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The map label for this gene is dxs

Identifier: 71892018

GI number: 71892018

Start: 274265

End: 276139

Strand: Reverse

Name: dxs

Synonym: BPEN_244

Alternate gene names: 71892018

Gene position: 276139-274265 (Counterclockwise)

Preceding gene: 71892019

Following gene: 71892009

Centisome position: 34.88

GC content: 34.35

Gene sequence:

>1875_bases
ATGAACTGTAATTCAAATAAATACCCCATATTAGGTTTAATCAATACTCCTAAAGAATTAAGACAATTATCTGAAGATCA
TTTAGCAAAGTTGTGTAATGAGTTACGTCAATTTCTTTTAACTAGTGTTAGCAAATCTAGCGGACATTTTGCATCTGGAT
TAGGGACTATTGAACTTACCGTAGCATTACATTACGTATATAATACTCCATTTGATTATTTAATTTGGGATGTAGGGCAT
CAGGCATATCCACATAAAATTCTTACGGGGCGGCGCGAACGTATTTTTAGTATTAGAAGGAAGAACGGATTACATCCATT
TCCTTGTCGTGATGAAAGCGAATATGATGTTTTATCAGTGGGACATTCCTCTACTTCAATTAGCGCGGGGTTAGGTCTAG
CAATAGCGGCAGAACGAGAAATGCTAGGACGTCGCACAGTATGCGTGATAGGAGACGGAGCAATAACTGCTGGGATGGCC
TTTGAAGCAATGAACCATGCTGGATTTACAAAATCTGATTTATTGATTATTTTAAATGATAACGAAATGTCTATTTCAGA
AAACGTAGGAGCATTAAACAATCATCATACTCATATTTTATCAAAAAAAGTATATTCCAATTTAAAAGTAGACAATAATA
AAATATTATCTGACGTTCTTTCAACTAATACATTGATTAAACATATTGGTAACCAAATCAAAAATTTTAATGGCACATCA
AGTTCATTATTTTCACAACTTGGTTTTAATTATATTGGCCCCGTTAATGGACACGATGTATTAGAATTAGTATATATTTT
GAGAAATATACGTGATATGAAAGGTCCACAATTCTTACATATTATTACCAAAAAAGGTTGCGGCTATGAACCTGCAGAAA
AAGATCCTATTAAGTGGCACGCAGTACCAAAATTTAATCCTGAAAGCGGATCGTTACCTGTAGAGCATTCTAAAAATATA
ACTTATTCTGCAATTTTTGGTGATTGGTTATGCCAAGTTGCGGCTCGAGATAATAAGATTATAGGAATTACGCCCGCGAT
GAGAGAAGGTTCTGGAATGAGTATCTTCTCTCAGAAATATCCAAAACAGTATTTTGATGTTGCAATTGCTGAACAACATG
CTGTGACATTTGCTGCTGGATTAGCTATAGCGGGTTATAAACCTATTGTCGCTATTTATTCAACATTTTTACAACGCGCA
TATGATCAAGTAATCCATGACGTAGCAATTCAGAATTTGCCTGTGTTATTTGCTGTCGATCGAGGAGGTATTGTCGGAGC
AGATGGGCAAACTCACCAAGGCGCTTTTGATTTATCGTATTTACGTTGTATTCCGAATATGATAATAATGACCCCAAGTG
ATGCGTGTGAATGTAAGTTGATGTTATATACAGGATATCGTTATCGATATGGACCTAGTGTTGTACGTTATCCTAAGGGA
TATGCTGTACCCGGTAATTTAGCAGATACAACAAAATTGTATACTTTACCATTAAGTAAAGGTGTGATACGTCGCCAAGG
AAATTGCATTGCAATTCTTAATTTCGGAACTTTATTGCAATCAGCCTATAATGTTGCATCTAAATTAAATGCGACCCTAG
TAGATATGAGATTTGTTAAGCCATTAGATGAAAACTTAATAAAAACTCTTGCTAAAAATCATCAAGTATTAATAACATTA
GAGGAAAATACAGTAATGGGTGGAGCCGGAAGCGGGGTAAATGAATTTATTATGCAAAATAAGCTATCAATTCCTGTTTT
AAATATTGGTTTGCCTGATTTTTTTATTTCTCAAGGTTCACAATCAGAGATACTTTCTGAATTGGGATTAGATAGCATAG
GCATTTATAAAAAAATTATAAAATGGATACATTAA

Upstream 100 bases:

>100_bases
AATTAGGCTATAACGTTAATATTTTATCTGCATTTTCGCGTTATATTATTAAACGTAACAACTAAAATTACATAAATAAA
CAATATTAAATAAATTTAAT

Downstream 100 bases:

>100_bases
CAAGGTTATATTCAATGTAGTATGACGTTTGAATAATCTAACGCGCATAAATTTAACTTTCAATATTATTGACATATATA
TGTTTTATAAAACATTTTAA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MNCNSNKYPILGLINTPKELRQLSEDHLAKLCNELRQFLLTSVSKSSGHFASGLGTIELTVALHYVYNTPFDYLIWDVGH
QAYPHKILTGRRERIFSIRRKNGLHPFPCRDESEYDVLSVGHSSTSISAGLGLAIAAEREMLGRRTVCVIGDGAITAGMA
FEAMNHAGFTKSDLLIILNDNEMSISENVGALNNHHTHILSKKVYSNLKVDNNKILSDVLSTNTLIKHIGNQIKNFNGTS
SSLFSQLGFNYIGPVNGHDVLELVYILRNIRDMKGPQFLHIITKKGCGYEPAEKDPIKWHAVPKFNPESGSLPVEHSKNI
TYSAIFGDWLCQVAARDNKIIGITPAMREGSGMSIFSQKYPKQYFDVAIAEQHAVTFAAGLAIAGYKPIVAIYSTFLQRA
YDQVIHDVAIQNLPVLFAVDRGGIVGADGQTHQGAFDLSYLRCIPNMIIMTPSDACECKLMLYTGYRYRYGPSVVRYPKG
YAVPGNLADTTKLYTLPLSKGVIRRQGNCIAILNFGTLLQSAYNVASKLNATLVDMRFVKPLDENLIKTLAKNHQVLITL
EENTVMGGAGSGVNEFIMQNKLSIPVLNIGLPDFFISQGSQSEILSELGLDSIGIYKKIIKWIH

Sequences:

>Translated_624_residues
MNCNSNKYPILGLINTPKELRQLSEDHLAKLCNELRQFLLTSVSKSSGHFASGLGTIELTVALHYVYNTPFDYLIWDVGH
QAYPHKILTGRRERIFSIRRKNGLHPFPCRDESEYDVLSVGHSSTSISAGLGLAIAAEREMLGRRTVCVIGDGAITAGMA
FEAMNHAGFTKSDLLIILNDNEMSISENVGALNNHHTHILSKKVYSNLKVDNNKILSDVLSTNTLIKHIGNQIKNFNGTS
SSLFSQLGFNYIGPVNGHDVLELVYILRNIRDMKGPQFLHIITKKGCGYEPAEKDPIKWHAVPKFNPESGSLPVEHSKNI
TYSAIFGDWLCQVAARDNKIIGITPAMREGSGMSIFSQKYPKQYFDVAIAEQHAVTFAAGLAIAGYKPIVAIYSTFLQRA
YDQVIHDVAIQNLPVLFAVDRGGIVGADGQTHQGAFDLSYLRCIPNMIIMTPSDACECKLMLYTGYRYRYGPSVVRYPKG
YAVPGNLADTTKLYTLPLSKGVIRRQGNCIAILNFGTLLQSAYNVASKLNATLVDMRFVKPLDENLIKTLAKNHQVLITL
EENTVMGGAGSGVNEFIMQNKLSIPVLNIGLPDFFISQGSQSEILSELGLDSIGIYKKIIKWIH
>Mature_624_residues
MNCNSNKYPILGLINTPKELRQLSEDHLAKLCNELRQFLLTSVSKSSGHFASGLGTIELTVALHYVYNTPFDYLIWDVGH
QAYPHKILTGRRERIFSIRRKNGLHPFPCRDESEYDVLSVGHSSTSISAGLGLAIAAEREMLGRRTVCVIGDGAITAGMA
FEAMNHAGFTKSDLLIILNDNEMSISENVGALNNHHTHILSKKVYSNLKVDNNKILSDVLSTNTLIKHIGNQIKNFNGTS
SSLFSQLGFNYIGPVNGHDVLELVYILRNIRDMKGPQFLHIITKKGCGYEPAEKDPIKWHAVPKFNPESGSLPVEHSKNI
TYSAIFGDWLCQVAARDNKIIGITPAMREGSGMSIFSQKYPKQYFDVAIAEQHAVTFAAGLAIAGYKPIVAIYSTFLQRA
YDQVIHDVAIQNLPVLFAVDRGGIVGADGQTHQGAFDLSYLRCIPNMIIMTPSDACECKLMLYTGYRYRYGPSVVRYPKG
YAVPGNLADTTKLYTLPLSKGVIRRQGNCIAILNFGTLLQSAYNVASKLNATLVDMRFVKPLDENLIKTLAKNHQVLITL
EENTVMGGAGSGVNEFIMQNKLSIPVLNIGLPDFFISQGSQSEILSELGLDSIGIYKKIIKWIH

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=531, Percent_Identity=23.1638418079096, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4507521, Length=531, Percent_Identity=23.1638418079096, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI225637463, Length=516, Percent_Identity=21.5116279069767, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI225637459, Length=516, Percent_Identity=21.5116279069767, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI225637461, Length=516, Percent_Identity=21.5116279069767, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI156564403, Length=279, Percent_Identity=24.3727598566308, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=68.8603531300161, Blast_Score=898, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=499, Percent_Identity=23.0460921843687, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24666278, Length=671, Percent_Identity=21.7585692995529, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24645119, Length=474, Percent_Identity=23.8396624472574, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45551847, Length=474, Percent_Identity=23.8396624472574, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI45550715, Length=474, Percent_Identity=23.8396624472574, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI21358145, Length=288, Percent_Identity=23.2638888888889, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650940, Length=288, Percent_Identity=23.2638888888889, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_BLOPB (Q493G7)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277748.1
- ProteinModelPortal:   Q493G7
- SMR:   Q493G7
- STRING:   Q493G7
- GeneID:   3562778
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_244
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   CBLO291272:BPEN_244-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68960; Mature: 68960

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCNSNKYPILGLINTPKELRQLSEDHLAKLCNELRQFLLTSVSKSSGHFASGLGTIELT
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEE
VALHYVYNTPFDYLIWDVGHQAYPHKILTGRRERIFSIRRKNGLHPFPCRDESEYDVLSV
EEEEEECCCCHHHEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
GHSSTSISAGLGLAIAAEREMLGRRTVCVIGDGAITAGMAFEAMNHAGFTKSDLLIILND
CCCCCCCCCCCCEEEEHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECC
NEMSISENVGALNNHHTHILSKKVYSNLKVDNNKILSDVLSTNTLIKHIGNQIKNFNGTS
CCEEHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SSLFSQLGFNYIGPVNGHDVLELVYILRNIRDMKGPQFLHIITKKGCGYEPAEKDPIKWH
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEE
AVPKFNPESGSLPVEHSKNITYSAIFGDWLCQVAARDNKIIGITPAMREGSGMSIFSQKY
ECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHC
PKQYFDVAIAEQHAVTFAAGLAIAGYKPIVAIYSTFLQRAYDQVIHDVAIQNLPVLFAVD
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
RGGIVGADGQTHQGAFDLSYLRCIPNMIIMTPSDACECKLMLYTGYRYRYGPSVVRYPKG
CCCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCEEEEEEECEEEEECCCEEECCCC
YAVPGNLADTTKLYTLPLSKGVIRRQGNCIAILNFGTLLQSAYNVASKLNATLVDMRFVK
CCCCCCCCCCCEEEEEECCCCHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCEEHHHHHC
PLDENLIKTLAKNHQVLITLEENTVMGGAGSGVNEFIMQNKLSIPVLNIGLPDFFISQGS
HHHHHHHHHHHCCCEEEEEEECCEEECCCCCCHHHHHHHCCCCCEEEECCCCHHHHCCCC
QSEILSELGLDSIGIYKKIIKWIH
HHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNCNSNKYPILGLINTPKELRQLSEDHLAKLCNELRQFLLTSVSKSSGHFASGLGTIELT
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEE
VALHYVYNTPFDYLIWDVGHQAYPHKILTGRRERIFSIRRKNGLHPFPCRDESEYDVLSV
EEEEEECCCCHHHEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
GHSSTSISAGLGLAIAAEREMLGRRTVCVIGDGAITAGMAFEAMNHAGFTKSDLLIILND
CCCCCCCCCCCCEEEEHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEECC
NEMSISENVGALNNHHTHILSKKVYSNLKVDNNKILSDVLSTNTLIKHIGNQIKNFNGTS
CCEEHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SSLFSQLGFNYIGPVNGHDVLELVYILRNIRDMKGPQFLHIITKKGCGYEPAEKDPIKWH
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEE
AVPKFNPESGSLPVEHSKNITYSAIFGDWLCQVAARDNKIIGITPAMREGSGMSIFSQKY
ECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHC
PKQYFDVAIAEQHAVTFAAGLAIAGYKPIVAIYSTFLQRAYDQVIHDVAIQNLPVLFAVD
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
RGGIVGADGQTHQGAFDLSYLRCIPNMIIMTPSDACECKLMLYTGYRYRYGPSVVRYPKG
CCCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCEEEEEEECEEEEECCCEEECCCC
YAVPGNLADTTKLYTLPLSKGVIRRQGNCIAILNFGTLLQSAYNVASKLNATLVDMRFVK
CCCCCCCCCCCEEEEEECCCCHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCEEHHHHHC
PLDENLIKTLAKNHQVLITLEENTVMGGAGSGVNEFIMQNKLSIPVLNIGLPDFFISQGS
HHHHHHHHHHHCCCEEEEEEECCEEECCCCCCHHHHHHHCCCCCEEEECCCCHHHHCCCC
QSEILSELGLDSIGIYKKIIKWIH
HHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA