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The map label for this gene is ilvR [H]

Identifier: 73537977

GI number: 73537977

Start: 785308

End: 786183

Strand: Direct

Name: ilvR [H]

Synonym: Reut_B4146

Alternate gene names: 73537977

Gene position: 785308-786183 (Clockwise)

Preceding gene: 73537975

Following gene: 73537981

Centisome position: 28.81

GC content: 68.61

Gene sequence:

>876_bases
ATGCTGCGTGAACTGCGCACCTTCATCGCCGTGGCCCGACACGGCACCTTTGCCGGCGCCGGCGCGCGGATCGGCCTGAC
CCAGTCGGCCGTCAGCGCGCAAATTCAGCGGCTGGAGGAAGAAGTCGGTTTCCCGCTGTTCGATCGCACCGGGCGCTCGG
CACGGCTCAATGCCGCCGGCCGCGACACGCTGGCGCTGGCCGAGGAACTCGTTGCCCTGTATGAGCGTATCGGCCACCAG
GGGCCGGACGCGCAAGGCGGCATGGTGCGTATCGGCGCCATTGCTTCCGCGCAGGTGACGTTCCTGCCGGATGCCATTGC
AAGTTTCCGCGCCGAATTGCCGGCCTGCCGCGTGCGCATGGTGCCGGGGGTGTCGCTGAGCCTGCTCGGGCAGGTCGATG
CCGGCGATATCGATATCGCCGTGCTGATCCGGCCGCCCTATGCGCTGCCTGCCGAATTGGACTGGCGCCCGCTGCTGCGC
GAGCCGTTCGAATTGCTGGTGCCGGCTGCCATGGCCGGCCTCCACTGGCGTGAAGCGATCGAATCGGCGCCGTTCATCCG
CTATGACCGGGGTTCGTTTGGCGGCCGGCTGGTCGACCAGTTCCTGCGCCAGCAGCGCGTGGTCGTGCAGGAAGCGATCG
AACTCGATGAACTGGAAGGCATCGCGCAACTCGTCGCACGCGGGCTCGGTGTCGGGCTGTCGCCGCGTACGCTGGCTGAG
GGCCAACGGCCCGCCGGCGTCACCGCGCTGTCGCTGGGAGACGATACGTTCTATCGCGAAGTCGGGCTGGTCGAACGTGC
GCCGCATAGCCGCCAGCCCGTCGCGAGCCGGCTCGCGGAGCGTATCGGGGAAGCTGCCAAAGCGCTGGCGGGATAG

Upstream 100 bases:

>100_bases
TCCTCCGCCGACCCATGGAGCCAAGTCTAAGCATGACGAATGATGATGAAAAGCGATATATTTTCGCTCTGAGCAACACA
AATTTCGATCATTCGCCATC

Downstream 100 bases:

>100_bases
CGCTACAGCCCGATGGCGGGCCCGCGGCTGCGCTTGAGCTGGAATGCCACCGACACGCGGTCGGCCGGATAGACGGTGTC
CGTAATCTCGAGGATCTTGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLRELRTFIAVARHGTFAGAGARIGLTQSAVSAQIQRLEEEVGFPLFDRTGRSARLNAAGRDTLALAEELVALYERIGHQ
GPDAQGGMVRIGAIASAQVTFLPDAIASFRAELPACRVRMVPGVSLSLLGQVDAGDIDIAVLIRPPYALPAELDWRPLLR
EPFELLVPAAMAGLHWREAIESAPFIRYDRGSFGGRLVDQFLRQQRVVVQEAIELDELEGIAQLVARGLGVGLSPRTLAE
GQRPAGVTALSLGDDTFYREVGLVERAPHSRQPVASRLAERIGEAAKALAG

Sequences:

>Translated_291_residues
MLRELRTFIAVARHGTFAGAGARIGLTQSAVSAQIQRLEEEVGFPLFDRTGRSARLNAAGRDTLALAEELVALYERIGHQ
GPDAQGGMVRIGAIASAQVTFLPDAIASFRAELPACRVRMVPGVSLSLLGQVDAGDIDIAVLIRPPYALPAELDWRPLLR
EPFELLVPAAMAGLHWREAIESAPFIRYDRGSFGGRLVDQFLRQQRVVVQEAIELDELEGIAQLVARGLGVGLSPRTLAE
GQRPAGVTALSLGDDTFYREVGLVERAPHSRQPVASRLAERIGEAAKALAG
>Mature_291_residues
MLRELRTFIAVARHGTFAGAGARIGLTQSAVSAQIQRLEEEVGFPLFDRTGRSARLNAAGRDTLALAEELVALYERIGHQ
GPDAQGGMVRIGAIASAQVTFLPDAIASFRAELPACRVRMVPGVSLSLLGQVDAGDIDIAVLIRPPYALPAELDWRPLLR
EPFELLVPAAMAGLHWREAIESAPFIRYDRGSFGGRLVDQFLRQQRVVVQEAIELDELEGIAQLVARGLGVGLSPRTLAE
GQRPAGVTALSLGDDTFYREVGLVERAPHSRQPVASRLAERIGEAAKALAG

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693105, Length=286, Percent_Identity=26.2237762237762, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1788481, Length=257, Percent_Identity=31.1284046692607, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1790208, Length=249, Percent_Identity=28.5140562248996, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787879, Length=293, Percent_Identity=29.0102389078498, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788887, Length=247, Percent_Identity=28.7449392712551, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI157672245, Length=289, Percent_Identity=26.643598615917, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=28.3400809716599, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787601, Length=173, Percent_Identity=31.2138728323699, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082132, Length=242, Percent_Identity=25.2066115702479, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787806, Length=241, Percent_Identity=24.4813278008299, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87081904, Length=169, Percent_Identity=28.4023668639053, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786713, Length=109, Percent_Identity=36.697247706422, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790399, Length=145, Percent_Identity=28.2758620689655, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31312; Mature: 31312

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRELRTFIAVARHGTFAGAGARIGLTQSAVSAQIQRLEEEVGFPLFDRTGRSARLNAAG
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCC
RDTLALAEELVALYERIGHQGPDAQGGMVRIGAIASAQVTFLPDAIASFRAELPACRVRM
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEECHHHHHHHHHHCCHHEEEE
VPGVSLSLLGQVDAGDIDIAVLIRPPYALPAELDWRPLLREPFELLVPAAMAGLHWREAI
CCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ESAPFIRYDRGSFGGRLVDQFLRQQRVVVQEAIELDELEGIAQLVARGLGVGLSPRTLAE
HCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
GQRPAGVTALSLGDDTFYREVGLVERAPHSRQPVASRLAERIGEAAKALAG
CCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRELRTFIAVARHGTFAGAGARIGLTQSAVSAQIQRLEEEVGFPLFDRTGRSARLNAAG
CHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCC
RDTLALAEELVALYERIGHQGPDAQGGMVRIGAIASAQVTFLPDAIASFRAELPACRVRM
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCEEEECHHHHHHHHHHCCHHEEEE
VPGVSLSLLGQVDAGDIDIAVLIRPPYALPAELDWRPLLREPFELLVPAAMAGLHWREAI
CCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ESAPFIRYDRGSFGGRLVDQFLRQQRVVVQEAIELDELEGIAQLVARGLGVGLSPRTLAE
HCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
GQRPAGVTALSLGDDTFYREVGLVERAPHSRQPVASRLAERIGEAAKALAG
CCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]