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The map label for this gene is bioC [H]

Identifier: 66766738

GI number: 66766738

Start: 457378

End: 458262

Strand: Reverse

Name: bioC [H]

Synonym: XC_0395

Alternate gene names: 66766738

Gene position: 458262-457378 (Counterclockwise)

Preceding gene: 66766739

Following gene: 66766737

Centisome position: 8.9

GC content: 70.51

Gene sequence:

>885_bases
ATGAACAGCACTTTCGACCCCCGCCACGTCCGGCGCGCCTTCGCGCGTGCCGCCAGCAGCTATGCCGCCGCCGCCGCCCT
GCAACGCGAGGTGGAAACGCGCCTGCTGGAGTCGCTCGACTATCTCGGCGACACCGCGCCCAAGGTGGTGCTGGATGTGG
GTGCCGGCCCGGGCCATGCCAGCGCCACGATCAAGAAACGCTGGCCCAAGGCGCAGGTGATCGCGCTCGACCAGGCACTG
CCGATGCTGCGCCAGGCGCGCAAGACTGCGGGTTGGTGGAAGCCGTTTGCGCAGGTCTGCGCCGATGCCCGCGCGCTGCC
GGTGGCCGATGGCAGCGTGGATGTGATCTTCAGCAATCTGTGCCTGCAGTGGGTGGAAGACCTGCCGGCGGTGTTTGCCG
GCTTTCGGCGTGCGTTGCGGCCCGGCGGCCTGCTGCTGTGCTCCACCTTCGGCCCGGAAACGTTGATCGAACTGCGCGAG
GCCTTCGCGCAGGCCGACCCGGCCCCGCATGTGAGCCGGTTCCCGCCGATTGCGCAGTTTGGCGATGCGCTGATGATGTC
CGGCTTCCGCGACCCGGTGCTGGACCGCGACCTGTTCACCCTCACCTACAACGACCTGCCGGCCTTGATGCGCGAGTTGC
GCGCGATGGGCGCCACCAATGCGCTCAGCAACCGCCGCGCCACGCTGACCGGCCGCGGCCGCTTCGCCGCCGCCAGTGCG
GCCTACGAACCCCTGCGGCGGCCCGATGGCACCCTGCCCAGTTCGTGGGAAGTCATCTACGCGCACGCCTGGGCACCGGC
GCCGGGCGCTCCGATCCGCGAACGCGGGCAGGACATCGCCAGCGTGCCGGTGGGCGCGATCCCGATCCGCCGCCGCCAGG
ACTAA

Upstream 100 bases:

>100_bases
TTGACGCCACTGGCGCTGCGCATCAACACGCCGCCGCGCATCACACCGTGTCGCTGCGGCAATTCCCTCGGCGGCGTGCA
GCGGCGACAATAGCGCGGCA

Downstream 100 bases:

>100_bases
GCGTGGCGATCACTGCGCGCGCGCAGCCGCCAGGCAGGCGCGGCCGCGGCATGCACCAGTCGCCTGCTTCGGTCCCCGTT
GCCTCCGACAGCACCCCGGC

Product: biotin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNSTFDPRHVRRAFARAASSYAAAAALQREVETRLLESLDYLGDTAPKVVLDVGAGPGHASATIKKRWPKAQVIALDQAL
PMLRQARKTAGWWKPFAQVCADARALPVADGSVDVIFSNLCLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELRE
AFAQADPAPHVSRFPPIAQFGDALMMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIRERGQDIASVPVGAIPIRRRQD

Sequences:

>Translated_294_residues
MNSTFDPRHVRRAFARAASSYAAAAALQREVETRLLESLDYLGDTAPKVVLDVGAGPGHASATIKKRWPKAQVIALDQAL
PMLRQARKTAGWWKPFAQVCADARALPVADGSVDVIFSNLCLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELRE
AFAQADPAPHVSRFPPIAQFGDALMMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIRERGQDIASVPVGAIPIRRRQD
>Mature_294_residues
MNSTFDPRHVRRAFARAASSYAAAAALQREVETRLLESLDYLGDTAPKVVLDVGAGPGHASATIKKRWPKAQVIALDQAL
PMLRQARKTAGWWKPFAQVCADARALPVADGSVDVIFSNLCLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELRE
AFAQADPAPHVSRFPPIAQFGDALMMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIRERGQDIASVPVGAIPIRRRQD

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=244, Percent_Identity=29.5081967213115, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI86792933, Length=151, Percent_Identity=33.112582781457, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI1786994, Length=223, Percent_Identity=30.9417040358744, Blast_Score=92, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17535003, Length=268, Percent_Identity=24.6268656716418, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922210, Length=250, Percent_Identity=32.8, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 32038; Mature: 32038

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTFDPRHVRRAFARAASSYAAAAALQREVETRLLESLDYLGDTAPKVVLDVGAGPGHA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
SATIKKRWPKAQVIALDQALPMLRQARKTAGWWKPFAQVCADARALPVADGSVDVIFSNL
CCHHHHHCCCHHEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
CLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELREAFAQADPAPHVSRFPPIAQF
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
GDALMMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
HHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCHHHHHH
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIRERGQDIASVPVGAIPIRRRQD
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MNSTFDPRHVRRAFARAASSYAAAAALQREVETRLLESLDYLGDTAPKVVLDVGAGPGHA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCC
SATIKKRWPKAQVIALDQALPMLRQARKTAGWWKPFAQVCADARALPVADGSVDVIFSNL
CCHHHHHCCCHHEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
CLQWVEDLPAVFAGFRRALRPGGLLLCSTFGPETLIELREAFAQADPAPHVSRFPPIAQF
HHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
GDALMMSGFRDPVLDRDLFTLTYNDLPALMRELRAMGATNALSNRRATLTGRGRFAAASA
HHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHCCCCEEEECCCCHHHHHH
AYEPLRRPDGTLPSSWEVIYAHAWAPAPGAPIRERGQDIASVPVGAIPIRRRQD
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHCCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]