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The map label for this gene is mntH [H]

Identifier: 73538239

GI number: 73538239

Start: 1068132

End: 1069439

Strand: Reverse

Name: mntH [H]

Synonym: Reut_B4410

Alternate gene names: 73538239

Gene position: 1069439-1068132 (Counterclockwise)

Preceding gene: 73538241

Following gene: 73538238

Centisome position: 39.23

GC content: 67.97

Gene sequence:

>1308_bases
ATGCCGCCGCCGGAACACTGCGCGCCGGCAATAGCCCGGGCCTGCACGTCTCCTGACGGCTGGCGGGGCATGCTGCGCTT
TGCCGGCCCGGGGTACCTCGTTGCCGTCGGCTACATGGATCCGGGAAACTGGGCCACCGACCTGGCCGGCGGTTCAGCCT
ATGGGTATCGCCTGTTGTGGGTCATCGCCATGTCGAGCTGCATGGCGGTGCTGCTGCAGATACTCGCGAGCCGGCTCGGC
CTGGTGGCGGGCATGGACCTCGCGCAAGCGTGCAGGCACCGTAGTCCGCGGCTGTCGGCCCTGGCGCAGTGGGTGCTGTG
CGAGATCGCGATCTGCGCCGCCGACCTCGCCGAAGTGCTCGGCACGGCCATAGCGCTGAACCTGCTGTTCGGGCTGCCGC
TGGCGTGGGGGGTCGCGCTGACGGTGTTCGACGTGCTTCTGGTGCTGGTGCTGCAACAGCGCGGCTATCGCCGCCTGGAA
GCGTTCGTCATCAGCATGGTGGCGCTGGTGCTGTGCTGCTTCATCCTGATGCTGCTGATCTCGCGCCCCGCATGGCCCGA
CGTGGCGGCCGGCCTGGTGCCGTACGGGCCGACGATGCGCGATCCGTCCGCGCTTTATATCGCCATCGGCATCATCGGCG
CGACCGTGATGCCGCACAACCTCTACCTCCATTCGGCGGCGGTGCGCACGCGTGCGCTGGACGGAAGCCCCCAGGATCTG
CGGCGGGCCCTGCGTTTCATCGCCATCGATACCGTGATTGCACTGTCGCTCGCGTTCGTCATCAACGCTGCCATCCTGAT
TACGGCTGCCGGCGTGTTTTTCAAGGCCGGCCGTACCGACGTGGCGGAAATCCAGGAAGCCTACCGGCTGCTCAGCCCGC
TGACCGGCGCGGCCTGGGCGAGCGTGGTGTTTGGCGTGGCCCTGCTGGCCTCGGGACAATGTTCGGCGGTCACTGCCACG
CTGGCCGGGCAGGTCGTGATGGAGGGTTTCCTGCGTACGCGGCTGCCGCCGTGGCTGCGGCGGCTTGCGACCCGCTGCGT
CGCTATCGTTCCGGCATTGGTGGTCGCGATCCTGTACGCGGAACGCGGCATCGCTCAGCTCCTGCTGGCAAGCCAGGTGA
TCCTGAGCCTGCAGTTGCCGTTCGCCGCCATTCCCCTGGTGCGCAGCACAAGCAGCTGCGCGCTGATGCGCGAGCACGTG
AATCCGCGCTGGCTCGCGGTCCTGGCCTGGATCGCAGTCGCCGTCATCGTGTCGATGAACGCGACCATGCTCTGGATGCT
GGCGGGCTCTCCCGCTGCAGGCGGTTGA

Upstream 100 bases:

>100_bases
TTCTGGCGCGTTCATCCATTCCGGATGACAGCTGGCATGCTCGTGCTGGGCGGCGGCGCGCTGTCGTTGCTGAGCCGCCT
TTGCGCCTTCCTTGGCTGAG

Downstream 100 bases:

>100_bases
GGGCTGAGCAATTTCCGCTGTGGCCACCGCGGTAGCGAGCGACATCACATCATGCGAGCCGTTGAAATTGCTACATCGCT
GCACCTGAAGAACAAGGCGG

Product: natural resistance-associated macrophage protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MPPPEHCAPAIARACTSPDGWRGMLRFAGPGYLVAVGYMDPGNWATDLAGGSAYGYRLLWVIAMSSCMAVLLQILASRLG
LVAGMDLAQACRHRSPRLSALAQWVLCEIAICAADLAEVLGTAIALNLLFGLPLAWGVALTVFDVLLVLVLQQRGYRRLE
AFVISMVALVLCCFILMLLISRPAWPDVAAGLVPYGPTMRDPSALYIAIGIIGATVMPHNLYLHSAAVRTRALDGSPQDL
RRALRFIAIDTVIALSLAFVINAAILITAAGVFFKAGRTDVAEIQEAYRLLSPLTGAAWASVVFGVALLASGQCSAVTAT
LAGQVVMEGFLRTRLPPWLRRLATRCVAIVPALVVAILYAERGIAQLLLASQVILSLQLPFAAIPLVRSTSSCALMREHV
NPRWLAVLAWIAVAVIVSMNATMLWMLAGSPAAGG

Sequences:

>Translated_435_residues
MPPPEHCAPAIARACTSPDGWRGMLRFAGPGYLVAVGYMDPGNWATDLAGGSAYGYRLLWVIAMSSCMAVLLQILASRLG
LVAGMDLAQACRHRSPRLSALAQWVLCEIAICAADLAEVLGTAIALNLLFGLPLAWGVALTVFDVLLVLVLQQRGYRRLE
AFVISMVALVLCCFILMLLISRPAWPDVAAGLVPYGPTMRDPSALYIAIGIIGATVMPHNLYLHSAAVRTRALDGSPQDL
RRALRFIAIDTVIALSLAFVINAAILITAAGVFFKAGRTDVAEIQEAYRLLSPLTGAAWASVVFGVALLASGQCSAVTAT
LAGQVVMEGFLRTRLPPWLRRLATRCVAIVPALVVAILYAERGIAQLLLASQVILSLQLPFAAIPLVRSTSSCALMREHV
NPRWLAVLAWIAVAVIVSMNATMLWMLAGSPAAGG
>Mature_434_residues
PPPEHCAPAIARACTSPDGWRGMLRFAGPGYLVAVGYMDPGNWATDLAGGSAYGYRLLWVIAMSSCMAVLLQILASRLGL
VAGMDLAQACRHRSPRLSALAQWVLCEIAICAADLAEVLGTAIALNLLFGLPLAWGVALTVFDVLLVLVLQQRGYRRLEA
FVISMVALVLCCFILMLLISRPAWPDVAAGLVPYGPTMRDPSALYIAIGIIGATVMPHNLYLHSAAVRTRALDGSPQDLR
RALRFIAIDTVIALSLAFVINAAILITAAGVFFKAGRTDVAEIQEAYRLLSPLTGAAWASVVFGVALLASGQCSAVTATL
AGQVVMEGFLRTRLPPWLRRLATRCVAIVPALVVAILYAERGIAQLLLASQVILSLQLPFAAIPLVRSTSSCALMREHVN
PRWLAVLAWIAVAVIVSMNATMLWMLAGSPAAGG

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=432, Percent_Identity=36.1111111111111, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI295293167, Length=438, Percent_Identity=34.703196347032, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI295293175, Length=438, Percent_Identity=34.703196347032, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI295293173, Length=438, Percent_Identity=34.703196347032, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI10835169, Length=438, Percent_Identity=34.703196347032, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI295293178, Length=438, Percent_Identity=34.703196347032, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI295293171, Length=438, Percent_Identity=34.703196347032, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI295293169, Length=438, Percent_Identity=34.703196347032, Blast_Score=222, Evalue=4e-58,
Organism=Escherichia coli, GI1788736, Length=402, Percent_Identity=38.0597014925373, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI193210616, Length=442, Percent_Identity=32.3529411764706, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17569473, Length=371, Percent_Identity=34.2318059299191, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71999499, Length=450, Percent_Identity=32.4444444444444, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI71993856, Length=219, Percent_Identity=36.0730593607306, Blast_Score=144, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6323062, Length=394, Percent_Identity=41.8781725888325, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6321841, Length=413, Percent_Identity=40.6779661016949, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6324450, Length=426, Percent_Identity=36.3849765258216, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24648607, Length=431, Percent_Identity=34.1067285382831, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI281362176, Length=431, Percent_Identity=34.1067285382831, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24648609, Length=431, Percent_Identity=34.1067285382831, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI45553443, Length=412, Percent_Identity=35.1941747572816, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46262; Mature: 46131

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPEHCAPAIARACTSPDGWRGMLRFAGPGYLVAVGYMDPGNWATDLAGGSAYGYRLLW
CCCCHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCCHHHCCCCCHHHHHHHH
VIAMSSCMAVLLQILASRLGLVAGMDLAQACRHRSPRLSALAQWVLCEIAICAADLAEVL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GTAIALNLLFGLPLAWGVALTVFDVLLVLVLQQRGYRRLEAFVISMVALVLCCFILMLLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRPAWPDVAAGLVPYGPTMRDPSALYIAIGIIGATVMPHNLYLHSAAVRTRALDGSPQDL
CCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
RRALRFIAIDTVIALSLAFVINAAILITAAGVFFKAGRTDVAEIQEAYRLLSPLTGAAWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHH
SVVFGVALLASGQCSAVTATLAGQVVMEGFLRTRLPPWLRRLATRCVAIVPALVVAILYA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ERGIAQLLLASQVILSLQLPFAAIPLVRSTSSCALMREHVNPRWLAVLAWIAVAVIVSMN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
ATMLWMLAGSPAAGG
CCEEEEEECCCCCCC
>Mature Secondary Structure 
PPPEHCAPAIARACTSPDGWRGMLRFAGPGYLVAVGYMDPGNWATDLAGGSAYGYRLLW
CCCHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCCHHHCCCCCHHHHHHHH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CCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]