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The map label for this gene is 73538432

Identifier: 73538432

GI number: 73538432

Start: 1291711

End: 1292655

Strand: Direct

Name: 73538432

Synonym: Reut_B4605

Alternate gene names: NA

Gene position: 1291711-1292655 (Clockwise)

Preceding gene: 73538431

Following gene: 73538434

Centisome position: 47.38

GC content: 62.12

Gene sequence:

>945_bases
ATGACGCCCACAATCATCTATACCCACACCGCGTGTCTCGAACACCGCCCCGGACCGCACCACCCGGAATCGCCTGAACG
CCTGAAAGCCGTCGTGGAGGCGTTGCGAACGCCGGAATTCGCATCTCTGGAATGGCGCGATGCGCCGATGGGGACCGTCG
AACAGTTGCAATTGATCCACGATACGGACTACATCGACGAGATCGCACAACGCGCGCCCACACACGGATACGTGCCGCTG
GACGCGGGGGATACGGTCATGTCGCCAGGGTCGTGGGAAGCCGTGATGCGCTGCGTCGGCGCGGCTTGCGCGGGTGTCGA
TACCGTGATGAACGGCGACGCGCGTAACGTGTTCTGCGCGACGCGGCCGTGCGGCCATCACGCTGAACCGGCGAAGGCAA
TGGGATTTTGCATTTTCAACCAGGCGGCGATCGCCGCGGCTTACGCCTGTGAGGTCCACAAACTCGAGCGCGTTGCCGTG
GTTGATTTCGACGTGCATCACGGCAATGGAACCCAGGCAGCGTTCTTCAACCGCCCGGAACTGTTCTACGCATCCAGCCA
TCAGTCGCCGTTCTATCCGGGCACCGGAGCGCGGTCCGAGACAGGGGTGAACCACAATATCGTCAACGTTCCGTTGCCTC
GCGGCTGCGAGTCAGCGCAGTTCCGTGCGGCGATTTCCGCTCTCGTGCTTCCTTCGCTAAGAGCGTTCGCCCCCGACCTC
CTCATTATCTCGGCGGGATTCGATGCGCACCGCCTGGATCCCCTCGCTGGCATGAACCTGGAGGACAGCGACTTCCATTG
GATCACCCGGGAACTGATGCAAATTGCCGACGAGGCGTGCAACGGCCGTATCGTATCGATTCTGGAAGGCGGCTATAGCC
TGGACGCCTTGGCCACGAGTTCGATGGCGCATGTCGGCGCACTGATGCAGGACGCTGGCATCTAG

Upstream 100 bases:

>100_bases
CTGATATATTACATATCTGATGAGATTGCCGTGACGATCGACGTAGCACGCAATGCGCGATTCAAAGAACGCCACCGGTT
GAAACGGAGACCAGCCGAAC

Downstream 100 bases:

>100_bases
TCCGTGCTGAAGTTCAAGCGGCCGAGGAGTTCTTGATTTTCCCGGCCGCGTGGGAAATCCGGTCCCTGACGACACCAATC
GCCTGCTTGAGTGCGTAGAC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTPTIIYTHTACLEHRPGPHHPESPERLKAVVEALRTPEFASLEWRDAPMGTVEQLQLIHDTDYIDEIAQRAPTHGYVPL
DAGDTVMSPGSWEAVMRCVGAACAGVDTVMNGDARNVFCATRPCGHHAEPAKAMGFCIFNQAAIAAAYACEVHKLERVAV
VDFDVHHGNGTQAAFFNRPELFYASSHQSPFYPGTGARSETGVNHNIVNVPLPRGCESAQFRAAISALVLPSLRAFAPDL
LIISAGFDAHRLDPLAGMNLEDSDFHWITRELMQIADEACNGRIVSILEGGYSLDALATSSMAHVGALMQDAGI

Sequences:

>Translated_314_residues
MTPTIIYTHTACLEHRPGPHHPESPERLKAVVEALRTPEFASLEWRDAPMGTVEQLQLIHDTDYIDEIAQRAPTHGYVPL
DAGDTVMSPGSWEAVMRCVGAACAGVDTVMNGDARNVFCATRPCGHHAEPAKAMGFCIFNQAAIAAAYACEVHKLERVAV
VDFDVHHGNGTQAAFFNRPELFYASSHQSPFYPGTGARSETGVNHNIVNVPLPRGCESAQFRAAISALVLPSLRAFAPDL
LIISAGFDAHRLDPLAGMNLEDSDFHWITRELMQIADEACNGRIVSILEGGYSLDALATSSMAHVGALMQDAGI
>Mature_313_residues
TPTIIYTHTACLEHRPGPHHPESPERLKAVVEALRTPEFASLEWRDAPMGTVEQLQLIHDTDYIDEIAQRAPTHGYVPLD
AGDTVMSPGSWEAVMRCVGAACAGVDTVMNGDARNVFCATRPCGHHAEPAKAMGFCIFNQAAIAAAYACEVHKLERVAVV
DFDVHHGNGTQAAFFNRPELFYASSHQSPFYPGTGARSETGVNHNIVNVPLPRGCESAQFRAAISALVLPSLRAFAPDLL
IISAGFDAHRLDPLAGMNLEDSDFHWITRELMQIADEACNGRIVSILEGGYSLDALATSSMAHVGALMQDAGI

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=307, Percent_Identity=36.1563517915309, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI153085395, Length=224, Percent_Identity=39.7321428571429, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI17158039, Length=229, Percent_Identity=38.4279475982533, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI30795202, Length=229, Percent_Identity=38.4279475982533, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI30795204, Length=229, Percent_Identity=38.4279475982533, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI62750347, Length=231, Percent_Identity=39.3939393939394, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI62750349, Length=231, Percent_Identity=39.3939393939394, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI20070354, Length=307, Percent_Identity=34.5276872964169, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI148539870, Length=214, Percent_Identity=38.785046728972, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI169234807, Length=213, Percent_Identity=38.9671361502347, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI226529806, Length=307, Percent_Identity=31.5960912052117, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI13128862, Length=214, Percent_Identity=28.5046728971963, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI8923769, Length=140, Percent_Identity=32.1428571428571, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI13128860, Length=255, Percent_Identity=23.921568627451, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI293336691, Length=255, Percent_Identity=23.1372549019608, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073088, Length=140, Percent_Identity=30.7142857142857, Blast_Score=72, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17540334, Length=305, Percent_Identity=33.1147540983607, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI193206283, Length=305, Percent_Identity=33.1147540983607, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17540332, Length=305, Percent_Identity=33.1147540983607, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI193209491, Length=304, Percent_Identity=33.5526315789474, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17537347, Length=325, Percent_Identity=31.3846153846154, Blast_Score=130, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI25154020, Length=279, Percent_Identity=31.5412186379928, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25154022, Length=279, Percent_Identity=30.8243727598566, Blast_Score=117, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17534739, Length=319, Percent_Identity=22.884012539185, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17561978, Length=139, Percent_Identity=31.6546762589928, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508561, Length=139, Percent_Identity=30.2158273381295, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=317, Percent_Identity=29.6529968454259, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6325141, Length=294, Percent_Identity=26.1904761904762, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323999, Length=257, Percent_Identity=26.4591439688716, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=126, Percent_Identity=34.9206349206349, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6321244, Length=276, Percent_Identity=25, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281360801, Length=218, Percent_Identity=42.6605504587156, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24641720, Length=218, Percent_Identity=42.6605504587156, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI281360799, Length=218, Percent_Identity=42.6605504587156, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI281360899, Length=308, Percent_Identity=31.4935064935065, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24642142, Length=308, Percent_Identity=31.4935064935065, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24642144, Length=308, Percent_Identity=31.4935064935065, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24642146, Length=308, Percent_Identity=31.4935064935065, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24657891, Length=256, Percent_Identity=23.828125, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644244, Length=140, Percent_Identity=31.4285714285714, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 33901; Mature: 33769

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTIIYTHTACLEHRPGPHHPESPERLKAVVEALRTPEFASLEWRDAPMGTVEQLQLIH
CCCEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHH
DTDYIDEIAQRAPTHGYVPLDAGDTVMSPGSWEAVMRCVGAACAGVDTVMNGDARNVFCA
CHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCCCEEEEE
TRPCGHHAEPAKAMGFCIFNQAAIAAAYACEVHKLERVAVVDFDVHHGNGTQAAFFNRPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCEEEECCCC
LFYASSHQSPFYPGTGARSETGVNHNIVNVPLPRGCESAQFRAAISALVLPSLRAFAPDL
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCE
LIISAGFDAHRLDPLAGMNLEDSDFHWITRELMQIADEACNGRIVSILEGGYSLDALATS
EEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
SMAHVGALMQDAGI
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TPTIIYTHTACLEHRPGPHHPESPERLKAVVEALRTPEFASLEWRDAPMGTVEQLQLIH
CCEEEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCHHHHHHHHH
DTDYIDEIAQRAPTHGYVPLDAGDTVMSPGSWEAVMRCVGAACAGVDTVMNGDARNVFCA
CHHHHHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCCCEEEEE
TRPCGHHAEPAKAMGFCIFNQAAIAAAYACEVHKLERVAVVDFDVHHGNGTQAAFFNRPE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCEEEECCCC
LFYASSHQSPFYPGTGARSETGVNHNIVNVPLPRGCESAQFRAAISALVLPSLRAFAPDL
EEEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCE
LIISAGFDAHRLDPLAGMNLEDSDFHWITRELMQIADEACNGRIVSILEGGYSLDALATS
EEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
SMAHVGALMQDAGI
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]