Click here to switch to the map view.

The map label for this gene is nat [H]

Identifier: 73537877

GI number: 73537877

Start: 687008

End: 687853

Strand: Reverse

Name: nat [H]

Synonym: Reut_B4044

Alternate gene names: 73537877

Gene position: 687853-687008 (Counterclockwise)

Preceding gene: 73537878

Following gene: 73537876

Centisome position: 25.23

GC content: 67.14

Gene sequence:

>846_bases
ATGATCACGCTTGACGCTCCCCGCCTGGACGCCTACCTCGCACGCCTTGGCCTCGACGCACCACCGTCCCCCACGCTGGA
ATCCCTTGATGCGCTCATCGCGGCGCAGCTCGCACGCATCCCCTTCGAGAACATCGACCCGCTGCTGGGCCGCCCTGTAC
GGATCGACATCGATGCCGTGTTCGACAAGCTGGTCACGCGCGGACGCGGCGGGTATTGCTTCGAACTCAACACGCTGCTG
GCCGCAGCGCTGACGGCGCTGGGCTACACCGTAACGCCGCTGGCCGCGCGTGTACGCTGGGGGGTGGCCAATGACGTGCA
GACCATGGCTTCGCACATGCTGCTGCGCGTAGAAGTCGCGCATCGCAGCTATCTTGCCGATGTTGGCTTTGGCGGCCCCT
CGCCGTTCAGGTCGCTGCCATTGTCGGCGCCGGCCGCGTCAGCATTCCCCTATCGGCTGGTCCCGGCTCCGGACGACACC
ACTGCCAGCACGTTCCATGGCCAGGATCTCGAAGTGCGCGGAGACGAGGGCTGGCTCAAGGTCTACCGCTTCGACCTGAC
ACCGCAGCCGTGGATCGATTTCATCGCGCGCAACTGGTACATCTGCACGCATCCGGACAGCCCTTTCACGCAGCGGCTGA
TGGTGGCCCGTACCGATGGCGATCTGCGACTGACCCTGGCCAACGGCGAACTGGCCGCGCGCGCTGCGGACGGCACCGTG
CACCGGCAGCCGTTGTCCACCGCGGGCGATGTCATCGACGTGCTGGCCGACCGCTTTCACGTGGCACTGGATGCCGACAG
CCGCGCCGGGCTCGAGCGTGTGCTGCCTGCGCTGCTGGGCGCCTGA

Upstream 100 bases:

>100_bases
GCGAACTCGAATCGCGAGGGCTGCTGCGGTTGCGGTATGGCAGCATCGAACTGCTCGATCTGACCGCACTCGAAATGCTC
AACTGAACTCGGTACGCGAC

Downstream 100 bases:

>100_bases
ATATCGTTGCCATATCCCTGCCGCAAGACCGCCCCACCGGTCCCATGCACGCCGCGCATTGCCCGCAGAAAGAATACTGA
TATGGGCCCGCTGGCAGGGG

Product: N-acetyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MITLDAPRLDAYLARLGLDAPPSPTLESLDALIAAQLARIPFENIDPLLGRPVRIDIDAVFDKLVTRGRGGYCFELNTLL
AAALTALGYTVTPLAARVRWGVANDVQTMASHMLLRVEVAHRSYLADVGFGGPSPFRSLPLSAPAASAFPYRLVPAPDDT
TASTFHGQDLEVRGDEGWLKVYRFDLTPQPWIDFIARNWYICTHPDSPFTQRLMVARTDGDLRLTLANGELAARAADGTV
HRQPLSTAGDVIDVLADRFHVALDADSRAGLERVLPALLGA

Sequences:

>Translated_281_residues
MITLDAPRLDAYLARLGLDAPPSPTLESLDALIAAQLARIPFENIDPLLGRPVRIDIDAVFDKLVTRGRGGYCFELNTLL
AAALTALGYTVTPLAARVRWGVANDVQTMASHMLLRVEVAHRSYLADVGFGGPSPFRSLPLSAPAASAFPYRLVPAPDDT
TASTFHGQDLEVRGDEGWLKVYRFDLTPQPWIDFIARNWYICTHPDSPFTQRLMVARTDGDLRLTLANGELAARAADGTV
HRQPLSTAGDVIDVLADRFHVALDADSRAGLERVLPALLGA
>Mature_281_residues
MITLDAPRLDAYLARLGLDAPPSPTLESLDALIAAQLARIPFENIDPLLGRPVRIDIDAVFDKLVTRGRGGYCFELNTLL
AAALTALGYTVTPLAARVRWGVANDVQTMASHMLLRVEVAHRSYLADVGFGGPSPFRSLPLSAPAASAFPYRLVPAPDDT
TASTFHGQDLEVRGDEGWLKVYRFDLTPQPWIDFIARNWYICTHPDSPFTQRLMVARTDGDLRLTLANGELAARAADGTV
HRQPLSTAGDVIDVLADRFHVALDADSRAGLERVLPALLGA

Specific function: Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid [H]

COG id: COG2162

COG function: function code Q; Arylamine N-acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arylamine N-acetyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI237649128, Length=278, Percent_Identity=28.0575539568345, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649126, Length=278, Percent_Identity=28.0575539568345, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649124, Length=278, Percent_Identity=28.0575539568345, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649122, Length=278, Percent_Identity=28.0575539568345, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649119, Length=278, Percent_Identity=28.0575539568345, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI42741671, Length=278, Percent_Identity=28.0575539568345, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649009, Length=278, Percent_Identity=28.0575539568345, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649132, Length=279, Percent_Identity=27.9569892473118, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI237649130, Length=279, Percent_Identity=27.9569892473118, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI116295260, Length=220, Percent_Identity=29.0909090909091, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1787736, Length=273, Percent_Identity=31.1355311355311, Blast_Score=111, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001447 [H]

Pfam domain/function: PF00797 Acetyltransf_2 [H]

EC number: =2.3.1.5 [H]

Molecular weight: Translated: 30521; Mature: 30521

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLDAPRLDAYLARLGLDAPPSPTLESLDALIAAQLARIPFENIDPLLGRPVRIDIDAV
CEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEHHHH
FDKLVTRGRGGYCFELNTLLAAALTALGYTVTPLAARVRWGVANDVQTMASHMLLRVEVA
HHHHHHCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHEEHH
HRSYLADVGFGGPSPFRSLPLSAPAASAFPYRLVPAPDDTTASTFHGQDLEVRGDEGWLK
HHHHHHHCCCCCCCCHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEECCCCEEE
VYRFDLTPQPWIDFIARNWYICTHPDSPFTQRLMVARTDGDLRLTLANGELAARAADGTV
EEEECCCCCHHHHHHHCCCEEEECCCCHHHHEEEEEECCCCEEEEEECCCEEEECCCCCC
HRQPLSTAGDVIDVLADRFHVALDADSRAGLERVLPALLGA
CCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MITLDAPRLDAYLARLGLDAPPSPTLESLDALIAAQLARIPFENIDPLLGRPVRIDIDAV
CEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEHHHH
FDKLVTRGRGGYCFELNTLLAAALTALGYTVTPLAARVRWGVANDVQTMASHMLLRVEVA
HHHHHHCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHEEHH
HRSYLADVGFGGPSPFRSLPLSAPAASAFPYRLVPAPDDTTASTFHGQDLEVRGDEGWLK
HHHHHHHCCCCCCCCHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEECCCCEEE
VYRFDLTPQPWIDFIARNWYICTHPDSPFTQRLMVARTDGDLRLTLANGELAARAADGTV
EEEECCCCCHHHHHHHCCCEEEECCCCHHHHEEEEEECCCCEEEEEECCCEEEECCCCCC
HRQPLSTAGDVIDVLADRFHVALDADSRAGLERVLPALLGA
CCCCCHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9973365; 12054803 [H]