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The map label for this gene is hpd [H]

Identifier: 73538328

GI number: 73538328

Start: 1173069

End: 1174148

Strand: Direct

Name: hpd [H]

Synonym: Reut_B4501

Alternate gene names: 73538328

Gene position: 1173069-1174148 (Clockwise)

Preceding gene: 73538325

Following gene: 73538329

Centisome position: 43.03

GC content: 63.43

Gene sequence:

>1080_bases
ATGGCCGACCTCTTTGACAACCCGATGCAACTGATGGGCTTCGAATTCGTCGAATTCGCCTCGCCCACCCCCAATGTGCT
CGAGCCGCTGTTCGAGAAGATGGGTTTCACGCTGGTCGCCCGCCACCGTTCCAAGGACGTGCTGCTGTATCGCCAGGGCG
AGGTCAACTTCATCGTCAACCGCGAGCCCCACAGCCACGCCGCCTACTTCGCCGCCGAGCACGGCCCGAGCGCCTGCGGC
ATGGCGTTCCGCGTGAAGGATTCGCACAAGGCCTATGCCCGCGCGCTGGAACTGGGCGCGCAGCCGGTTGAAATCCCGAC
CGGGCCGATGGAACTGCGCCTGCCCGCGATCAAGGGCATCGGCGGCGCGCCGCTGTACCTGATCGACCGCTTCGAGGAAG
GCAAGTCGATCTATGACATCGACTTCGAATTCATCGAAGGCGTGGACCGCCACCCCGTGGGCCACGGCCTGAAGCTGGTC
GACCACCTGACGCACAACGTCTACCGTGGCCGCATGGCCTACTGGGCCAACTTCTACGAGAAGCTGTTCAACTTCCGGGA
AATCCGCTACTTCGACATCAAGGGCGAATACACCGGCCTGACCTCCAAGGCCATGACCGCGCCGGATGGCAAGATCCGCA
TTCCGCTGAACGAAGAGTCGTCGAAGGGCGCGGGCCAGATCGAGGAATTCCTGATGGCCTTCAACGGCGAGGGCATCCAG
CACATCGCCTTCCTGACGGACAACCTGATCGAAGTCATCGACAACCTGCAGCTCGCCGGCGTCGAACTGATGACCGCGCC
GAACGACTACTACTACCAGGCCCTGGAAAATCGCCTGCCGGGCCACGGCCAGCCGGTGGACCAGCTCAAGGCCCGCGGCA
TCCTGCTGGACGGCACCACCGAAGGCGGCAAGCCGCGCCTGCTGCTGCAGATCTTTTCGAAGACCGTGCTCGGCCCGGTG
TTCTTCGAATACATCCAGCGCAGCGGCGACGACGGCTTCGGCGAAGGCAACTTCAAGGCGCTGTTCGAGTCGCTGGAACG
CGACCAGATCGAGCGCGGCACCCTCAAGGTCGAAGCCTGA

Upstream 100 bases:

>100_bases
GCTCCCGGCGCTTGCCCGCCTTCCCTGATTCCACGCCGCCACGCGGCACTCCGCGCGGCGCGTGAGATCGAAATACTTAC
CTTCCCCTGTGAGACACACC

Downstream 100 bases:

>100_bases
TCCGGCTCTGACCGTCACCGTCGCCGGGCGCGGTACCCCGTTCCCGGCGGTCTTCAAGGCCCAGGCGTCCCACCCTCCTC
ACATTAAGAGACGCCAGGCT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: NA

Alternate protein names: 4HPPD; HPD; HPPDase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MADLFDNPMQLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVLLYRQGEVNFIVNREPHSHAAYFAAEHGPSACG
MAFRVKDSHKAYARALELGAQPVEIPTGPMELRLPAIKGIGGAPLYLIDRFEEGKSIYDIDFEFIEGVDRHPVGHGLKLV
DHLTHNVYRGRMAYWANFYEKLFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQ
HIAFLTDNLIEVIDNLQLAGVELMTAPNDYYYQALENRLPGHGQPVDQLKARGILLDGTTEGGKPRLLLQIFSKTVLGPV
FFEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKVEA

Sequences:

>Translated_359_residues
MADLFDNPMQLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVLLYRQGEVNFIVNREPHSHAAYFAAEHGPSACG
MAFRVKDSHKAYARALELGAQPVEIPTGPMELRLPAIKGIGGAPLYLIDRFEEGKSIYDIDFEFIEGVDRHPVGHGLKLV
DHLTHNVYRGRMAYWANFYEKLFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQ
HIAFLTDNLIEVIDNLQLAGVELMTAPNDYYYQALENRLPGHGQPVDQLKARGILLDGTTEGGKPRLLLQIFSKTVLGPV
FFEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKVEA
>Mature_358_residues
ADLFDNPMQLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVLLYRQGEVNFIVNREPHSHAAYFAAEHGPSACGM
AFRVKDSHKAYARALELGAQPVEIPTGPMELRLPAIKGIGGAPLYLIDRFEEGKSIYDIDFEFIEGVDRHPVGHGLKLVD
HLTHNVYRGRMAYWANFYEKLFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQH
IAFLTDNLIEVIDNLQLAGVELMTAPNDYYYQALENRLPGHGQPVDQLKARGILLDGTTEGGKPRLLLQIFSKTVLGPVF
FEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKVEA

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI4504477, Length=351, Percent_Identity=27.6353276353276, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI285002264, Length=341, Percent_Identity=27.2727272727273, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI14249394, Length=333, Percent_Identity=29.1291291291291, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17555220, Length=333, Percent_Identity=30.9309309309309, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550752, Length=226, Percent_Identity=34.5132743362832, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21356105, Length=304, Percent_Identity=31.5789473684211, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24667510, Length=304, Percent_Identity=31.5789473684211, Blast_Score=124, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =1.13.11.27 [H]

Molecular weight: Translated: 40388; Mature: 40256

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLFDNPMQLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVLLYRQGEVNFIVN
CCCCCCCHHHHHCHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEECCCEEEEEE
REPHSHAAYFAAEHGPSACGMAFRVKDSHKAYARALELGAQPVEIPTGPMELRLPAIKGI
CCCCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHCCC
GGAPLYLIDRFEEGKSIYDIDFEFIEGVDRHPVGHGLKLVDHLTHNVYRGRMAYWANFYE
CCCCEEEEEEHHCCCEEEEECHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KLFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
HIAFLTDNLIEVIDNLQLAGVELMTAPNDYYYQALENRLPGHGQPVDQLKARGILLDGTT
HHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHCEEEEECCC
EGGKPRLLLQIFSKTVLGPVFFEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKVEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECC
>Mature Secondary Structure 
ADLFDNPMQLMGFEFVEFASPTPNVLEPLFEKMGFTLVARHRSKDVLLYRQGEVNFIVN
CCCCCCHHHHHCHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCEEEEECCCEEEEEE
REPHSHAAYFAAEHGPSACGMAFRVKDSHKAYARALELGAQPVEIPTGPMELRLPAIKGI
CCCCCCCEEEEECCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHCCC
GGAPLYLIDRFEEGKSIYDIDFEFIEGVDRHPVGHGLKLVDHLTHNVYRGRMAYWANFYE
CCCCEEEEEEHHCCCEEEEECHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KLFNFREIRYFDIKGEYTGLTSKAMTAPDGKIRIPLNEESSKGAGQIEEFLMAFNGEGIQ
HHHCHHHEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
HIAFLTDNLIEVIDNLQLAGVELMTAPNDYYYQALENRLPGHGQPVDQLKARGILLDGTT
HHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHCEEEEECCC
EGGKPRLLLQIFSKTVLGPVFFEYIQRSGDDGFGEGNFKALFESLERDQIERGTLKVEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1572351; 10467142 [H]