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The map label for this gene is acdA [H]

Identifier: 73537670

GI number: 73537670

Start: 448328

End: 449533

Strand: Direct

Name: acdA [H]

Synonym: Reut_B3835

Alternate gene names: 73537670

Gene position: 448328-449533 (Clockwise)

Preceding gene: 73537669

Following gene: 73537671

Centisome position: 16.45

GC content: 66.92

Gene sequence:

>1206_bases
ATGGATTTTCAGCCTGACCTCAGCCTGGAGGCGTTCCGCGAAAGCGTGCGCGCCTTCCTGCGCGACAAGCTGCCGGCCGA
CCTGGCCGGCCGTCCGCGTATCGGCACGCGCTCGCCGCGCGAGGAACTGTCGCGCTGGCAGCGCATCCTCAACGAACAGG
GCTGGGGGGCGCCGTACTGGCCGACAGCGCATGGCGGTACCGGATGGAATGTGCTCGAGCGCCTGGCGTTCGATGAAGAA
TGCACGTTGGCCGGCGCGCCGACGCAGGACGTCGGCGCACAGAAGCTGCTCGGACCGGTGCTAAACGAGTTCGCCACACC
CGAGCAAAAGGCCGAGCACCTGCCGCATATCTTCGGCGGCACGCGTACCTGGTGCCAGGGCTTTTCCGAGCCGGGCTCGG
GCTCCGACCTGGCGTCGCTGCGCACGGCGGCCGTGCGCGACGGCGACGAGTACGTGGTCAATGGCCAGAAGATCTGGACC
AGCCACGGTCACCGCGCCGACTGGATCTTCCTGCTGGTGCGCACCAACACCGAAGTCAAGAAGCAGGCCGGCATCAGCTT
CCTGCTGGTGGACATGAAGACGCCGGGCATCACCGTGCGTTCGATCCACACGATCGACGGTTGCCATCACCTGAACGAGA
CCTTCTTCGACAACGTGCGCGTGCCGGTGAAGAACCTCGTCGGCGCCGAAGGCGACGGCTGGAAGATCACCAAGTTCCTG
CTGAACAACGAACACGCCGCCGCAGCCGACTTGCCGATGCTGCGGCGCTATATGCGCCAGCTCGGCAGCCTGGCGCGGCA
ACGCGACGCCAAAGGCTGCGCACTGATCGAGCGGCCGCATATCGCGCAGCAGGTCGCCCGCTTCGAAGCCGAGCTGAACG
CCATTGCCATGCTGGTGCAGCGCGTGGCCGCGCTGGAGCAGGCCGAGGACCACAGTCCCGCCGCGCATGCGCTGGGTTCG
ATGCTGAAGGTCCGCGGCACGGAACTGCAGCAGCGCATCAGCTCCTTTGTCGTGGAAGCGCTTGGCGACTACGGCCCGGT
GGCATACGCCGCGCCCGAGGGCGATACCAGCGGCGAACCGCTGCCGATGCAGCACGTGGCGCGCGGCATGGCCAACGAAC
TGTTCTTCCGCCGAGCCTCGACCATTTACGGCGGCACCAGCGAAGTCCAGCGCGGCATCATCGCCCGCGCCCTGTTCCAA
CTCTGA

Upstream 100 bases:

>100_bases
GTTCGCCTGGGACCCGGTCTGAGCATTGCCACGGGGGTAGTAGCTGGTGGCCGGCCGCTGGGGGGCGGCTGGCCACCATG
TTGGATGACAAGGAAGAGAC

Downstream 100 bases:

>100_bases
CGCCGCGACGCGCGTCTCCTGGCACATAACGATCATGAACTTCAATCTCACTTCCGAGCAGCAGATGCTGCAGGACAGCG
TGGCCCGCTTCGTCGAGAAG

Product: acyl-CoA dehydrogenase

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MDFQPDLSLEAFRESVRAFLRDKLPADLAGRPRIGTRSPREELSRWQRILNEQGWGAPYWPTAHGGTGWNVLERLAFDEE
CTLAGAPTQDVGAQKLLGPVLNEFATPEQKAEHLPHIFGGTRTWCQGFSEPGSGSDLASLRTAAVRDGDEYVVNGQKIWT
SHGHRADWIFLLVRTNTEVKKQAGISFLLVDMKTPGITVRSIHTIDGCHHLNETFFDNVRVPVKNLVGAEGDGWKITKFL
LNNEHAAAADLPMLRRYMRQLGSLARQRDAKGCALIERPHIAQQVARFEAELNAIAMLVQRVAALEQAEDHSPAAHALGS
MLKVRGTELQQRISSFVVEALGDYGPVAYAAPEGDTSGEPLPMQHVARGMANELFFRRASTIYGGTSEVQRGIIARALFQ
L

Sequences:

>Translated_401_residues
MDFQPDLSLEAFRESVRAFLRDKLPADLAGRPRIGTRSPREELSRWQRILNEQGWGAPYWPTAHGGTGWNVLERLAFDEE
CTLAGAPTQDVGAQKLLGPVLNEFATPEQKAEHLPHIFGGTRTWCQGFSEPGSGSDLASLRTAAVRDGDEYVVNGQKIWT
SHGHRADWIFLLVRTNTEVKKQAGISFLLVDMKTPGITVRSIHTIDGCHHLNETFFDNVRVPVKNLVGAEGDGWKITKFL
LNNEHAAAADLPMLRRYMRQLGSLARQRDAKGCALIERPHIAQQVARFEAELNAIAMLVQRVAALEQAEDHSPAAHALGS
MLKVRGTELQQRISSFVVEALGDYGPVAYAAPEGDTSGEPLPMQHVARGMANELFFRRASTIYGGTSEVQRGIIARALFQ
L
>Mature_401_residues
MDFQPDLSLEAFRESVRAFLRDKLPADLAGRPRIGTRSPREELSRWQRILNEQGWGAPYWPTAHGGTGWNVLERLAFDEE
CTLAGAPTQDVGAQKLLGPVLNEFATPEQKAEHLPHIFGGTRTWCQGFSEPGSGSDLASLRTAAVRDGDEYVVNGQKIWT
SHGHRADWIFLLVRTNTEVKKQAGISFLLVDMKTPGITVRSIHTIDGCHHLNETFFDNVRVPVKNLVGAEGDGWKITKFL
LNNEHAAAADLPMLRRYMRQLGSLARQRDAKGCALIERPHIAQQVARFEAELNAIAMLVQRVAALEQAEDHSPAAHALGS
MLKVRGTELQQRISSFVVEALGDYGPVAYAAPEGDTSGEPLPMQHVARGMANELFFRRASTIYGGTSEVQRGIIARALFQ
L

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=353, Percent_Identity=26.0623229461756, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI4557231, Length=353, Percent_Identity=26.0623229461756, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4557233, Length=350, Percent_Identity=28.2857142857143, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4501857, Length=410, Percent_Identity=24.390243902439, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI7656849, Length=359, Percent_Identity=26.4623955431755, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501859, Length=396, Percent_Identity=26.5151515151515, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI226958414, Length=394, Percent_Identity=25.1269035532995, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI226958412, Length=406, Percent_Identity=24.1379310344828, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI21361497, Length=383, Percent_Identity=24.5430809399478, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4557235, Length=150, Percent_Identity=36.6666666666667, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI76496475, Length=150, Percent_Identity=36.6666666666667, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38505218, Length=258, Percent_Identity=28.2945736434109, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI48976061, Length=308, Percent_Identity=26.2987012987013, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI211971008, Length=308, Percent_Identity=26.2987012987013, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI87081958, Length=316, Percent_Identity=23.7341772151899, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786223, Length=275, Percent_Identity=26.5454545454545, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17570075, Length=412, Percent_Identity=26.2135922330097, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17534899, Length=351, Percent_Identity=27.0655270655271, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17569725, Length=352, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17533517, Length=359, Percent_Identity=25.0696378830084, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=353, Percent_Identity=27.4787535410765, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71990804, Length=265, Percent_Identity=29.0566037735849, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538396, Length=396, Percent_Identity=26.010101010101, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17506239, Length=401, Percent_Identity=25.4364089775561, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17551932, Length=350, Percent_Identity=23.7142857142857, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=313, Percent_Identity=24.9201277955272, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=147, Percent_Identity=37.4149659863946, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985192, Length=147, Percent_Identity=37.4149659863946, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=192, Percent_Identity=29.6875, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356377, Length=404, Percent_Identity=26.7326732673267, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24666513, Length=358, Percent_Identity=27.0949720670391, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24660351, Length=303, Percent_Identity=27.0627062706271, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281363737, Length=352, Percent_Identity=26.1363636363636, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21355753, Length=343, Percent_Identity=27.4052478134111, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646207, Length=389, Percent_Identity=25.9640102827763, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 44306; Mature: 44306

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFQPDLSLEAFRESVRAFLRDKLPADLAGRPRIGTRSPREELSRWQRILNEQGWGAPYW
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
PTAHGGTGWNVLERLAFDEECTLAGAPTQDVGAQKLLGPVLNEFATPEQKAEHLPHIFGG
CCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCC
TRTWCQGFSEPGSGSDLASLRTAAVRDGDEYVVNGQKIWTSHGHRADWIFLLVRTNTEVK
CHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEECCEEEECCCCCCCCEEEEEEECCCHHH
KQAGISFLLVDMKTPGITVRSIHTIDGCHHLNETFFDNVRVPVKNLVGAEGDGWKITKFL
HHCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEHHH
LNNEHAAAADLPMLRRYMRQLGSLARQRDAKGCALIERPHIAQQVARFEAELNAIAMLVQ
HCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHH
RVAALEQAEDHSPAAHALGSMLKVRGTELQQRISSFVVEALGDYGPVAYAAPEGDTSGEP
HHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
LPMQHVARGMANELFFRRASTIYGGTSEVQRGIIARALFQL
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDFQPDLSLEAFRESVRAFLRDKLPADLAGRPRIGTRSPREELSRWQRILNEQGWGAPYW
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
PTAHGGTGWNVLERLAFDEECTLAGAPTQDVGAQKLLGPVLNEFATPEQKAEHLPHIFGG
CCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCC
TRTWCQGFSEPGSGSDLASLRTAAVRDGDEYVVNGQKIWTSHGHRADWIFLLVRTNTEVK
CHHHHCCCCCCCCCCHHHHHHHHHHCCCCCEEECCEEEECCCCCCCCEEEEEEECCCHHH
KQAGISFLLVDMKTPGITVRSIHTIDGCHHLNETFFDNVRVPVKNLVGAEGDGWKITKFL
HHCCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEHHH
LNNEHAAAADLPMLRRYMRQLGSLARQRDAKGCALIERPHIAQQVARFEAELNAIAMLVQ
HCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHH
RVAALEQAEDHSPAAHALGSMLKVRGTELQQRISSFVVEALGDYGPVAYAAPEGDTSGEP
HHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
LPMQHVARGMANELFFRRASTIYGGTSEVQRGIIARALFQL
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]