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The map label for this gene is ubiB

Identifier: 71892389

GI number: 71892389

Start: 775575

End: 777215

Strand: Reverse

Name: ubiB

Synonym: BPEN_648

Alternate gene names: 71892389

Gene position: 777215-775575 (Counterclockwise)

Preceding gene: 71892390

Following gene: 71892388

Centisome position: 98.18

GC content: 29.13

Gene sequence:

>1641_bases
ATGCTTGTTGATGAGTTATGTCGACTGTATTCTATAATTAAAACAATATTAAATTATGGGCTAAGTGATTTTGTTCCTAC
TCATCGACTAATTTTTCCATTAAGAATAGGTAGTAGATTTCTTTTACGTGTTTTAAATAAGCATTCTCAACTAACTTTAG
GGGAACGATTTCGTTTAGCATTACAGGAGTTAGGTCCAATATGGATTAAATTTGGGCAAATGCTTTCTACTCGACGCGAT
ATCTTTCCAGATTCTGTTGCAGATCAATTATCAATACTACAAGATCGTGTGGCGCCTTTCGATGGGATTATTGCTAAAAT
GTGCATAGAACGAGCTATCGGGAATTCATTAGAAACATGGTTTAAAGATTTTCAAGAAATACCATTAGCATCTGCATCTA
TTTCACAGGTACATTCTGCCAGATTAAAAAAAAACAATAAAGATATAGTAATTAAAATTATTCGACCCGGTCTTTTGCCT
GTTATTAAAATAGATATATGTTTAATGTATAGATTAGCCAAATGGATTTGTAAATTTTTACCAGAAGGACGGAAATTTAA
GTTCTCAGAAGTTGTTTCAGAATATGAAAAAACTCTTTTTAATGAGCTCAATTTGCTAAAAGAAACAGCGAATACTATTC
AATTGAGAAGAAATTTTAAAAAAAGTCAAATATTATATATACCCAAAGTATACGTAGATTTTTGTAGCGAAAACGTTATG
GTTATGGAGCGTATCTATGGTATACCAGTATATAATTTAGTTGCGCTTAAAAAACAAAAAACTAATATGAAATTATTAGC
AGAACGTGGAATAGAAATATTTTTTACTCAAGTATTTCGAGATAGTTTTTTTCACGGAGATATGCATCCTGGTAATATTT
TTATTAGCTATAAACACCCAGGAAATCCAAAATATATTAGTGTTGATTGCGGCATTGTAGGATCTTTAAATAAAAAAGAT
AAATACTATTTAGCAGCAAATTTCATAGCATTTTTCAATCATGATTATCGTAAAATAGCTGAATTGCATCTTGATTCAGG
TTGGATACCTTTGGATACCAACATTGAAGATTTTGAATGTGCTATGAGAACAGTATTTGAACCAATTTTTGAACAACCGT
TAGAAAAAATTCCTTTTAGTAAAATATTGTTGTACTTATTTAATACTGCACGATATTTTAATATGGAAATACAACCCCAA
TTAATTTTATTACAAAAAACTTTATTGTACATCGAAGGAATAGTTAGACAATTATATCCAAATCTAAATCTTTGGAAATC
TGCTCAACCTTTTTTAGAAAGATGGATGCGGGACCAATTAAAATTGTCAACAACAATATGTGCTTTAAAAGACAAGATAC
CTCATTGGATCGATAAAATACCAGAATTACCGAATTTATTATCTCATGAATTTAAACGTTCTTGTATGTTACAAAAAAAA
ATAGAAATATTAATAAGAGAATTAAGAACTCAGCGAACTAATCATGGTCAAGCGTTATTTTTATTCGGTGTTGGTGCAAC
ATTAGTTACCAGCAGTATTTTTTTGTATATACAGGATAAATATTTAAAAATTTTTTCTATTTTTTTATTTGTAATTGGAA
TCTTTATTTGGACAATAGGTTGGAAACGTATCATACAATAA

Upstream 100 bases:

>100_bases
ATAAGTCTAATGAACTAAAATTAATCCTTATAAAGATGTATTATTTAAATATAAAACTGAATATTTTCCTAATCATTTTA
AACAAATTATAGGCAATCTG

Downstream 100 bases:

>100_bases
CAATATACTATTACTATTTAATTGAATTTTATTTTCTAATACAAGTTTATTTGAACAATTCAACGAAACATTTTATATTA
AATGAATTCTGAAATATAAT

Product: 2-octaprenylphenol hydroxylase of ubiquinone biosynthetic pathway

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MLVDELCRLYSIIKTILNYGLSDFVPTHRLIFPLRIGSRFLLRVLNKHSQLTLGERFRLALQELGPIWIKFGQMLSTRRD
IFPDSVADQLSILQDRVAPFDGIIAKMCIERAIGNSLETWFKDFQEIPLASASISQVHSARLKKNNKDIVIKIIRPGLLP
VIKIDICLMYRLAKWICKFLPEGRKFKFSEVVSEYEKTLFNELNLLKETANTIQLRRNFKKSQILYIPKVYVDFCSENVM
VMERIYGIPVYNLVALKKQKTNMKLLAERGIEIFFTQVFRDSFFHGDMHPGNIFISYKHPGNPKYISVDCGIVGSLNKKD
KYYLAANFIAFFNHDYRKIAELHLDSGWIPLDTNIEDFECAMRTVFEPIFEQPLEKIPFSKILLYLFNTARYFNMEIQPQ
LILLQKTLLYIEGIVRQLYPNLNLWKSAQPFLERWMRDQLKLSTTICALKDKIPHWIDKIPELPNLLSHEFKRSCMLQKK
IEILIRELRTQRTNHGQALFLFGVGATLVTSSIFLYIQDKYLKIFSIFLFVIGIFIWTIGWKRIIQ

Sequences:

>Translated_546_residues
MLVDELCRLYSIIKTILNYGLSDFVPTHRLIFPLRIGSRFLLRVLNKHSQLTLGERFRLALQELGPIWIKFGQMLSTRRD
IFPDSVADQLSILQDRVAPFDGIIAKMCIERAIGNSLETWFKDFQEIPLASASISQVHSARLKKNNKDIVIKIIRPGLLP
VIKIDICLMYRLAKWICKFLPEGRKFKFSEVVSEYEKTLFNELNLLKETANTIQLRRNFKKSQILYIPKVYVDFCSENVM
VMERIYGIPVYNLVALKKQKTNMKLLAERGIEIFFTQVFRDSFFHGDMHPGNIFISYKHPGNPKYISVDCGIVGSLNKKD
KYYLAANFIAFFNHDYRKIAELHLDSGWIPLDTNIEDFECAMRTVFEPIFEQPLEKIPFSKILLYLFNTARYFNMEIQPQ
LILLQKTLLYIEGIVRQLYPNLNLWKSAQPFLERWMRDQLKLSTTICALKDKIPHWIDKIPELPNLLSHEFKRSCMLQKK
IEILIRELRTQRTNHGQALFLFGVGATLVTSSIFLYIQDKYLKIFSIFLFVIGIFIWTIGWKRIIQ
>Mature_546_residues
MLVDELCRLYSIIKTILNYGLSDFVPTHRLIFPLRIGSRFLLRVLNKHSQLTLGERFRLALQELGPIWIKFGQMLSTRRD
IFPDSVADQLSILQDRVAPFDGIIAKMCIERAIGNSLETWFKDFQEIPLASASISQVHSARLKKNNKDIVIKIIRPGLLP
VIKIDICLMYRLAKWICKFLPEGRKFKFSEVVSEYEKTLFNELNLLKETANTIQLRRNFKKSQILYIPKVYVDFCSENVM
VMERIYGIPVYNLVALKKQKTNMKLLAERGIEIFFTQVFRDSFFHGDMHPGNIFISYKHPGNPKYISVDCGIVGSLNKKD
KYYLAANFIAFFNHDYRKIAELHLDSGWIPLDTNIEDFECAMRTVFEPIFEQPLEKIPFSKILLYLFNTARYFNMEIQPQ
LILLQKTLLYIEGIVRQLYPNLNLWKSAQPFLERWMRDQLKLSTTICALKDKIPHWIDKIPELPNLLSHEFKRSCMLQKK
IEILIRELRTQRTNHGQALFLFGVGATLVTSSIFLYIQDKYLKIFSIFLFVIGIFIWTIGWKRIIQ

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily

Homologues:

Organism=Homo sapiens, GI40254938, Length=237, Percent_Identity=27.0042194092827, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI32261307, Length=332, Percent_Identity=23.4939759036145, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI41393593, Length=271, Percent_Identity=25.830258302583, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI217035081, Length=184, Percent_Identity=29.3478260869565, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI34147522, Length=215, Percent_Identity=28.3720930232558, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI2367309, Length=544, Percent_Identity=60.1102941176471, Blast_Score=708, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=248, Percent_Identity=27.4193548387097, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI32565180, Length=292, Percent_Identity=27.0547945205479, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=438, Percent_Identity=23.972602739726, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323282, Length=249, Percent_Identity=26.1044176706827, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22024280, Length=317, Percent_Identity=26.4984227129338, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24662575, Length=253, Percent_Identity=27.6679841897233, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIB_BLOPB (Q491V8)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278123.1
- STRING:   Q491V8
- GeneID:   3562725
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_648
- eggNOG:   COG0661
- HOGENOM:   HBG593509
- OMA:   RIQRVVI
- ProtClustDB:   CLSK280960
- BioCyc:   CBLO291272:BPEN_648-MONOMER
- HAMAP:   MF_00414
- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232
- TIGRFAMs:   TIGR01982

Pfam domain/function: PF03109 ABC1; SSF56112 Kinase_like

EC number: NA

Molecular weight: Translated: 64035; Mature: 64035

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x11a87a38)-; HASH(0x1220ddac)-;

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVDELCRLYSIIKTILNYGLSDFVPTHRLIFPLRIGSRFLLRVLNKHSQLTLGERFRLA
CCHHHHHHHHHHHHHHHHCCHHHCCCCHHEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQELGPIWIKFGQMLSTRRDIFPDSVADQLSILQDRVAPFDGIIAKMCIERAIGNSLETW
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHH
FKDFQEIPLASASISQVHSARLKKNNKDIVIKIIRPGLLPVIKIDICLMYRLAKWICKFL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
PEGRKFKFSEVVSEYEKTLFNELNLLKETANTIQLRRNFKKSQILYIPKVYVDFCSENVM
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCHH
VMERIYGIPVYNLVALKKQKTNMKLLAERGIEIFFTQVFRDSFFHGDMHPGNIFISYKHP
HHHHHHCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
GNPKYISVDCGIVGSLNKKDKYYLAANFIAFFNHDYRKIAELHLDSGWIPLDTNIEDFEC
CCCCEEEEECCEEECCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCCEECCCCCHHHHH
AMRTVFEPIFEQPLEKIPFSKILLYLFNTARYFNMEIQPQLILLQKTLLYIEGIVRQLYP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCC
NLNLWKSAQPFLERWMRDQLKLSTTICALKDKIPHWIDKIPELPNLLSHEFKRSCMLQKK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHH
IEILIRELRTQRTNHGQALFLFGVGATLVTSSIFLYIQDKYLKIFSIFLFVIGIFIWTIG
HHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHH
WKRIIQ
HHHHCH
>Mature Secondary Structure
MLVDELCRLYSIIKTILNYGLSDFVPTHRLIFPLRIGSRFLLRVLNKHSQLTLGERFRLA
CCHHHHHHHHHHHHHHHHCCHHHCCCCHHEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHH
LQELGPIWIKFGQMLSTRRDIFPDSVADQLSILQDRVAPFDGIIAKMCIERAIGNSLETW
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHH
FKDFQEIPLASASISQVHSARLKKNNKDIVIKIIRPGLLPVIKIDICLMYRLAKWICKFL
HHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
PEGRKFKFSEVVSEYEKTLFNELNLLKETANTIQLRRNFKKSQILYIPKVYVDFCSENVM
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCHH
VMERIYGIPVYNLVALKKQKTNMKLLAERGIEIFFTQVFRDSFFHGDMHPGNIFISYKHP
HHHHHHCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
GNPKYISVDCGIVGSLNKKDKYYLAANFIAFFNHDYRKIAELHLDSGWIPLDTNIEDFEC
CCCCEEEEECCEEECCCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCCEECCCCCHHHHH
AMRTVFEPIFEQPLEKIPFSKILLYLFNTARYFNMEIQPQLILLQKTLLYIEGIVRQLYP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCC
NLNLWKSAQPFLERWMRDQLKLSTTICALKDKIPHWIDKIPELPNLLSHEFKRSCMLQKK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHH
IEILIRELRTQRTNHGQALFLFGVGATLVTSSIFLYIQDKYLKIFSIFLFVIGIFIWTIG
HHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHH
WKRIIQ
HHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA