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The map label for this gene is adh [H]

Identifier: 71910647

GI number: 71910647

Start: 828540

End: 829631

Strand: Reverse

Name: adh [H]

Synonym: M5005_Spy_0834

Alternate gene names: 71910647

Gene position: 829631-828540 (Counterclockwise)

Preceding gene: 71910654

Following gene: 71910644

Centisome position: 45.12

GC content: 38.19

Gene sequence:

>1092_bases
ATGAATTGGTTGATTACCTCTCAACCTTATAAGAAGTTAAATATGAAAGCAGCAACTTACCTTTCAACCGGAAATCTACA
GCTCATAGACAAACCAAAACCAGTCATTATAAAGCCTACAGATGCTATCGTCCAGTTGGTAAAAACCACTATTTGTGGAA
CTGATTTGCATATCTTAGGTGGGGATGTTCCCGCATGTAAAGAAGGAACAATCCTTGGTCATGAAGGAATTGGAATTGTT
AAGGAGGTCGGTGATGCGGTTACTAACTTTAAAATCGGAGATAAAGTGATTATTTCTTGCGTCACATCATGTCATACCTG
TTATTATTGTAAACGAGGCCTTTCGTCACATTGTCAAGATGGCGGTTGGATTCTTGGCCATTTAATTAATGGAACACAAG
CAGAATATGTCCATATCCCACATGCAGATGGTAGTCTCTATCATGCTCCTGATACGATTGATGATGAGGCACTTGTCATG
CTTTCTGATATTTTACCAACTTCATATGAAATTGGTGTCTTGCCATCACATGTCAAGCCTGGAGATAATGTTTGTATTGT
TGGTGCCGGTCCAGTAGGACTCGCAGCCCTACTAACCGTTCAATTTTTCTCTCCAGCCAATATTATTATGGTCGACTTAT
CTCAAAATCGCCTTGAAGCAGCTAAAACATTTGGAGCCACACACACGATTTGTTCAGGAAGTAGTGAAGAAGTCAAGGCT
ATCATTGACGATATAACCAATGGACGTGGTGTCGATATTTCCATGGAGTGTGTTGGTTATCCCGCGACATTTGATATTTG
TCAAAAAATTATATCAGTAGGTGGGCATATTGCTAACGTTGGGGTTCATGGGAAACCAGTTGATTTCAACCTGGATGAAT
TATGGATTAAAAATATCACCTTAAACACTGGACTTGTTAATGCCAATACAACTGAAATGCTACTAAATGTCTTGAAAACT
GGAAAGATTGACGCAACAAGACTTATTACACATCATTTTAAACTTTCAGAAGTTGAAAAAGCTTATGAAACCTTTAAACA
TGCTGGTGCAAATAACGCCTTGAAAGTTATTATTGATAATGATATTAGCTAA

Upstream 100 bases:

>100_bases
AGGATGAAGTTATTCAACAAAGATGATCTAAAAAATTATCATAATCGATTTAAAAAATATTGAAAACCCTTTCTTAAAAT
ATTATAATATCTGTGTAAAA

Downstream 100 bases:

>100_bases
TCACAAAATAAGTAGAAGCTAGAAATATGCTTCTACTTATTTTGTGATTTAAAGTATAACTTTCTCTTTTTTTTCATATA
TTCTATGATTTAAGGACTAC

Product: Zn-dependent alcohol dehydrogenase and related dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNWLITSQPYKKLNMKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILGGDVPACKEGTILGHEGIGIV
KEVGDAVTNFKIGDKVIISCVTSCHTCYYCKRGLSSHCQDGGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVM
LSDILPTSYEIGVLPSHVKPGDNVCIVGAGPVGLAALLTVQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKA
IIDDITNGRGVDISMECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNITLNTGLVNANTTEMLLNVLKT
GKIDATRLITHHFKLSEVEKAYETFKHAGANNALKVIIDNDIS

Sequences:

>Translated_363_residues
MNWLITSQPYKKLNMKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILGGDVPACKEGTILGHEGIGIV
KEVGDAVTNFKIGDKVIISCVTSCHTCYYCKRGLSSHCQDGGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVM
LSDILPTSYEIGVLPSHVKPGDNVCIVGAGPVGLAALLTVQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKA
IIDDITNGRGVDISMECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNITLNTGLVNANTTEMLLNVLKT
GKIDATRLITHHFKLSEVEKAYETFKHAGANNALKVIIDNDIS
>Mature_363_residues
MNWLITSQPYKKLNMKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILGGDVPACKEGTILGHEGIGIV
KEVGDAVTNFKIGDKVIISCVTSCHTCYYCKRGLSSHCQDGGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVM
LSDILPTSYEIGVLPSHVKPGDNVCIVGAGPVGLAALLTVQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKA
IIDDITNGRGVDISMECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNITLNTGLVNANTTEMLLNVLKT
GKIDATRLITHHFKLSEVEKAYETFKHAGANNALKVIIDNDIS

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=26.6304347826087, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=25.8620689655172, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI34577061, Length=341, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4501929, Length=335, Percent_Identity=27.4626865671642, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI4501933, Length=235, Percent_Identity=31.063829787234, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI71743840, Length=334, Percent_Identity=26.0479041916168, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073058, Length=334, Percent_Identity=26.0479041916168, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=24.7933884297521, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=24.7933884297521, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1786825, Length=376, Percent_Identity=27.3936170212766, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=27.3743016759777, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788075, Length=373, Percent_Identity=26.2734584450402, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082125, Length=340, Percent_Identity=28.8235294117647, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788073, Length=331, Percent_Identity=28.3987915407855, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787863, Length=333, Percent_Identity=26.4264264264264, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI226510992, Length=333, Percent_Identity=25.8258258258258, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788407, Length=272, Percent_Identity=25.7352941176471, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081918, Length=271, Percent_Identity=29.520295202952, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=26.4462809917355, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790718, Length=313, Percent_Identity=23.961661341853, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=353, Percent_Identity=28.328611898017, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17562876, Length=355, Percent_Identity=28.4507042253521, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI25146526, Length=380, Percent_Identity=26.8421052631579, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71997431, Length=340, Percent_Identity=27.6470588235294, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17565904, Length=352, Percent_Identity=26.9886363636364, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=348, Percent_Identity=29.8850574712644, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319955, Length=348, Percent_Identity=29.8850574712644, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323099, Length=356, Percent_Identity=26.4044943820225, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=385, Percent_Identity=25.974025974026, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=350, Percent_Identity=25.1428571428571, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=23.7704918032787, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=233, Percent_Identity=26.1802575107296, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=132, Percent_Identity=34.8484848484849, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737897, Length=342, Percent_Identity=30.4093567251462, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI17137530, Length=341, Percent_Identity=29.6187683284457, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737895, Length=353, Percent_Identity=26.9121813031161, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551930, Length=334, Percent_Identity=23.9520958083832, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550770, Length=334, Percent_Identity=23.9520958083832, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221457811, Length=334, Percent_Identity=23.9520958083832, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 38980; Mature: 38980

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLITSQPYKKLNMKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILG
CCCEECCCCHHHHCCEEEEEEECCCEEEEECCCCEEECCHHHHHHHHHHHHCCCCEEEEC
GDVPACKEGTILGHEGIGIVKEVGDAVTNFKIGDKVIISCVTSCHTCYYCKRGLSSHCQD
CCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVMLSDILPTSYEIGVLPSHVKP
CCEEEEEEECCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCEEECCCCCCCCC
GDNVCIVGAGPVGLAALLTVQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKA
CCCEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCEEEECCCHHHHHH
IIDDITNGRGVDISMECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNIT
HHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHEEEEEEE
LNTGLVNANTTEMLLNVLKTGKIDATRLITHHFKLSEVEKAYETFKHAGANNALKVIIDN
EECCEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
DIS
CCC
>Mature Secondary Structure
MNWLITSQPYKKLNMKAATYLSTGNLQLIDKPKPVIIKPTDAIVQLVKTTICGTDLHILG
CCCEECCCCHHHHCCEEEEEEECCCEEEEECCCCEEECCHHHHHHHHHHHHCCCCEEEEC
GDVPACKEGTILGHEGIGIVKEVGDAVTNFKIGDKVIISCVTSCHTCYYCKRGLSSHCQD
CCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGWILGHLINGTQAEYVHIPHADGSLYHAPDTIDDEALVMLSDILPTSYEIGVLPSHVKP
CCEEEEEEECCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHCCCCEEECCCCCCCCC
GDNVCIVGAGPVGLAALLTVQFFSPANIIMVDLSQNRLEAAKTFGATHTICSGSSEEVKA
CCCEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCEEEECCCHHHHHH
IIDDITNGRGVDISMECVGYPATFDICQKIISVGGHIANVGVHGKPVDFNLDELWIKNIT
HHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHEEEEEEE
LNTGLVNANTTEMLLNVLKTGKIDATRLITHHFKLSEVEKAYETFKHAGANNALKVIIDN
EECCEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
DIS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2846513 [H]