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The map label for this gene is pdxH

Identifier: 71892148

GI number: 71892148

Start: 447480

End: 448130

Strand: Direct

Name: pdxH

Synonym: BPEN_381

Alternate gene names: 71892148

Gene position: 447480-448130 (Clockwise)

Preceding gene: 71892147

Following gene: 71892149

Centisome position: 56.52

GC content: 30.88

Gene sequence:

>651_bases
ATGCTAATAGACAAAACTAACATTTCTAACATCAGACGAGAATATATATCTGGCCAATTGCGTCATACAGATTTAACTAA
TCAGCCTATTCAGTTATTTTCAGTATGGTTGCATCAGGCGTATTTTTCAAAAATACCTGATCCTACTGCAATGTGTTTAG
CTACAGTAGATCACACTGGTCAACCCTATCAACGTGTGGTGTTATTAAAGAATTTTACTAATAAAGAAATGATATTCTAT
ACTAATCTTAGTAGCCGTAAGGCTATGCATTTAGCCAATAACCCAAAAGTTAGTTTATGTTTTCTTTGGAATGTTATAGA
TAGGCAAGTAATAATAACAGGCAGTGTAGATAAACTTCCAGAAAAAGAAGTATTAAAATATTTTTATACACGCCCAAAAA
ATAATCAAATTAGTACATGGGTATCTAATCAATCTAAAGTTATTTCCTCTAAAGATTTACTAGAAAATAAATTTTTAGAA
TTTAAAAAAAATCATCTCCATAAAAAAGTACCATTTCCCGAATTTTGGGGCGGATATAAAATTAATATAAATAGCATGGA
GTTCTGGCAAGGCGGAACACATCGATTACATGATCGATTCATATATCAACGATATAAACATACATGGCGTATTTACCGTT
TATCTCCATAA

Upstream 100 bases:

>100_bases
AAAACTACTATTATATCTCTTGTAGTACTTCTTGTTTATTTTAGATACAAACAAAAATGTGTTATTATACTTTATAACAA
TCAACATAATACCATCTATT

Downstream 100 bases:

>100_bases
TTACAATTACAATTTAATTTCGGTGAATTTTATGATATATAAAAAATATAACTAAACTTAATAAAGTAGTATTGACTTTT
ATAAAAGTCATATAAATACT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MLIDKTNISNIRREYISGQLRHTDLTNQPIQLFSVWLHQAYFSKIPDPTAMCLATVDHTGQPYQRVVLLKNFTNKEMIFY
TNLSSRKAMHLANNPKVSLCFLWNVIDRQVIITGSVDKLPEKEVLKYFYTRPKNNQISTWVSNQSKVISSKDLLENKFLE
FKKNHLHKKVPFPEFWGGYKININSMEFWQGGTHRLHDRFIYQRYKHTWRIYRLSP

Sequences:

>Translated_216_residues
MLIDKTNISNIRREYISGQLRHTDLTNQPIQLFSVWLHQAYFSKIPDPTAMCLATVDHTGQPYQRVVLLKNFTNKEMIFY
TNLSSRKAMHLANNPKVSLCFLWNVIDRQVIITGSVDKLPEKEVLKYFYTRPKNNQISTWVSNQSKVISSKDLLENKFLE
FKKNHLHKKVPFPEFWGGYKININSMEFWQGGTHRLHDRFIYQRYKHTWRIYRLSP
>Mature_216_residues
MLIDKTNISNIRREYISGQLRHTDLTNQPIQLFSVWLHQAYFSKIPDPTAMCLATVDHTGQPYQRVVLLKNFTNKEMIFY
TNLSSRKAMHLANNPKVSLCFLWNVIDRQVIITGSVDKLPEKEVLKYFYTRPKNNQISTWVSNQSKVISSKDLLENKFLE
FKKNHLHKKVPFPEFWGGYKININSMEFWQGGTHRLHDRFIYQRYKHTWRIYRLSP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=202, Percent_Identity=40.5940594059406, Blast_Score=160, Evalue=8e-40,
Organism=Escherichia coli, GI1787926, Length=210, Percent_Identity=53.3333333333333, Blast_Score=258, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17553712, Length=229, Percent_Identity=34.4978165938865, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6319509, Length=211, Percent_Identity=33.6492890995261, Blast_Score=126, Evalue=3e-30,
Organism=Drosophila melanogaster, GI45551845, Length=178, Percent_Identity=39.3258426966292, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24644901, Length=178, Percent_Identity=39.3258426966292, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24644903, Length=171, Percent_Identity=29.2397660818713, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_BLOPB (Q492T8)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277880.1
- ProteinModelPortal:   Q492T8
- SMR:   Q492T8
- STRING:   Q492T8
- GeneID:   3562646
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_381
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   CLSK280838
- BioCyc:   CBLO291272:BPEN_381-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 25738; Mature: 25738

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 65-65 BINDING 68-68 BINDING 70-70 BINDING 87-87 BINDING 127-127 BINDING 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDKTNISNIRREYISGQLRHTDLTNQPIQLFSVWLHQAYFSKIPDPTAMCLATVDHTG
CCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCC
QPYQRVVLLKNFTNKEMIFYTNLSSRKAMHLANNPKVSLCFLWNVIDRQVIITGSVDKLP
CCHHEEEEEECCCCCEEEEEECCCCCCEEEECCCCCEEEEEEEEHHCCEEEEECCCCCCC
EKEVLKYFYTRPKNNQISTWVSNQSKVISSKDLLENKFLEFKKNHLHKKVPFPEFWGGYK
HHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEE
ININSMEFWQGGTHRLHDRFIYQRYKHTWRIYRLSP
EEECCEEECCCCCHHHHHHHHHHHHHCEEEEEEECC
>Mature Secondary Structure
MLIDKTNISNIRREYISGQLRHTDLTNQPIQLFSVWLHQAYFSKIPDPTAMCLATVDHTG
CCCCCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCC
QPYQRVVLLKNFTNKEMIFYTNLSSRKAMHLANNPKVSLCFLWNVIDRQVIITGSVDKLP
CCHHEEEEEECCCCCEEEEEECCCCCCEEEECCCCCEEEEEEEEHHCCEEEEECCCCCCC
EKEVLKYFYTRPKNNQISTWVSNQSKVISSKDLLENKFLEFKKNHLHKKVPFPEFWGGYK
HHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEE
ININSMEFWQGGTHRLHDRFIYQRYKHTWRIYRLSP
EEECCEEECCCCCHHHHHHHHHHHHHCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA