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The map label for this gene is nuoF [H]

Identifier: 71892262

GI number: 71892262

Start: 604984

End: 606315

Strand: Reverse

Name: nuoF [H]

Synonym: BPEN_505

Alternate gene names: 71892262

Gene position: 606315-604984 (Counterclockwise)

Preceding gene: 71892263

Following gene: 71892261

Centisome position: 76.59

GC content: 35.74

Gene sequence:

>1332_bases
ATGAGCAATACTTATGATGTTAGTGCAGAAAATAATCCACTTACATGGAGAATGCGTGACGATAAACAACCAGTATGGTT
GCATGAATATAAATCTAAAAATGGGTATCGAGCTGCGTATAAAGCAATTACTCAAATGTCTCCAGAAGAGATTATTGAAT
TAGTTAGAAATTCAGGTTTAAGAGGTCGTGGAGGTGGGGGTTTTTTTACTGGAATAAAATGGTCTATGATGTCTCAAAGT
AAGTCAGTCTGCTCTCGTTATTTAGTGTGTAATGCAGACGAAATGGAGCCAGGAACTTATAAAGATCGATTTTTAATGGA
ACGATTGCCTCATTTATTATTAGAAGGTATATTAATTTCAAGTTATGCTTTAGGAGCGTCACGAGCGTATATTTTTTTGA
GATATGAATACATAATCGTTGCGAAATATTTAACTCGTGCTATAGCCGAGATTAAATCAATTGGATTGATTGGTAAAAAC
ATATTGAATAGTGAGTTTAATTTTGAGTTATTCTTGCATACAGGAGCTGGAAGATATATTTGTGGAGAAGAAACAGCGTT
GATTAACGCTTTAGAAGGGCGTCGAGCAGTGCCGCGTGCTAAACCACCTTTTCCAAGTCATGTAGGATTGTGGGGAAAAC
CTACATGTGTCAATAATGTTGAGACGTTATGCAATATTCCAGGAATTATTGAGCATGGGACCACTTGGTATCGGAATATT
TCTTCTAAAAAAAGTAATGATTCAGGTACAAAATTAATGGGATTTTCTGGTCGAGTTAAAAACCCAGGGGTTTGGGAGCT
ACCTTTTGGTACGACTGCTAGAGAAATTTTAGAAGATTATTCTCGAGGCATGTGTCCTGGTTTTAGTTTAAAAGCATGGC
AACCTGGGGGTGTAAGTACAGATTTTTTAACTACAGATCATTTAGATACACCTATGGATTTTGATAAAATTGCTATTTCT
GGTAGTAGATTTGGAACTGGTATGGCAATAGCGATAGATAATACTGTAAATATGGTGTCTTTAGTGCGTAATTTAGAAGA
GTTTTTTTCAAGAGAATCTTGTGGTTGGTGTACTCCTTGTAGAGATGGGTTACCGTGGATAGTAAAATTGTTGATTTCTT
TGGAAAATAAAGACGGCAGACCTGGAGACATAGAATTATTAGAGAAATTGTGTTGTGTACTCGGACCTGGAAGGACTTTT
TGCGCTCACGCCCCAGGAGCTATAGAACCTTTGAAAAGTGCTTTAAAATATTTTAAAAATGAATTTGAATTGGGTATTCA
TGAATTTTATAAACAGGAACCGAATCGTATTATTTGTGTGCAAATTAATTAA

Upstream 100 bases:

>100_bases
GTTTAGGTATTTGCGACAAAGCTCCAGTCATTATGATAGACAAAGATATTTATCCTTATATAGTTCCGGAAACAATTACA
AAATTGTTAGGACAGTATTT

Downstream 100 bases:

>100_bases
AAAACTTTTTATCAAAAAAAATAAATATAATCATTTATATGATTAACATAAATAATATACATTGATGATTTTTAAACTTT
TTCAGGCACCAAAAAATATA

Product: NADH dehydrogenase I chain F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F; NUO6 [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSNTYDVSAENNPLTWRMRDDKQPVWLHEYKSKNGYRAAYKAITQMSPEEIIELVRNSGLRGRGGGGFFTGIKWSMMSQS
KSVCSRYLVCNADEMEPGTYKDRFLMERLPHLLLEGILISSYALGASRAYIFLRYEYIIVAKYLTRAIAEIKSIGLIGKN
ILNSEFNFELFLHTGAGRYICGEETALINALEGRRAVPRAKPPFPSHVGLWGKPTCVNNVETLCNIPGIIEHGTTWYRNI
SSKKSNDSGTKLMGFSGRVKNPGVWELPFGTTAREILEDYSRGMCPGFSLKAWQPGGVSTDFLTTDHLDTPMDFDKIAIS
GSRFGTGMAIAIDNTVNMVSLVRNLEEFFSRESCGWCTPCRDGLPWIVKLLISLENKDGRPGDIELLEKLCCVLGPGRTF
CAHAPGAIEPLKSALKYFKNEFELGIHEFYKQEPNRIICVQIN

Sequences:

>Translated_443_residues
MSNTYDVSAENNPLTWRMRDDKQPVWLHEYKSKNGYRAAYKAITQMSPEEIIELVRNSGLRGRGGGGFFTGIKWSMMSQS
KSVCSRYLVCNADEMEPGTYKDRFLMERLPHLLLEGILISSYALGASRAYIFLRYEYIIVAKYLTRAIAEIKSIGLIGKN
ILNSEFNFELFLHTGAGRYICGEETALINALEGRRAVPRAKPPFPSHVGLWGKPTCVNNVETLCNIPGIIEHGTTWYRNI
SSKKSNDSGTKLMGFSGRVKNPGVWELPFGTTAREILEDYSRGMCPGFSLKAWQPGGVSTDFLTTDHLDTPMDFDKIAIS
GSRFGTGMAIAIDNTVNMVSLVRNLEEFFSRESCGWCTPCRDGLPWIVKLLISLENKDGRPGDIELLEKLCCVLGPGRTF
CAHAPGAIEPLKSALKYFKNEFELGIHEFYKQEPNRIICVQIN
>Mature_442_residues
SNTYDVSAENNPLTWRMRDDKQPVWLHEYKSKNGYRAAYKAITQMSPEEIIELVRNSGLRGRGGGGFFTGIKWSMMSQSK
SVCSRYLVCNADEMEPGTYKDRFLMERLPHLLLEGILISSYALGASRAYIFLRYEYIIVAKYLTRAIAEIKSIGLIGKNI
LNSEFNFELFLHTGAGRYICGEETALINALEGRRAVPRAKPPFPSHVGLWGKPTCVNNVETLCNIPGIIEHGTTWYRNIS
SKKSNDSGTKLMGFSGRVKNPGVWELPFGTTAREILEDYSRGMCPGFSLKAWQPGGVSTDFLTTDHLDTPMDFDKIAISG
SRFGTGMAIAIDNTVNMVSLVRNLEEFFSRESCGWCTPCRDGLPWIVKLLISLENKDGRPGDIELLEKLCCVLGPGRTFC
AHAPGAIEPLKSALKYFKNEFELGIHEFYKQEPNRIICVQIN

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=391, Percent_Identity=41.4322250639386, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI260656005, Length=391, Percent_Identity=41.4322250639386, Blast_Score=296, Evalue=2e-80,
Organism=Escherichia coli, GI1788620, Length=421, Percent_Identity=69.833729216152, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17531727, Length=411, Percent_Identity=39.1727493917275, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI19920794, Length=412, Percent_Identity=39.0776699029126, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI45550452, Length=405, Percent_Identity=38.2716049382716, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24653819, Length=392, Percent_Identity=32.3979591836735, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24653817, Length=362, Percent_Identity=30.6629834254144, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 49681; Mature: 49550

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTYDVSAENNPLTWRMRDDKQPVWLHEYKSKNGYRAAYKAITQMSPEEIIELVRNSGL
CCCCEECCCCCCCEEEEECCCCCCEEEEHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCC
RGRGGGGFFTGIKWSMMSQSKSVCSRYLVCNADEMEPGTYKDRFLMERLPHLLLEGILIS
CCCCCCCEECCEEHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SYALGASRAYIFLRYEYIIVAKYLTRAIAEIKSIGLIGKNILNSEFNFELFLHTGAGRYI
HHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
CGEETALINALEGRRAVPRAKPPFPSHVGLWGKPTCVNNVETLCNIPGIIEHGTTWYRNI
ECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCHHHHHCCCCHHHCCCHHHHCC
SSKKSNDSGTKLMGFSGRVKNPGVWELPFGTTAREILEDYSRGMCPGFSLKAWQPGGVST
CCCCCCCCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DFLTTDHLDTPMDFDKIAISGSRFGTGMAIAIDNTVNMVSLVRNLEEFFSRESCGWCTPC
CCEECCCCCCCCCCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCC
RDGLPWIVKLLISLENKDGRPGDIELLEKLCCVLGPGRTFCAHAPGAIEPLKSALKYFKN
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
EFELGIHEFYKQEPNRIICVQIN
HHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure 
SNTYDVSAENNPLTWRMRDDKQPVWLHEYKSKNGYRAAYKAITQMSPEEIIELVRNSGL
CCCEECCCCCCCEEEEECCCCCCEEEEHHCCCCCHHHHHHHHHCCCHHHHHHHHHCCCC
RGRGGGGFFTGIKWSMMSQSKSVCSRYLVCNADEMEPGTYKDRFLMERLPHLLLEGILIS
CCCCCCCEECCEEHHHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SYALGASRAYIFLRYEYIIVAKYLTRAIAEIKSIGLIGKNILNSEFNFELFLHTGAGRYI
HHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEE
CGEETALINALEGRRAVPRAKPPFPSHVGLWGKPTCVNNVETLCNIPGIIEHGTTWYRNI
ECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCHHHHHCCCCHHHCCCHHHHCC
SSKKSNDSGTKLMGFSGRVKNPGVWELPFGTTAREILEDYSRGMCPGFSLKAWQPGGVST
CCCCCCCCCCEEEECCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
DFLTTDHLDTPMDFDKIAISGSRFGTGMAIAIDNTVNMVSLVRNLEEFFSRESCGWCTPC
CCEECCCCCCCCCCCCEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCC
RDGLPWIVKLLISLENKDGRPGDIELLEKLCCVLGPGRTFCAHAPGAIEPLKSALKYFKN
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHHHH
EFELGIHEFYKQEPNRIICVQIN
HHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7690854; 8157582; 9205837; 9278503; 8366049 [H]