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The map label for this gene is murC

Identifier: 68535826

GI number: 68535826

Start: 897878

End: 899374

Strand: Direct

Name: murC

Synonym: jk0751

Alternate gene names: 68535826

Gene position: 897878-899374 (Clockwise)

Preceding gene: 68535825

Following gene: 68535827

Centisome position: 36.46

GC content: 62.12

Gene sequence:

>1497_bases
ATGAGCGATCAGCTTCAGACCACGGACCTCTCCCGCGTGCACATGGTGGGCATCGGTGGTGCCGGCATGTCCGGTATCGC
CCGCATCCTGCTGGATCGCGGCTACCAGGTCAGTGGGTCGGATATGAAGGAGTCGCGCAGCATCATGGCGCTGCGTGCGG
CCGGCGCGCAGATTCAGGTCGGGCACGCTGAGGATAACCTGCGCTTGTCCGGGGAGATGCCGACGGTAGTCGTTACCTCT
TTCGCCGCGATTCCGCAGGATAACCCGGAGCTCGTTGGTGCCCGCGAAGCAGGTATTCCGGTGCTTCGCCGTTCGGACAT
TCTGGCGCTATTGCTGCAGGATCGCCGTGCTTTTTTGCTGGCGGGTACGCACGGTAAGACTTCCACGACGTCGATGGCTG
TCGCGGCGCTTCAGGCTGCAGGCCAGGACCCTTCCTTCGCCATCGGTGGCCAGCTGAACCGCGCGGGCACGAATGCCCAC
AACGGCACCGGTGAAGTTTTCGTCGCGGAGGCCGACGAATCCGATGGGTCTTTCCTGTCCTACTCTCCTGAGATCGCGGT
GGTTACGAACATAGAGCCCGACCACCTGGATTATTTCAAGACTGAATCTGCCTACCGCGAGGTCTTCGAAAAATTTGCTC
ACCGCATTGTGCCGGGCGGCTTCCTGGTTGTGTGCCTCGACGATCCAGGTTCGGCAGCACTCGCCGAGGAGCTCATCGCC
GGTGCCGAGGAAGGCAATCCCTTGCCGTTTACCGTCGTTGGTTATGGCACTGCCGAGGGGTGTGACGCCCACCCCTCCGT
GCCCCCAGCAGCGATCATCGAAAGCACGGAGGTTACTGCCGAGGGCACAGTTTCTGCCCTGCGGCTGACCGAAGAAGTCA
AGAAGGCAGCCGAGGAGGCGGCGGGAACTTACTCGCTGCGTGTGGCCATCCCAGGTATCCACATGGTGTTGAATGCTGCG
GCCGCCGTACTGGGCAGCGTGCTGCTGGGCGCTGATGTGGATAAGGTCATCGCAGGTATCGGTGGTTTCGACGGTGTGCG
CCGTCGCTTCGAGTACCACGGGACCCGTCAGGACGTGGAAGTCTACGACGATTACGCTCACCACCCGACCGAGGTTGCGG
CTGTTTTAGCTGCGGCGCGTCAACGGGTGGAGGCACGCGGCGGGCGTATCGTGGCCGTTTTCCAGCCGCACCTCTACTCG
CGCACGATGAACTTCGCCGACGAGTTTGCCGAGGCATTGTCCCTGGCCGATCAGGTAGTTTTGCTGGACATCTTCGGCGC
CCGCGAAGAGCCCGTGGAGGGAGTGGATTCGCGCATCATCGGAAACAAGATCGACGCTTCCACCGACTGGGTTTTCGAAC
CTGACTTCTCGAAGGTCTCCAGCGTAGTCGCCGGGCTGGTGCAGCCTGGCGACATGGTGCTGACGATTGGCGCGGGCACC
GTGACGATGCTGGCGGACGAGATTCTACTGGAACTGGACCGTGGTGATCGCGGGTGA

Upstream 100 bases:

>100_bases
CGGCCGAGAAGATCGCCGAGAAGATCATCGCAGCAGCCGACGCTTAAGCACCGTTCCCAATTATTCCCCCCTCCCTTTTA
GAAAGGCATCTTCTTCCACG

Downstream 100 bases:

>100_bases
GCAGGGCGTCAAAAATAGGCAACAAGAAGAAGCAGCAGAAGCAAAACCTGCCACGTAAGCGCCTGCAGCGATTGGTAGCA
GGGCTGGTGGCTCTCGTCGT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSDQLQTTDLSRVHMVGIGGAGMSGIARILLDRGYQVSGSDMKESRSIMALRAAGAQIQVGHAEDNLRLSGEMPTVVVTS
FAAIPQDNPELVGAREAGIPVLRRSDILALLLQDRRAFLLAGTHGKTSTTSMAVAALQAAGQDPSFAIGGQLNRAGTNAH
NGTGEVFVAEADESDGSFLSYSPEIAVVTNIEPDHLDYFKTESAYREVFEKFAHRIVPGGFLVVCLDDPGSAALAEELIA
GAEEGNPLPFTVVGYGTAEGCDAHPSVPPAAIIESTEVTAEGTVSALRLTEEVKKAAEEAAGTYSLRVAIPGIHMVLNAA
AAVLGSVLLGADVDKVIAGIGGFDGVRRRFEYHGTRQDVEVYDDYAHHPTEVAAVLAAARQRVEARGGRIVAVFQPHLYS
RTMNFADEFAEALSLADQVVLLDIFGAREEPVEGVDSRIIGNKIDASTDWVFEPDFSKVSSVVAGLVQPGDMVLTIGAGT
VTMLADEILLELDRGDRG

Sequences:

>Translated_498_residues
MSDQLQTTDLSRVHMVGIGGAGMSGIARILLDRGYQVSGSDMKESRSIMALRAAGAQIQVGHAEDNLRLSGEMPTVVVTS
FAAIPQDNPELVGAREAGIPVLRRSDILALLLQDRRAFLLAGTHGKTSTTSMAVAALQAAGQDPSFAIGGQLNRAGTNAH
NGTGEVFVAEADESDGSFLSYSPEIAVVTNIEPDHLDYFKTESAYREVFEKFAHRIVPGGFLVVCLDDPGSAALAEELIA
GAEEGNPLPFTVVGYGTAEGCDAHPSVPPAAIIESTEVTAEGTVSALRLTEEVKKAAEEAAGTYSLRVAIPGIHMVLNAA
AAVLGSVLLGADVDKVIAGIGGFDGVRRRFEYHGTRQDVEVYDDYAHHPTEVAAVLAAARQRVEARGGRIVAVFQPHLYS
RTMNFADEFAEALSLADQVVLLDIFGAREEPVEGVDSRIIGNKIDASTDWVFEPDFSKVSSVVAGLVQPGDMVLTIGAGT
VTMLADEILLELDRGDRG
>Mature_497_residues
SDQLQTTDLSRVHMVGIGGAGMSGIARILLDRGYQVSGSDMKESRSIMALRAAGAQIQVGHAEDNLRLSGEMPTVVVTSF
AAIPQDNPELVGAREAGIPVLRRSDILALLLQDRRAFLLAGTHGKTSTTSMAVAALQAAGQDPSFAIGGQLNRAGTNAHN
GTGEVFVAEADESDGSFLSYSPEIAVVTNIEPDHLDYFKTESAYREVFEKFAHRIVPGGFLVVCLDDPGSAALAEELIAG
AEEGNPLPFTVVGYGTAEGCDAHPSVPPAAIIESTEVTAEGTVSALRLTEEVKKAAEEAAGTYSLRVAIPGIHMVLNAAA
AVLGSVLLGADVDKVIAGIGGFDGVRRRFEYHGTRQDVEVYDDYAHHPTEVAAVLAAARQRVEARGGRIVAVFQPHLYSR
TMNFADEFAEALSLADQVVLLDIFGAREEPVEGVDSRIIGNKIDASTDWVFEPDFSKVSSVVAGLVQPGDMVLTIGAGTV
TMLADEILLELDRGDRG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=488, Percent_Identity=35.4508196721311, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1790680, Length=482, Percent_Identity=29.045643153527, Blast_Score=154, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_CORJK (Q4JW94)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250531.1
- ProteinModelPortal:   Q4JW94
- SMR:   Q4JW94
- STRING:   Q4JW94
- GeneID:   3432773
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0751
- NMPDR:   fig|306537.3.peg.1610
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   CJEI306537:JK0751-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 52582; Mature: 52451

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQLQTTDLSRVHMVGIGGAGMSGIARILLDRGYQVSGSDMKESRSIMALRAAGAQIQV
CCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEECCCEEEE
GHAEDNLRLSGEMPTVVVTSFAAIPQDNPELVGAREAGIPVLRRSDILALLLQDRRAFLL
ECCCCCEEECCCCCEEEEEHHHHCCCCCCCEECCHHCCCCEEEHHHHHHHHHHCCCEEEE
AGTHGKTSTTSMAVAALQAAGQDPSFAIGGQLNRAGTNAHNGTGEVFVAEADESDGSFLS
EECCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEE
YSPEIAVVTNIEPDHLDYFKTESAYREVFEKFAHRIVPGGFLVVCLDDPGSAALAEELIA
ECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHC
GAEEGNPLPFTVVGYGTAEGCDAHPSVPPAAIIESTEVTAEGTVSALRLTEEVKKAAEEA
CCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHC
AGTYSLRVAIPGIHMVLNAAAAVLGSVLLGADVDKVIAGIGGFDGVRRRFEYHGTRQDVE
CCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHCCCCCCHH
VYDDYAHHPTEVAAVLAAARQRVEARGGRIVAVFQPHLYSRTMNFADEFAEALSLADQVV
HHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHEE
LLDIFGAREEPVEGVDSRIIGNKIDASTDWVFEPDFSKVSSVVAGLVQPGDMVLTIGAGT
EEEECCCCCCCCCCHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCEEEEECCCH
VTMLADEILLELDRGDRG
HHHHHHHHHHEECCCCCC
>Mature Secondary Structure 
SDQLQTTDLSRVHMVGIGGAGMSGIARILLDRGYQVSGSDMKESRSIMALRAAGAQIQV
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEECCCEEEE
GHAEDNLRLSGEMPTVVVTSFAAIPQDNPELVGAREAGIPVLRRSDILALLLQDRRAFLL
ECCCCCEEECCCCCEEEEEHHHHCCCCCCCEECCHHCCCCEEEHHHHHHHHHHCCCEEEE
AGTHGKTSTTSMAVAALQAAGQDPSFAIGGQLNRAGTNAHNGTGEVFVAEADESDGSFLS
EECCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCEEE
YSPEIAVVTNIEPDHLDYFKTESAYREVFEKFAHRIVPGGFLVVCLDDPGSAALAEELIA
ECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHC
GAEEGNPLPFTVVGYGTAEGCDAHPSVPPAAIIESTEVTAEGTVSALRLTEEVKKAAEEA
CCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHC
AGTYSLRVAIPGIHMVLNAAAAVLGSVLLGADVDKVIAGIGGFDGVRRRFEYHGTRQDVE
CCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHCCCCCCHH
VYDDYAHHPTEVAAVLAAARQRVEARGGRIVAVFQPHLYSRTMNFADEFAEALSLADQVV
HHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHEE
LLDIFGAREEPVEGVDSRIIGNKIDASTDWVFEPDFSKVSSVVAGLVQPGDMVLTIGAGT
EEEECCCCCCCCCCHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCEEEEECCCH
VTMLADEILLELDRGDRG
HHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA