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The map label for this gene is upp

Identifier: 71892291

GI number: 71892291

Start: 643556

End: 644182

Strand: Reverse

Name: upp

Synonym: BPEN_538

Alternate gene names: 71892291

Gene position: 644182-643556 (Counterclockwise)

Preceding gene: 71892293

Following gene: 71892289

Centisome position: 81.37

GC content: 33.01

Gene sequence:

>627_bases
ATGAAAATAGTTGAAATTAAACATCCATTAGTACGTCACAAATTAGGGCTAATGCGTATTTGTGATATTAGCACGAAACG
TTTTAGAGAATTGTCTTCAGAATTAGGTAGTCTATTAACTTATGTAGCTACCGATGATTTAGAAGTGGAAATAGTAACTA
TTAAAGGGTGGTGTGGATTGGTGAAAATTGCGCGTATTAAGGGAAAAAAAATAACAGTGGTACCAATTTTACGCGCTGGA
TTAGGCATGATGAATGGTGTATTGGAGCATCTTCCAAGTGCACGTATTAGTATAATAGGGATTTATCGTAATGAAATTAC
TTTTGAGCCGATTCCGTATTTTCATAAATTAGTTTCTAATATTAATGAACGTATGGCTATGGTGTTAGATCCTATGTTAG
CTACTGGCGGATCAATAATTGCTACTATTGATTTATTAAAGAAATTTGGATGTAATAATATAAAGGTTTTGTCGATAGTA
GCGGCCCCAGAAGGAATTAAAGCTTTGGAAGAAAAGCATCCAGATATTGAATTATACTTAGCCTCTATAGATCAAAAAAT
TAATAAAAACGGTTACATTATACCGGGATTTGGAGATGCAGGTGATAAAACATTTGGAACTAAATAA

Upstream 100 bases:

>100_bases
CCCATATTTATTATCTAAATATGGGATATTATTTAAATTGATATTTGAAAGTATAATTGCTTAGGTTTAAGTATTTGCTT
TCATGGAGAACAAAATTGAT

Downstream 100 bases:

>100_bases
TATATGATCTCTTATAATTAAGGATTTTTTAATTATTTTAAGTGTATTTGCTATACAGATCTTATATTACGGATTTTTCA
TCGAAAATTAATAATAATAA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKIVEIKHPLVRHKLGLMRICDISTKRFRELSSELGSLLTYVATDDLEVEIVTIKGWCGLVKIARIKGKKITVVPILRAG
LGMMNGVLEHLPSARISIIGIYRNEITFEPIPYFHKLVSNINERMAMVLDPMLATGGSIIATIDLLKKFGCNNIKVLSIV
AAPEGIKALEEKHPDIELYLASIDQKINKNGYIIPGFGDAGDKTFGTK

Sequences:

>Translated_208_residues
MKIVEIKHPLVRHKLGLMRICDISTKRFRELSSELGSLLTYVATDDLEVEIVTIKGWCGLVKIARIKGKKITVVPILRAG
LGMMNGVLEHLPSARISIIGIYRNEITFEPIPYFHKLVSNINERMAMVLDPMLATGGSIIATIDLLKKFGCNNIKVLSIV
AAPEGIKALEEKHPDIELYLASIDQKINKNGYIIPGFGDAGDKTFGTK
>Mature_208_residues
MKIVEIKHPLVRHKLGLMRICDISTKRFRELSSELGSLLTYVATDDLEVEIVTIKGWCGLVKIARIKGKKITVVPILRAG
LGMMNGVLEHLPSARISIIGIYRNEITFEPIPYFHKLVSNINERMAMVLDPMLATGGSIIATIDLLKKFGCNNIKVLSIV
AAPEGIKALEEKHPDIELYLASIDQKINKNGYIIPGFGDAGDKTFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=206, Percent_Identity=27.1844660194175, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI57863312, Length=206, Percent_Identity=27.1844660194175, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=77.4038461538462, Blast_Score=336, Evalue=7e-94,
Organism=Caenorhabditis elegans, GI17539892, Length=171, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=171, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=37.6811594202899, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573516, Length=146, Percent_Identity=32.1917808219178, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573514, Length=146, Percent_Identity=32.1917808219178, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573512, Length=146, Percent_Identity=32.1917808219178, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550449, Length=146, Percent_Identity=32.1917808219178, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_BLOPB (Q492F3)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_278025.1
- HSSP:   Q9WZI0
- ProteinModelPortal:   Q492F3
- SMR:   Q492F3
- STRING:   Q492F3
- GeneID:   3562875
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_538
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- ProtClustDB:   PRK00129
- BioCyc:   CBLO291272:BPEN_538-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22996; Mature: 22996

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVEIKHPLVRHKLGLMRICDISTKRFRELSSELGSLLTYVATDDLEVEIVTIKGWCGL
CEEEECCCHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCH
VKIARIKGKKITVVPILRAGLGMMNGVLEHLPSARISIIGIYRNEITFEPIPYFHKLVSN
HHHEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEECCCCHHHHHHHHH
INERMAMVLDPMLATGGSIIATIDLLKKFGCNNIKVLSIVAAPEGIKALEEKHPDIELYL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCCCEEEE
ASIDQKINKNGYIIPGFGDAGDKTFGTK
EHHHHHHCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKIVEIKHPLVRHKLGLMRICDISTKRFRELSSELGSLLTYVATDDLEVEIVTIKGWCGL
CEEEECCCHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCH
VKIARIKGKKITVVPILRAGLGMMNGVLEHLPSARISIIGIYRNEITFEPIPYFHKLVSN
HHHEEECCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEECCCCHHHHHHHHH
INERMAMVLDPMLATGGSIIATIDLLKKFGCNNIKVLSIVAAPEGIKALEEKHPDIELYL
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHCCCCCEEEE
ASIDQKINKNGYIIPGFGDAGDKTFGTK
EHHHHHHCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA