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The map label for this gene is crt [H]

Identifier: 73538376

GI number: 73538376

Start: 1226358

End: 1227188

Strand: Reverse

Name: crt [H]

Synonym: Reut_B4549

Alternate gene names: 73538376

Gene position: 1227188-1226358 (Counterclockwise)

Preceding gene: 73538383

Following gene: 73538374

Centisome position: 45.02

GC content: 65.1

Gene sequence:

>831_bases
ATGACAGCCACGGAACATACCCTGCGGAACACCACGCTAAGCATTCGCGATGGCATCGCCGAGTTTACGCACCAGCGACC
CGAGATCCGGAACGCGCTGACACCTGAACTGAAGCACGATTATGTCGATATGCTCGATATCGTCGAAGACGACCGCAGTG
TCCGGGCGCTGATCCTTACGGGATCGGGCGGAAGCTTCTGTGCGGGCGGAGACCTGAAGTCTTTGCTGGCCATGCGCGAC
GATCCGTCCCTGGCGGCGCACCAGCCGGAAGCCATGCGCCGGCGTGTGAAACGTGGTCAGGGCTGGCTGCGGCGGCTTCG
CGACCTCGAGGTTCCTGTCGTTGCCGCGGTGGATGGTCCGGCTGCCGGAGCCGGCTTCTCGATTGCGCTCACCGCGGACT
TCGTGCTGGCTTCGGAACGCGCATCGTTCTCGATGGTTTTTGTGAAAATCGGGCTGGTACCGGACATGGGAGCGATGTAC
TCGCTGCCGCGAACGGTGGGCTTAAGCATGGCGAAGGAGTTGATGCTGACCGGGCGCCGCGTTGGCGCGGCGGAGGCGCA
CAAGCTCGGCATCGTGCATGCGATCCACTCGGCCGATGCGCTGGCCGAAGACGCGCGCCGGTTCGCCGCGCGCTTCGTTG
ACGGGCCCCGGGAAGCCATGGCTTTGACCAAGAACGCGCTCAATGGCACGTTCGAAGCGCCGTATGAAACGATGCTGGCG
GCGGAGGCCCAGGGCCAGGCCGTTGCCGCGGCGGCGCCGTATTACGGCGAGGCGGTGCAGGCCTTCCTGCGCGGGGAGCC
GGCGAAGTTCGACTGGGATCGTCGACGCTAA

Upstream 100 bases:

>100_bases
GGGAAACCATGGTTGATTCCTGCCATATCGAGTTCCGAGATACCCGACAAAAGCCGCGCCAGGCAGGGTGCCTGGCGCCT
ACAAAGTGAGGAGACAGCCA

Downstream 100 bases:

>100_bases
CGTCGATTCACGCAACGCCGATATCGACGATAACGTGCCTTGCCTGACGCTGAACGTGGCTACTCCGCCCTGTACCACAA
CCCCGAGTCGGGGCGGACGC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTATEHTLRNTTLSIRDGIAEFTHQRPEIRNALTPELKHDYVDMLDIVEDDRSVRALILTGSGGSFCAGGDLKSLLAMRD
DPSLAAHQPEAMRRRVKRGQGWLRRLRDLEVPVVAAVDGPAAGAGFSIALTADFVLASERASFSMVFVKIGLVPDMGAMY
SLPRTVGLSMAKELMLTGRRVGAAEAHKLGIVHAIHSADALAEDARRFAARFVDGPREAMALTKNALNGTFEAPYETMLA
AEAQGQAVAAAAPYYGEAVQAFLRGEPAKFDWDRRR

Sequences:

>Translated_276_residues
MTATEHTLRNTTLSIRDGIAEFTHQRPEIRNALTPELKHDYVDMLDIVEDDRSVRALILTGSGGSFCAGGDLKSLLAMRD
DPSLAAHQPEAMRRRVKRGQGWLRRLRDLEVPVVAAVDGPAAGAGFSIALTADFVLASERASFSMVFVKIGLVPDMGAMY
SLPRTVGLSMAKELMLTGRRVGAAEAHKLGIVHAIHSADALAEDARRFAARFVDGPREAMALTKNALNGTFEAPYETMLA
AEAQGQAVAAAAPYYGEAVQAFLRGEPAKFDWDRRR
>Mature_275_residues
TATEHTLRNTTLSIRDGIAEFTHQRPEIRNALTPELKHDYVDMLDIVEDDRSVRALILTGSGGSFCAGGDLKSLLAMRDD
PSLAAHQPEAMRRRVKRGQGWLRRLRDLEVPVVAAVDGPAAGAGFSIALTADFVLASERASFSMVFVKIGLVPDMGAMYS
LPRTVGLSMAKELMLTGRRVGAAEAHKLGIVHAIHSADALAEDARRFAARFVDGPREAMALTKNALNGTFEAPYETMLAA
EAQGQAVAAAAPYYGEAVQAFLRGEPAKFDWDRRR

Specific function: Could Possibly Oxidizes Fatty Acids Using Specific Components (By Similarity). [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=210, Percent_Identity=31.9047619047619, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI68989263, Length=198, Percent_Identity=31.3131313131313, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI260274832, Length=215, Percent_Identity=26.5116279069767, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI45643119, Length=219, Percent_Identity=26.027397260274, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI260275230, Length=219, Percent_Identity=26.027397260274, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI116235487, Length=178, Percent_Identity=30.3370786516854, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI25453481, Length=200, Percent_Identity=27.5, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI51538573, Length=200, Percent_Identity=27.5, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4757966, Length=200, Percent_Identity=27.5, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI51538581, Length=200, Percent_Identity=27.5, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4757968, Length=197, Percent_Identity=26.9035532994924, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI49355787, Length=197, Percent_Identity=26.9035532994924, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4502327, Length=273, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI221307494, Length=200, Percent_Identity=28, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221136756, Length=200, Percent_Identity=28, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI221136753, Length=200, Percent_Identity=28, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI37594469, Length=186, Percent_Identity=30.1075268817204, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI70995211, Length=171, Percent_Identity=28.6549707602339, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI37594471, Length=186, Percent_Identity=30.1075268817204, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI20127408, Length=168, Percent_Identity=27.3809523809524, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI31542718, Length=226, Percent_Identity=28.3185840707965, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=34.765625, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI221142681, Length=238, Percent_Identity=34.453781512605, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=32.5301204819277, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1790281, Length=248, Percent_Identity=26.6129032258064, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788597, Length=217, Percent_Identity=29.0322580645161, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788682, Length=205, Percent_Identity=27.8048780487805, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87082183, Length=258, Percent_Identity=25.5813953488372, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=217, Percent_Identity=30.8755760368664, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=228, Percent_Identity=32.0175438596491, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=242, Percent_Identity=32.2314049586777, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17536985, Length=236, Percent_Identity=26.271186440678, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=207, Percent_Identity=24.6376811594203, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=196, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=218, Percent_Identity=26.605504587156, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=202, Percent_Identity=26.2376237623762, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=165, Percent_Identity=28.4848484848485, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25144160, Length=180, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=180, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=28.9156626506024, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=28.9156626506024, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653139, Length=207, Percent_Identity=31.8840579710145, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19920382, Length=216, Percent_Identity=31.9444444444444, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=31.1475409836066, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21357171, Length=221, Percent_Identity=28.9592760180996, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28571730, Length=178, Percent_Identity=30.3370786516854, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571729, Length=178, Percent_Identity=30.3370786516854, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 29935; Mature: 29803

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATEHTLRNTTLSIRDGIAEFTHQRPEIRNALTPELKHDYVDMLDIVEDDRSVRALILT
CCCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEE
GSGGSFCAGGDLKSLLAMRDDPSLAAHQPEAMRRRVKRGQGWLRRLRDLEVPVVAAVDGP
CCCCCEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
AAGAGFSIALTADFVLASERASFSMVFVKIGLVPDMGAMYSLPRTVGLSMAKELMLTGRR
CCCCCEEEEEEEHHHEECCCCCEEEEEEEECCCCCCHHHHHCHHHHHHHHHHHHHHHCCC
VGAAEAHKLGIVHAIHSADALAEDARRFAARFVDGPREAMALTKNALNGTFEAPYETMLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHH
AEAQGQAVAAAAPYYGEAVQAFLRGEPAKFDWDRRR
HHCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TATEHTLRNTTLSIRDGIAEFTHQRPEIRNALTPELKHDYVDMLDIVEDDRSVRALILT
CCCHHHHHCCCHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEE
GSGGSFCAGGDLKSLLAMRDDPSLAAHQPEAMRRRVKRGQGWLRRLRDLEVPVVAAVDGP
CCCCCEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
AAGAGFSIALTADFVLASERASFSMVFVKIGLVPDMGAMYSLPRTVGLSMAKELMLTGRR
CCCCCEEEEEEEHHHEECCCCCEEEEEEEECCCCCCHHHHHCHHHHHHHHHHHHHHHCCC
VGAAEAHKLGIVHAIHSADALAEDARRFAARFVDGPREAMALTKNALNGTFEAPYETMLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHH
AEAQGQAVAAAAPYYGEAVQAFLRGEPAKFDWDRRR
HHCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]