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The map label for this gene is cqsS [H]

Identifier: 73537341

GI number: 73537341

Start: 45178

End: 46668

Strand: Direct

Name: cqsS [H]

Synonym: Reut_B3506

Alternate gene names: 73537341

Gene position: 45178-46668 (Clockwise)

Preceding gene: 73537340

Following gene: 73537344

Centisome position: 1.66

GC content: 64.65

Gene sequence:

>1491_bases
ATGATGCACGCCGCAGCCTGTCGCGACTTAATATGTCATGTTGCTTCGGAGACACCCCTAATCGCGCCACGCATGTACGC
CGCCCTGCCAGCCTTCGTCTCGTCCACCTTTCTTGGTTACGGCCTTTATGTGCTCGTGACCAAGGGCGTGACGCGCGTGT
CGGCGTCGTTCTTCCTGCTGTGCGTGACCACGTTTGCGTGGCAGGGAACCTGGGTCTTCCTGTTCCAGGCCGAACATCCC
GACGTGGCGACGCTGCTGGCGCGGCTCGGCTACCTGTTCATCCTGTTCCTGCCGACCACGTATTACCACTTCATTGCCGA
AGTCACCGAACGGCGCCAGGAACGGCCGATCCTGCTCGCCTCATACGGCATGAGCCTGCTGCTTGCCGTGATGCTGCTCA
CCAGCAACAAGGTGGTGGCGGGCTACTACACATACTTTTTCGGCGACTATCCGAAGGCTGGACCCCTGCATCCACTGCAT
CTGGTGCAGACCGTCCTGGTCGCGATGCGCAGCGCATGGATCCTCTTCGAAGCGCGCCGAAACGCCACTGCGGAACGCCG
CAAGCGCTATAACCTGTGCCTCGTGGCGGTGGTGCTCTACTCGATCGCGGCAGTCGATTACGCGGTCAACTATGGCTACG
CCTTCTATCCGCCTGGCGTGGTGTTCGTGGCGCTGAGCCTTGGCATCCTCGCGCTGAGCGTGGTGCGCTACGACCTCATG
CATCCGTATTCGCTCGCCGCCACGGTCGCACACGAAGTGCGCACGCCGCTCGCGTCGATCCGCATGCAGGCGCAGGAAAT
GGCGCGGACCTGGCCGGAAGTGCTGCAGGGCTATCGGCTCGCCGTCGAACATGGGCTGTGCGAAGACCGCATGCGCCCGG
GGCAGCTCGAACGCGTGTCCAGCCTTGTGGGCGCAATCACCCGCGAGGTTGATGGCACCAGCACGGTCATCGACATGGCG
CTGGCCTCGGTCACGCTCGAGCGGCTGGACCGCAGCACGTTCGCACCGCATGGCATCGGCGAATGCGTACACGAGGCGCT
GGAGCGCTATCCGTTCCAGGGCGACGACAGGGTGCGCGTGCAGGTGCGTGGCATCGACGACGCCTGGCGCTTCGTGGGAT
CGGACACGCTGCTGGTCTACGTCCTGTTCAACCTGCTCAAGAACGCACTACATGCGATCCGCGCCCGGGGTGACGGTAGT
ATCGAGATCGCAGGCGCGGCCGAAGGCCCGTACCACGTCGTGCGCTTCCGCGACACCGGCTGCGGCATTCCCGCCAATGT
GCTGCCGCGCATTTTCGACCCGTTCTTCTCGACCAAGGCCCATGGCAGTGGCGCCGGCCTGGGGCTGGCCTTCTGCCGCC
GCGCGATCGAGTCGTTCGGCGGCCGCATTGAATGCGAGTCCATGCCGGGCTCCCATACCACCTTCACGCTGAAGCTGCCG
CGCTTCACGCCCATGGCCGACAGCCAGTTGCGCGCCAGCGCCGCCGGCTGA

Upstream 100 bases:

>100_bases
CGGCCGGGTACGAAATGTGTCCGGCCGCCGCCCTGCTGTTTTGGCAATCCCCGGGTAGTAGGGAGCGCGTTAAGCGCAGG
TTAGCTCAGAATGCAATCAA

Downstream 100 bases:

>100_bases
CCAGTCCGGCGGCGCTGTGCTTGCGTATCGGCCAGCGGCTTTGCCCAGCCGCCGGCCTTAACTAGCTGCTTCGCAGGCAC
TTAGCTGGCCAGCCCCGGCA

Product: ATP-binding protein

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MMHAAACRDLICHVASETPLIAPRMYAALPAFVSSTFLGYGLYVLVTKGVTRVSASFFLLCVTTFAWQGTWVFLFQAEHP
DVATLLARLGYLFILFLPTTYYHFIAEVTERRQERPILLASYGMSLLLAVMLLTSNKVVAGYYTYFFGDYPKAGPLHPLH
LVQTVLVAMRSAWILFEARRNATAERRKRYNLCLVAVVLYSIAAVDYAVNYGYAFYPPGVVFVALSLGILALSVVRYDLM
HPYSLAATVAHEVRTPLASIRMQAQEMARTWPEVLQGYRLAVEHGLCEDRMRPGQLERVSSLVGAITREVDGTSTVIDMA
LASVTLERLDRSTFAPHGIGECVHEALERYPFQGDDRVRVQVRGIDDAWRFVGSDTLLVYVLFNLLKNALHAIRARGDGS
IEIAGAAEGPYHVVRFRDTGCGIPANVLPRIFDPFFSTKAHGSGAGLGLAFCRRAIESFGGRIECESMPGSHTTFTLKLP
RFTPMADSQLRASAAG

Sequences:

>Translated_496_residues
MMHAAACRDLICHVASETPLIAPRMYAALPAFVSSTFLGYGLYVLVTKGVTRVSASFFLLCVTTFAWQGTWVFLFQAEHP
DVATLLARLGYLFILFLPTTYYHFIAEVTERRQERPILLASYGMSLLLAVMLLTSNKVVAGYYTYFFGDYPKAGPLHPLH
LVQTVLVAMRSAWILFEARRNATAERRKRYNLCLVAVVLYSIAAVDYAVNYGYAFYPPGVVFVALSLGILALSVVRYDLM
HPYSLAATVAHEVRTPLASIRMQAQEMARTWPEVLQGYRLAVEHGLCEDRMRPGQLERVSSLVGAITREVDGTSTVIDMA
LASVTLERLDRSTFAPHGIGECVHEALERYPFQGDDRVRVQVRGIDDAWRFVGSDTLLVYVLFNLLKNALHAIRARGDGS
IEIAGAAEGPYHVVRFRDTGCGIPANVLPRIFDPFFSTKAHGSGAGLGLAFCRRAIESFGGRIECESMPGSHTTFTLKLP
RFTPMADSQLRASAAG
>Mature_496_residues
MMHAAACRDLICHVASETPLIAPRMYAALPAFVSSTFLGYGLYVLVTKGVTRVSASFFLLCVTTFAWQGTWVFLFQAEHP
DVATLLARLGYLFILFLPTTYYHFIAEVTERRQERPILLASYGMSLLLAVMLLTSNKVVAGYYTYFFGDYPKAGPLHPLH
LVQTVLVAMRSAWILFEARRNATAERRKRYNLCLVAVVLYSIAAVDYAVNYGYAFYPPGVVFVALSLGILALSVVRYDLM
HPYSLAATVAHEVRTPLASIRMQAQEMARTWPEVLQGYRLAVEHGLCEDRMRPGQLERVSSLVGAITREVDGTSTVIDMA
LASVTLERLDRSTFAPHGIGECVHEALERYPFQGDDRVRVQVRGIDDAWRFVGSDTLLVYVLFNLLKNALHAIRARGDGS
IEIAGAAEGPYHVVRFRDTGCGIPANVLPRIFDPFFSTKAHGSGAGLGLAFCRRAIESFGGRIECESMPGSHTTFTLKLP
RFTPMADSQLRASAAG

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=32.6359832635983, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790436, Length=254, Percent_Identity=30.7086614173228, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=28.8, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081816, Length=110, Percent_Identity=33.6363636363636, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54871; Mature: 54871

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMHAAACRDLICHVASETPLIAPRMYAALPAFVSSTFLGYGLYVLVTKGVTRVSASFFLL
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
CVTTFAWQGTWVFLFQAEHPDVATLLARLGYLFILFLPTTYYHFIAEVTERRQERPILLA
HHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
SYGMSLLLAVMLLTSNKVVAGYYTYFFGDYPKAGPLHPLHLVQTVLVAMRSAWILFEARR
HHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEHHH
NATAERRKRYNLCLVAVVLYSIAAVDYAVNYGYAFYPPGVVFVALSLGILALSVVRYDLM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHC
HPYSLAATVAHEVRTPLASIRMQAQEMARTWPEVLQGYRLAVEHGLCEDRMRPGQLERVS
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHH
SLVGAITREVDGTSTVIDMALASVTLERLDRSTFAPHGIGECVHEALERYPFQGDDRVRV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEE
QVRGIDDAWRFVGSDTLLVYVLFNLLKNALHAIRARGDGSIEIAGAAEGPYHVVRFRDTG
EEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCC
CGIPANVLPRIFDPFFSTKAHGSGAGLGLAFCRRAIESFGGRIECESMPGSHTTFTLKLP
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECC
RFTPMADSQLRASAAG
CCCCCCCCHHHHCCCC
>Mature Secondary Structure
MMHAAACRDLICHVASETPLIAPRMYAALPAFVSSTFLGYGLYVLVTKGVTRVSASFFLL
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
CVTTFAWQGTWVFLFQAEHPDVATLLARLGYLFILFLPTTYYHFIAEVTERRQERPILLA
HHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
SYGMSLLLAVMLLTSNKVVAGYYTYFFGDYPKAGPLHPLHLVQTVLVAMRSAWILFEARR
HHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEHHH
NATAERRKRYNLCLVAVVLYSIAAVDYAVNYGYAFYPPGVVFVALSLGILALSVVRYDLM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHHHC
HPYSLAATVAHEVRTPLASIRMQAQEMARTWPEVLQGYRLAVEHGLCEDRMRPGQLERVS
CCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHH
SLVGAITREVDGTSTVIDMALASVTLERLDRSTFAPHGIGECVHEALERYPFQGDDRVRV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEE
QVRGIDDAWRFVGSDTLLVYVLFNLLKNALHAIRARGDGSIEIAGAAEGPYHVVRFRDTG
EEECCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCC
CGIPANVLPRIFDPFFSTKAHGSGAGLGLAFCRRAIESFGGRIECESMPGSHTTFTLKLP
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECC
RFTPMADSQLRASAAG
CCCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA