Click here to switch to the map view.

The map label for this gene is cap3A [H]

Identifier: 71910262

GI number: 71910262

Start: 444552

End: 445709

Strand: Direct

Name: cap3A [H]

Synonym: M5005_Spy_0449

Alternate gene names: 71910262

Gene position: 444552-445709 (Clockwise)

Preceding gene: 71910261

Following gene: 71910263

Centisome position: 24.18

GC content: 30.4

Gene sequence:

>1158_bases
ATGAAAATTACAGTTGTAGGCATTGGATACGTTGGATTATCGATAGGGCTCCTACTTGCAAAGGAACACGACGTCACCTT
TTTTGATATTGATAATAAAAAAATTGATTTAATAAATAAAAGGCAATCCCCTCTTAAAGAAGCAGCTATAAACAAACTTT
TATGTAAGGCAAAAAATATTAATGCAACTTCTTCTGAAGAATTAGCATATAAGGATGCGACTTTCATAATCTTGTCTTTG
CCAACCAACCTAAAATTTAATAAGCTTGATACTTCCATTATCGAAATTTCTGTAAGTAATATTTTAAAGATAAACAAAAA
GGCTACAATTGTAATAAAGTCGACAGTTCCAATTGGTTTTACAGAATATTTAAGGAATCGATTTCACTACAACGATATCA
TTTTTTCACCTGAGTTCCTTAGGGAAGGATCAACTATTCATGATCAATTGTATCCTTCGAGAACTATAGTTGGAAATGAA
TCTAGAAATTCTCAATTATTCTTAGACATACTAACAGATATATCGGTTGAAAAAGACTCGCCATCTTTATTAGTTGGCTC
TTCTGAAGCAGAAGCGATAAAGTTATTTTCGAATGCATACTTGGCACAAAAAATTGCTTTTTTTAATGAGTTGGATACGT
TTGCTGAAATGCAAAATTTGGACTCAAAAAAAATTATTGAGGCTATGGGATATGACCAGAGAATAGGAAATTCGCACAAT
AATCCTTCTTTCGGTTTTGGTGGGTACTGTCTTCCTAAGGATATTAAGCAATTAGAGTATCATTTTAAAGAAATTCCAGC
ACCAATTATTACCAGTATAAGTGAATCTAATTTATTAAGAAAAATTCATATAGCAAAAATGATTTTGAACAGCTCAGCTA
AAACAATAGGAATTTATAGAATTAATTCCAAAAAAGATTCGGATAATTGTAGGGAATCTTCTACAATTGATGTTGCTAAA
CTTCTAAAAAGCAGTGGTAAGGATGTTATCATCTTTGAGCCCTTAATTAACCAAAAAAAGTTTTTGGGGTGCCCTTTAAT
TAATGATTTTAATGAATTTATTAAATATTCGGATATTATAGTTGCCAATAGAATAGATGATGCTCTGAGAAAATGTAATT
CAAAAGTTTTTACACGTGATATTTTTCAGTATGATTAA

Upstream 100 bases:

>100_bases
ATCCAAAAATTTATATCATCTCATTTAGGTATAAAAATCAATTTTATATTCTTTCTAACAAAAAAATTGATTTATAAAAA
GTTTTAGAATAGAGGTTAAC

Downstream 100 bases:

>100_bases
CAAAAACATTTTTGCGAAAAAATATTTTTAAGTAATAAATTCAGTTAAAAGTTATTATATCTGAAAATTTTAAAGGTCTT
TAAAATGAACAATAGGAAAA

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNINATSSEELAYKDATFIILSL
PTNLKFNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSPSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD

Sequences:

>Translated_385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNINATSSEELAYKDATFIILSL
PTNLKFNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSPSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD
>Mature_385_residues
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNINATSSEELAYKDATFIILSL
PTNLKFNKLDTSIIEISVSNILKINKKATIVIKSTVPIGFTEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNE
SRNSQLFLDILTDISVEKDSPSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYRINSKKDSDNCRESSTIDVAK
LLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDIIVANRIDDALRKCNSKVFTRDIFQYD

Specific function: Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis. Directly responsible for the transformation of some unencapsulated serotype-3 SP mutants to the encapsulated phenotype [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=373, Percent_Identity=29.2225201072386, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI296040438, Length=279, Percent_Identity=30.1075268817204, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI296040443, Length=359, Percent_Identity=25.3481894150418, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI1788340, Length=388, Percent_Identity=43.5567010309278, Blast_Score=342, Evalue=2e-95,
Organism=Escherichia coli, GI48994968, Length=406, Percent_Identity=22.6600985221675, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=376, Percent_Identity=28.1914893617021, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17136908, Length=414, Percent_Identity=29.4685990338164, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 43445; Mature: 43445

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNI
CEEEEEEECHHHHHHEEEEEECCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
NATSSEELAYKDATFIILSLPTNLKFNKLDTSIIEISVSNILKINKKATIVIKSTVPIGF
CCCCCCCEEECCEEEEEEECCCCCEECCCCCEEEEEEHHHHEEECCCEEEEEEECCCCCH
TEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNESRNSQLFLDILTDISVEKDS
HHHHHHHCCCCCEEECHHHHHCCCCHHHHHCCCCEEECCCCCCCEEEEEEHHCCEECCCC
PSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCC
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYR
CCCCCCCCEECCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEE
INSKKDSDNCRESSTIDVAKLLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDII
ECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHHHCEE
VANRIDDALRKCNSKVFTRDIFQYD
EEHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MKITVVGIGYVGLSIGLLLAKEHDVTFFDIDNKKIDLINKRQSPLKEAAINKLLCKAKNI
CEEEEEEECHHHHHHEEEEEECCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
NATSSEELAYKDATFIILSLPTNLKFNKLDTSIIEISVSNILKINKKATIVIKSTVPIGF
CCCCCCCEEECCEEEEEEECCCCCEECCCCCEEEEEEHHHHEEECCCEEEEEEECCCCCH
TEYLRNRFHYNDIIFSPEFLREGSTIHDQLYPSRTIVGNESRNSQLFLDILTDISVEKDS
HHHHHHHCCCCCEEECHHHHHCCCCHHHHHCCCCEEECCCCCCCEEEEEEHHCCEECCCC
PSLLVGSSEAEAIKLFSNAYLAQKIAFFNELDTFAEMQNLDSKKIIEAMGYDQRIGNSHN
CCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCC
NPSFGFGGYCLPKDIKQLEYHFKEIPAPIITSISESNLLRKIHIAKMILNSSAKTIGIYR
CCCCCCCCEECCHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEE
INSKKDSDNCRESSTIDVAKLLKSSGKDVIIFEPLINQKKFLGCPLINDFNEFIKYSDII
ECCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCHHHHHHHHHHHCEE
VANRIDDALRKCNSKVFTRDIFQYD
EEHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7929009; 8566758; 7869055 [H]