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The map label for this gene is folD

Identifier: 71892087

GI number: 71892087

Start: 371401

End: 372261

Strand: Reverse

Name: folD

Synonym: BPEN_313

Alternate gene names: 71892087

Gene position: 372261-371401 (Counterclockwise)

Preceding gene: 71892089

Following gene: 71892085

Centisome position: 47.02

GC content: 32.98

Gene sequence:

>861_bases
ATGATCGCTAAGATAATTGATGGTAAATATGTTTCTGAAAAAATAAAACAAGAAATAGCTAAACAAGTACGTAAAAATAT
GAATTCCGGAAAACGTGCCCCAGGTTTGGCTATGATTCTAGTAGGACATAATCCAATTTCTCAGATATATGTAACTAATA
AGAAAAAAGCATGTGAACAAGTGGGTTTGATTTCATTTCTTTATACTTTACCTATTACGGCTACAGAAAATGAGATTTTT
CAATTAATTGAAACTTTAAATAATGATAATCGTATAGATGGTATTTTAATTCAGTTGCCATTACCAAATAAGTTAAATAA
AATAAATGTTTTAGAACATATTGCTCCTGATAAGGATGTAGATGGTTTTCATCCATATAATGTCGGGCGTTTATGTCAAC
GATCTCCTACATTACGTCCTTGCACTTCTCGAGGTATTATTACTTTGTTAGAATGGTATAATATAGATATGTTTGTATTA
CATGCGGTTGTAGTTGGAGCATCAAATATCGTTGGTCGGCCTATGACTATGGAATTATTATTGGCAGGTTGTACGGTATC
TGTTACTCATCGTTTTACTCAAAATTTGAAAATATACATTGAAAATGCTGATTTATTAATTGTGGCGGTAGGTCAAGCAA
ATTTTATTCCCGGTAGTTGGATAAAACAAGGGGCTATAGTCATAGATGTTGGTATTAATCGATTAAATAACGGAAATATA
GTGGGTGATGTTCACTTTTCTAGCGCTTACGAACGAGCTGCATACATTACTCCTGTTCCGGGTGGAGTAGGTCCAATGAC
AGTAGTAACACTTATTCAAAATACCTTGCAAGCTTATGATGACCATCATTTAGTAAGATAA

Upstream 100 bases:

>100_bases
ATATGCTTAGAGAAAGTATATAATTTAAAATTAATAGTAATATATATTACAGAAAATAATATCATCGTGTTAATATATAA
TTCATTGGATATATTTTAAA

Downstream 100 bases:

>100_bases
TTTTTGTTTATTCCATTTTTAATTATTTTTATTACTATTTATATTATTTGAAATGCCATTTCGTTATTCCTGTAGGCCCA
TCTTCTAATGTTATTCCCAT

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MIAKIIDGKYVSEKIKQEIAKQVRKNMNSGKRAPGLAMILVGHNPISQIYVTNKKKACEQVGLISFLYTLPITATENEIF
QLIETLNNDNRIDGILIQLPLPNKLNKINVLEHIAPDKDVDGFHPYNVGRLCQRSPTLRPCTSRGIITLLEWYNIDMFVL
HAVVVGASNIVGRPMTMELLLAGCTVSVTHRFTQNLKIYIENADLLIVAVGQANFIPGSWIKQGAIVIDVGINRLNNGNI
VGDVHFSSAYERAAYITPVPGGVGPMTVVTLIQNTLQAYDDHHLVR

Sequences:

>Translated_286_residues
MIAKIIDGKYVSEKIKQEIAKQVRKNMNSGKRAPGLAMILVGHNPISQIYVTNKKKACEQVGLISFLYTLPITATENEIF
QLIETLNNDNRIDGILIQLPLPNKLNKINVLEHIAPDKDVDGFHPYNVGRLCQRSPTLRPCTSRGIITLLEWYNIDMFVL
HAVVVGASNIVGRPMTMELLLAGCTVSVTHRFTQNLKIYIENADLLIVAVGQANFIPGSWIKQGAIVIDVGINRLNNGNI
VGDVHFSSAYERAAYITPVPGGVGPMTVVTLIQNTLQAYDDHHLVR
>Mature_286_residues
MIAKIIDGKYVSEKIKQEIAKQVRKNMNSGKRAPGLAMILVGHNPISQIYVTNKKKACEQVGLISFLYTLPITATENEIF
QLIETLNNDNRIDGILIQLPLPNKLNKINVLEHIAPDKDVDGFHPYNVGRLCQRSPTLRPCTSRGIITLLEWYNIDMFVL
HAVVVGASNIVGRPMTMELLLAGCTVSVTHRFTQNLKIYIENADLLIVAVGQANFIPGSWIKQGAIVIDVGINRLNNGNI
VGDVHFSSAYERAAYITPVPGGVGPMTVVTLIQNTLQAYDDHHLVR

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=291, Percent_Identity=41.5807560137457, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI94721354, Length=291, Percent_Identity=41.9243986254296, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI222136639, Length=287, Percent_Identity=41.1149825783972, Blast_Score=206, Evalue=1e-53,
Organism=Homo sapiens, GI36796743, Length=228, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1786741, Length=283, Percent_Identity=68.5512367491166, Blast_Score=417, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17568735, Length=288, Percent_Identity=40.2777777777778, Blast_Score=183, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321643, Length=295, Percent_Identity=38.6440677966102, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319558, Length=283, Percent_Identity=39.2226148409894, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322933, Length=313, Percent_Identity=25.5591054313099, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136818, Length=299, Percent_Identity=39.7993311036789, Blast_Score=213, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17136816, Length=299, Percent_Identity=39.7993311036789, Blast_Score=212, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24645718, Length=286, Percent_Identity=38.1118881118881, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137370, Length=286, Percent_Identity=38.1118881118881, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI62472483, Length=286, Percent_Identity=38.1118881118881, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI45551871, Length=286, Percent_Identity=38.1118881118881, Blast_Score=191, Evalue=4e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_BLOPB (Q493A0)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277817.1
- HSSP:   O50385
- ProteinModelPortal:   Q493A0
- SMR:   Q493A0
- STRING:   Q493A0
- GeneID:   3562590
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_313
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   GIDNTKV
- ProtClustDB:   PRK10792
- BioCyc:   CBLO291272:BPEN_313-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 31630; Mature: 31630

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAKIIDGKYVSEKIKQEIAKQVRKNMNSGKRAPGLAMILVGHNPISQIYVTNKKKACEQ
CCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCHHHHHH
VGLISFLYTLPITATENEIFQLIETLNNDNRIDGILIQLPLPNKLNKINVLEHIAPDKDV
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCC
DGFHPYNVGRLCQRSPTLRPCTSRGIITLLEWYNIDMFVLHAVVVGASNIVGRPMTMELL
CCCCCCCHHHHHHCCCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHCCHHHCCCCHHHHHH
LAGCTVSVTHRFTQNLKIYIENADLLIVAVGQANFIPGSWIKQGAIVIDVGINRLNNGNI
HHCCEEEEHHHHCCCEEEEEECCCEEEEEECCCCCCCCHHHHCCCEEEEECCCCCCCCCE
VGDVHFSSAYERAAYITPVPGGVGPMTVVTLIQNTLQAYDDHHLVR
EEEEECCCHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIAKIIDGKYVSEKIKQEIAKQVRKNMNSGKRAPGLAMILVGHNPISQIYVTNKKKACEQ
CCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEECCHHHHHH
VGLISFLYTLPITATENEIFQLIETLNNDNRIDGILIQLPLPNKLNKINVLEHIAPDKDV
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCC
DGFHPYNVGRLCQRSPTLRPCTSRGIITLLEWYNIDMFVLHAVVVGASNIVGRPMTMELL
CCCCCCCHHHHHHCCCCCCCCCCCCCEEEHHHHCCHHHHHHHHHHCCHHHCCCCHHHHHH
LAGCTVSVTHRFTQNLKIYIENADLLIVAVGQANFIPGSWIKQGAIVIDVGINRLNNGNI
HHCCEEEEHHHHCCCEEEEEECCCEEEEEECCCCCCCCHHHHCCCEEEEECCCCCCCCCE
VGDVHFSSAYERAAYITPVPGGVGPMTVVTLIQNTLQAYDDHHLVR
EEEEECCCHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA