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The map label for this gene is atpA [H]

Identifier: 71893827

GI number: 71893827

Start: 602431

End: 603969

Strand: Reverse

Name: atpA [H]

Synonym: MHJ_0476

Alternate gene names: 71893827

Gene position: 603969-602431 (Counterclockwise)

Preceding gene: 71893828

Following gene: 161611218

Centisome position: 67.3

GC content: 35.02

Gene sequence:

>1539_bases
ATGGCATTAAAAGTTGCATCCGTTCTAGATTATGTAGTTCTTGTTAAAGGTGAGTATAACTGGCAGGAACAACAATTTTT
TCAAGTAAAAGATAAACCAGAGATTAAAGCTGTCGTAATTCAGGCCTCTCAGGATCAAGCTTATTTACTTTTTAATAACC
AAAAAGGGAAAATTCAGATCAATGATGAACTAATCGAACTTCCAAATTTTGATAAAGTCCTTACTTCAATGGAATATTTT
GGCAAAATCATTGATTTATCAGGAAATATAATCGAGCCGCGCGCGGCTAGACCAACAACTTTTTTACAATATCGGCACTC
GGCATTCGAGACTGCCGCCGGCGTTTTACGCCGTGAATTACTTGATCGGCAAATTTATACCGGAATTTATGCAATCGATC
TTTTTAACCCGATAGGTTTTGGACAACGTGAATTAATTGTCGGCGATCGTCAAACTGGAAAAACGCATATCGGAATTAAT
ACAATAATTAACCAAAAAGACTCACGAACTACAAAATGTATTTATGTCTCAATCGGTCAAAAACGGCAAAACTTAGTTTC
TTTATATCACGATTTGGTCCAAAATGAAGCAATGGCGAATACAATTGTGCTCCATGCCCCTTCAACTAGCCCTTTTGATC
AGTATTTAGCTCCTTATTTTGCAATGGCTCATGCTGAAAATCTTAGTTATAATTATGATGTTTTAATTGTTTTTGATGAT
CTAACAAAACATGCTAGTGTCTGGCGTGAAGTCGCCCTTTTAACAAATCAGCCAATTGGGAAAGAAGCCTTCCCAGCTGA
TATTTTCTTTGCTCATTCTAAACTTTTAGAACGATCAGGAAAATTTATTGGCCGCAAATCAATTACGGCCCTGCCAATTC
TCCAGACCGTTGATAATGATATCACCGCCCTTGTCTCTTCAAATGTAATTTCGATTACCGATGGGCAAATTATTACTTCT
TCTGCCCTTTTTGCTCAGGGAAAAATCCCGGCTATTAATATCGGACTTTCGGTATCTCGGACTGGATCATCGGTTCAAGC
TCAAAATATTCGTCTAATTTCAAAAGAAATTTCCTCACTTTATTATAACTACCAAAAACAAATAAAGCTAGCAAAACTAG
AAAAATTAGACTATGATCTTAACAAGGAAACTTCCGATCTTTTATTTAAAGGATCACAAGTTGAACAGTTCTTGATTCAA
AAAGGGTATTCTCATTATTCTTTAACAAGTGTTTTAATGGGGATTAAAATAATTTCTTGAGGACTTTTAAAAGATGTTCA
AGATCCTACAAAAGTTGTTGATTTTATAAGGGTGCTTGTGGAAACAGATCCATTTGCGAAACAAGTTTTTAATAAATATA
CAAATAATGAATTTGTTGATAATGAACTTGCTGGTTCATATTTTGCAACTCTAACAAATCAGTTTCTAGCAAAAACCGGA
TCACTAACTCAGTTGGAAATTCCCCTTAGTTTTCCGAAAATGGAAGAGAGCTTACTTGATAATATCATTAAAAAATCGCA
GACAATTGGAGGTAGATAA

Upstream 100 bases:

>100_bases
CAATTTCCGGAATTTTAATTACCTTAACCGTCTTTTTACGCCGAATTATTTATAAAAGAAAACAAAATTTAGTAAGTCAA
AAAAATAAAGGAGATCAATA

Downstream 100 bases:

>100_bases
AAATGGTTGGCTATATATCACAGATCTGGACAAACGTTGCTGAGATCAAATTCACAAGTGAATTGGAAAAAATTCAGCTC
GAACAAGCATTAGTTATGCA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha 2; F-ATPase subunit alpha 2 [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MALKVASVLDYVVLVKGEYNWQEQQFFQVKDKPEIKAVVIQASQDQAYLLFNNQKGKIQINDELIELPNFDKVLTSMEYF
GKIIDLSGNIIEPRAARPTTFLQYRHSAFETAAGVLRRELLDRQIYTGIYAIDLFNPIGFGQRELIVGDRQTGKTHIGIN
TIINQKDSRTTKCIYVSIGQKRQNLVSLYHDLVQNEAMANTIVLHAPSTSPFDQYLAPYFAMAHAENLSYNYDVLIVFDD
LTKHASVWREVALLTNQPIGKEAFPADIFFAHSKLLERSGKFIGRKSITALPILQTVDNDITALVSSNVISITDGQIITS
SALFAQGKIPAINIGLSVSRTGSSVQAQNIRLISKEISSLYYNYQKQIKLAKLEKLDYDLNKETSDLLFKGSQVEQFLIQ
KGYSHYSLTSVLMGIKIISWGLLKDVQDPTKVVDFIRVLVETDPFAKQVFNKYTNNEFVDNELAGSYFATLTNQFLAKTG
SLTQLEIPLSFPKMEESLLDNIIKKSQTIGGR

Sequences:

>Translated_512_residues
MALKVASVLDYVVLVKGEYNWQEQQFFQVKDKPEIKAVVIQASQDQAYLLFNNQKGKIQINDELIELPNFDKVLTSMEYF
GKIIDLSGNIIEPRAARPTTFLQYRHSAFETAAGVLRRELLDRQIYTGIYAIDLFNPIGFGQRELIVGDRQTGKTHIGIN
TIINQKDSRTTKCIYVSIGQKRQNLVSLYHDLVQNEAMANTIVLHAPSTSPFDQYLAPYFAMAHAENLSYNYDVLIVFDD
LTKHASVWREVALLTNQPIGKEAFPADIFFAHSKLLERSGKFIGRKSITALPILQTVDNDITALVSSNVISITDGQIITS
SALFAQGKIPAINIGLSVSRTGSSVQAQNIRLISKEISSLYYNYQKQIKLAKLEKLDYDLNKETSDLLFKGSQVEQFLIQ
KGYSHYSLTSVLMGIKIIS*GLLKDVQDPTKVVDFIRVLVETDPFAKQVFNKYTNNEFVDNELAGSYFATLTNQFLAKTG
SLTQLEIPLSFPKMEESLLDNIIKKSQTIGGR
>Mature_511_residues
ALKVASVLDYVVLVKGEYNWQEQQFFQVKDKPEIKAVVIQASQDQAYLLFNNQKGKIQINDELIELPNFDKVLTSMEYFG
KIIDLSGNIIEPRAARPTTFLQYRHSAFETAAGVLRRELLDRQIYTGIYAIDLFNPIGFGQRELIVGDRQTGKTHIGINT
IINQKDSRTTKCIYVSIGQKRQNLVSLYHDLVQNEAMANTIVLHAPSTSPFDQYLAPYFAMAHAENLSYNYDVLIVFDDL
TKHASVWREVALLTNQPIGKEAFPADIFFAHSKLLERSGKFIGRKSITALPILQTVDNDITALVSSNVISITDGQIITSS
ALFAQGKIPAINIGLSVSRTGSSVQAQNIRLISKEISSLYYNYQKQIKLAKLEKLDYDLNKETSDLLFKGSQVEQFLIQK
GYSHYSLTSVLMGIKIIS*GLLKDVQDPTKVVDFIRVLVETDPFAKQVFNKYTNNEFVDNELAGSYFATLTNQFLAKTGS
LTQLEIPLSFPKMEESLLDNIIKKSQTIGGR

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=446, Percent_Identity=35.8744394618834, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI4757810, Length=446, Percent_Identity=35.8744394618834, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI19913426, Length=236, Percent_Identity=27.5423728813559, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI19913428, Length=236, Percent_Identity=27.5423728813559, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790172, Length=498, Percent_Identity=34.136546184739, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1788251, Length=348, Percent_Identity=22.9885057471264, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988063, Length=455, Percent_Identity=35.8241758241758, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71988080, Length=455, Percent_Identity=35.8241758241758, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71988074, Length=348, Percent_Identity=39.9425287356322, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17570191, Length=319, Percent_Identity=26.0188087774295, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17510931, Length=289, Percent_Identity=24.5674740484429, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319370, Length=414, Percent_Identity=34.5410628019324, Blast_Score=240, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6319603, Length=288, Percent_Identity=27.0833333333333, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24658560, Length=451, Percent_Identity=35.0332594235033, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI281361666, Length=236, Percent_Identity=26.271186440678, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646341, Length=236, Percent_Identity=26.271186440678, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17136796, Length=236, Percent_Identity=26.271186440678, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR000793 [H]

Pfam domain/function: PF00006 ATP-synt_ab [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 57438; Mature: 57306

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALKVASVLDYVVLVKGEYNWQEQQFFQVKDKPEIKAVVIQASQDQAYLLFNNQKGKIQI
CCEEHHHHHCEEEEEECCCCCCHHHHEECCCCCCEEEEEEEECCCCEEEEEECCCCEEEE
NDELIELPNFDKVLTSMEYFGKIIDLSGNIIEPRAARPTTFLQYRHSAFETAAGVLRREL
CCCEECCCCHHHHHHHHHHHCEEEECCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LDRQIYTGIYAIDLFNPIGFGQRELIVGDRQTGKTHIGINTIINQKDSRTTKCIYVSIGQ
HHHHHHHCEEEEEECCCCCCCCEEEEECCCCCCCEEEEHHHHCCCCCCCCEEEEEEEECC
KRQNLVSLYHDLVQNEAMANTIVLHAPSTSPFDQYLAPYFAMAHAENLSYNYDVLIVFDD
HHHHHHHHHHHHHHCCHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECC
LTKHASVWREVALLTNQPIGKEAFPADIFFAHSKLLERSGKFIGRKSITALPILQTVDND
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCH
ITALVSSNVISITDGQIITSSALFAQGKIPAINIGLSVSRTGSSVQAQNIRLISKEISSL
HHHHHCCCEEEEECCCEEECHHHHCCCCCCEEEECEEEECCCCCCCHHHHHHHHHHHHHH
YYNYQKQIKLAKLEKLDYDLNKETSDLLFKGSQVEQFLIQKGYSHYSLTSVLMGIKIISG
HHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LLKDVQDPTKVVDFIRVLVETDPFAKQVFNKYTNNEFVDNELAGSYFATLTNQFLAKTGS
HHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
LTQLEIPLSFPKMEESLLDNIIKKSQTIGGR
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALKVASVLDYVVLVKGEYNWQEQQFFQVKDKPEIKAVVIQASQDQAYLLFNNQKGKIQI
CEEHHHHHCEEEEEECCCCCCHHHHEECCCCCCEEEEEEEECCCCEEEEEECCCCEEEE
NDELIELPNFDKVLTSMEYFGKIIDLSGNIIEPRAARPTTFLQYRHSAFETAAGVLRREL
CCCEECCCCHHHHHHHHHHHCEEEECCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LDRQIYTGIYAIDLFNPIGFGQRELIVGDRQTGKTHIGINTIINQKDSRTTKCIYVSIGQ
HHHHHHHCEEEEEECCCCCCCCEEEEECCCCCCCEEEEHHHHCCCCCCCCEEEEEEEECC
KRQNLVSLYHDLVQNEAMANTIVLHAPSTSPFDQYLAPYFAMAHAENLSYNYDVLIVFDD
HHHHHHHHHHHHHHCCHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECC
LTKHASVWREVALLTNQPIGKEAFPADIFFAHSKLLERSGKFIGRKSITALPILQTVDND
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCH
ITALVSSNVISITDGQIITSSALFAQGKIPAINIGLSVSRTGSSVQAQNIRLISKEISSL
HHHHHCCCEEEEECCCEEECHHHHCCCCCCEEEECEEEECCCCCCCHHHHHHHHHHHHHH
YYNYQKQIKLAKLEKLDYDLNKETSDLLFKGSQVEQFLIQKGYSHYSLTSVLMGIKIISG
HHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LLKDVQDPTKVVDFIRVLVETDPFAKQVFNKYTNNEFVDNELAGSYFATLTNQFLAKTGS
HHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
LTQLEIPLSFPKMEESLLDNIIKKSQTIGGR
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11353084 [H]