAYKANGGYGLLKALVQEGSLDPAAVICTMEDSGLRGLGGAGFPTGRKWR
IVSGEPAPRLMAVNIDEGEPGTFKDRVYLERDPHRFLEGMLIAAAVTQVAAIYIYLRDEYAGCRAILTQALQELHDDPPV
PDLPRIELRRGAGAYICGEESAMIESIEGKRGMPRLRPPYVAQVGLFGRPTLEHNFETLYWVRDILEKGAEWFASQGRHG
RKGLRSFSVSGRVRQPGVHLAPAGITVRELIDEYCGGMIDGHTFYAYLPGGASGGILPASMGNIPLDFDTLQPHGCFIGS
AAIIVLSDHDSAVAAARNLMHFFKHESCGQCTPCRVGTAKALDLIRQPQWDLPALEDLSAVMRDASICGLGQAAPNPVDC
VIRYFPHELQAAPDRPEAQA
>Mature_580_residues
MNQVVIPIEATGLGRLRKRRQPKGRQVDAAALAEVRAALGDMPRRRDLLIEHLHCIQDRYGQLAMPHLVALAQELGLAMT
EVYEVATFYHHFDVVREDADGHIAPPPALTVRVCEGIACEMAGAQVLIDKLPAVLGTDVRVVAAPCIGRCEKAPAVLAGQ
KPVDGATVEAVASCVAAGTVRDAIAAQNSYGAYKANGGYGLLKALVQEGSLDPAAVICTMEDSGLRGLGGAGFPTGRKWR
IVSGEPAPRLMAVNIDEGEPGTFKDRVYLERDPHRFLEGMLIAAAVTQVAAIYIYLRDEYAGCRAILTQALQELHDDPPV
PDLPRIELRRGAGAYICGEESAMIESIEGKRGMPRLRPPYVAQVGLFGRPTLEHNFETLYWVRDILEKGAEWFASQGRHG
RKGLRSFSVSGRVRQPGVHLAPAGITVRELIDEYCGGMIDGHTFYAYLPGGASGGILPASMGNIPLDFDTLQPHGCFIGS
AAIIVLSDHDSAVAAARNLMHFFKHESCGQCTPCRVGTAKALDLIRQPQWDLPALEDLSAVMRDASICGLGQAAPNPVDC
VIRYFPHELQAAPDRPEAQA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=381, Percent_Identity=39.3700787401575, Blast_Score=255, Evalue=9e-68,
Organism=Homo sapiens, GI260656005, Length=381, Percent_Identity=39.3700787401575, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1788620, Length=403, Percent_Identity=36.7245657568238, Blast_Score=252, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17531727, Length=397, Percent_Identity=38.2871536523929, Blast_Score=264, Evalue=9e-71,
Organism=Drosophila melanogaster, GI19920794, Length=373, Percent_Identity=39.4101876675603, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI45550452, Length=367, Percent_Identity=36.7847411444142, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24653819, Length=414, Percent_Identity=30.1932367149758, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24653817, Length=357, Percent_Identity=29.4117647058824, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 62476; Mature: 62476

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQVVIPIEATGLGRLRKRRQPKGRQVDAAALAEVRAALGDMPRRRDLLIEHLHCIQDRY
CCCEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GQLAMPHLVALAQELGLAMTEVYEVATFYHHFDVVREDADGHIAPPPALTVRVCEGIACE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHH
MAGAQVLIDKLPAVLGTDVRVVAAPCIGRCEKAPAVLAGQKPVDGATVEAVASCVAAGTV
HCCHHHHHHHHHHHHCCCCEEEECHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHH
RDAIAAQNSYGAYKANGGYGLLKALVQEGSLDPAAVICTMEDSGLRGLGGAGFPTGRKWR
HHHHHHCCCCCCEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
IVSGEPAPRLMAVNIDEGEPGTFKDRVYLERDPHRFLEGMLIAAAVTQVAAIYIYLRDEY
EECCCCCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHEEEEEEECCC
AGCRAILTQALQELHDDPPVPDLPRIELRRGAGAYICGEESAMIESIEGKRGMPRLRPPY
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCCCCH
VAQVGLFGRPTLEHNFETLYWVRDILEKGAEWFASQGRHGRKGLRSFSVSGRVRQPGVHL
HEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEECCCCEE
APAGITVRELIDEYCGGMIDGHTFYAYLPGGASGGILPASMGNIPLDFDTLQPHGCFIGS
ECCCCHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC
AAIIVLSDHDSAVAAARNLMHFFKHESCGQCTPCRVGTAKALDLIRQPQWDLPALEDLSA
EEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
VMRDASICGLGQAAPNPVDCVIRYFPHELQAAPDRPEAQA
HHHHHHHCCCCCCCCCHHHHHHHHCCHHHCCCCCCCCCCC
>Mature Secondary Structure
MNQVVIPIEATGLGRLRKRRQPKGRQVDAAALAEVRAALGDMPRRRDLLIEHLHCIQDRY
CCCEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GQLAMPHLVALAQELGLAMTEVYEVATFYHHFDVVREDADGHIAPPPALTVRVCEGIACE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHH
MAGAQVLIDKLPAVLGTDVRVVAAPCIGRCEKAPAVLAGQKPVDGATVEAVASCVAAGTV
HCCHHHHHHHHHHHHCCCCEEEECHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHH
RDAIAAQNSYGAYKANGGYGLLKALVQEGSLDPAAVICTMEDSGLRGLGGAGFPTGRKWR
HHHHHHCCCCCCEECCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEE
IVSGEPAPRLMAVNIDEGEPGTFKDRVYLERDPHRFLEGMLIAAAVTQVAAIYIYLRDEY
EECCCCCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHEEEEEEECCC
AGCRAILTQALQELHDDPPVPDLPRIELRRGAGAYICGEESAMIESIEGKRGMPRLRPPY
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCEEEECCCHHHHHHHCCCCCCCCCCCCH
VAQVGLFGRPTLEHNFETLYWVRDILEKGAEWFASQGRHGRKGLRSFSVSGRVRQPGVHL
HEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEECCCCEE
APAGITVRELIDEYCGGMIDGHTFYAYLPGGASGGILPASMGNIPLDFDTLQPHGCFIGS
ECCCCHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC
AAIIVLSDHDSAVAAARNLMHFFKHESCGQCTPCRVGTAKALDLIRQPQWDLPALEDLSA
EEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
VMRDASICGLGQAAPNPVDCVIRYFPHELQAAPDRPEAQA
HHHHHHHCCCCCCCCCHHHHHHHHCCHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]