Click here to switch to the map view.

The map label for this gene is prsA [H]

Identifier: 71892124

GI number: 71892124

Start: 420762

End: 421700

Strand: Reverse

Name: prsA [H]

Synonym: BPEN_356

Alternate gene names: 71892124

Gene position: 421700-420762 (Counterclockwise)

Preceding gene: 71892125

Following gene: 71892123

Centisome position: 53.27

GC content: 36.21

Gene sequence:

>939_bases
ATGAAACTGTTTACTGGAAATGCTATTCCAGAATTAGCCCAGCGTATTGCTAATAGATTATACATTAATCTCGGTAAAGC
TTCTGTTGGTCGTTTTAGTGATGGAGAAGTAAGTGTTCAAATTAATGAAAACGTGCGCGGTGGAGATGTGTTTATTATTC
AATCGACTTGTGCTCCAACAAATGATAATTTAATGGAATTAATTGTTATGGTTGATGCATTAAAACGCGCGTCAGCCGCT
AGAATTACCGCTGTAATTCCTTATTTTGGATACGCTCGTCAAGATCGAAGAGTGCGATCTGCTAGAGTACCTATTACTTC
TAGAGTTGTAGCAAATTTTTTATCTAGTGTGGGAGTGGATCGAATTTTAACGGTAGATTTACATGCTGAACAAATACAAG
GATTTTTTGATGTGCCAGTAGATAATGTTTTCGGGAGTCCAATCTTATTGGAAGATATGACGCAACAGAATTTTAATAAT
CCTATTATAGTATCCCCAGATATTGGAGGGGTAGTACGTGCTCGTGCTATTGCAAAATTACTTAACGATACTGATATGGC
AATTATAGACAAACGAAGGTCTCGCGCTAATATTTCTCAAGTTATGCATATTATTGGGGATATATGTAATCGTGATTGTA
TATTGGTAGATGACATGATTGATACGGGGGGAACATTGTGTAAAGCCGCAGATGTTTTGAAAGAAAGAGGAGCGCGCCGT
GTATTTGCGTACACTACCCACCCAATTTTTTCTGGAGATGCTTATGAGAATATTCAAAATTCTATGATAGATGAAATTAT
TGTTTGTGACACTATTCCATTAAAACCAAAAATAAAATCTTTATCTAACGTACGTGTGTTAACCTTATCTGGTATGCTTG
CTGAAACAATTCGGCGTATTAGCAATGAGGAATCAATTTCTGCTATGTTTGATCATTAA

Upstream 100 bases:

>100_bases
ATTTTTTTATCTTAATAAATGTCTTACTATCATCGTCATTATTAATTATATAAATACTTAATAGTATTAGCAAATATAAA
ATTAAGAGATGCTTCTAAAT

Downstream 100 bases:

>100_bases
TAAGATTATGTTGTATATATAAAAATATTAATTTATGTAAATATTGTATTTTTCTTCATGTTAATTGTTTTATTATCATT
TTAATGATAGAAGATCTAGT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKLFTGNAIPELAQRIANRLYINLGKASVGRFSDGEVSVQINENVRGGDVFIIQSTCAPTNDNLMELIVMVDALKRASAA
RITAVIPYFGYARQDRRVRSARVPITSRVVANFLSSVGVDRILTVDLHAEQIQGFFDVPVDNVFGSPILLEDMTQQNFNN
PIIVSPDIGGVVRARAIAKLLNDTDMAIIDKRRSRANISQVMHIIGDICNRDCILVDDMIDTGGTLCKAADVLKERGARR
VFAYTTHPIFSGDAYENIQNSMIDEIIVCDTIPLKPKIKSLSNVRVLTLSGMLAETIRRISNEESISAMFDH

Sequences:

>Translated_312_residues
MKLFTGNAIPELAQRIANRLYINLGKASVGRFSDGEVSVQINENVRGGDVFIIQSTCAPTNDNLMELIVMVDALKRASAA
RITAVIPYFGYARQDRRVRSARVPITSRVVANFLSSVGVDRILTVDLHAEQIQGFFDVPVDNVFGSPILLEDMTQQNFNN
PIIVSPDIGGVVRARAIAKLLNDTDMAIIDKRRSRANISQVMHIIGDICNRDCILVDDMIDTGGTLCKAADVLKERGARR
VFAYTTHPIFSGDAYENIQNSMIDEIIVCDTIPLKPKIKSLSNVRVLTLSGMLAETIRRISNEESISAMFDH
>Mature_312_residues
MKLFTGNAIPELAQRIANRLYINLGKASVGRFSDGEVSVQINENVRGGDVFIIQSTCAPTNDNLMELIVMVDALKRASAA
RITAVIPYFGYARQDRRVRSARVPITSRVVANFLSSVGVDRILTVDLHAEQIQGFFDVPVDNVFGSPILLEDMTQQNFNN
PIIVSPDIGGVVRARAIAKLLNDTDMAIIDKRRSRANISQVMHIIGDICNRDCILVDDMIDTGGTLCKAADVLKERGARR
VFAYTTHPIFSGDAYENIQNSMIDEIIVCDTIPLKPKIKSLSNVRVLTLSGMLAETIRRISNEESISAMFDH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506129, Length=312, Percent_Identity=49.6794871794872, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI4506127, Length=314, Percent_Identity=49.6815286624204, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=49.3630573248408, Blast_Score=305, Evalue=3e-83,
Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=49.0445859872611, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=35.2769679300292, Blast_Score=194, Evalue=7e-50,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=34.9854227405248, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=32.4137931034483, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=32.4137931034483, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=32.4137931034483, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=32.4137931034483, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=85.8974358974359, Blast_Score=560, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17554702, Length=314, Percent_Identity=47.1337579617834, Blast_Score=295, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI25149168, Length=314, Percent_Identity=47.1337579617834, Blast_Score=295, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71989924, Length=314, Percent_Identity=47.1337579617834, Blast_Score=294, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=47.1153846153846, Blast_Score=293, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=33.7278106508876, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=45.7142857142857, Blast_Score=273, Evalue=4e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=45.253164556962, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321776, Length=312, Percent_Identity=46.1538461538462, Blast_Score=270, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6322667, Length=202, Percent_Identity=41.0891089108911, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=43.4782608695652, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21355239, Length=312, Percent_Identity=48.0769230769231, Blast_Score=290, Evalue=6e-79,
Organism=Drosophila melanogaster, GI45551540, Length=334, Percent_Identity=44.9101796407186, Blast_Score=282, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24651458, Length=352, Percent_Identity=34.0909090909091, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24651456, Length=352, Percent_Identity=34.0909090909091, Blast_Score=195, Evalue=3e-50,
Organism=Drosophila melanogaster, GI281362873, Length=352, Percent_Identity=34.0909090909091, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24651454, Length=352, Percent_Identity=34.0909090909091, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24651462, Length=371, Percent_Identity=32.3450134770889, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24651464, Length=371, Percent_Identity=32.3450134770889, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI45552010, Length=371, Percent_Identity=32.3450134770889, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34438; Mature: 34438

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFTGNAIPELAQRIANRLYINLGKASVGRFSDGEVSVQINENVRGGDVFIIQSTCAPT
CCEECCCCHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCC
NDNLMELIVMVDALKRASAARITAVIPYFGYARQDRRVRSARVPITSRVVANFLSSVGVD
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
RILTVDLHAEQIQGFFDVPVDNVFGSPILLEDMTQQNFNNPIIVSPDIGGVVRARAIAKL
EEEEEEEEHHHHCCEECCCHHHHCCCCCEEHHHHHHCCCCCEEECCCCCHHHHHHHHHHH
LNDTDMAIIDKRRSRANISQVMHIIGDICNRDCILVDDMIDTGGTLCKAADVLKERGARR
HCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECHHCCCCHHHHHHHHHHHCCCCE
VFAYTTHPIFSGDAYENIQNSMIDEIIVCDTIPLKPKIKSLSNVRVLTLSGMLAETIRRI
EEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHCCCCEEEEEEHHHHHHHHHHH
SNEESISAMFDH
CCCCHHHHHCCC
>Mature Secondary Structure
MKLFTGNAIPELAQRIANRLYINLGKASVGRFSDGEVSVQINENVRGGDVFIIQSTCAPT
CCEECCCCHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCC
NDNLMELIVMVDALKRASAARITAVIPYFGYARQDRRVRSARVPITSRVVANFLSSVGVD
CCHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
RILTVDLHAEQIQGFFDVPVDNVFGSPILLEDMTQQNFNNPIIVSPDIGGVVRARAIAKL
EEEEEEEEHHHHCCEECCCHHHHCCCCCEEHHHHHHCCCCCEEECCCCCHHHHHHHHHHH
LNDTDMAIIDKRRSRANISQVMHIIGDICNRDCILVDDMIDTGGTLCKAADVLKERGARR
HCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEECHHCCCCHHHHHHHHHHHCCCCE
VFAYTTHPIFSGDAYENIQNSMIDEIIVCDTIPLKPKIKSLSNVRVLTLSGMLAETIRRI
EEEEECCCCCCCHHHHHHHHHHHHHEEEECCCCCCHHHHCCCCEEEEEEHHHHHHHHHHH
SNEESISAMFDH
CCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12886019 [H]