BacMap

Definition	Ralstonia eutropha JMP134 chromosome chromosome 2, complete sequence.
Accession	NC_007348
Length	2,726,152

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The map label for this gene is pldh-t [H]

Identifier: 73538217

GI number: 73538217

Start: 1045009

End: 1045758

Strand: Reverse

Name: pldh-t [H]

Synonym: Reut_B4388

Alternate gene names: 73538217

Gene position: 1045758-1045009 (Counterclockwise)

Preceding gene: 73538218

Following gene: 73538216

Centisome position: 38.36

GC content: 66.53

Gene sequence:

>750_bases
ATGTCGGGTAACGACCCTCAACTGGAAGGCAAGCGGTTCCTTGTCAGCGGTGGCGGCCGCGGGCTTGGCGGCGAGATCTG
CCGCATGCTCGGCGAAGCCGGCGCAAGCGTGATCGTTGCGGACCTTGACCTGTCGCGCGCCACAGAGTGCGCGGCGTCGC
TCGAGCAGACCGGCGTCAAGGCGCACGCGGTCGGCGTGGATGTGTCCGACGCGCAGGCCGTGGACCGGTTGTTCAAAGAG
ATCGGGCGCGCAGGCGGACAACTGGCCGGGCGCATCGACGGCATCATCAACAACGCGGCCATCGACATCACCCTGCCCGT
GGAGGAGGTCGATACGGAGCAATGGCGGCGCGTGCTGATGGTCAATCTCTATGGCCCGTACCTGCTGGTCCATGCCGCCG
TGCCGCTGATGAAGGCGCAGGGCGGCGGGCACATTGTCAATATCGCGTCGACGGCGTCCAAGCGCGCATGGCCGAATGCG
TCCGCCTATCACGCGACCAAGTGGGGCGTGCTGGGCTTCTCGCATGCCTTGCATGCGGAACTGCGTCCGCATCGGATCAA
AGTGTCGGCCATCGTGGCGGGCGGCATGCGTACGCCGTTCCTGCTCGACCGCTTCCCCGACATCGACACGTCCACGCTGC
AGGACCCGGCCAATGTCGCGCGCGCCGTGCGCTTCGTGCTGACCCAGCCCGAAGAGACGGTCATCCCCGAGGTGATGGTG
CTCCCGATGAAGGAGACCTCATGGCCCTGA

Upstream 100 bases:

>100_bases
ACGCGGCAGGGCCATGCCGCACTGGCATGCATTTCGCTGTGCTGACGCTGACCGGCCGCCCGGGGCGGCCCTGGTTTGAC
CTTCGGATCGGAGAGACCAC

Downstream 100 bases:

>100_bases
ACCGACCGGCGCGCGGCGCGGTGCTGCTCGACAAGGACGGCACGCTGCTCAGGAACGTGCCCTATAACGTGGATCCCCAC
CACATGCAACTGGCGGACAC

Product: Short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: tPLDH [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSGNDPQLEGKRFLVSGGGRGLGGEICRMLGEAGASVIVADLDLSRATECAASLEQTGVKAHAVGVDVSDAQAVDRLFKE
IGRAGGQLAGRIDGIINNAAIDITLPVEEVDTEQWRRVLMVNLYGPYLLVHAAVPLMKAQGGGHIVNIASTASKRAWPNA
SAYHATKWGVLGFSHALHAELRPHRIKVSAIVAGGMRTPFLLDRFPDIDTSTLQDPANVARAVRFVLTQPEETVIPEVMV
LPMKETSWP

Sequences:

>Translated_249_residues
MSGNDPQLEGKRFLVSGGGRGLGGEICRMLGEAGASVIVADLDLSRATECAASLEQTGVKAHAVGVDVSDAQAVDRLFKE
IGRAGGQLAGRIDGIINNAAIDITLPVEEVDTEQWRRVLMVNLYGPYLLVHAAVPLMKAQGGGHIVNIASTASKRAWPNA
SAYHATKWGVLGFSHALHAELRPHRIKVSAIVAGGMRTPFLLDRFPDIDTSTLQDPANVARAVRFVLTQPEETVIPEVMV
LPMKETSWP
>Mature_248_residues
SGNDPQLEGKRFLVSGGGRGLGGEICRMLGEAGASVIVADLDLSRATECAASLEQTGVKAHAVGVDVSDAQAVDRLFKEI
GRAGGQLAGRIDGIINNAAIDITLPVEEVDTEQWRRVLMVNLYGPYLLVHAAVPLMKAQGGGHIVNIASTASKRAWPNAS
AYHATKWGVLGFSHALHAELRPHRIKVSAIVAGGMRTPFLLDRFPDIDTSTLQDPANVARAVRFVLTQPEETVIPEVMVL
PMKETSWP

Specific function: Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Oxidizes pyridoxal to 4-pyridoxolactone, but does not have activity toward pyridoxal 5'-phosphate, pyridoxine, pyridoxamine, pyridoxamine 5'-phosphat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=27.7777777777778, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI20149619, Length=237, Percent_Identity=28.2700421940928, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI126723191, Length=192, Percent_Identity=30.2083333333333, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI32455239, Length=187, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI5031765, Length=187, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI7705925, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI40254992, Length=224, Percent_Identity=29.4642857142857, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI210032110, Length=208, Percent_Identity=24.5192307692308, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI15277342, Length=232, Percent_Identity=28.0172413793103, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI126723750, Length=242, Percent_Identity=26.0330578512397, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI31542939, Length=202, Percent_Identity=27.7227722772277, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=26.8, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI142976729, Length=238, Percent_Identity=23.9495798319328, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI157739938, Length=196, Percent_Identity=24.4897959183673, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI19923817, Length=238, Percent_Identity=25.2100840336134, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI302344755, Length=106, Percent_Identity=33.9622641509434, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI66933014, Length=173, Percent_Identity=27.7456647398844, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4503817, Length=221, Percent_Identity=21.7194570135747, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI59889578, Length=175, Percent_Identity=30.2857142857143, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI44680136, Length=103, Percent_Identity=35.9223300970874, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI44680133, Length=103, Percent_Identity=35.9223300970874, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI17738292, Length=103, Percent_Identity=35.9223300970874, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790717, Length=191, Percent_Identity=29.3193717277487, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788459, Length=193, Percent_Identity=30.0518134715026, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI87082160, Length=216, Percent_Identity=28.2407407407407, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787526, Length=217, Percent_Identity=26.7281105990783, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1787905, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1789208, Length=213, Percent_Identity=28.6384976525822, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082100, Length=196, Percent_Identity=31.1224489795918, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367175, Length=193, Percent_Identity=31.6062176165803, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1789057, Length=212, Percent_Identity=27.3584905660377, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787820, Length=245, Percent_Identity=27.3469387755102, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786701, Length=226, Percent_Identity=30.5309734513274, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789378, Length=245, Percent_Identity=24.0816326530612, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787335, Length=241, Percent_Identity=26.1410788381743, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=206, Percent_Identity=33.495145631068, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508895, Length=249, Percent_Identity=25.7028112449799, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193203117, Length=189, Percent_Identity=29.6296296296296, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=238, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI193203115, Length=188, Percent_Identity=29.7872340425532, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=199, Percent_Identity=31.1557788944724, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71982365, Length=201, Percent_Identity=31.3432835820896, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=200, Percent_Identity=27.5, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=197, Percent_Identity=27.4111675126904, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=204, Percent_Identity=31.3725490196078, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555612, Length=217, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=201, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=212, Percent_Identity=29.7169811320755, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=210, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17558628, Length=198, Percent_Identity=28.7878787878788, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=256, Percent_Identity=25.78125, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322227, Length=231, Percent_Identity=27.7056277056277, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322861, Length=182, Percent_Identity=30.7692307692308, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355319, Length=200, Percent_Identity=28.5, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281364892, Length=244, Percent_Identity=29.0983606557377, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21358495, Length=251, Percent_Identity=27.0916334661355, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24639444, Length=236, Percent_Identity=33.4745762711864, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24643142, Length=185, Percent_Identity=31.3513513513514, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355631, Length=247, Percent_Identity=27.5303643724696, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=193, Percent_Identity=29.0155440414508, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644339, Length=190, Percent_Identity=27.8947368421053, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737361, Length=200, Percent_Identity=31, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=24.2990654205607, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28571526, Length=192, Percent_Identity=28.125, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=28.8770053475936, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357673, Length=206, Percent_Identity=30.5825242718447, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI18859837, Length=198, Percent_Identity=29.7979797979798, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281364494, Length=251, Percent_Identity=27.8884462151394, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.107 [H]

Molecular weight: Translated: 26605; Mature: 26474

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNDPQLEGKRFLVSGGGRGLGGEICRMLGEAGASVIVADLDLSRATECAASLEQTGVK
CCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCE
AHAVGVDVSDAQAVDRLFKEIGRAGGQLAGRIDGIINNAAIDITLPVEEVDTEQWRRVLM
EEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHEECCEEEEEEECHHHCCHHHHHHEEE
VNLYGPYLLVHAAVPLMKAQGGGHIVNIASTASKRAWPNASAYHATKWGVLGFSHALHAE
EECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LRPHRIKVSAIVAGGMRTPFLLDRFPDIDTSTLQDPANVARAVRFVLTQPEETVIPEVMV
CCCCEEEEEEEEECCCCCCHHHHCCCCCCCHHCCCHHHHHHHHHHHHCCCCHHHCCCEEE
LPMKETSWP
EECCCCCCC
>Mature Secondary Structure 
SGNDPQLEGKRFLVSGGGRGLGGEICRMLGEAGASVIVADLDLSRATECAASLEQTGVK
CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCE
AHAVGVDVSDAQAVDRLFKEIGRAGGQLAGRIDGIINNAAIDITLPVEEVDTEQWRRVLM
EEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHEECCEEEEEEECHHHCCHHHHHHEEE
VNLYGPYLLVHAAVPLMKAQGGGHIVNIASTASKRAWPNASAYHATKWGVLGFSHALHAE
EECCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LRPHRIKVSAIVAGGMRTPFLLDRFPDIDTSTLQDPANVARAVRFVLTQPEETVIPEVMV
CCCCEEEEEEEEECCCCCCHHHHCCCCCCCHHCCCHHHHHHHHHHHHCCCCHHHCCCEEE
LPMKETSWP
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]