Click here to switch to the map view.

The map label for this gene is emrE [H]

Identifier: 71892322

GI number: 71892322

Start: 678687

End: 679016

Strand: Direct

Name: emrE [H]

Synonym: BPEN_570

Alternate gene names: 71892322

Gene position: 678687-679016 (Clockwise)

Preceding gene: 71892321

Following gene: 71892323

Centisome position: 85.73

GC content: 27.88

Gene sequence:

>330_bases
ATGGATTATTTATATTTATTTATTGCTATTCTTTCCGAGGTTATTGCTACTTCTTACTTAAAAGCATCTGAAGGATTTAG
TAAATTATATCCTGTTATTGTAGTAATAATTGGTTATACATTCTCTTTTATGTTGTTATCTTTAGTGTTGCAAACAATAC
CGATGGGTATTGCATATTCCTGTTGGGCTGGACTTGGTATTGTGTTTATTACTGCAGCGGGATATATATTTTATGATCAA
AAATTAGATAGTTTAGCTGTTATTGGTATTGCTTTCATTATTATTGGTGTTGTATTAATTAATATATTTTCCAATACGAT
AAAACACTAA

Upstream 100 bases:

>100_bases
TCATGAAAAAAATAAATTTTTTCATGAAAGAATTTTATTTAATACAAGAATATCTATTGCGTGTAATTAAAAAGTTTTAA
AGAATGAAGAATAAAATCTT

Downstream 100 bases:

>100_bases
TTTTTTAAAAAAGTAATTTACTAATTTATTGTGTTTTTGAAGATATGTATGAGATACTTTTTAAGTATATTTATTATGTA
TAATATATTTTATTATAAAT

Product: auxillary SMR family multidrug transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
MDYLYLFIAILSEVIATSYLKASEGFSKLYPVIVVIIGYTFSFMLLSLVLQTIPMGIAYSCWAGLGIVFITAAGYIFYDQ
KLDSLAVIGIAFIIIGVVLINIFSNTIKH

Sequences:

>Translated_109_residues
MDYLYLFIAILSEVIATSYLKASEGFSKLYPVIVVIIGYTFSFMLLSLVLQTIPMGIAYSCWAGLGIVFITAAGYIFYDQ
KLDSLAVIGIAFIIIGVVLINIFSNTIKH
>Mature_109_residues
MDYLYLFIAILSEVIATSYLKASEGFSKLYPVIVVIIGYTFSFMLLSLVLQTIPMGIAYSCWAGLGIVFITAAGYIFYDQ
KLDSLAVIGIAFIIIGVVLINIFSNTIKH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=108, Percent_Identity=47.2222222222222, Blast_Score=99, Evalue=5e-23,
Organism=Escherichia coli, GI87082378, Length=105, Percent_Identity=27.6190476190476, Blast_Score=60, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 12015; Mature: 12015

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYLYLFIAILSEVIATSYLKASEGFSKLYPVIVVIIGYTFSFMLLSLVLQTIPMGIAYS
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
CWAGLGIVFITAAGYIFYDQKLDSLAVIGIAFIIIGVVLINIFSNTIKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDYLYLFIAILSEVIATSYLKASEGFSKLYPVIVVIIGYTFSFMLLSLVLQTIPMGIAYS
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
CWAGLGIVFITAAGYIFYDQKLDSLAVIGIAFIIIGVVLINIFSNTIKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]