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The map label for this gene is pth [H]

Identifier: 71892123

GI number: 71892123

Start: 419924

End: 420517

Strand: Reverse

Name: pth [H]

Synonym: BPEN_355

Alternate gene names: 71892123

Gene position: 420517-419924 (Counterclockwise)

Preceding gene: 71892124

Following gene: 71892122

Centisome position: 53.12

GC content: 27.95

Gene sequence:

>594_bases
ATGACTATTAAGCTTATTGCTGGATTAGGAAATTCTGAAACGAGTTATTTTAATACCAGACATAATTTTGGTGCCAGATA
TGTTAAATCTTTAGCAACAAGATATAAAGTAATACTAAGTAAAAATACTATATTATGTGGATATGTTGGGAGGTTAAAAT
TAGCAACTAATATTGTGCATTTATTAATACCAGATTCGAATATGAACAATAATGGACTTTCAATATCTAAATGTGTTGAT
TTTTATCAATTATGTCCACAGGAAATATTGATTGCACATGATGATCTTGATCTACCGCCTGGCGTAATGCGTATTAAATT
AGGTAAAAACATTAATAATAGTCATCGTGGCGTCAAGGATGTTATCGTTAAACTTCATAATAAATATGATTTTTATCGTT
TACGTATTGGGATAGGTCATCCTGGTAACAAAAGTAAAGTCATTGGTTTTGTGTTAAATAAACCAACTATTTATGAGAAA
TATAAGATTAACCGTGTAATTAATGAAGCAATACTACATACTGAAAGTATAGTTAATAAAAAATTTATTGAAGTTATGAA
TCAACTACATTCCTATAATCCTGATTTTTTATAG

Upstream 100 bases:

>100_bases
TATATGTATATGTGTTCAAGTAAAAATATATTTTTATAACATAAATATTGGGATTAATTAAATTTTAAATTTATAAAATT
GTGTAGTGGTGTATATAATA

Downstream 100 bases:

>100_bases
AAATGTTGATTTAAAAATGTTTAATTTTAATTATAAAAATATTGGTTGCAACAATGGATTTTAATATTTATTTTTTGATT
GTTAAAAAAATTTATGCAAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTIKLIAGLGNSETSYFNTRHNFGARYVKSLATRYKVILSKNTILCGYVGRLKLATNIVHLLIPDSNMNNNGLSISKCVD
FYQLCPQEILIAHDDLDLPPGVMRIKLGKNINNSHRGVKDVIVKLHNKYDFYRLRIGIGHPGNKSKVIGFVLNKPTIYEK
YKINRVINEAILHTESIVNKKFIEVMNQLHSYNPDFL

Sequences:

>Translated_197_residues
MTIKLIAGLGNSETSYFNTRHNFGARYVKSLATRYKVILSKNTILCGYVGRLKLATNIVHLLIPDSNMNNNGLSISKCVD
FYQLCPQEILIAHDDLDLPPGVMRIKLGKNINNSHRGVKDVIVKLHNKYDFYRLRIGIGHPGNKSKVIGFVLNKPTIYEK
YKINRVINEAILHTESIVNKKFIEVMNQLHSYNPDFL
>Mature_196_residues
TIKLIAGLGNSETSYFNTRHNFGARYVKSLATRYKVILSKNTILCGYVGRLKLATNIVHLLIPDSNMNNNGLSISKCVDF
YQLCPQEILIAHDDLDLPPGVMRIKLGKNINNSHRGVKDVIVKLHNKYDFYRLRIGIGHPGNKSKVIGFVLNKPTIYEKY
KINRVINEAILHTESIVNKKFIEVMNQLHSYNPDFL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=30.952380952381, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1787455, Length=192, Percent_Identity=45.3125, Blast_Score=168, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 22442; Mature: 22310

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKLIAGLGNSETSYFNTRHNFGARYVKSLATRYKVILSKNTILCGYVGRLKLATNIVH
CEEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHEEECCEEEEEHHHHHHHHHCEEE
LLIPDSNMNNNGLSISKCVDFYQLCPQEILIAHDDLDLPPGVMRIKLGKNINNSHRGVKD
EEECCCCCCCCCCCHHHHHHHHHHCCHHEEEEECCCCCCCCEEEEEECCCCCCCCCCHHH
VIVKLHNKYDFYRLRIGIGHPGNKSKVIGFVLNKPTIYEKYKINRVINEAILHTESIVNK
HHHHHCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KFIEVMNQLHSYNPDFL
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TIKLIAGLGNSETSYFNTRHNFGARYVKSLATRYKVILSKNTILCGYVGRLKLATNIVH
EEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHEEECCEEEEEHHHHHHHHHCEEE
LLIPDSNMNNNGLSISKCVDFYQLCPQEILIAHDDLDLPPGVMRIKLGKNINNSHRGVKD
EEECCCCCCCCCCCHHHHHHHHHHCCHHEEEEECCCCCCCCEEEEEECCCCCCCCCCHHH
VIVKLHNKYDFYRLRIGIGHPGNKSKVIGFVLNKPTIYEKYKINRVINEAILHTESIVNK
HHHHHCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
KFIEVMNQLHSYNPDFL
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA