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The map label for this gene is ctaD [H]

Identifier: 73538264

GI number: 73538264

Start: 1095574

End: 1097211

Strand: Direct

Name: ctaD [H]

Synonym: Reut_B4436

Alternate gene names: 73538264

Gene position: 1095574-1097211 (Clockwise)

Preceding gene: 73538263

Following gene: 73538265

Centisome position: 40.19

GC content: 64.71

Gene sequence:

>1638_bases
ATGCGAGCACAAGCCGCTGAACGCGCCAGCACCGTGGCGCAGCCCGATTACCTGAGCGACGGCTTCTCGCTCGCCTCATG
GCTGGGCTCGACGGACCACAAGCGCATTGCGTGGCTGTACATGGGCGCGATCACGCTGTTCTTCTTTATCGGCGGCGCGG
CGGCCACGCTGATCCGGCTCGATCTCGTCACGCCGCAAGGCTCGCTGATGGCGGCCGATACCTACAACCGTCTGTTCACC
GCGCATGGCGTGATCATGGTCTGGCTGTTCCTGATCCCGTCGATTCCGTCGGTGCTGGGCAACTTCCTGGTGCCGCTCAT
GATCGGCGCGCGCGACATGGCGTTCCCGCGGCTGAACCTCGCGAGCTGGTACCTGTACGTGGCGGGCGGCCTGCTGACGC
TTGGCGCGATGATCGCCGGCGGCGTCGATACCGGCTGGACGTTCTACACGCCATACTCGACCATGTTCTCGAACAGCCAT
GTGGTGATGACGCTGGCCGGCGTATTCGTTACTGGCTTTTCCTCGATCCTGACCGGCCTGAACATCATCGTTACGGTGCA
TACGCTGCGGGCGCCGGGCATGACGTGGCTGCGCCTGCCGCTGTTCGTGTGGGCGGCCTACGGCACGAGCCTGATCCTGG
TGCTGGCCACGCCGGTGCTGGCCATGACGCTCTGCCTCGTGGCGCTCGAGCGGCTCGCGCATATCGGCATCTTCGACCCC
GCGCTTGGCGGCGACCCGCTGCTGTTCCAGCACCTGTTCTGGTTCTACTCGCATCCCGCCGTGTACATCATGATCCTGCC
CGCGATGGGCGTGGCCAGCGAGATCATCCCGTGTTTTGCGCGGCGCCCCGTGTTCGGCTACCGCGCCATGGTGTGGGCGA
TCGTCGGCATCGCCAGCCTCGGCTTCCTGGTATGGGGCCACCACATGTTCGTGAGCGGCCAGTCCTACCGCGCGAGCGTG
ACGTTCTCGCTGCTGAGCTTTCTGGTGGCGGTGCCGTCGGCCATCAAGGTCTTCAACTGGACCGCGACGCTGTACAAGGG
CAGCATCCGCCTGTCCGCGCCGATGCTGTACGCGCTCGGCTTTGTCGGGCTGTTCACGATAGGCGGCCTTACGGGGCTGA
TCCTGGCGGCGCTGGCGCTCGACGTCCACCTGACCGATACCTACTTCGTAATCGCGCATTTCCACTACATCATGGTGGGC
GGCGCGGTCATGGCCTATCTTGGCGGCCTGCATTTCTGGTGGCCGAAAATGACGGGCCGCCGCTACCCGGAGAACTGGGC
GCGCATCGCGGCCGTGGTGATCTTCCTCGGCTTCAACATGACCTTCTTTCCGCAGTTCCTGCTCGGTTTCGAAGGGATGC
CGCGCCGCTACCACGCCTACCCGCCCGAATTCCAGGTGCTCAATATCCTGTCTTCCGCGGGCGGTTCGATCCTCGCGATC
GGCTACCTGATGCCGCTGGTCTACCTGATCCACTCGCTGTTCCGCGCAGAACGCGCGCCAGCCAACCCATGGCATGCCAC
AGGCCTTGAATGGCAGACCACATCGCCGCCGCCGACCCGCAACTTTGCGCAAGTGCCCAAGGTCGGTGCCGACCCCTACT
GCTACGACCCCGTTTCGGGCAAGGAGACGCCGCAATGA

Upstream 100 bases:

>100_bases
GTCGCGGGCTATGCGCCCATCATGCCGACCTACCAGGGCCAGATCGACGAGCAGGACATTCTCGCCATCATCGAATACCT
GCGCAGCATGGGAGCCGCCG

Downstream 100 bases:

>100_bases
GCGCGCCGCCGTTCCAGTTCGACAGTACCGGACAGCAAGCTGTGGCCTCGCGGCTCGGCATGTGGGTCTTCCTGGGCACC
GAGCTGATGTTCTTCGGCCC

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MRAQAAERASTVAQPDYLSDGFSLASWLGSTDHKRIAWLYMGAITLFFFIGGAAATLIRLDLVTPQGSLMAADTYNRLFT
AHGVIMVWLFLIPSIPSVLGNFLVPLMIGARDMAFPRLNLASWYLYVAGGLLTLGAMIAGGVDTGWTFYTPYSTMFSNSH
VVMTLAGVFVTGFSSILTGLNIIVTVHTLRAPGMTWLRLPLFVWAAYGTSLILVLATPVLAMTLCLVALERLAHIGIFDP
ALGGDPLLFQHLFWFYSHPAVYIMILPAMGVASEIIPCFARRPVFGYRAMVWAIVGIASLGFLVWGHHMFVSGQSYRASV
TFSLLSFLVAVPSAIKVFNWTATLYKGSIRLSAPMLYALGFVGLFTIGGLTGLILAALALDVHLTDTYFVIAHFHYIMVG
GAVMAYLGGLHFWWPKMTGRRYPENWARIAAVVIFLGFNMTFFPQFLLGFEGMPRRYHAYPPEFQVLNILSSAGGSILAI
GYLMPLVYLIHSLFRAERAPANPWHATGLEWQTTSPPPTRNFAQVPKVGADPYCYDPVSGKETPQ

Sequences:

>Translated_545_residues
MRAQAAERASTVAQPDYLSDGFSLASWLGSTDHKRIAWLYMGAITLFFFIGGAAATLIRLDLVTPQGSLMAADTYNRLFT
AHGVIMVWLFLIPSIPSVLGNFLVPLMIGARDMAFPRLNLASWYLYVAGGLLTLGAMIAGGVDTGWTFYTPYSTMFSNSH
VVMTLAGVFVTGFSSILTGLNIIVTVHTLRAPGMTWLRLPLFVWAAYGTSLILVLATPVLAMTLCLVALERLAHIGIFDP
ALGGDPLLFQHLFWFYSHPAVYIMILPAMGVASEIIPCFARRPVFGYRAMVWAIVGIASLGFLVWGHHMFVSGQSYRASV
TFSLLSFLVAVPSAIKVFNWTATLYKGSIRLSAPMLYALGFVGLFTIGGLTGLILAALALDVHLTDTYFVIAHFHYIMVG
GAVMAYLGGLHFWWPKMTGRRYPENWARIAAVVIFLGFNMTFFPQFLLGFEGMPRRYHAYPPEFQVLNILSSAGGSILAI
GYLMPLVYLIHSLFRAERAPANPWHATGLEWQTTSPPPTRNFAQVPKVGADPYCYDPVSGKETPQ
>Mature_545_residues
MRAQAAERASTVAQPDYLSDGFSLASWLGSTDHKRIAWLYMGAITLFFFIGGAAATLIRLDLVTPQGSLMAADTYNRLFT
AHGVIMVWLFLIPSIPSVLGNFLVPLMIGARDMAFPRLNLASWYLYVAGGLLTLGAMIAGGVDTGWTFYTPYSTMFSNSH
VVMTLAGVFVTGFSSILTGLNIIVTVHTLRAPGMTWLRLPLFVWAAYGTSLILVLATPVLAMTLCLVALERLAHIGIFDP
ALGGDPLLFQHLFWFYSHPAVYIMILPAMGVASEIIPCFARRPVFGYRAMVWAIVGIASLGFLVWGHHMFVSGQSYRASV
TFSLLSFLVAVPSAIKVFNWTATLYKGSIRLSAPMLYALGFVGLFTIGGLTGLILAALALDVHLTDTYFVIAHFHYIMVG
GAVMAYLGGLHFWWPKMTGRRYPENWARIAAVVIFLGFNMTFFPQFLLGFEGMPRRYHAYPPEFQVLNILSSAGGSILAI
GYLMPLVYLIHSLFRAERAPANPWHATGLEWQTTSPPPTRNFAQVPKVGADPYCYDPVSGKETPQ

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=506, Percent_Identity=42.2924901185771, Blast_Score=369, Evalue=1e-102,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=35.6031128404669, Blast_Score=336, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6226519, Length=523, Percent_Identity=37.8585086042065, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6226524, Length=322, Percent_Identity=37.888198757764, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6226523, Length=246, Percent_Identity=35.3658536585366, Blast_Score=130, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 59860; Mature: 59860

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAQAAERASTVAQPDYLSDGFSLASWLGSTDHKRIAWLYMGAITLFFFIGGAAATLIRL
CCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEE
DLVTPQGSLMAADTYNRLFTAHGVIMVWLFLIPSIPSVLGNFLVPLMIGARDMAFPRLNL
EEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHH
ASWYLYVAGGLLTLGAMIAGGVDTGWTFYTPYSTMFSNSHVVMTLAGVFVTGFSSILTGL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHCCCEEEHHHHHHHHHHHHHHHCCC
NIIVTVHTLRAPGMTWLRLPLFVWAAYGTSLILVLATPVLAMTLCLVALERLAHIGIFDP
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALGGDPLLFQHLFWFYSHPAVYIMILPAMGVASEIIPCFARRPVFGYRAMVWAIVGIASL
CCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GFLVWGHHMFVSGQSYRASVTFSLLSFLVAVPSAIKVFNWTATLYKGSIRLSAPMLYALG
HHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHEEECCEEECHHHHHHHH
FVGLFTIGGLTGLILAALALDVHLTDTYFVIAHFHYIMVGGAVMAYLGGLHFWWPKMTGR
HHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCC
RYPENWARIAAVVIFLGFNMTFFPQFLLGFEGMPRRYHAYPPEFQVLNILSSAGGSILAI
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHH
GYLMPLVYLIHSLFRAERAPANPWHATGLEWQTTSPPPTRNFAQVPKVGADPYCYDPVSG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCHHHCCCCCCCCCCCCCCCC
KETPQ
CCCCC
>Mature Secondary Structure
MRAQAAERASTVAQPDYLSDGFSLASWLGSTDHKRIAWLYMGAITLFFFIGGAAATLIRL
CCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEE
DLVTPQGSLMAADTYNRLFTAHGVIMVWLFLIPSIPSVLGNFLVPLMIGARDMAFPRLNL
EEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCHH
ASWYLYVAGGLLTLGAMIAGGVDTGWTFYTPYSTMFSNSHVVMTLAGVFVTGFSSILTGL
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHCCCEEEHHHHHHHHHHHHHHHCCC
NIIVTVHTLRAPGMTWLRLPLFVWAAYGTSLILVLATPVLAMTLCLVALERLAHIGIFDP
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
ALGGDPLLFQHLFWFYSHPAVYIMILPAMGVASEIIPCFARRPVFGYRAMVWAIVGIASL
CCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
GFLVWGHHMFVSGQSYRASVTFSLLSFLVAVPSAIKVFNWTATLYKGSIRLSAPMLYALG
HHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEHEEECCEEECHHHHHHHH
FVGLFTIGGLTGLILAALALDVHLTDTYFVIAHFHYIMVGGAVMAYLGGLHFWWPKMTGR
HHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCC
RYPENWARIAAVVIFLGFNMTFFPQFLLGFEGMPRRYHAYPPEFQVLNILSSAGGSILAI
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHH
GYLMPLVYLIHSLFRAERAPANPWHATGLEWQTTSPPPTRNFAQVPKVGADPYCYDPVSG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCHHHCCCCCCCCCCCCCCCC
KETPQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8387368; 8905231 [H]