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The map label for this gene is cynR [H]

Identifier: 73537975

GI number: 73537975

Start: 783779

End: 784702

Strand: Direct

Name: cynR [H]

Synonym: Reut_B4144

Alternate gene names: 73537975

Gene position: 783779-784702 (Clockwise)

Preceding gene: 73537970

Following gene: 73537977

Centisome position: 28.75

GC content: 67.64

Gene sequence:

>924_bases
ATGCTGTCGCACCGTCTGCAGGACACCTCGCTGCGCTATTTCCTGGAAGTCGTTCGCACCGGCTCGCTGACCGAGGCGGC
GCAGCGGCTAAACGTCACGGTGTCCGCGGTCAGCCGGCAGGTTGCGGCGCTCGAGTCATGGCTGGGGGTGCCGCTGTTCG
ACCGCCGGCCGCGCGGCATGGTGGCCAGCGCGGCGGGCGAGTTGCTGGCCGCCTATGCGCTGCGCAATGCGCTGGAGGCT
GATCGTGTCGTGACGGAAATCGATGCGCTGCAAGGTCTGCGGCGCGGGCGCGTGCGGGTGGCGAGTTCGGCCGGGTTTGC
GATCGAATTCCTGCCACGCGCCATTGCCGATTTCCGCGAACGCTATCCGGGGCTGCATTTCCATGTGCGCGTGGCACCGC
CGGCCGAGGTAACCGGCATTGTGCTGCACGGCGACGCCGATATCGGCATCACGTACAGCCGTGCCGCCGAACAAGGCATC
CGGGTCGAGCATAGGCAGGCGGCGCCCGTGATTGCGATCATGCGGCCCGATCACGCGCTCGCGCGGTTCCGCAGCATCAC
GCTGTCGCAGATGCTGCCGTATCCGCTTGCGCTGCCCGAGGGCGACAACACGGTGCGCCAGCTGTTCGACATTGCCTGCG
GTGAGCGTGGCGTTGCGTTCGAACCGGTGCTGGTCAGCAACCAGTTCGAGACGCTGACCAGCTTTGTGCTGCACGGTGGC
GGGCTGTCGATTTCAGGCGGGGTCACGGTCGGCGACCGCCTGCGCCGTGGCGAACTCCATGCCGCGACAATCCGCGAGCG
CGGCATGAAAAGCCGCGCCATCGAACTGCAGACGCTGGCCGGCCGCACGCTGCCCGAGGGCGTGCGTACGTTTTTGGGCT
TCGTGCGGGACCGTCTGGTGGAGGAGGCCGGAATCGGATCCTGA

Upstream 100 bases:

>100_bases
GGGCGGCGTGGTTTTCCTACAATCGAGGAATTTTTCAAATACCCTTGCGTAAAACGCAAACGTGGTACAAACCCGGAAGC
CAATCCCAAAGCCACGATCG

Downstream 100 bases:

>100_bases
AAGGCGTCCGGCCAGAGACGCCTACTTCGCGAACAGCGACGACATATCCGCAAACGCCTTGAATTCGAGCGCATTGCCCG
ACGGGTCCAGGAAGAACATG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLSHRLQDTSLRYFLEVVRTGSLTEAAQRLNVTVSAVSRQVAALESWLGVPLFDRRPRGMVASAAGELLAAYALRNALEA
DRVVTEIDALQGLRRGRVRVASSAGFAIEFLPRAIADFRERYPGLHFHVRVAPPAEVTGIVLHGDADIGITYSRAAEQGI
RVEHRQAAPVIAIMRPDHALARFRSITLSQMLPYPLALPEGDNTVRQLFDIACGERGVAFEPVLVSNQFETLTSFVLHGG
GLSISGGVTVGDRLRRGELHAATIRERGMKSRAIELQTLAGRTLPEGVRTFLGFVRDRLVEEAGIGS

Sequences:

>Translated_307_residues
MLSHRLQDTSLRYFLEVVRTGSLTEAAQRLNVTVSAVSRQVAALESWLGVPLFDRRPRGMVASAAGELLAAYALRNALEA
DRVVTEIDALQGLRRGRVRVASSAGFAIEFLPRAIADFRERYPGLHFHVRVAPPAEVTGIVLHGDADIGITYSRAAEQGI
RVEHRQAAPVIAIMRPDHALARFRSITLSQMLPYPLALPEGDNTVRQLFDIACGERGVAFEPVLVSNQFETLTSFVLHGG
GLSISGGVTVGDRLRRGELHAATIRERGMKSRAIELQTLAGRTLPEGVRTFLGFVRDRLVEEAGIGS
>Mature_307_residues
MLSHRLQDTSLRYFLEVVRTGSLTEAAQRLNVTVSAVSRQVAALESWLGVPLFDRRPRGMVASAAGELLAAYALRNALEA
DRVVTEIDALQGLRRGRVRVASSAGFAIEFLPRAIADFRERYPGLHFHVRVAPPAEVTGIVLHGDADIGITYSRAAEQGI
RVEHRQAAPVIAIMRPDHALARFRSITLSQMLPYPLALPEGDNTVRQLFDIACGERGVAFEPVLVSNQFETLTSFVLHGG
GLSISGGVTVGDRLRRGELHAATIRERGMKSRAIELQTLAGRTLPEGVRTFLGFVRDRLVEEAGIGS

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=231, Percent_Identity=27.7056277056277, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=30.5220883534137, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788748, Length=234, Percent_Identity=28.6324786324786, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693105, Length=195, Percent_Identity=26.1538461538462, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787530, Length=254, Percent_Identity=26.3779527559055, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788296, Length=231, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=262, Percent_Identity=26.3358778625954, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1789204, Length=250, Percent_Identity=24, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789173, Length=169, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081904, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786401, Length=264, Percent_Identity=26.5151515151515, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787601, Length=191, Percent_Identity=25.6544502617801, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33480; Mature: 33480

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSHRLQDTSLRYFLEVVRTGSLTEAAQRLNVTVSAVSRQVAALESWLGVPLFDRRPRGM
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
VASAAGELLAAYALRNALEADRVVTEIDALQGLRRGRVRVASSAGFAIEFLPRAIADFRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
RYPGLHFHVRVAPPAEVTGIVLHGDADIGITYSRAAEQGIRVEHRQAAPVIAIMRPDHAL
HCCCCEEEEEECCCCCEEEEEEECCCCCCEEEHHHHHCCCCEECCCCCCEEEEECCCHHH
ARFRSITLSQMLPYPLALPEGDNTVRQLFDIACGERGVAFEPVLVSNQFETLTSFVLHGG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCEEECCHHHHHHHHHHHCC
GLSISGGVTVGDRLRRGELHAATIRERGMKSRAIELQTLAGRTLPEGVRTFLGFVRDRLV
CEEECCCCCHHHHHHCCCHHHHHHHHCCCHHHHEEHHHHCCCCCHHHHHHHHHHHHHHHH
EEAGIGS
HHCCCCC
>Mature Secondary Structure
MLSHRLQDTSLRYFLEVVRTGSLTEAAQRLNVTVSAVSRQVAALESWLGVPLFDRRPRGM
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
VASAAGELLAAYALRNALEADRVVTEIDALQGLRRGRVRVASSAGFAIEFLPRAIADFRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHH
RYPGLHFHVRVAPPAEVTGIVLHGDADIGITYSRAAEQGIRVEHRQAAPVIAIMRPDHAL
HCCCCEEEEEECCCCCEEEEEEECCCCCCEEEHHHHHCCCCEECCCCCCEEEEECCCHHH
ARFRSITLSQMLPYPLALPEGDNTVRQLFDIACGERGVAFEPVLVSNQFETLTSFVLHGG
HHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCEEECCHHHHHHHHHHHCC
GLSISGGVTVGDRLRRGELHAATIRERGMKSRAIELQTLAGRTLPEGVRTFLGFVRDRLV
CEEECCCCCHHHHHHCCCHHHHHHHHCCCHHHHEEHHHHCCCCCHHHHHHHHHHHHHHHH
EEAGIGS
HHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]