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The map label for this gene is uvrB [H]

Identifier: 68535902

GI number: 68535902

Start: 983110

End: 985257

Strand: Direct

Name: uvrB [H]

Synonym: jk0827

Alternate gene names: 68535902

Gene position: 983110-985257 (Clockwise)

Preceding gene: 68535900

Following gene: 68535903

Centisome position: 39.92

GC content: 63.83

Gene sequence:

>2148_bases
ATGGCCTTTGCAGCAGAACGTCCCGAATTGTCGTACTCCGAGTTCCGTCCCGTGGGGGAGGTCGAACGCTCGAATGCGAA
GTTCGAAGTCATCAGCGACTACAAACCCGCCGGTGACCAGCCGAAGGCGATCGAAGAGCTGCACCAGCGCCTTGACCGTG
GCGAACGCGACGTGGTGTTGATGGGCGCCACCGGTACCGGTAAGTCCGCGACGGCCGCCTGGCTGATCGAAAAGGAGCAG
CGCCCCACCCTGGTGATGGCGCCGAATAAGACGCTGGCCGCCCAGCTGGCCAACGAGCTGCGCAGCCTGCTGCCGAATAA
CGCGGTGGAGTACTTCGTCTCCTACTACGACTACTACCAACCAGAGGCGTATATCGCGCAGACGGATACGTACATCGAGA
AAGACTCGTCCATCAACGAAGACGTGGAGCGCCTACGCCACTCCGCGACCTCCGCGCTGCTGTCGCGCCGGGACGTGGTG
GTTGTGTCCTCGGTCTCCTGCATCTACGGCCTCGGCACCCCGCAGTCTTACCTGGACCGCTCTGTGGTCTTGAAGGTCGA
CGAGGAGGTCGAACGCGATCGGTTCCTGCGCCTGCTGGTGGATATCCAATACTCCCGCAACGACGTCGCCTTTACCCGCG
GCACCTTCCGCGTGAAGGGCGATACGGTGGACATCATTCCGGCCTACGAGGAGCTGGCGGTGCGCGTGGAGTTCTTCGGT
GACGACATCGACGCGCTGTATTACATCCACCCGCTGACCGGCGACGTGATTCGCCAGGTAGACGAGCTGCGCATCTTCCC
GGCCACCCACTATGTGGCCGGCCCGGAGCGCATGGAAAAGGCCATGCAGGCCATCAAGGAGGAGCTGGCGCAGCGCCTGG
AAGAGCTGGAGAACCGCGGCAAGCTGCTGGAGGCCCAGCGCCTGCGCATGCGCACCGAATACGATCTGGAGATGATCCAG
CAGGTGGGCTTCACCAGTGGCATCGAGAACTACTCCCGCCACATCGACGGCCGCGCCGCCGGTTCCGCGCCCGCCACCCT
GATCGATTATTTTCCCGAGGACTTCCTCACCATCATCGACGAGTCTCACGTGACTGTCCCGCAGATCGGCGGAATGTTCG
AAGGCGACATGTCCCGCAAGCGCAACCTGGTGGAGCACGGCTTCCGTCTGCCCAGCGCGCTGGATAACCGGCCGCTGACG
TGGGAGGAGTTCGACGACCGCAAGGGCCAGTGCGTCTACATGTCCGCCACCCCCGGCGATTACGAGATCGCCGCCGCCCA
GGGCGAGTACGTCGAACAGGTCATTCGCCCGACCGGCCTGGTGGATCCGAAGGTGGAGGTGCGCCCGACCGAAGGCCAGA
TCGACGACCTGATCGAGCAGATCCGCCAGCGCACCGAAAAGAACGAGCGCGTGCTGGTCACCACACTGACCAAGCGCATG
GCCGAGGACCTCACCGACTACCTACTGGAGCACGGCGTGAAGGTCCGCTACATGCACTCGGATATCGATACCCTCAAGCG
CGTGGAGCTGCTCCGCCAGCTGCGCCTGGGCGAGTTCGACGTGCTGGTGGGAATCAACCTGCTGCGCGAGGGCCTGGACC
TGCCGGAGGTCTCGCTGGTCGCCATCCTGGACGCGGACAAGGAGGGCTTCCTGCGCTCCGAACGCTCGCTGATCCAGACC
ATCGGCCGTGCTGCCCGTAACGTCTCCGGCGAGGTCATCATGTACGCCGACCAGGTCACCGACTCGATGCAGTACGCCAT
CGACGAGACGGAGCGCCGCCGCGCCAAGCAGATCGCCTACAACGAAGAGCACGGCATTGATCCGCAGCCTTTGCGTAAGA
AGATCGCCGATATCTTGGACCAGGTCGCGGAGCTAGAAGCGGAATCTGGTGCGGACGCCGCAGGCGGCGCCGGCGCCGAT
TCCAGCGCCGGTGGGCGGGGTGAATCGCCCGAGGCCGACTGGGCGCTGGTGCGCGGTTCCAGCGAGGAACCGATGGCCCG
CCCGCAGCTGGAGAAGCTGATCCAGGAGATGACAGAGCAGATGAAATCGGCGGCCAAGGAACTGAAGTTCGAGCTCGCCG
GCCGTCTCCGCGACGAAATCGCGGACCTAAAAAAGGAACTACGGGGCATGATCGAAGCTGGGTTGTAA

Upstream 100 bases:

>100_bases
GGAGAAGAGCTTCATGTGATTAACCTTAGAACGGCCACAGTAAAAGCGCTGGGTGACAGCACGGCAGGTGGTGTCCGGTG
CGGTAAGTAGACTGGTGCGC

Downstream 100 bases:

>100_bases
TATTAGAGTTATGTACAACACAGTCGTGGTCGGAACCGATGGGTCGGAATCTTCTTTTCTAGCAGTGCGACGCGCCGCGG
GCGTAGCCGCCGCCATGGAC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 715; Mature: 714

Protein sequence:

>715_residues
MAFAAERPELSYSEFRPVGEVERSNAKFEVISDYKPAGDQPKAIEELHQRLDRGERDVVLMGATGTGKSATAAWLIEKEQ
RPTLVMAPNKTLAAQLANELRSLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINEDVERLRHSATSALLSRRDVV
VVSSVSCIYGLGTPQSYLDRSVVLKVDEEVERDRFLRLLVDIQYSRNDVAFTRGTFRVKGDTVDIIPAYEELAVRVEFFG
DDIDALYYIHPLTGDVIRQVDELRIFPATHYVAGPERMEKAMQAIKEELAQRLEELENRGKLLEAQRLRMRTEYDLEMIQ
QVGFTSGIENYSRHIDGRAAGSAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEHGFRLPSALDNRPLT
WEEFDDRKGQCVYMSATPGDYEIAAAQGEYVEQVIRPTGLVDPKVEVRPTEGQIDDLIEQIRQRTEKNERVLVTTLTKRM
AEDLTDYLLEHGVKVRYMHSDIDTLKRVELLRQLRLGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSERSLIQT
IGRAARNVSGEVIMYADQVTDSMQYAIDETERRRAKQIAYNEEHGIDPQPLRKKIADILDQVAELEAESGADAAGGAGAD
SSAGGRGESPEADWALVRGSSEEPMARPQLEKLIQEMTEQMKSAAKELKFELAGRLRDEIADLKKELRGMIEAGL

Sequences:

>Translated_715_residues
MAFAAERPELSYSEFRPVGEVERSNAKFEVISDYKPAGDQPKAIEELHQRLDRGERDVVLMGATGTGKSATAAWLIEKEQ
RPTLVMAPNKTLAAQLANELRSLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINEDVERLRHSATSALLSRRDVV
VVSSVSCIYGLGTPQSYLDRSVVLKVDEEVERDRFLRLLVDIQYSRNDVAFTRGTFRVKGDTVDIIPAYEELAVRVEFFG
DDIDALYYIHPLTGDVIRQVDELRIFPATHYVAGPERMEKAMQAIKEELAQRLEELENRGKLLEAQRLRMRTEYDLEMIQ
QVGFTSGIENYSRHIDGRAAGSAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEHGFRLPSALDNRPLT
WEEFDDRKGQCVYMSATPGDYEIAAAQGEYVEQVIRPTGLVDPKVEVRPTEGQIDDLIEQIRQRTEKNERVLVTTLTKRM
AEDLTDYLLEHGVKVRYMHSDIDTLKRVELLRQLRLGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSERSLIQT
IGRAARNVSGEVIMYADQVTDSMQYAIDETERRRAKQIAYNEEHGIDPQPLRKKIADILDQVAELEAESGADAAGGAGAD
SSAGGRGESPEADWALVRGSSEEPMARPQLEKLIQEMTEQMKSAAKELKFELAGRLRDEIADLKKELRGMIEAGL
>Mature_714_residues
AFAAERPELSYSEFRPVGEVERSNAKFEVISDYKPAGDQPKAIEELHQRLDRGERDVVLMGATGTGKSATAAWLIEKEQR
PTLVMAPNKTLAAQLANELRSLLPNNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINEDVERLRHSATSALLSRRDVVV
VSSVSCIYGLGTPQSYLDRSVVLKVDEEVERDRFLRLLVDIQYSRNDVAFTRGTFRVKGDTVDIIPAYEELAVRVEFFGD
DIDALYYIHPLTGDVIRQVDELRIFPATHYVAGPERMEKAMQAIKEELAQRLEELENRGKLLEAQRLRMRTEYDLEMIQQ
VGFTSGIENYSRHIDGRAAGSAPATLIDYFPEDFLTIIDESHVTVPQIGGMFEGDMSRKRNLVEHGFRLPSALDNRPLTW
EEFDDRKGQCVYMSATPGDYEIAAAQGEYVEQVIRPTGLVDPKVEVRPTEGQIDDLIEQIRQRTEKNERVLVTTLTKRMA
EDLTDYLLEHGVKVRYMHSDIDTLKRVELLRQLRLGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSERSLIQTI
GRAARNVSGEVIMYADQVTDSMQYAIDETERRRAKQIAYNEEHGIDPQPLRKKIADILDQVAELEAESGADAAGGAGADS
SAGGRGESPEADWALVRGSSEEPMARPQLEKLIQEMTEQMKSAAKELKFELAGRLRDEIADLKKELRGMIEAGL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=680, Percent_Identity=56.7647058823529, Blast_Score=744, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 80687; Mature: 80556

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFAAERPELSYSEFRPVGEVERSNAKFEVISDYKPAGDQPKAIEELHQRLDRGERDVVL
CCCCCCCCCCCHHHCCCCCCHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEE
MGATGTGKSATAAWLIEKEQRPTLVMAPNKTLAAQLANELRSLLPNNAVEYFVSYYDYYQ
EECCCCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
PEAYIAQTDTYIEKDSSINEDVERLRHSATSALLSRRDVVVVSSVSCIYGLGTPQSYLDR
CCEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHCC
SVVLKVDEEVERDRFLRLLVDIQYSRNDVAFTRGTFRVKGDTVDIIPAYEELAVRVEFFG
EEEEEEHHHHHHHHHHHHHHHHEECCCCEEEECCEEEECCCEEEEEECHHHHEEEEEEEC
DDIDALYYIHPLTGDVIRQVDELRIFPATHYVAGPERMEKAMQAIKEELAQRLEELENRG
CCCCEEEEEECCCHHHHHHHHHHEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KLLEAQRLRMRTEYDLEMIQQVGFTSGIENYSRHIDGRAAGSAPATLIDYFPEDFLTIID
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHC
ESHVTVPQIGGMFEGDMSRKRNLVEHGFRLPSALDNRPLTWEEFDDRKGQCVYMSATPGD
CCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCHHHCCCCCCEEEEECCCCC
YEIAAAQGEYVEQVIRPTGLVDPKVEVRPTEGQIDDLIEQIRQRTEKNERVLVTTLTKRM
EEEEECCHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHH
AEDLTDYLLEHGVKVRYMHSDIDTLKRVELLRQLRLGEFDVLVGINLLREGLDLPEVSLV
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEE
AILDADKEGFLRSERSLIQTIGRAARNVSGEVIMYADQVTDSMQYAIDETERRRAKQIAY
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCC
NEEHGIDPQPLRKKIADILDQVAELEAESGADAAGGAGADSSAGGRGESPEADWALVRGS
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
SEEPMARPQLEKLIQEMTEQMKSAAKELKFELAGRLRDEIADLKKELRGMIEAGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFAAERPELSYSEFRPVGEVERSNAKFEVISDYKPAGDQPKAIEELHQRLDRGERDVVL
CCCCCCCCCCHHHCCCCCCHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCEEE
MGATGTGKSATAAWLIEKEQRPTLVMAPNKTLAAQLANELRSLLPNNAVEYFVSYYDYYQ
EECCCCCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
PEAYIAQTDTYIEKDSSINEDVERLRHSATSALLSRRDVVVVSSVSCIYGLGTPQSYLDR
CCEEEECCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCHHHHCC
SVVLKVDEEVERDRFLRLLVDIQYSRNDVAFTRGTFRVKGDTVDIIPAYEELAVRVEFFG
EEEEEEHHHHHHHHHHHHHHHHEECCCCEEEECCEEEECCCEEEEEECHHHHEEEEEEEC
DDIDALYYIHPLTGDVIRQVDELRIFPATHYVAGPERMEKAMQAIKEELAQRLEELENRG
CCCCEEEEEECCCHHHHHHHHHHEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KLLEAQRLRMRTEYDLEMIQQVGFTSGIENYSRHIDGRAAGSAPATLIDYFPEDFLTIID
CHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHC
ESHVTVPQIGGMFEGDMSRKRNLVEHGFRLPSALDNRPLTWEEFDDRKGQCVYMSATPGD
CCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCCCCCHHHCCCCCCEEEEECCCCC
YEIAAAQGEYVEQVIRPTGLVDPKVEVRPTEGQIDDLIEQIRQRTEKNERVLVTTLTKRM
EEEEECCHHHHHHHHCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCEEEEHHHHHHH
AEDLTDYLLEHGVKVRYMHSDIDTLKRVELLRQLRLGEFDVLVGINLLREGLDLPEVSLV
HHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEE
AILDADKEGFLRSERSLIQTIGRAARNVSGEVIMYADQVTDSMQYAIDETERRRAKQIAY
EEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCC
NEEHGIDPQPLRKKIADILDQVAELEAESGADAAGGAGADSSAGGRGESPEADWALVRGS
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
SEEPMARPQLEKLIQEMTEQMKSAAKELKFELAGRLRDEIADLKKELRGMIEAGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]