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The map label for this gene is pepA [H]

Identifier: 71893812

GI number: 71893812

Start: 584676

End: 586037

Strand: Reverse

Name: pepA [H]

Synonym: MHJ_0461

Alternate gene names: 71893812

Gene position: 586037-584676 (Counterclockwise)

Preceding gene: 71893813

Following gene: 71893808

Centisome position: 65.3

GC content: 35.02

Gene sequence:

>1362_bases
ATTTTTATCAAGTATTCAAATAAATTTGAATCCAATCGAATAACCATTGAACCAGCTTATTCTGATTCGCAAATTCCAAT
GTTGATAAAAGAAGATTTAGCTATTACCGAGTATCTTGGGCAAAAAAAGGCTTATATTAATTTAGGCTCCCGCTCAAAAG
AATTAACTCCGAACCGTTTTCGCAAAATTGCTGCAAAATTAGGTCATTATCCCCGTGATATGCAAATTAATTTTGATAAA
TTTCCAAATTCTTTCTTGAGATATTTAATCGAAGTTATTGCTTTTCAAAGATCTGATATCTTCTCGCTAAGAGCCGATTA
TGCTAAAAATCGAGCTAAAAATCGTGATATTTTAGTGGTTTCAAGTTATTTAGATGAACTAAAACCGATAATTGATAAAT
ACCAAATAATTAATAACAGCGTCAATTATGCCCGTTATTACCAAAATATGCCCCCTAATATGGCAAGTTCTGAATTTCTT
GCAAGCGAGATTCAGAAGAAAATGAACCTAAATCCAAAATTAACGGTCAAGGTTTTAGGCGAAAATGAAGTGCGAAAATT
AGGAATGAACCTGCTTTTAGCGGTCAATAGAGGATCAACTTATGATGCTAAATTAGTAGTGATTTCTTATGAAGGGCTTC
CAGGATCACAATATAAAACTGCTTTTATTGGTAAAGGAATTACTTTTGATTCAGGTGGTTATAATATCAAAACTGGCATG
TATATGAATGATATGAAAATTGATATGTCAGGAGCGATAATCTGTGCAGCTGCAATTGATGCCTTATCACAATTTAATCC
CTTAGCAAATGTTGTCGCTGTTTTACCACTTACCGATAACCGTCTTAATGGCGATGCAAATACGCCCGATGCAGTATGAA
GATCAATGAATGGTAAAACAGTTGAGATTAATAATACTGACGCCGAGGGTCGGCTCATTTTAGCAGATGCAATCACTTAT
GCGATTAGACAAGAAAAAGCAAGTGAAATTATTTCGATTGCAACTCTGACAGGAGCAATTCGTATTGCTTTAGGGGAAAC
CTTTACTGGAGCTTTTGCAAATGAGGAAAAAATTTGAAAGAACTTTAACGAGGCATCAAAAGAAGCCGGAGAACTAATTT
GAAGAATGCCTCTTCATCAGGATTTTGCCCAAAATATCCGTGATTCAAAAGTGGCGGATTTAAAAAATACTGATTTTTCC
GGCAAAGCCGGTTCTTCTTCTGCCGCAATGTTTCTAGCTGAGTTTGTCGAAGATAAACCGTTTATTCATTTGGATATTGC
CGCGACTGCTTTTGTCAAAAATACCCCAACTGGTGTTATGGTTAGGTCTTTAGTTGAATATATTTTAGCAAAGCAAAACT
AA

Upstream 100 bases:

>100_bases
TCTAATTTTTTAACTTTTTTGTGTTATAATTTTATTTACTGCATTGCTATTAAAATGTATTACTAGGACTATCAAAGTTA
GTATGAAAAATTTTTCTGAA

Downstream 100 bases:

>100_bases
TTCTAAAATATTTTTTTAGTTTAAAAAAGAAACCTAAAGATTTTTTTGTATCTTCAAGCTACTTTTTGTTTAACTTATAA
CTTAAAAACTAAAAAAAGTA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRFRKIAAKLGHYPRDMQINFDK
FPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFL
ASEIQKKMNLNPKLTVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGYNIKTGM
YMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAVWRSMNGKTVEINNTDAEGRLILADAITY
AIRQEKASEIISIATLTGAIRIALGETFTGAFANEEKIWKNFNEASKEAGELIWRMPLHQDFAQNIRDSKVADLKNTDFS
GKAGSSSAAMFLAEFVEDKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN

Sequences:

>Translated_453_residues
MFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRFRKIAAKLGHYPRDMQINFDK
FPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFL
ASEIQKKMNLNPKLTVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGYNIKTGM
YMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAV*RSMNGKTVEINNTDAEGRLILADAITY
AIRQEKASEIISIATLTGAIRIALGETFTGAFANEEKI*KNFNEASKEAGELI*RMPLHQDFAQNIRDSKVADLKNTDFS
GKAGSSSAAMFLAEFVEDKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN
>Mature_453_residues
MFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRFRKIAAKLGHYPRDMQINFDK
FPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFL
ASEIQKKMNLNPKLTVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGYNIKTGM
YMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAV*RSMNGKTVEINNTDAEGRLILADAITY
AIRQEKASEIISIATLTGAIRIALGETFTGAFANEEKI*KNFNEASKEAGELI*RMPLHQDFAQNIRDSKVADLKNTDFS
GKAGSSSAAMFLAEFVEDKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=317, Percent_Identity=37.5394321766561, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI47155554, Length=332, Percent_Identity=31.9277108433735, Blast_Score=129, Evalue=7e-30,
Organism=Escherichia coli, GI1790710, Length=307, Percent_Identity=36.4820846905537, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87082123, Length=292, Percent_Identity=35.2739726027397, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17556903, Length=401, Percent_Identity=32.9177057356608, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=290, Percent_Identity=28.2758620689655, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24661038, Length=318, Percent_Identity=29.2452830188679, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=29.559748427673, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21357381, Length=337, Percent_Identity=33.2344213649852, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI221379063, Length=337, Percent_Identity=33.2344213649852, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI221379062, Length=337, Percent_Identity=33.2344213649852, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI20129969, Length=318, Percent_Identity=28.9308176100629, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24662227, Length=372, Percent_Identity=27.9569892473118, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI19922386, Length=321, Percent_Identity=31.1526479750779, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161077148, Length=319, Percent_Identity=26.9592476489028, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI20130057, Length=319, Percent_Identity=26.9592476489028, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355645, Length=318, Percent_Identity=27.3584905660377, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24662223, Length=318, Percent_Identity=27.3584905660377, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129963, Length=320, Percent_Identity=29.0625, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24646701, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 50077; Mature: 50077

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRF
CEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHH
RKIAAKLGHYPRDMQINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVV
HHHHHHHCCCCCCCEEEHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
SSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFLASEIQKKMNLNPKLTVKVLG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEC
ENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGYNIKTGM
CHHHHHHCCEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEEECCEEECCCCCEEEECE
YMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAVRSMNGKTV
EEECEEEECCCCCHHHHHHHHHHHCCHHHHEEEEEEECCCCCCCCCCCCHHHHHCCCCEE
EINNTDAEGRLILADAITYAIRQEKASEIISIATLTGAIRIALGETFTGAFANEEKIKNF
EECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHCH
NEASKEAGELIRMPLHQDFAQNIRDSKVADLKNTDFSGKAGSSSAAMFLAEFVEDKPFIH
HHHHHHHHHHHCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
LDIAATAFVKNTPTGVMVRSLVEYILAKQN
EEEEEEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRF
CEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHH
RKIAAKLGHYPRDMQINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVV
HHHHHHHCCCCCCCEEEHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEE
SSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFLASEIQKKMNLNPKLTVKVLG
HHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEC
ENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGYNIKTGM
CHHHHHHCCEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEEECCEEECCCCCEEEECE
YMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAVRSMNGKTV
EEECEEEECCCCCHHHHHHHHHHHCCHHHHEEEEEEECCCCCCCCCCCCHHHHHCCCCEE
EINNTDAEGRLILADAITYAIRQEKASEIISIATLTGAIRIALGETFTGAFANEEKIKNF
EECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCHHHHHCH
NEASKEAGELIRMPLHQDFAQNIRDSKVADLKNTDFSGKAGSSSAAMFLAEFVEDKPFIH
HHHHHHHHHHHCCCHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
LDIAATAFVKNTPTGVMVRSLVEYILAKQN
EEEEEEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557291 [H]