Click here to switch to the map view.

The map label for this gene is arnA [H]

Identifier: 73537807

GI number: 73537807

Start: 611657

End: 612709

Strand: Reverse

Name: arnA [H]

Synonym: Reut_B3974

Alternate gene names: 73537807

Gene position: 612709-611657 (Counterclockwise)

Preceding gene: 73537808

Following gene: 73537806

Centisome position: 22.48

GC content: 62.2

Gene sequence:

>1053_bases
ATGAAAAAGGTCCTGATTCTTGGCGTCAACGGCTTCATCGGCCACCACTTGACGCGCCGCATCCTGGAAACGACGTCGTG
GGAGGTCTACGGCATGGACATGTCGTCCGACCGCCTCGGTGACCTCGTCGACCATCCGCGCATGCACTTCTTTGAAGGTG
ACATCACCATCAACAAGGAGTGGATCGAGTACAACATCCGCAAGTGCGACGTGGTGCTGCCGCTGGTGGCCATCGCCACG
CCCGCGACCTACGTGCGCCAGCCGCTGCGCGTGTTCGAGCTCGACTTCGAGGCGAACCTGCCGATCGTGCGCGCCGCCGT
GAAGTACGGCAAGCACCTGGTGTTCCCGTCGACCTCCGAGGTCTACGGCATGTGCGCCGACGACGAATTCGATCCCGAGT
CGTCGCCGCTGATCTACGGTCCGATCAACAAGCCGCGCTGGATCTACGCCTGCTCCAAGCAGCTCATGGATCGCGTGATC
CACGCTTACGGCATGGAGCAAGGCCTGAACTACACGCTGTTCCGCCCGTTCAACTGGATCGGTGCGGGACTCGACTCGAT
CTTCGAATCGAAGGAAGGTTCGTCGCGCGTGGTCACGCAGTTCCTCGGCCACATCGTGCGCGGCGAGCCGATCAAGCTCG
TCGACGGCGGCGAGCAGAAGCGTGCGTTTGCCGATATCTCGGACGGCATCTCGGCGCTGATGCGCATCATCGAGAACCCG
AACGGCATCGCCACGGGCAAGATCTTCAATATCGGCAACCCGTCGAACATCCACTCGGTGCGCGAGCTCGCCGAGATGAT
GCTGAAGATGGCCGCCGACTATCCCGAATACGCCGAGGAAGCGCGCAAGACGCAAATCGTCGAGACCTCGTCGGGCGACT
TCTACGGCAAGGGCTACCAGGACGTGCAGCACCGCGTGCCGAAGATCGACAACACCATGCAGGAACTCGGCTGGAAGCCC
GAGGTGACGATGGAACAGGCGCTGCGCCGGATCTTCGAGGCGTATCGCGAGAAGGTCGTCGAGGCCCGCACGCTGGTCGA
CGGCGACAACTGA

Upstream 100 bases:

>100_bases
AGGTGCGCATCGACACTCTGCTTAATGCCGCGACATCCGCGCCGGTCACCGCGCAAGCGCTGGCACCCATTCTTACCGAA
CAGTCCAACGAGGAAAACCG

Downstream 100 bases:

>100_bases
GTACGGACCCATGGCCAGAATCGCCCTCAAGGTCGACGTCGACACGCTGCGCGGTACGCGCGAAGGCGTGCCGACGCTGT
TGTCCATGCTGGACGCGGTG

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKKVLILGVNGFIGHHLTRRILETTSWEVYGMDMSSDRLGDLVDHPRMHFFEGDITINKEWIEYNIRKCDVVLPLVAIAT
PATYVRQPLRVFELDFEANLPIVRAAVKYGKHLVFPSTSEVYGMCADDEFDPESSPLIYGPINKPRWIYACSKQLMDRVI
HAYGMEQGLNYTLFRPFNWIGAGLDSIFESKEGSSRVVTQFLGHIVRGEPIKLVDGGEQKRAFADISDGISALMRIIENP
NGIATGKIFNIGNPSNIHSVRELAEMMLKMAADYPEYAEEARKTQIVETSSGDFYGKGYQDVQHRVPKIDNTMQELGWKP
EVTMEQALRRIFEAYREKVVEARTLVDGDN

Sequences:

>Translated_350_residues
MKKVLILGVNGFIGHHLTRRILETTSWEVYGMDMSSDRLGDLVDHPRMHFFEGDITINKEWIEYNIRKCDVVLPLVAIAT
PATYVRQPLRVFELDFEANLPIVRAAVKYGKHLVFPSTSEVYGMCADDEFDPESSPLIYGPINKPRWIYACSKQLMDRVI
HAYGMEQGLNYTLFRPFNWIGAGLDSIFESKEGSSRVVTQFLGHIVRGEPIKLVDGGEQKRAFADISDGISALMRIIENP
NGIATGKIFNIGNPSNIHSVRELAEMMLKMAADYPEYAEEARKTQIVETSSGDFYGKGYQDVQHRVPKIDNTMQELGWKP
EVTMEQALRRIFEAYREKVVEARTLVDGDN
>Mature_350_residues
MKKVLILGVNGFIGHHLTRRILETTSWEVYGMDMSSDRLGDLVDHPRMHFFEGDITINKEWIEYNIRKCDVVLPLVAIAT
PATYVRQPLRVFELDFEANLPIVRAAVKYGKHLVFPSTSEVYGMCADDEFDPESSPLIYGPINKPRWIYACSKQLMDRVI
HAYGMEQGLNYTLFRPFNWIGAGLDSIFESKEGSSRVVTQFLGHIVRGEPIKLVDGGEQKRAFADISDGISALMRIIENP
NGIATGKIFNIGNPSNIHSVRELAEMMLKMAADYPEYAEEARKTQIVETSSGDFYGKGYQDVQHRVPKIDNTMQELGWKP
EVTMEQALRRIFEAYREKVVEARTLVDGDN

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=340, Percent_Identity=27.6470588235294, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI7657641, Length=345, Percent_Identity=22.0289855072464, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788589, Length=339, Percent_Identity=55.7522123893805, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17539532, Length=347, Percent_Identity=23.0547550432277, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356223, Length=360, Percent_Identity=23.8888888888889, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 39759; Mature: 39759

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLILGVNGFIGHHLTRRILETTSWEVYGMDMSSDRLGDLVDHPRMHFFEGDITINKE
CCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCEEEECCEEEEHH
WIEYNIRKCDVVLPLVAIATPATYVRQPLRVFELDFEANLPIVRAAVKYGKHLVFPSTSE
HHHCCCHHHHHHHHHHHHHCCHHHHHCCHHEEEECCCCCCHHHHHHHHHCCEEECCCCHH
VYGMCADDEFDPESSPLIYGPINKPRWIYACSKQLMDRVIHAYGMEQGLNYTLFRPFNWI
HEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHH
GAGLDSIFESKEGSSRVVTQFLGHIVRGEPIKLVDGGEQKRAFADISDGISALMRIIENP
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
NGIATGKIFNIGNPSNIHSVRELAEMMLKMAADYPEYAEEARKTQIVETSSGDFYGKGYQ
CCEEECEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCCCHH
DVQHRVPKIDNTMQELGWKPEVTMEQALRRIFEAYREKVVEARTLVDGDN
HHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKVLILGVNGFIGHHLTRRILETTSWEVYGMDMSSDRLGDLVDHPRMHFFEGDITINKE
CCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHCCCCCEEEECCEEEEHH
WIEYNIRKCDVVLPLVAIATPATYVRQPLRVFELDFEANLPIVRAAVKYGKHLVFPSTSE
HHHCCCHHHHHHHHHHHHHCCHHHHHCCHHEEEECCCCCCHHHHHHHHHCCEEECCCCHH
VYGMCADDEFDPESSPLIYGPINKPRWIYACSKQLMDRVIHAYGMEQGLNYTLFRPFNWI
HEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHH
GAGLDSIFESKEGSSRVVTQFLGHIVRGEPIKLVDGGEQKRAFADISDGISALMRIIENP
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCC
NGIATGKIFNIGNPSNIHSVRELAEMMLKMAADYPEYAEEARKTQIVETSSGDFYGKGYQ
CCEEECEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCCCCCCCCHH
DVQHRVPKIDNTMQELGWKPEVTMEQALRRIFEAYREKVVEARTLVDGDN
HHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]