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The map label for this gene is zwf [H]

Identifier: 71892226

GI number: 71892226

Start: 551437

End: 552921

Strand: Reverse

Name: zwf [H]

Synonym: BPEN_464

Alternate gene names: 71892226

Gene position: 552921-551437 (Counterclockwise)

Preceding gene: 71892228

Following gene: 71892225

Centisome position: 69.84

GC content: 33.6

Gene sequence:

>1485_bases
ATGAGATCAACATCTATCACTCGAGCATGTAATTTAATTATTTTTGGAGCAAAAGGTGATTTGGCACGCAGAAAATTGTT
TCCATCATTATATCAATTAGAAAAAATAGGCGCTATTCATCCTGACACACGTATTATAGGAGTAGGTCGTGCAGAATGGA
GTCTTATTATGTATATCGAAGTCGTATATGTTGCTTTAAAAACATTTATGCCAGACCCCATTGATGAATCGCTATGGAAT
GTGTTTAGAGCACGACTTGATTTTTGTAATTTGGATGTATATCAAACTGAACGATTTGTTTTGTTGTTAGATAAGCTAAA
GAGCATAGATATAGAGACAGTAAATTATCTTGCTATGCCTCCTGACACGTTTGGTGTTATATGTAAAGGGTTAAGTACTA
TTGGATTAAATAAAAAATCAAATCGTGTAGTCATAGAAAAACCGTTGGGTACTAATTTAACTTCTGCTCGTATTATTAAT
GCGCAGATATCAGAATATTTTGAGGAAAAGCAAATTTATCGCATTGATCATTATTTAGGAAAAGAAACAGTTTTGAACTT
ATTGGCATTACGTTTTGCGAACTATTTATTTTCTTCAAATTGGGATAATAATACTATTGATCATGTGCAGATTACTGTGG
CGGAAGAAGTAGGTATTGAAGGTCGTTGGAAATATTTTGATTCGGTAGGGCAAATGCGTGATATGATACAAAGTCATTTA
TTACAGATTTTGACCATCATAGCTATGTCACCCCCAACTAATTTAAGCGCTGACTGTATTCGAGATGAAAAAGTTAAAGT
GCTTCATTCGTTGAGGAAAATTAATTGTAATAATGTACATGATGTTACGGTGCGTGGACAATATACGTCTGGTTTTATTC
AAGGGAAACCAGTACCTGGTTATTTAGAAGAAGAAGGGGCTAATAAAAGCAGCAATACTGAAACATTTGTATCTATTTGT
GTCAACATAGATGATTGGCGTTGGACTGGTGTGCCATTTTATCTACGTACTGGGAAAAGGTTACCGATTAAATGTTCTGA
AATTGTAATTTTTTTTAAAAAACCAATAATTAATTTATTTTCTGATTCGTATAAAGACTTACCTAACAATAAGTTGACTA
TTCGATTACAGCCAGATGAAGGGATAGATGTTCAAATTTTGAATAAAGTACCCGGATTAGGCCATAAACATCGATTACGT
ACTACCAAATTAAATTTAAGTTTTTATAAAGATTTTTGTCCAGAACATGTAATTGATGCATATGAACGATTATTGTTAGA
GACTATGCGTGGTATTCAAGCATTATTCGTTCGTTGTGATGAAATAGAAGGTGCTTGGAAATGGGTTGATTCTATTGTGC
AAGCTTGGGAATTGGAAAATAACGCTCCCAAGCTTTATCAAGCTGGTACTTGGGGGCCTACAGATTCTGTGACAATGATT
GCTAAAGATGGTCGTTTTTGGAATGAATATAAATTTTATACGTAA

Upstream 100 bases:

>100_bases
TATTTTGATTAAATATAACAAGTTTATACTTGTTATATAACCTACCTATATATGATGAATATTAAAGATTTATATTCATC
TGACATATCAGAGAATAAAT

Downstream 100 bases:

>100_bases
TGATTTTATATATTATAGTGATCATTAATGTGTCTATTCTAATTAATAGAAGTTTAAAATTTTTTATTTTTAAAAAAGAT
ATTTGTAACAATTGGATGTT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MRSTSITRACNLIIFGAKGDLARRKLFPSLYQLEKIGAIHPDTRIIGVGRAEWSLIMYIEVVYVALKTFMPDPIDESLWN
VFRARLDFCNLDVYQTERFVLLLDKLKSIDIETVNYLAMPPDTFGVICKGLSTIGLNKKSNRVVIEKPLGTNLTSARIIN
AQISEYFEEKQIYRIDHYLGKETVLNLLALRFANYLFSSNWDNNTIDHVQITVAEEVGIEGRWKYFDSVGQMRDMIQSHL
LQILTIIAMSPPTNLSADCIRDEKVKVLHSLRKINCNNVHDVTVRGQYTSGFIQGKPVPGYLEEEGANKSSNTETFVSIC
VNIDDWRWTGVPFYLRTGKRLPIKCSEIVIFFKKPIINLFSDSYKDLPNNKLTIRLQPDEGIDVQILNKVPGLGHKHRLR
TTKLNLSFYKDFCPEHVIDAYERLLLETMRGIQALFVRCDEIEGAWKWVDSIVQAWELENNAPKLYQAGTWGPTDSVTMI
AKDGRFWNEYKFYT

Sequences:

>Translated_494_residues
MRSTSITRACNLIIFGAKGDLARRKLFPSLYQLEKIGAIHPDTRIIGVGRAEWSLIMYIEVVYVALKTFMPDPIDESLWN
VFRARLDFCNLDVYQTERFVLLLDKLKSIDIETVNYLAMPPDTFGVICKGLSTIGLNKKSNRVVIEKPLGTNLTSARIIN
AQISEYFEEKQIYRIDHYLGKETVLNLLALRFANYLFSSNWDNNTIDHVQITVAEEVGIEGRWKYFDSVGQMRDMIQSHL
LQILTIIAMSPPTNLSADCIRDEKVKVLHSLRKINCNNVHDVTVRGQYTSGFIQGKPVPGYLEEEGANKSSNTETFVSIC
VNIDDWRWTGVPFYLRTGKRLPIKCSEIVIFFKKPIINLFSDSYKDLPNNKLTIRLQPDEGIDVQILNKVPGLGHKHRLR
TTKLNLSFYKDFCPEHVIDAYERLLLETMRGIQALFVRCDEIEGAWKWVDSIVQAWELENNAPKLYQAGTWGPTDSVTMI
AKDGRFWNEYKFYT
>Mature_494_residues
MRSTSITRACNLIIFGAKGDLARRKLFPSLYQLEKIGAIHPDTRIIGVGRAEWSLIMYIEVVYVALKTFMPDPIDESLWN
VFRARLDFCNLDVYQTERFVLLLDKLKSIDIETVNYLAMPPDTFGVICKGLSTIGLNKKSNRVVIEKPLGTNLTSARIIN
AQISEYFEEKQIYRIDHYLGKETVLNLLALRFANYLFSSNWDNNTIDHVQITVAEEVGIEGRWKYFDSVGQMRDMIQSHL
LQILTIIAMSPPTNLSADCIRDEKVKVLHSLRKINCNNVHDVTVRGQYTSGFIQGKPVPGYLEEEGANKSSNTETFVSIC
VNIDDWRWTGVPFYLRTGKRLPIKCSEIVIFFKKPIINLFSDSYKDLPNNKLTIRLQPDEGIDVQILNKVPGLGHKHRLR
TTKLNLSFYKDFCPEHVIDAYERLLLETMRGIQALFVRCDEIEGAWKWVDSIVQAWELENNAPKLYQAGTWGPTDSVTMI
AKDGRFWNEYKFYT

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=479, Percent_Identity=33.8204592901879, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI109389365, Length=479, Percent_Identity=33.8204592901879, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI52145310, Length=510, Percent_Identity=26.2745098039216, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=70.2647657841141, Blast_Score=732, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=484, Percent_Identity=33.8842975206612, Blast_Score=282, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6324088, Length=473, Percent_Identity=35.5179704016913, Blast_Score=280, Evalue=5e-76,
Organism=Drosophila melanogaster, GI24643350, Length=473, Percent_Identity=34.8837209302326, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24643352, Length=473, Percent_Identity=34.8837209302326, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI221513548, Length=481, Percent_Identity=28.8981288981289, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56788; Mature: 56788

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSTSITRACNLIIFGAKGDLARRKLFPSLYQLEKIGAIHPDTRIIGVGRAEWSLIMYIE
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHH
VVYVALKTFMPDPIDESLWNVFRARLDFCNLDVYQTERFVLLLDKLKSIDIETVNYLAMP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHEEHHHHCCCEEEEEEEECC
PDTFGVICKGLSTIGLNKKSNRVVIEKPLGTNLTSARIINAQISEYFEEKQIYRIDHYLG
CCHHHHHHHCHHHCCCCCCCCEEEEECCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHCC
KETVLNLLALRFANYLFSSNWDNNTIDHVQITVAEEVGIEGRWKYFDSVGQMRDMIQSHL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHH
LQILTIIAMSPPTNLSADCIRDEKVKVLHSLRKINCNNVHDVTVRGQYTSGFIQGKPVPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEECCCCCC
YLEEEGANKSSNTETFVSICVNIDDWRWTGVPFYLRTGKRLPIKCSEIVIFFKKPIINLF
CHHHCCCCCCCCCEEEEEEEEECCCCEECCCCEEEECCCCCCCCHHHEEEEHHHHHHHHH
SDSYKDLPNNKLTIRLQPDEGIDVQILNKVPGLGHKHRLRTTKLNLSFYKDFCPEHVIDA
HHHHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHH
YERLLLETMRGIQALFVRCDEIEGAWKWVDSIVQAWELENNAPKLYQAGTWGPTDSVTMI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEE
AKDGRFWNEYKFYT
EECCCEECCCCCCC
>Mature Secondary Structure
MRSTSITRACNLIIFGAKGDLARRKLFPSLYQLEKIGAIHPDTRIIGVGRAEWSLIMYIE
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHH
VVYVALKTFMPDPIDESLWNVFRARLDFCNLDVYQTERFVLLLDKLKSIDIETVNYLAMP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHEEHHHHCCCEEEEEEEECC
PDTFGVICKGLSTIGLNKKSNRVVIEKPLGTNLTSARIINAQISEYFEEKQIYRIDHYLG
CCHHHHHHHCHHHCCCCCCCCEEEEECCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHCC
KETVLNLLALRFANYLFSSNWDNNTIDHVQITVAEEVGIEGRWKYFDSVGQMRDMIQSHL
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHHHH
LQILTIIAMSPPTNLSADCIRDEKVKVLHSLRKINCNNVHDVTVRGQYTSGFIQGKPVPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEECCCCCC
YLEEEGANKSSNTETFVSICVNIDDWRWTGVPFYLRTGKRLPIKCSEIVIFFKKPIINLF
CHHHCCCCCCCCCEEEEEEEEECCCCEECCCCEEEECCCCCCCCHHHEEEEHHHHHHHHH
SDSYKDLPNNKLTIRLQPDEGIDVQILNKVPGLGHKHRLRTTKLNLSFYKDFCPEHVIDA
HHHHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHH
YERLLLETMRGIQALFVRCDEIEGAWKWVDSIVQAWELENNAPKLYQAGTWGPTDSVTMI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCEEEE
AKDGRFWNEYKFYT
EECCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]