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The map label for this gene is recQ [H]

Identifier: 73538374

GI number: 73538374

Start: 1223650

End: 1225320

Strand: Reverse

Name: recQ [H]

Synonym: Reut_B4547

Alternate gene names: 73538374

Gene position: 1225320-1223650 (Counterclockwise)

Preceding gene: 73538376

Following gene: 73538368

Centisome position: 44.95

GC content: 66.61

Gene sequence:

>1671_bases
ATGCCCGAGACGCTGCCGCCAGACATCATGGAGATCCTGCGGGATCAGTTTGGCGTCGCACGCCTGCGCCCCGGGCAGGC
TGACGTCCTGGCCAGCGTGCTGCAGGGCCACGACACGATCGCTGTCATGCCGACCGGGAGTGGAAAGTCGCTGTGTTTCC
AGCTGCCTGCCCGCGTACTGGACGGCCTGACGGTGGCGATATCGCCGCTGATCGCATTGATGCAGGATCAGGCCGGCAAG
CTGGACCAGCTCGATTTGCCGCCCGCGGTGGTCAACAGTGCCGTGGGCGACGCGGCGCTGGACAGTCTCGCGCGCGGCGG
CGAGCGCATCCTGTTGACGACGCCCGAGCAGCTCGAAGGCAAGGCCGTCATTGAAGCGCTGCGCCGCAACCGCGTTGCAT
TGTTCGTGGTCGACGAGGCGCACTGCATTTCGCAATGGGGCCACGATTTTCGGCCCGCATACCTCGGATTGCGGGAGGTC
GTGTCGGCGCTGTCGCGGCCGCCGGTACTGGCGCTGACCGCCACGGCGACCGACGCCGTCGTCAAGGACATCGCGCACCA
CCTCGGCATGCGCCATCCGCGTGTCGTGCGTGCGCCGCTGTTTCGGCCCAACCTTGTCTATGCCGTCGAGCATCTGTCGG
AGGCGCCCACGCGGCCTGATGCGGTACGCCGCCTGGTTTCGGCCGAAAGCGGTGGAAGCGGTGGAAGCGGCAGGAGGGGT
GCAGGCATCGTCTACACTGCGACGGTCGCGCTGGCGGAACAGTTGTACGATGCACTGCGGGGTGCAGGCATGAACGTCGC
GCTGTATCACGGCCAGCGCACCGCGGTGCAACGCCGCGACGCGCAGGACGCTTTCATGGCGGGGCGCGCGGACGTGATGG
TGGCGACCAATGCCTTTGGCATGGGGATCGACAAGCCCGACGTCCGGTTCATCGTTCATGCGCAATGTCCCGGCAGCCTG
GATGCCTATTACCAGGAGTCCGGAAGAGCAGGGCGCGACGGCGGGTTGGCGCGCTGTACGCTGCTGTTCGACGAGAAGGA
CAAGCGCATCCACCAGTTCTTTCTTGCTAACCGTTACCCGGCCGCGACGGACCTGCGGCAGATGGTGACGGCGCTCAGGG
GCACGCCAACGGTCCTGCCGGCGTTGCGAGAGGCACTTCCCCACATCGGTGTGCGGCGCTTGCAGTCAGGCATGCGGATG
CTTGGCGATTTTGGCATCGTGCAGCGCGATCGCCGAGGGCGCTTCTCGCTGCGCGATGGCAGTGCCGACAGCATCGAAGA
CATCGCCGCCCTGTACGAGGCCCGCAGTCGTGAGGACCGCGAAACCCTGCAGGCGATGCTCGATTACGCGCGCAGCGGGC
GTTGCCGCTGGATGCTGCTGCTCGAGTACTACGGCGAATCCGAGGACCTGGAACCATGCGGCATCTGCGACAGTTGCCGG
CGCTTGGCGGAGGCTGCCACACATGAGGCTGACGGCGAGAAGACGGTGGCTGCCAGCGCGACAGCCGTGCCGTTCGCCGA
AGGCGACACGGTAAAGGCGCGCCGGTTCGGCAAAGGCACGGTGGTGTCAGTTACCAGTGAATGGGTGGAAGTCCGCTTCC
CCGATGAGAGCGTGCGCCGCTTTCTGCCGGATCGCCTGCTTCGCATGGGCAAGCGCCGTGGCGCCGCGTAG

Upstream 100 bases:

>100_bases
AGGCAAAAAGCGGGAATCGGCCCGTACTGCCCACGGCGTGCGCCAACTTTCGAACGGCACGGATATTGCTCGGGAACGAA
GATACTGTCGCCGAACGCCC

Downstream 100 bases:

>100_bases
CGGCCCCCTCGCAGCCTTGGCTATCAGGCAGGCCACGCCACCTGCTTCCAATACGCATCTTTCATCTGCATCTTCCCATC
TGCCACGCGAAACAAGTCCA

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MPETLPPDIMEILRDQFGVARLRPGQADVLASVLQGHDTIAVMPTGSGKSLCFQLPARVLDGLTVAISPLIALMQDQAGK
LDQLDLPPAVVNSAVGDAALDSLARGGERILLTTPEQLEGKAVIEALRRNRVALFVVDEAHCISQWGHDFRPAYLGLREV
VSALSRPPVLALTATATDAVVKDIAHHLGMRHPRVVRAPLFRPNLVYAVEHLSEAPTRPDAVRRLVSAESGGSGGSGRRG
AGIVYTATVALAEQLYDALRGAGMNVALYHGQRTAVQRRDAQDAFMAGRADVMVATNAFGMGIDKPDVRFIVHAQCPGSL
DAYYQESGRAGRDGGLARCTLLFDEKDKRIHQFFLANRYPAATDLRQMVTALRGTPTVLPALREALPHIGVRRLQSGMRM
LGDFGIVQRDRRGRFSLRDGSADSIEDIAALYEARSREDRETLQAMLDYARSGRCRWMLLLEYYGESEDLEPCGICDSCR
RLAEAATHEADGEKTVAASATAVPFAEGDTVKARRFGKGTVVSVTSEWVEVRFPDESVRRFLPDRLLRMGKRRGAA

Sequences:

>Translated_556_residues
MPETLPPDIMEILRDQFGVARLRPGQADVLASVLQGHDTIAVMPTGSGKSLCFQLPARVLDGLTVAISPLIALMQDQAGK
LDQLDLPPAVVNSAVGDAALDSLARGGERILLTTPEQLEGKAVIEALRRNRVALFVVDEAHCISQWGHDFRPAYLGLREV
VSALSRPPVLALTATATDAVVKDIAHHLGMRHPRVVRAPLFRPNLVYAVEHLSEAPTRPDAVRRLVSAESGGSGGSGRRG
AGIVYTATVALAEQLYDALRGAGMNVALYHGQRTAVQRRDAQDAFMAGRADVMVATNAFGMGIDKPDVRFIVHAQCPGSL
DAYYQESGRAGRDGGLARCTLLFDEKDKRIHQFFLANRYPAATDLRQMVTALRGTPTVLPALREALPHIGVRRLQSGMRM
LGDFGIVQRDRRGRFSLRDGSADSIEDIAALYEARSREDRETLQAMLDYARSGRCRWMLLLEYYGESEDLEPCGICDSCR
RLAEAATHEADGEKTVAASATAVPFAEGDTVKARRFGKGTVVSVTSEWVEVRFPDESVRRFLPDRLLRMGKRRGAA
>Mature_555_residues
PETLPPDIMEILRDQFGVARLRPGQADVLASVLQGHDTIAVMPTGSGKSLCFQLPARVLDGLTVAISPLIALMQDQAGKL
DQLDLPPAVVNSAVGDAALDSLARGGERILLTTPEQLEGKAVIEALRRNRVALFVVDEAHCISQWGHDFRPAYLGLREVV
SALSRPPVLALTATATDAVVKDIAHHLGMRHPRVVRAPLFRPNLVYAVEHLSEAPTRPDAVRRLVSAESGGSGGSGRRGA
GIVYTATVALAEQLYDALRGAGMNVALYHGQRTAVQRRDAQDAFMAGRADVMVATNAFGMGIDKPDVRFIVHAQCPGSLD
AYYQESGRAGRDGGLARCTLLFDEKDKRIHQFFLANRYPAATDLRQMVTALRGTPTVLPALREALPHIGVRRLQSGMRML
GDFGIVQRDRRGRFSLRDGSADSIEDIAALYEARSREDRETLQAMLDYARSGRCRWMLLLEYYGESEDLEPCGICDSCRR
LAEAATHEADGEKTVAASATAVPFAEGDTVKARRFGKGTVVSVTSEWVEVRFPDESVRRFLPDRLLRMGKRRGAA

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=370, Percent_Identity=38.3783783783784, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI51242943, Length=370, Percent_Identity=38.3783783783784, Blast_Score=229, Evalue=5e-60,
Organism=Homo sapiens, GI148612816, Length=398, Percent_Identity=36.4321608040201, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI4557365, Length=360, Percent_Identity=37.2222222222222, Blast_Score=224, Evalue=2e-58,
Organism=Homo sapiens, GI14591902, Length=354, Percent_Identity=35.8757062146893, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI14591904, Length=354, Percent_Identity=35.8757062146893, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI110735439, Length=347, Percent_Identity=35.4466858789625, Blast_Score=218, Evalue=2e-56,
Organism=Homo sapiens, GI169218196, Length=347, Percent_Identity=35.4466858789625, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI284005309, Length=373, Percent_Identity=35.1206434316354, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI45446747, Length=346, Percent_Identity=25.1445086705202, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI45446743, Length=346, Percent_Identity=25.1445086705202, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI301171467, Length=439, Percent_Identity=23.0068337129841, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI41327771, Length=376, Percent_Identity=25.7978723404255, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI169881239, Length=455, Percent_Identity=23.5164835164835, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI13514809, Length=455, Percent_Identity=23.5164835164835, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI48994977, Length=341, Percent_Identity=41.0557184750733, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI87082221, Length=363, Percent_Identity=23.1404958677686, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25145561, Length=354, Percent_Identity=38.7005649717514, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI32564293, Length=397, Percent_Identity=36.0201511335013, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71987993, Length=346, Percent_Identity=36.9942196531792, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71987997, Length=346, Percent_Identity=36.9942196531792, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17552866, Length=462, Percent_Identity=31.6017316017316, Blast_Score=205, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6323844, Length=364, Percent_Identity=35.7142857142857, Blast_Score=224, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6324217, Length=336, Percent_Identity=24.702380952381, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321267, Length=330, Percent_Identity=24.2424242424242, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6325138, Length=391, Percent_Identity=25.3196930946292, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324778, Length=393, Percent_Identity=24.9363867684478, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664226, Length=373, Percent_Identity=37.5335120643432, Blast_Score=232, Evalue=6e-61,
Organism=Drosophila melanogaster, GI62472181, Length=373, Percent_Identity=37.5335120643432, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24664230, Length=373, Percent_Identity=37.5335120643432, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI24646066, Length=350, Percent_Identity=37.1428571428571, Blast_Score=229, Evalue=4e-60,
Organism=Drosophila melanogaster, GI21358123, Length=368, Percent_Identity=34.5108695652174, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24666101, Length=350, Percent_Identity=26.2857142857143, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI18857967, Length=368, Percent_Identity=23.6413043478261, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 60612; Mature: 60481

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETLPPDIMEILRDQFGVARLRPGQADVLASVLQGHDTIAVMPTGSGKSLCFQLPARVL
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
DGLTVAISPLIALMQDQAGKLDQLDLPPAVVNSAVGDAALDSLARGGERILLTTPEQLEG
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCC
KAVIEALRRNRVALFVVDEAHCISQWGHDFRPAYLGLREVVSALSRPPVLALTATATDAV
HHHHHHHHCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
VKDIAHHLGMRHPRVVRAPLFRPNLVYAVEHLSEAPTRPDAVRRLVSAESGGSGGSGRRG
HHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCC
AGIVYTATVALAEQLYDALRGAGMNVALYHGQRTAVQRRDAQDAFMAGRADVMVATNAFG
CCEEEHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCHHHHHCCCCCEEEEECCCC
MGIDKPDVRFIVHAQCPGSLDAYYQESGRAGRDGGLARCTLLFDEKDKRIHQFFLANRYP
CCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCC
AATDLRQMVTALRGTPTVLPALREALPHIGVRRLQSGMRMLGDFGIVQRDRRGRFSLRDG
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCEECCC
SADSIEDIAALYEARSREDRETLQAMLDYARSGRCRWMLLLEYYGESEDLEPCGICDSCR
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHH
RLAEAATHEADGEKTVAASATAVPFAEGDTVKARRFGKGTVVSVTSEWVEVRFPDESVRR
HHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEHHCCCCCCEEEEEECEEEEECCHHHHHH
FLPDRLLRMGKRRGAA
HHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PETLPPDIMEILRDQFGVARLRPGQADVLASVLQGHDTIAVMPTGSGKSLCFQLPARVL
CCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
DGLTVAISPLIALMQDQAGKLDQLDLPPAVVNSAVGDAALDSLARGGERILLTTPEQLEG
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCC
KAVIEALRRNRVALFVVDEAHCISQWGHDFRPAYLGLREVVSALSRPPVLALTATATDAV
HHHHHHHHCCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHH
VKDIAHHLGMRHPRVVRAPLFRPNLVYAVEHLSEAPTRPDAVRRLVSAESGGSGGSGRRG
HHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCC
AGIVYTATVALAEQLYDALRGAGMNVALYHGQRTAVQRRDAQDAFMAGRADVMVATNAFG
CCEEEHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCHHHHHCCCCCEEEEECCCC
MGIDKPDVRFIVHAQCPGSLDAYYQESGRAGRDGGLARCTLLFDEKDKRIHQFFLANRYP
CCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCC
AATDLRQMVTALRGTPTVLPALREALPHIGVRRLQSGMRMLGDFGIVQRDRRGRFSLRDG
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCEECCC
SADSIEDIAALYEARSREDRETLQAMLDYARSGRCRWMLLLEYYGESEDLEPCGICDSCR
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHH
RLAEAATHEADGEKTVAASATAVPFAEGDTVKARRFGKGTVVSVTSEWVEVRFPDESVRR
HHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEHHCCCCCCEEEEEECEEEEECCHHHHHH
FLPDRLLRMGKRRGAA
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]