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The map label for this gene is gmhB [H]

Identifier: 73538216

GI number: 73538216

Start: 1044407

End: 1045018

Strand: Reverse

Name: gmhB [H]

Synonym: Reut_B4387

Alternate gene names: 73538216

Gene position: 1045018-1044407 (Counterclockwise)

Preceding gene: 73538217

Following gene: 73538215

Centisome position: 38.33

GC content: 68.95

Gene sequence:

>612_bases
ATGGCCCTGAACCGACCGGCGCGCGGCGCGGTGCTGCTCGACAAGGACGGCACGCTGCTCAGGAACGTGCCCTATAACGT
GGATCCCCACCACATGCAACTGGCGGACACCGCCGGCGACGCACTGCGCATACTGGGCGCGACAGGCCGGCCGCTGGTGG
TGGTCAGCAATCAGCCCGGCGTCGCGCTCGGCGGCTTTCAGGAGAGCGCGCTGCAAGCGGTGCACCGCAGGCTGGCCGAG
CTGTTCCGCCTGCACGGGGCCCGTCTGTCGGGCTTCTTCTACTGTCCGCACCATCCGGATGGCGCGGTCGCGCAGTACGC
GGTGCCGTGCAGTTGCCGCAAGCCGTCGCCTGGCATGCTGCAGGCGGCGTCATCGGTGCTCGGCTTCGATCTGCGCACGT
CATGGATGATCGGCGATATCCTCGACGACATCGAGGCAGGGCGGCGCGTGGGCTGCAACACCATCCTTGTCGACTGCGGT
GGCGAAACCGAATGGGTTACCGGGGCATGGCGCACGCCGGACTTCATCGTGCCGACGCTCGGACAGGCCGCGCAGATCGT
GGCGGGCGAGCCTGTGGCCGCCTGCGCACCCTTCGTGGCGGGGCAAGCATGA

Upstream 100 bases:

>100_bases
AGGACCCGGCCAATGTCGCGCGCGCCGTGCGCTTCGTGCTGACCCAGCCCGAAGAGACGGTCATCCCCGAGGTGATGGTG
CTCCCGATGAAGGAGACCTC

Downstream 100 bases:

>100_bases
CGACATGGGATCGCGCACGCCGGATCCTGTGTGTCCGGCTCGACAATATGGGCGATGTCCTGATGACCACGCCCGCGATG
CAGGCCCTTGCCGAAGCAGC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MALNRPARGAVLLDKDGTLLRNVPYNVDPHHMQLADTAGDALRILGATGRPLVVVSNQPGVALGGFQESALQAVHRRLAE
LFRLHGARLSGFFYCPHHPDGAVAQYAVPCSCRKPSPGMLQAASSVLGFDLRTSWMIGDILDDIEAGRRVGCNTILVDCG
GETEWVTGAWRTPDFIVPTLGQAAQIVAGEPVAACAPFVAGQA

Sequences:

>Translated_203_residues
MALNRPARGAVLLDKDGTLLRNVPYNVDPHHMQLADTAGDALRILGATGRPLVVVSNQPGVALGGFQESALQAVHRRLAE
LFRLHGARLSGFFYCPHHPDGAVAQYAVPCSCRKPSPGMLQAASSVLGFDLRTSWMIGDILDDIEAGRRVGCNTILVDCG
GETEWVTGAWRTPDFIVPTLGQAAQIVAGEPVAACAPFVAGQA
>Mature_202_residues
ALNRPARGAVLLDKDGTLLRNVPYNVDPHHMQLADTAGDALRILGATGRPLVVVSNQPGVALGGFQESALQAVHRRLAEL
FRLHGARLSGFFYCPHHPDGAVAQYAVPCSCRKPSPGMLQAASSVLGFDLRTSWMIGDILDDIEAGRRVGCNTILVDCGG
ETEWVTGAWRTPDFIVPTLGQAAQIVAGEPVAACAPFVAGQA

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=152, Percent_Identity=37.5, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI87082027, Length=156, Percent_Identity=26.9230769230769, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: NA

Molecular weight: Translated: 21479; Mature: 21348

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNRPARGAVLLDKDGTLLRNVPYNVDPHHMQLADTAGDALRILGATGRPLVVVSNQPG
CCCCCCCCCEEEECCCCCEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCEEEEECCCC
VALGGFQESALQAVHRRLAELFRLHGARLSGFFYCPHHPDGAVAQYAVPCSCRKPSPGML
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCHHH
QAASSVLGFDLRTSWMIGDILDDIEAGRRVGCNTILVDCGGETEWVTGAWRTPDFIVPTL
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCCCEECCCC
GQAAQIVAGEPVAACAPFVAGQA
CCHHEEECCCCHHHHHHHHCCCC
>Mature Secondary Structure 
ALNRPARGAVLLDKDGTLLRNVPYNVDPHHMQLADTAGDALRILGATGRPLVVVSNQPG
CCCCCCCCEEEECCCCCEEECCCCCCCCCEEEEECCCCCEEEEECCCCCCEEEEECCCC
VALGGFQESALQAVHRRLAELFRLHGARLSGFFYCPHHPDGAVAQYAVPCSCRKPSPGML
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCCCCCCCCCHHH
QAASSVLGFDLRTSWMIGDILDDIEAGRRVGCNTILVDCGGETEWVTGAWRTPDFIVPTL
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCCCCCEECCCC
GQAAQIVAGEPVAACAPFVAGQA
CCHHEEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430; 12101286 [H]