| Definition | Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome. |
|---|---|
| Accession | NC_007292 |
| Length | 791,654 |
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The map label for this gene is gyrA [H]
Identifier: 71892249
GI number: 71892249
Start: 586917
End: 589448
Strand: Reverse
Name: gyrA [H]
Synonym: BPEN_492
Alternate gene names: 71892249
Gene position: 589448-586917 (Counterclockwise)
Preceding gene: 71892254
Following gene: 71892248
Centisome position: 74.46
GC content: 34.16
Gene sequence:
>2532_bases ATGAATGATTTTGCTAAAGAAATCACACAAATTAACATAGAAGAAGAATTAACACATTCTTATTTAGATTATGCCATGTC AGTGATCGTTGGGCGCGCATTGCCAGATGTTCGAGATGGATTAAAACCCGTGCATCGGCGTATATTATTTGCCATGCAAG TACTTGGGAATTGTTGGAATAGAAATTATAAAAAATCAGCTAGAGTAGTAGGTGATGTTATTGGAAAATATCATCCTCAT GGGGATACCGCAGTATATGAAACTATAGTACGCATGGCACAACCTTTTTTAATGCGCTATGCTTTAGTAGATGGACAGGG TAATTTTGGTTCAGTAGATGGTGATCCAGCGGCAGCTATGCGTTACACTGAAGTACGTATGTCTAAAATAGCAAATGAAT TATTGTTAGATTTAGACAAAGAAACTGTTGATTATGAACTAAATTATGATGGCACTGAAAGTATCCCAGGAATATTACCT GCTAGAATTCCAAATCTTTTGGTTAATGGTTCTTCTGGTATTGCTGTAGGAATGGCTACTAATATCCCTCCTCACAATCT TTCTGAGGTAATTAATGGATGTTTGGCGTTTATAGATAATGAGGATATTACTATTGAAGAATTAATGAAATATATTCCGG GCCCAGATTTTCCTACTGCTGCTATTATTAATGATAGCGGTGGTTTGAAAGAAGCATATAGCACCGGACGAGGTAAAATT TATATTCGCGCTCGGTCGGAAATTGAAACTGATGTTAAAAGTGGTCGTGAATCTATCGTAATATATGAAATTCCTTATCA AGTTAATAAGGCTCGATTGTTAGAAAAGATCGCGGAATTAGCAAAATTAAAACGCATTGAGGGAATATATAATTTGCGTG ATGAATCTGATAAGGATGGTATGCGAATAGTTGTTGAAATTAAACGTGATGCTATTAGTGAGGTAATTTTAAATAATTTA TATTCTTTAACTTCGTTACAAACTTCATTCGGTATTAATATGGTAGCGTTACATCAAGGCCAACCAAAAATTATGTCATT AAAAGACATTTTATCTGCCTTTGTATGTCATCGTCGCGCAGTGGTAATACGTCGTGTTACTTTTGAATTAAAGAAAGCTC GTAGTCGTATTCATATTTTAGAGGGGTTAGCGATTGCATTATTTAATATTGATTCAGTTATTAAACTTATTCGTCAATCT AATAGTTCGGTGGAAGCTAGTTCTGTTTTAATATCTTCATCGTGGAATATAGGCAATGTCTTTGATATGAAACAGAGAAC TTCTATTAATTTGATGAAATCTGAGGGGTCAGAAGTCAAGAATGCTGTTCACAATAATCAATATTGTCTTACCAAGAATC AAGCACAAGCTATTTTAGATTTAAAATTACATAAACTTACTACTTTGGAGTATGAAAAATTATTGCAAGAATATAGCAGT TTGTTAGAAAAAATAAAAAATTTAATCTCTATCTTAAAAGATCCTAAATGCCTTATGAGGGTAATTCGTCAAGAACTATT GATGATACAAGAAGAGTATAACGATTCTCGTCGTACTGAAATTAGTAGCAATATTGAAAATATTAATGTTGAAAATTTAA TTAATCAAAAAGATGTAGTAGTAACTTTATCATATCAAGGTTATGTTAAATATCAACCATTAACAGATTATGAGGCGCAA AAACGAGGAGGAAAAGGAAAATTAGCAACACGAATTAAGGAAGAAGATTTTATTACGCGATTATTAATAGCTAATACTCA TGATACGGTTTTGTTATTTTCTAATTATGGGCGTATATATTGGATGAAAGTTTATCGATTACCTGCAGCTAGTCGTGGAT CACGAGGTAAACCAATTATTAACTTGTTACCATTAGATGTGAATGAACGAATTACTGCTATTTTACCAATTCAAAATTAT ACAACAGGACATCAAGTATTTATGGCGACTAGTAGTGGAGTTGTAAAAAAAACGCCACTTACTGAGTTTAGTCGGCCACG TAATGTTGGTATTATTGCATTGAATCTTAATGATGGGGACGAATTAATTGGAGCTGATGTAACCGATGGTAGTAATGAGG TAATGTTGTTTACTGCTTACGGAAAAGTTGTACGATTTAAAGAAACGCAGGTGCGCAGTGTAGGTCGCTCGGCGATTGGC GTGAAAGGTATTCATTTATTACAAGGTGATCGCGTAGTATCTTTAATTATACCAAAAGATAAGAGTTCTATTCTTACTGT TACTCGAAATGGTTTTGGAAAACGTACTAATCAATCAGAATATCCAATCAAGTCTCGCGCGACTCAAGGTGTGATTTCTA TTAAGGTTACGGAGCGAAATGGTAATGTAATTGGTGCTGTGCAAGTAAATCAATCTGATCAAATAGTAATGATCACTGAC TTAGGTCGATTAGTGCGCACTCGTGTTTCTGAAGTTAATATCATTAGACGTAATACTCAAGGAGTTATGTTAATTCGTAC AGCATGCAATGAATGCGTCGTTGGATTACAGTGTGTTGTGGAATCGGTATAG
Upstream 100 bases:
>100_bases AATTTAAATATTATTAAAACAGTTTATATTACAGTTTAATAGATTATTTAAATAATTTTTAATATATATAAATTAAAAAA TAAATAGAGGATATAAATGC
Downstream 100 bases:
>100_bases AAATTAAAATTTTTTTATTTGACTCAGTATTGAAGAGAATTTATCGTTATTAATTGTTGGGTTTAATAGTGAAATTTTAT TCAATAATATGGGATTTTTA
Product: DNA gyrase, subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 843; Mature: 843
Protein sequence:
>843_residues MNDFAKEITQINIEEELTHSYLDYAMSVIVGRALPDVRDGLKPVHRRILFAMQVLGNCWNRNYKKSARVVGDVIGKYHPH GDTAVYETIVRMAQPFLMRYALVDGQGNFGSVDGDPAAAMRYTEVRMSKIANELLLDLDKETVDYELNYDGTESIPGILP ARIPNLLVNGSSGIAVGMATNIPPHNLSEVINGCLAFIDNEDITIEELMKYIPGPDFPTAAIINDSGGLKEAYSTGRGKI YIRARSEIETDVKSGRESIVIYEIPYQVNKARLLEKIAELAKLKRIEGIYNLRDESDKDGMRIVVEIKRDAISEVILNNL YSLTSLQTSFGINMVALHQGQPKIMSLKDILSAFVCHRRAVVIRRVTFELKKARSRIHILEGLAIALFNIDSVIKLIRQS NSSVEASSVLISSSWNIGNVFDMKQRTSINLMKSEGSEVKNAVHNNQYCLTKNQAQAILDLKLHKLTTLEYEKLLQEYSS LLEKIKNLISILKDPKCLMRVIRQELLMIQEEYNDSRRTEISSNIENINVENLINQKDVVVTLSYQGYVKYQPLTDYEAQ KRGGKGKLATRIKEEDFITRLLIANTHDTVLLFSNYGRIYWMKVYRLPAASRGSRGKPIINLLPLDVNERITAILPIQNY TTGHQVFMATSSGVVKKTPLTEFSRPRNVGIIALNLNDGDELIGADVTDGSNEVMLFTAYGKVVRFKETQVRSVGRSAIG VKGIHLLQGDRVVSLIIPKDKSSILTVTRNGFGKRTNQSEYPIKSRATQGVISIKVTERNGNVIGAVQVNQSDQIVMITD LGRLVRTRVSEVNIIRRNTQGVMLIRTACNECVVGLQCVVESV
Sequences:
>Translated_843_residues MNDFAKEITQINIEEELTHSYLDYAMSVIVGRALPDVRDGLKPVHRRILFAMQVLGNCWNRNYKKSARVVGDVIGKYHPH GDTAVYETIVRMAQPFLMRYALVDGQGNFGSVDGDPAAAMRYTEVRMSKIANELLLDLDKETVDYELNYDGTESIPGILP ARIPNLLVNGSSGIAVGMATNIPPHNLSEVINGCLAFIDNEDITIEELMKYIPGPDFPTAAIINDSGGLKEAYSTGRGKI YIRARSEIETDVKSGRESIVIYEIPYQVNKARLLEKIAELAKLKRIEGIYNLRDESDKDGMRIVVEIKRDAISEVILNNL YSLTSLQTSFGINMVALHQGQPKIMSLKDILSAFVCHRRAVVIRRVTFELKKARSRIHILEGLAIALFNIDSVIKLIRQS NSSVEASSVLISSSWNIGNVFDMKQRTSINLMKSEGSEVKNAVHNNQYCLTKNQAQAILDLKLHKLTTLEYEKLLQEYSS LLEKIKNLISILKDPKCLMRVIRQELLMIQEEYNDSRRTEISSNIENINVENLINQKDVVVTLSYQGYVKYQPLTDYEAQ KRGGKGKLATRIKEEDFITRLLIANTHDTVLLFSNYGRIYWMKVYRLPAASRGSRGKPIINLLPLDVNERITAILPIQNY TTGHQVFMATSSGVVKKTPLTEFSRPRNVGIIALNLNDGDELIGADVTDGSNEVMLFTAYGKVVRFKETQVRSVGRSAIG VKGIHLLQGDRVVSLIIPKDKSSILTVTRNGFGKRTNQSEYPIKSRATQGVISIKVTERNGNVIGAVQVNQSDQIVMITD LGRLVRTRVSEVNIIRRNTQGVMLIRTACNECVVGLQCVVESV >Mature_843_residues MNDFAKEITQINIEEELTHSYLDYAMSVIVGRALPDVRDGLKPVHRRILFAMQVLGNCWNRNYKKSARVVGDVIGKYHPH GDTAVYETIVRMAQPFLMRYALVDGQGNFGSVDGDPAAAMRYTEVRMSKIANELLLDLDKETVDYELNYDGTESIPGILP ARIPNLLVNGSSGIAVGMATNIPPHNLSEVINGCLAFIDNEDITIEELMKYIPGPDFPTAAIINDSGGLKEAYSTGRGKI YIRARSEIETDVKSGRESIVIYEIPYQVNKARLLEKIAELAKLKRIEGIYNLRDESDKDGMRIVVEIKRDAISEVILNNL YSLTSLQTSFGINMVALHQGQPKIMSLKDILSAFVCHRRAVVIRRVTFELKKARSRIHILEGLAIALFNIDSVIKLIRQS NSSVEASSVLISSSWNIGNVFDMKQRTSINLMKSEGSEVKNAVHNNQYCLTKNQAQAILDLKLHKLTTLEYEKLLQEYSS LLEKIKNLISILKDPKCLMRVIRQELLMIQEEYNDSRRTEISSNIENINVENLINQKDVVVTLSYQGYVKYQPLTDYEAQ KRGGKGKLATRIKEEDFITRLLIANTHDTVLLFSNYGRIYWMKVYRLPAASRGSRGKPIINLLPLDVNERITAILPIQNY TTGHQVFMATSSGVVKKTPLTEFSRPRNVGIIALNLNDGDELIGADVTDGSNEVMLFTAYGKVVRFKETQVRSVGRSAIG VKGIHLLQGDRVVSLIIPKDKSSILTVTRNGFGKRTNQSEYPIKSRATQGVISIKVTERNGNVIGAVQVNQSDQIVMITD LGRLVRTRVSEVNIIRRNTQGVMLIRTACNECVVGLQCVVESV
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=345, Percent_Identity=27.2463768115942, Blast_Score=84, Evalue=4e-16, Organism=Homo sapiens, GI19913406, Length=343, Percent_Identity=27.4052478134111, Blast_Score=80, Evalue=6e-15, Organism=Escherichia coli, GI1788562, Length=843, Percent_Identity=68.4460260972717, Blast_Score=1210, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=662, Percent_Identity=36.8580060422961, Blast_Score=390, Evalue=1e-109, Organism=Caenorhabditis elegans, GI17535065, Length=180, Percent_Identity=32.2222222222222, Blast_Score=70, Evalue=6e-12, Organism=Caenorhabditis elegans, GI212645845, Length=190, Percent_Identity=28.9473684210526, Blast_Score=70, Evalue=6e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=194, Percent_Identity=29.8969072164948, Blast_Score=79, Evalue=2e-15, Organism=Drosophila melanogaster, GI17136538, Length=183, Percent_Identity=31.1475409836066, Blast_Score=80, Evalue=4e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 94383; Mature: 94383
Theoretical pI: Translated: 9.27; Mature: 9.27
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNDFAKEITQINIEEELTHSYLDYAMSVIVGRALPDVRDGLKPVHRRILFAMQVLGNCWN CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC RNYKKSARVVGDVIGKYHPHGDTAVYETIVRMAQPFLMRYALVDGQGNFGSVDGDPAAAM CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHH RYTEVRMSKIANELLLDLDKETVDYELNYDGTESIPGILPARIPNLLVNGSSGIAVGMAT HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHCCCCEEEECCCCEEEEEEC NIPPHNLSEVINGCLAFIDNEDITIEELMKYIPGPDFPTAAIINDSGGLKEAYSTGRGKI CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCHHHHCCCCCEE YIRARSEIETDVKSGRESIVIYEIPYQVNKARLLEKIAELAKLKRIEGIYNLRDESDKDG EEEECCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC MRIVVEIKRDAISEVILNNLYSLTSLQTSFGINMVALHQGQPKIMSLKDILSAFVCHRRA CEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHHH VVIRRVTFELKKARSRIHILEGLAIALFNIDSVIKLIRQSNSSVEASSVLISSSWNIGNV HHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCCEEHEEEEECCCCCCCE FDMKQRTSINLMKSEGSEVKNAVHNNQYCLTKNQAQAILDLKLHKLTTLEYEKLLQEYSS ECCCCCCCEEEECCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH LLEKIKNLISILKDPKCLMRVIRQELLMIQEEYNDSRRTEISSNIENINVENLINQKDVV HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCCCEE VTLSYQGYVKYQPLTDYEAQKRGGKGKLATRIKEEDFITRLLIANTHDTVLLFSNYGRIY EEEEECCEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEECCCEEE WMKVYRLPAASRGSRGKPIINLLPLDVNERITAILPIQNYTTGHQVFMATSSGVVKKTPL EEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCEEEEEECCCCEECCCC TEFSRPRNVGIIALNLNDGDELIGADVTDGSNEVMLFTAYGKVVRFKETQVRSVGRSAIG HHCCCCCCEEEEEEEECCCCCEEECCCCCCCCCEEEEEECCCEEEEHHHHHHHHCCHHCC VKGIHLLQGDRVVSLIIPKDKSSILTVTRNGFGKRTNQSEYPIKSRATQGVISIKVTERN CCCEEEECCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHCCCCCEEEEEEEECC GNVIGAVQVNQSDQIVMITDLGRLVRTRVSEVNIIRRNTQGVMLIRTACNECVVGLQCVV CCEEEEEEECCCCCEEEEECHHHHHHHHHHHHEEEEECCCCEEEEEHHHHHHHHHHHHHH ESV HCC >Mature Secondary Structure MNDFAKEITQINIEEELTHSYLDYAMSVIVGRALPDVRDGLKPVHRRILFAMQVLGNCWN CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC RNYKKSARVVGDVIGKYHPHGDTAVYETIVRMAQPFLMRYALVDGQGNFGSVDGDPAAAM CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCHHHHH RYTEVRMSKIANELLLDLDKETVDYELNYDGTESIPGILPARIPNLLVNGSSGIAVGMAT HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCHHCCCCEEEECCCCEEEEEEC NIPPHNLSEVINGCLAFIDNEDITIEELMKYIPGPDFPTAAIINDSGGLKEAYSTGRGKI CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCHHHHCCCCCEE YIRARSEIETDVKSGRESIVIYEIPYQVNKARLLEKIAELAKLKRIEGIYNLRDESDKDG EEEECCHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC MRIVVEIKRDAISEVILNNLYSLTSLQTSFGINMVALHQGQPKIMSLKDILSAFVCHRRA CEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEECHHHHHHHHHHHHHH VVIRRVTFELKKARSRIHILEGLAIALFNIDSVIKLIRQSNSSVEASSVLISSSWNIGNV HHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCCEEHEEEEECCCCCCCE FDMKQRTSINLMKSEGSEVKNAVHNNQYCLTKNQAQAILDLKLHKLTTLEYEKLLQEYSS ECCCCCCCEEEECCCCHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH LLEKIKNLISILKDPKCLMRVIRQELLMIQEEYNDSRRTEISSNIENINVENLINQKDVV HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHCCCCCEE VTLSYQGYVKYQPLTDYEAQKRGGKGKLATRIKEEDFITRLLIANTHDTVLLFSNYGRIY EEEEECCEEEECCCCCCHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEEECCCEEE WMKVYRLPAASRGSRGKPIINLLPLDVNERITAILPIQNYTTGHQVFMATSSGVVKKTPL EEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCEEEEEECCCCEECCCC TEFSRPRNVGIIALNLNDGDELIGADVTDGSNEVMLFTAYGKVVRFKETQVRSVGRSAIG HHCCCCCCEEEEEEEECCCCCEEECCCCCCCCCEEEEEECCCEEEEHHHHHHHHCCHHCC VKGIHLLQGDRVVSLIIPKDKSSILTVTRNGFGKRTNQSEYPIKSRATQGVISIKVTERN CCCEEEECCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCCCHHCCCCCEEEEEEEECC GNVIGAVQVNQSDQIVMITDLGRLVRTRVSEVNIIRRNTQGVMLIRTACNECVVGLQCVV CCEEEEEEECCCCCEEEEECHHHHHHHHHHHHEEEEECCCCEEEEEHHHHHHHHHHHHHH ESV HCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11677609; 8849216 [H]