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The map label for this gene is dctB [H]

Identifier: 66047221

GI number: 66047221

Start: 4754002

End: 4755759

Strand: Direct

Name: dctB [H]

Synonym: Psyr_3994

Alternate gene names: 66047221

Gene position: 4754002-4755759 (Clockwise)

Preceding gene: 66047220

Following gene: 66047222

Centisome position: 78.02

GC content: 62.86

Gene sequence:

>1758_bases
ATGACGCTCAAGCATCGCTACTGGCGCATTACCCTGTACGTGCTGCTGATTCTGGCCGGTGCAGCCCTGTGCGCCGGGCT
CGCGATGCGTCAGGCGCAGCGTCACGCAATGTCTGAAGATGCCGCGCGTGCCGAAGGACAACTGGCACTGTATGCCAATA
CCCTGCACACCCTGATCGAGCGCTACCGCGCCCTGCCCTCCGTTCTGGCACTGGACCCGGAAATTCGTGCCGCGCTGAGC
GGCCCGGTAACCGGTGAAGTACAGAACGCACTCAACCTCAAGCTGGAAAAAATCAACAACGCGGCTCATTCGTCGACGCT
GGAGTTGCTCGACCTGCAGGGTCTGGCGATTGGCGCGAGCAACTGGCGCACGCCCAACAGCTATGTCGGTCACAACTACG
CTTTTCGACCCTACTTCCTGCAGACCCGCGCCAAGGGTACCGGGCGCTTTTATGCGGTCGGGGTGACCACCGGAATTCCG
GGGTACTTTCTGTCCAGCGCGGTGTTGAATGATACCGGTGGGTTCATGGGGGCGATGGTCGTCAAGCTGGAGTTCCCCAG
CCTCGAGCAGGAGTGGGATAAGGGCGGCGACCTGCTGCTGGTCAGCGATGAGAAAGGCATCGTGTTTATCGCCAATCAAC
CAGGCTGGCGCTATCGCGAGCTGCAGCCGATCTCGGTGGAAGACCGTGCCACCCTGTTGCGCACCCGCCAGTACGACAAG
CAGGTATTGTCACCGCTGCGCAGCCGGGTCATCGACAGCTTCAGCGAAAACAGCCATTTGAGCCGTGTCGACGGCCCGGA
CGGCACCACGGACTATCTCTGGCAGTCGCTGCCCCTTGCGGACGAGAACTGGACCCTGCACCTGTTGCGCAAGCCGCCCG
CGTCCAGCGAGGATGTGCGCAACGCAGGACTGGCCGCCGCAGGCATCTGGCTGGCGCTGGTATTTCTGAGCCTGTTTCTC
TATCAGCGCTGGCGACTGGCGCGATTGAGGGAGCGCAACCGGGATGAACTGGAGCGCCTGGTGCAAGAGCGCACACGCGA
TCTGCACACCGCGCAGGACGGTCTGGTGCAGTCGGCCAAACTCGCGGCGCTGGGGCAGATGTCGGCAGCGCTGGCCCACG
AAATCAACCAACCGCTGACCGCCCAGCGCATGCAGCTGGCGACCCTGCGACTGCTGCTCGATCAAGGCCGAATCGATGAA
GCCTGCAAAGCGCTGGTTCCCGTCGATCAGCAACTGACACGTATGGCCGCCTTGACCAGCCATTTGAAGACCTTCGCACG
CAAGAGCCCCAGCGGCCTGCGCGAGAGGCTGGACCTGGCCACGGTGGTCGATCAGGCCTTGCTGTTGCTCGACCCGCGCC
TGCGCGAGGAACACGTCGACTGCATCCTGCATCTGGCACGCCCGGCATGGGTGCGCGGCGACGCCATCCGCCTGGAGCAG
GTGCTGATAAACCTGCTGCGCAATGCACTGGACGCCATGCGCGAGTGCCGCTCCAGGCGCCTTGAAGTGCGTATCGACGC
CCTCGACAATCAGTGGCGGCTCAGCGTCAGGGACAACGGAAGCGGGATCGCTGCGGAAAATCTGCCCAGCATTTTCGATC
CGTTCTTCACCACCAAACCGGTAGGCGATGGTCTGGGCCTTGGCCTGGCGGTGTCGTACGCCATCATTCATGAACTGGGC
GGACAACTGACGGCGCAAAACCATGCGGACGGCGCCGAATTCTGGTTCAGCCTGCCCAACGACTTTCTGGAGGCCTGA

Upstream 100 bases:

>100_bases
TGTGAAAGAAGCGACCTTCAATCTGTTGTAACCCCTGCGCATGGCGCGTTCGTGAGCAGTCGCTCGGGAACGCGCCAACA
GGGTCCGATCAGGCTGCGAC

Downstream 100 bases:

>100_bases
CCCGGCATGTTGAATTCGGTCATCGTGGTAGACGACGAGGCGCCCATTCGGCAAGCCGTCGAACAATGGCTGACGCTGTC
GGGGTTCGAGGTGCAAGTCT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MTLKHRYWRITLYVLLILAGAALCAGLAMRQAQRHAMSEDAARAEGQLALYANTLHTLIERYRALPSVLALDPEIRAALS
GPVTGEVQNALNLKLEKINNAAHSSTLELLDLQGLAIGASNWRTPNSYVGHNYAFRPYFLQTRAKGTGRFYAVGVTTGIP
GYFLSSAVLNDTGGFMGAMVVKLEFPSLEQEWDKGGDLLLVSDEKGIVFIANQPGWRYRELQPISVEDRATLLRTRQYDK
QVLSPLRSRVIDSFSENSHLSRVDGPDGTTDYLWQSLPLADENWTLHLLRKPPASSEDVRNAGLAAAGIWLALVFLSLFL
YQRWRLARLRERNRDELERLVQERTRDLHTAQDGLVQSAKLAALGQMSAALAHEINQPLTAQRMQLATLRLLLDQGRIDE
ACKALVPVDQQLTRMAALTSHLKTFARKSPSGLRERLDLATVVDQALLLLDPRLREEHVDCILHLARPAWVRGDAIRLEQ
VLINLLRNALDAMRECRSRRLEVRIDALDNQWRLSVRDNGSGIAAENLPSIFDPFFTTKPVGDGLGLGLAVSYAIIHELG
GQLTAQNHADGAEFWFSLPNDFLEA

Sequences:

>Translated_585_residues
MTLKHRYWRITLYVLLILAGAALCAGLAMRQAQRHAMSEDAARAEGQLALYANTLHTLIERYRALPSVLALDPEIRAALS
GPVTGEVQNALNLKLEKINNAAHSSTLELLDLQGLAIGASNWRTPNSYVGHNYAFRPYFLQTRAKGTGRFYAVGVTTGIP
GYFLSSAVLNDTGGFMGAMVVKLEFPSLEQEWDKGGDLLLVSDEKGIVFIANQPGWRYRELQPISVEDRATLLRTRQYDK
QVLSPLRSRVIDSFSENSHLSRVDGPDGTTDYLWQSLPLADENWTLHLLRKPPASSEDVRNAGLAAAGIWLALVFLSLFL
YQRWRLARLRERNRDELERLVQERTRDLHTAQDGLVQSAKLAALGQMSAALAHEINQPLTAQRMQLATLRLLLDQGRIDE
ACKALVPVDQQLTRMAALTSHLKTFARKSPSGLRERLDLATVVDQALLLLDPRLREEHVDCILHLARPAWVRGDAIRLEQ
VLINLLRNALDAMRECRSRRLEVRIDALDNQWRLSVRDNGSGIAAENLPSIFDPFFTTKPVGDGLGLGLAVSYAIIHELG
GQLTAQNHADGAEFWFSLPNDFLEA
>Mature_584_residues
TLKHRYWRITLYVLLILAGAALCAGLAMRQAQRHAMSEDAARAEGQLALYANTLHTLIERYRALPSVLALDPEIRAALSG
PVTGEVQNALNLKLEKINNAAHSSTLELLDLQGLAIGASNWRTPNSYVGHNYAFRPYFLQTRAKGTGRFYAVGVTTGIPG
YFLSSAVLNDTGGFMGAMVVKLEFPSLEQEWDKGGDLLLVSDEKGIVFIANQPGWRYRELQPISVEDRATLLRTRQYDKQ
VLSPLRSRVIDSFSENSHLSRVDGPDGTTDYLWQSLPLADENWTLHLLRKPPASSEDVRNAGLAAAGIWLALVFLSLFLY
QRWRLARLRERNRDELERLVQERTRDLHTAQDGLVQSAKLAALGQMSAALAHEINQPLTAQRMQLATLRLLLDQGRIDEA
CKALVPVDQQLTRMAALTSHLKTFARKSPSGLRERLDLATVVDQALLLLDPRLREEHVDCILHLARPAWVRGDAIRLEQV
LINLLRNALDAMRECRSRRLEVRIDALDNQWRLSVRDNGSGIAAENLPSIFDPFFTTKPVGDGLGLGLAVSYAIIHELGG
QLTAQNHADGAEFWFSLPNDFLEA

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=234, Percent_Identity=33.7606837606838, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790436, Length=279, Percent_Identity=30.8243727598566, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786783, Length=258, Percent_Identity=28.2945736434109, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=221, Percent_Identity=33.4841628959276, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=265, Percent_Identity=27.9245283018868, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=31.1688311688312, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65267; Mature: 65135

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKHRYWRITLYVLLILAGAALCAGLAMRQAQRHAMSEDAARAEGQLALYANTLHTLIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RYRALPSVLALDPEIRAALSGPVTGEVQNALNLKLEKINNAAHSSTLELLDLQGLAIGAS
HHHHCHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCC
NWRTPNSYVGHNYAFRPYFLQTRAKGTGRFYAVGVTTGIPGYFLSSAVLNDTGGFMGAMV
CCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEE
VKLEFPSLEQEWDKGGDLLLVSDEKGIVFIANQPGWRYRELQPISVEDRATLLRTRQYDK
EEEECCCCHHHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
QVLSPLRSRVIDSFSENSHLSRVDGPDGTTDYLWQSLPLADENWTLHLLRKPPASSEDVR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCHHHH
NAGLAAAGIWLALVFLSLFLYQRWRLARLRERNRDELERLVQERTRDLHTAQDGLVQSAK
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAALGQMSAALAHEINQPLTAQRMQLATLRLLLDQGRIDEACKALVPVDQQLTRMAALTS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHH
HLKTFARKSPSGLRERLDLATVVDQALLLLDPRLREEHVDCILHLARPAWVRGDAIRLEQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VLINLLRNALDAMRECRSRRLEVRIDALDNQWRLSVRDNGSGIAAENLPSIFDPFFTTKP
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCHHCCCHHHCCCCCCCC
VGDGLGLGLAVSYAIIHELGGQLTAQNHADGAEFWFSLPNDFLEA
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCHHHHCC
>Mature Secondary Structure 
TLKHRYWRITLYVLLILAGAALCAGLAMRQAQRHAMSEDAARAEGQLALYANTLHTLIE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
RYRALPSVLALDPEIRAALSGPVTGEVQNALNLKLEKINNAAHSSTLELLDLQGLAIGAS
HHHHCHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCC
NWRTPNSYVGHNYAFRPYFLQTRAKGTGRFYAVGVTTGIPGYFLSSAVLNDTGGFMGAMV
CCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEE
VKLEFPSLEQEWDKGGDLLLVSDEKGIVFIANQPGWRYRELQPISVEDRATLLRTRQYDK
EEEECCCCHHHHCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
QVLSPLRSRVIDSFSENSHLSRVDGPDGTTDYLWQSLPLADENWTLHLLRKPPASSEDVR
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCHHHH
NAGLAAAGIWLALVFLSLFLYQRWRLARLRERNRDELERLVQERTRDLHTAQDGLVQSAK
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAALGQMSAALAHEINQPLTAQRMQLATLRLLLDQGRIDEACKALVPVDQQLTRMAALTS
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHH
HLKTFARKSPSGLRERLDLATVVDQALLLLDPRLREEHVDCILHLARPAWVRGDAIRLEQ
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VLINLLRNALDAMRECRSRRLEVRIDALDNQWRLSVRDNGSGIAAENLPSIFDPFFTTKP
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCHHCCCHHHCCCCCCCC
VGDGLGLGLAVSYAIIHELGGQLTAQNHADGAEFWFSLPNDFLEA
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]