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The map label for this gene is menB [H]

Identifier: 73537750

GI number: 73537750

Start: 547597

End: 548379

Strand: Direct

Name: menB [H]

Synonym: Reut_B3916

Alternate gene names: 73537750

Gene position: 547597-548379 (Clockwise)

Preceding gene: 73537749

Following gene: 73537751

Centisome position: 20.09

GC content: 62.58

Gene sequence:

>783_bases
ATGCAATACGAAGACATCCTCTATGAAGTCCGCAACGGCGCGGCCTGGATCACCATCAATCGCGCGGAGAAGATGAATGC
CTTCCGCGGCCGCACGTGCGACGAACTGATCCACGCGATCAATCGCGCGGGCTATGACCGCGAGATCGGCACAATCGTGT
TGGCCGGCGCTGGCGACAAGGCGTTCTGCACCGGCGGCGACCAGTCCGCGCATGAAGGGCAGTACGACGGGCGGGGCACC
ATCGGCCTGCCGATGGAAGAACTGCACAACGCCATTCGCGACGTGCCCAAACCGGTCATTGCGCGAGTACAGGGCTATGC
CATCGGGGGCGGCAATGTGCTGTGCACGATCTGCGATTTCACCATCGCCTCCGAAAAGGCCGTGTTCGGGCAGGTCGGGC
CGAAGGTCGGCTCGGTCGATCCCGGCTATGGCACGGCCTATCTGGCCCGCGTCGTCGGCGAAAAGAAAGCGCGCGAAATC
TGGTACCTGTGCCGCCGCTATCCGGCAGCCGAAGCGCTGGCGATGGGCCTCGTCAACGCCGTGGTGCCGCACGAGCAGCT
CGATGCCGAGGTGCAGAAGTGGTGCGACGAGATTCTTGAGAAGAGCCCGACCGCGGTCGCCATCGCCAAGCGCTCGTTCA
ACATGGACACCGCTCACCAGAGTGGCATCGCCGGCATGGGCATGTATGCGCTGAAGCTCTATTACGACACCGAGGAATCA
CGCGAAGGCGTCAAGGCATTCCAGGAAAAGCGCAAGCCCGAATTCCGCAAGTACGCGAAGTAA

Upstream 100 bases:

>100_bases
CATCACCGGGCAGGTGCTCAGCGTGTCCGGCGGCCTGACCATGAACGGCTGAGCCCGGCGCTCGCCATCCTAATCGGCAA
TACACAGGAGACAGATCACC

Downstream 100 bases:

>100_bases
GGCGCCGACAGGCAGATCGAGGAAACATCATGAATCCCTACCTCAACGAAGACCTGCAGGCGCTGGCCGAGCATGCGCGC
CGGTTTGCCGATGCGTGCAT

Product: 1,4-dihydroxy-2-naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MQYEDILYEVRNGAAWITINRAEKMNAFRGRTCDELIHAINRAGYDREIGTIVLAGAGDKAFCTGGDQSAHEGQYDGRGT
IGLPMEELHNAIRDVPKPVIARVQGYAIGGGNVLCTICDFTIASEKAVFGQVGPKVGSVDPGYGTAYLARVVGEKKAREI
WYLCRRYPAAEALAMGLVNAVVPHEQLDAEVQKWCDEILEKSPTAVAIAKRSFNMDTAHQSGIAGMGMYALKLYYDTEES
REGVKAFQEKRKPEFRKYAK

Sequences:

>Translated_260_residues
MQYEDILYEVRNGAAWITINRAEKMNAFRGRTCDELIHAINRAGYDREIGTIVLAGAGDKAFCTGGDQSAHEGQYDGRGT
IGLPMEELHNAIRDVPKPVIARVQGYAIGGGNVLCTICDFTIASEKAVFGQVGPKVGSVDPGYGTAYLARVVGEKKAREI
WYLCRRYPAAEALAMGLVNAVVPHEQLDAEVQKWCDEILEKSPTAVAIAKRSFNMDTAHQSGIAGMGMYALKLYYDTEES
REGVKAFQEKRKPEFRKYAK
>Mature_260_residues
MQYEDILYEVRNGAAWITINRAEKMNAFRGRTCDELIHAINRAGYDREIGTIVLAGAGDKAFCTGGDQSAHEGQYDGRGT
IGLPMEELHNAIRDVPKPVIARVQGYAIGGGNVLCTICDFTIASEKAVFGQVGPKVGSVDPGYGTAYLARVVGEKKAREI
WYLCRRYPAAEALAMGLVNAVVPHEQLDAEVQKWCDEILEKSPTAVAIAKRSFNMDTAHQSGIAGMGMYALKLYYDTEES
REGVKAFQEKRKPEFRKYAK

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=269, Percent_Identity=33.8289962825279, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=30.2325581395349, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI31542718, Length=245, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI260274832, Length=213, Percent_Identity=27.6995305164319, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI45643119, Length=213, Percent_Identity=27.6995305164319, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI260275230, Length=213, Percent_Identity=27.6995305164319, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI70995211, Length=271, Percent_Identity=29.8892988929889, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI25453481, Length=210, Percent_Identity=27.6190476190476, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI51538573, Length=210, Percent_Identity=27.6190476190476, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4757966, Length=210, Percent_Identity=27.6190476190476, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI51538581, Length=210, Percent_Identity=27.6190476190476, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4757968, Length=187, Percent_Identity=28.8770053475936, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI49355787, Length=187, Percent_Identity=28.8770053475936, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI157694516, Length=217, Percent_Identity=24.4239631336406, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI213417737, Length=217, Percent_Identity=24.4239631336406, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI68989263, Length=220, Percent_Identity=28.6363636363636, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI37594469, Length=156, Percent_Identity=30.1282051282051, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI37594471, Length=156, Percent_Identity=30.1282051282051, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=262, Percent_Identity=50.763358778626, Blast_Score=263, Evalue=7e-72,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=30.188679245283, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787659, Length=243, Percent_Identity=28.8065843621399, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI221142681, Length=266, Percent_Identity=29.6992481203008, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787660, Length=258, Percent_Identity=28.6821705426357, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17554946, Length=255, Percent_Identity=32.9411764705882, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=262, Percent_Identity=33.969465648855, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=210, Percent_Identity=29.0476190476191, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17549921, Length=209, Percent_Identity=28.7081339712919, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17536985, Length=224, Percent_Identity=28.125, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=216, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=250, Percent_Identity=29.6, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=257, Percent_Identity=25.2918287937743, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129971, Length=241, Percent_Identity=34.4398340248963, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24653477, Length=241, Percent_Identity=34.4398340248963, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24653139, Length=258, Percent_Identity=31.7829457364341, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922422, Length=255, Percent_Identity=23.921568627451, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357171, Length=260, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650670, Length=180, Percent_Identity=30, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 28634; Mature: 28634

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYEDILYEVRNGAAWITINRAEKMNAFRGRTCDELIHAINRAGYDREIGTIVLAGAGDK
CCHHHHHHHHHCCEEEEEEECHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCC
AFCTGGDQSAHEGQYDGRGTIGLPMEELHNAIRDVPKPVIARVQGYAIGGGNVLCTICDF
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCEEECCCCEEEEEECC
TIASEKAVFGQVGPKVGSVDPGYGTAYLARVVGEKKAREIWYLCRRYPAAEALAMGLVNA
HHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VVPHEQLDAEVQKWCDEILEKSPTAVAIAKRSFNMDTAHQSGIAGMGMYALKLYYDTEES
HCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHCCCCCCCEEEEEEEECCHHH
REGVKAFQEKRKPEFRKYAK
HHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MQYEDILYEVRNGAAWITINRAEKMNAFRGRTCDELIHAINRAGYDREIGTIVLAGAGDK
CCHHHHHHHHHCCEEEEEEECHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCC
AFCTGGDQSAHEGQYDGRGTIGLPMEELHNAIRDVPKPVIARVQGYAIGGGNVLCTICDF
EEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCEEECCCCEEEEEECC
TIASEKAVFGQVGPKVGSVDPGYGTAYLARVVGEKKAREIWYLCRRYPAAEALAMGLVNA
HHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VVPHEQLDAEVQKWCDEILEKSPTAVAIAKRSFNMDTAHQSGIAGMGMYALKLYYDTEES
HCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHCCCCCCCEEEEEEEECCHHH
REGVKAFQEKRKPEFRKYAK
HHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]