Click here to switch to the map view.

The map label for this gene is hisI [H]

Identifier: 71892242

GI number: 71892242

Start: 576183

End: 576824

Strand: Direct

Name: hisI [H]

Synonym: BPEN_484

Alternate gene names: 71892242

Gene position: 576183-576824 (Clockwise)

Preceding gene: 71892241

Following gene: 71892244

Centisome position: 72.78

GC content: 30.69

Gene sequence:

>642_bases
ATGCTAATTAAAAATCAGCATCAGCAATTAAATTGGACTAAAAATCATGGTCTAATACCCGCTATCATACAACATGCTGA
ATCAGGAGAAGTATTAATGCTAGGGCATATGAATAAAGAATCAATAATAAAAACAGAACAAACTAAGCATATTACTTTTT
TTTCACGCAGCAAAAACAGATTATGGACTAAAGGAGAAAAATCTGGAAATATATTAAAATTAATCAATTGGTATTCAGAT
TGTGATCAGGATGCGTTATTAATTTTTGCTTTGCCTCATGGACCTACTTGTCATAATAATACTAGCAGCTGCTTCCATCC
TGGGATAGCAGAATTAAGTTTTCTTCATCAATTAGAAAATATTATATCCTCAAAAAAAAATATATCATCTTATCTCCCTA
ATACATCCTACACATCTCATTTGTATGCTAGTGGCGTCAAACGCATTGCTCAAAAAGTTGGTGAAGAAGGCCTGGAAACT
GCCCTTGCAGCTATTTCCTGTTGTAATACAAAAGAACTCATTAATGAAGCATCAGATCTAATTTACCATTTATTAGTCCT
ATTACAACATAAATCATTAAATTTTAATGCAATCATCAAGGAATTAAAAATTCGCAATAATAATAACAAATTAAACCAAT
AA

Upstream 100 bases:

>100_bases
ACGTAGATGGGGCGTTAGCAGCTTCAGTATTTCATAATCAAATTATTGACATTCATAAATTGAAACAATTTTTAAATAAA
GAAGGAATAAAAATTAGATT

Downstream 100 bases:

>100_bases
ACAATAATATTGTACATATATAAATATGTATAATGAAACCAAACAATTACTAATGTCATTAGTAATGACATATATAATCA
ATATTAATATATTTATAGGA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MLIKNQHQQLNWTKNHGLIPAIIQHAESGEVLMLGHMNKESIIKTEQTKHITFFSRSKNRLWTKGEKSGNILKLINWYSD
CDQDALLIFALPHGPTCHNNTSSCFHPGIAELSFLHQLENIISSKKNISSYLPNTSYTSHLYASGVKRIAQKVGEEGLET
ALAAISCCNTKELINEASDLIYHLLVLLQHKSLNFNAIIKELKIRNNNNKLNQ

Sequences:

>Translated_213_residues
MLIKNQHQQLNWTKNHGLIPAIIQHAESGEVLMLGHMNKESIIKTEQTKHITFFSRSKNRLWTKGEKSGNILKLINWYSD
CDQDALLIFALPHGPTCHNNTSSCFHPGIAELSFLHQLENIISSKKNISSYLPNTSYTSHLYASGVKRIAQKVGEEGLET
ALAAISCCNTKELINEASDLIYHLLVLLQHKSLNFNAIIKELKIRNNNNKLNQ
>Mature_213_residues
MLIKNQHQQLNWTKNHGLIPAIIQHAESGEVLMLGHMNKESIIKTEQTKHITFFSRSKNRLWTKGEKSGNILKLINWYSD
CDQDALLIFALPHGPTCHNNTSSCFHPGIAELSFLHQLENIISSKKNISSYLPNTSYTSHLYASGVKRIAQKVGEEGLET
ALAAISCCNTKELINEASDLIYHLLVLLQHKSLNFNAIIKELKIRNNNNKLNQ

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=205, Percent_Identity=55.609756097561, Blast_Score=236, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6319819, Length=176, Percent_Identity=32.9545454545455, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 24083; Mature: 24083

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKNQHQQLNWTKNHGLIPAIIQHAESGEVLMLGHMNKESIIKTEQTKHITFFSRSKNR
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCCEEEEEECCCCC
LWTKGEKSGNILKLINWYSDCDQDALLIFALPHGPTCHNNTSSCFHPGIAELSFLHQLEN
CCCCCCCCCCEEEEEHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IISSKKNISSYLPNTSYTSHLYASGVKRIAQKVGEEGLETALAAISCCNTKELINEASDL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHH
IYHLLVLLQHKSLNFNAIIKELKIRNNNNKLNQ
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLIKNQHQQLNWTKNHGLIPAIIQHAESGEVLMLGHMNKESIIKTEQTKHITFFSRSKNR
CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCHHHHHCCCCCCEEEEEECCCCC
LWTKGEKSGNILKLINWYSDCDQDALLIFALPHGPTCHNNTSSCFHPGIAELSFLHQLEN
CCCCCCCCCCEEEEEHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
IISSKKNISSYLPNTSYTSHLYASGVKRIAQKVGEEGLETALAAISCCNTKELINEASDL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHH
IYHLLVLLQHKSLNFNAIIKELKIRNNNNKLNQ
HHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12886019 [H]