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The map label for this gene is coxN [H]

Identifier: 73537468

GI number: 73537468

Start: 205512

End: 207269

Strand: Direct

Name: coxN [H]

Synonym: Reut_B3633

Alternate gene names: 73537468

Gene position: 205512-207269 (Clockwise)

Preceding gene: 73537467

Following gene: 73537469

Centisome position: 7.54

GC content: 62.34

Gene sequence:

>1758_bases
ATGGCTTACGCCGACGATGCCGACCACCACGCACCGCAGAGCTTCTGGACCCGCTACGTCTGGAGCCAGGACCACAAGGT
GATCGCCGTGCAGTACACCATCACGGCCATCGTGGTGGGGCTGGTGGGCGTGGCGCTGTCCAACCTGATGCGCATGCAGC
TCGGGTTCCCCGGCAAGTTCGATTTCATCGACGCCAACCGCTACTACCAGTTCGTCACCATGCACGGCATGATCATGGTG
ATCTACCTCCTGACGGCGCTGTTCCTTGGCGGCTTCGGCAACTACCTGATCCCGCTGATGGTCGGGGCGCGCGACATGGT
ATTCCCGTTCCTGAACATGCTCAGCTACTGGGTCTACCTGTTGTCGGTGATCGTGCTGCTGGCGAGCTTCTTCGTGCCGG
GCGGGCCCACCGGCGCGGGCTGGACGCTGTATCCGCCGCAGGCCATCCTGCCCGGCACGCCGGGCTACGAGTGGGGCATC
ATCCTGATGCTGGTGTCGCTGGGCATCTTTATCGTCGCGGCGACGATGGGCGGCCTCAACTACGTCACCACCGTGCTGCA
GGCCCGCACCGAAGGCATGACGCTGCTGCGCATGCCGTTGTCGGTATGGGGCATCTTCATGGCGACCATCCTGGCGCTGC
TGGCATTTCCGGCGCTGTTCGTCTCGGCCGTGATGATGCTGCTCGACAGGACGCTCGGCACGAGCTTCTTCATGCCGGCA
ATGGTCTCGATGGGCCAGCAGCTGAACTACAAGGGCGGCAGCCCGCTGCTGTTCCAGCACCTGTTCTGGTTCTTCGGGCA
CCCGGAGGTGTATATCGTCGCGCTGCCGGCGTTTGGCATCGTCTCGGACCTGGTCAGCGTGCATGCGCGCAAGAGCATCT
TCGGCTACCGCACCATGGTATGGGCCATCCTGGCGATCGGAGTGCTGTCGGTGGTGGTGTGGGCGCACCATATGTTCGTG
AGCGGCATGAACCCGTACTTCGGTTTCTTCTTCGCGACGACCACGCTGATCATTGCGATTCCGACCGCCATCAAGGTCTA
CAACTGGGTGCTCACGCTGTGGCGCGGCGATATCCATTTCACGGTGCCGATGCTGTTCGCGATTGCGTTTATCAGCACCT
TCGTCATCGGCGGATTGACCGGACTGTTCCTCGGCAACGTGAGCGTCGATATCCCGCTGTCGAACACGTATTTCGTGGTC
GCACACTTCCACATGGTGATGGGCGTGTCGCCAATCCTGGTGGTGTTCGGCGGTATCTACCATTGGTATCCGAAGGTGAC
GGGCCGCATGCTCGACGACACCATGGGCCGCGTTCACTTCTGGACGACGTTCATCGGCACCTACGCGATCTTCTTCCCGA
TGCACTACCTCGGCGTGCTAGGCATGCCGCGGCGCTATTACGCGTACGAGAACTACGCCTTCATTCCCGAATCGGCGCAC
GTGATGAACATGTATATCTCGATTGCCGCCTTCATCGTGGCAGCTGCCCAATTGCTGTTCGTCTTCAACCTTGCGTGGAG
CCTGTGGCATGGGCGCAAGGCCGATGGCAATCCGTGGCGCGCGGCGTCGCTCGAATGGCAGACGCCCGAGACGCCGCCTG
CGCATGGAAACTGGGGTCCGCACCTGCCGGTGGCGTACCGTTGGGCTTATGCCTACAGCGTGCCGGGTGCGAAAGAGGAC
TTCATCGCGCAGAACGCGCCGCCCGAAGCGGGCGGCGCCGAGCCTGAACCGCATGCAAGCCGTGGAGCCGTGGCATGA

Upstream 100 bases:

>100_bases
CAGGCAGCGTCGTCGGCATCGGGCACCTACACGACATCCAATGCCGCCGTGGTGCCGCCGTCGGCCTCGCCCAAGGCGGC
GACGAAGTGAGGAGAGACGC

Downstream 100 bases:

>100_bases
ACGCCGAAGCCGTCTACAAGGTCAGCCGCGATGATTTCGGCGGCAATCCGTCGGGAGGCGGACATACCCGCAACGGGCAG
GCAGGCGGCGCGCCCGCGAG

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide I; Cytochrome BB3 subunit 1; Oxidase BB(3) subunit 1 [H]

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MAYADDADHHAPQSFWTRYVWSQDHKVIAVQYTITAIVVGLVGVALSNLMRMQLGFPGKFDFIDANRYYQFVTMHGMIMV
IYLLTALFLGGFGNYLIPLMVGARDMVFPFLNMLSYWVYLLSVIVLLASFFVPGGPTGAGWTLYPPQAILPGTPGYEWGI
ILMLVSLGIFIVAATMGGLNYVTTVLQARTEGMTLLRMPLSVWGIFMATILALLAFPALFVSAVMMLLDRTLGTSFFMPA
MVSMGQQLNYKGGSPLLFQHLFWFFGHPEVYIVALPAFGIVSDLVSVHARKSIFGYRTMVWAILAIGVLSVVVWAHHMFV
SGMNPYFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHFTVPMLFAIAFISTFVIGGLTGLFLGNVSVDIPLSNTYFVV
AHFHMVMGVSPILVVFGGIYHWYPKVTGRMLDDTMGRVHFWTTFIGTYAIFFPMHYLGVLGMPRRYYAYENYAFIPESAH
VMNMYISIAAFIVAAAQLLFVFNLAWSLWHGRKADGNPWRAASLEWQTPETPPAHGNWGPHLPVAYRWAYAYSVPGAKED
FIAQNAPPEAGGAEPEPHASRGAVA

Sequences:

>Translated_585_residues
MAYADDADHHAPQSFWTRYVWSQDHKVIAVQYTITAIVVGLVGVALSNLMRMQLGFPGKFDFIDANRYYQFVTMHGMIMV
IYLLTALFLGGFGNYLIPLMVGARDMVFPFLNMLSYWVYLLSVIVLLASFFVPGGPTGAGWTLYPPQAILPGTPGYEWGI
ILMLVSLGIFIVAATMGGLNYVTTVLQARTEGMTLLRMPLSVWGIFMATILALLAFPALFVSAVMMLLDRTLGTSFFMPA
MVSMGQQLNYKGGSPLLFQHLFWFFGHPEVYIVALPAFGIVSDLVSVHARKSIFGYRTMVWAILAIGVLSVVVWAHHMFV
SGMNPYFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHFTVPMLFAIAFISTFVIGGLTGLFLGNVSVDIPLSNTYFVV
AHFHMVMGVSPILVVFGGIYHWYPKVTGRMLDDTMGRVHFWTTFIGTYAIFFPMHYLGVLGMPRRYYAYENYAFIPESAH
VMNMYISIAAFIVAAAQLLFVFNLAWSLWHGRKADGNPWRAASLEWQTPETPPAHGNWGPHLPVAYRWAYAYSVPGAKED
FIAQNAPPEAGGAEPEPHASRGAVA
>Mature_584_residues
AYADDADHHAPQSFWTRYVWSQDHKVIAVQYTITAIVVGLVGVALSNLMRMQLGFPGKFDFIDANRYYQFVTMHGMIMVI
YLLTALFLGGFGNYLIPLMVGARDMVFPFLNMLSYWVYLLSVIVLLASFFVPGGPTGAGWTLYPPQAILPGTPGYEWGII
LMLVSLGIFIVAATMGGLNYVTTVLQARTEGMTLLRMPLSVWGIFMATILALLAFPALFVSAVMMLLDRTLGTSFFMPAM
VSMGQQLNYKGGSPLLFQHLFWFFGHPEVYIVALPAFGIVSDLVSVHARKSIFGYRTMVWAILAIGVLSVVVWAHHMFVS
GMNPYFGFFFATTTLIIAIPTAIKVYNWVLTLWRGDIHFTVPMLFAIAFISTFVIGGLTGLFLGNVSVDIPLSNTYFVVA
HFHMVMGVSPILVVFGGIYHWYPKVTGRMLDDTMGRVHFWTTFIGTYAIFFPMHYLGVLGMPRRYYAYENYAFIPESAHV
MNMYISIAAFIVAAAQLLFVFNLAWSLWHGRKADGNPWRAASLEWQTPETPPAHGNWGPHLPVAYRWAYAYSVPGAKEDF
IAQNAPPEAGGAEPEPHASRGAVA

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=522, Percent_Identity=40.8045977011494, Blast_Score=359, Evalue=3e-99,
Organism=Escherichia coli, GI1786634, Length=523, Percent_Identity=37.8585086042065, Blast_Score=336, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6226519, Length=501, Percent_Identity=39.5209580838323, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6226524, Length=336, Percent_Identity=39.2857142857143, Blast_Score=247, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6226523, Length=258, Percent_Identity=36.4341085271318, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 65133; Mature: 65001

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCEEEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AYADDADHHAPQSFWTRYVWSQDHKVIAVQYTITAIVVGLVGVALSNLMRMQLGFPGKF
CCCCCCCCCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE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CCCCEEEEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]